Published in Nat Genet on May 17, 2009
Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol (2009) 4.41
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol (2010) 2.91
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
How does Lin28 let-7 control development and disease? Trends Cell Biol (2012) 2.09
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Res (2011) 1.64
Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases. Genet Epidemiol (2011) 1.57
A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet (2013) 1.50
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. J Gerontol A Biol Sci Med Sci (2012) 1.49
The timing of the age at which natural menopause occurs. Obstet Gynecol Clin North Am (2011) 1.45
Genetic modification of the association between peripubertal dioxin exposure and pubertal onset in a cohort of Russian boys. Environ Health Perspect (2012) 1.39
Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem (2010) 1.38
Distinct variants at LIN28B influence growth in height from birth to adulthood. Am J Hum Genet (2010) 1.37
Genetics of reproductive lifespan. Nat Genet (2009) 1.34
A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure. Am J Hum Genet (2010) 1.32
Genome-wide association analysis for multiple continuous secondary phenotypes. Am J Hum Genet (2013) 1.29
BR-squared: a practical solution to the winner's curse in genome-wide scans. Hum Genet (2011) 1.28
A large-scale candidate gene association study of age at menarche and age at natural menopause. Hum Genet (2010) 1.22
Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course. J Clin Endocrinol Metab (2010) 1.21
Environmental epigenetics: a role in endocrine disease? J Mol Endocrinol (2012) 1.20
miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. Dev Dyn (2010) 1.14
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet (2010) 1.10
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (2013) 1.09
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer. J Biol Chem (2012) 1.08
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study. Hum Mol Genet (2011) 1.07
Genetic determinants of pubertal timing in the general population. Mol Cell Endocrinol (2010) 1.07
Human fertility, molecular genetics, and natural selection in modern societies. PLoS One (2015) 1.05
The ageing ovary and uterus: new biological insights. Hum Reprod Update (2012) 1.04
Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Reprod (2013) 1.03
Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology (2013) 1.02
Association weight matrix for the genetic dissection of puberty in beef cattle. Proc Natl Acad Sci U S A (2010) 1.01
LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood (2013) 1.00
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol (2013) 0.98
9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev (2012) 0.95
Genomic markers of ovarian reserve. Semin Reprod Med (2013) 0.94
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet (2014) 0.94
Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. Am J Epidemiol (2013) 0.93
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLoS One (2013) 0.93
Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities. Hum Genet (2012) 0.92
Second to fourth digit ratio: a predictor of adult penile length. Asian J Androl (2011) 0.91
LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty. BMC Res Notes (2011) 0.91
The transcriptional control of female puberty. Brain Res (2010) 0.90
DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density. Oncotarget (2015) 0.89
Lin28a regulates germ cell pool size and fertility. Stem Cells (2013) 0.88
Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet (2014) 0.88
The genetics of bone loss: challenges and prospects. J Clin Endocrinol Metab (2011) 0.88
Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies. Sci Rep (2015) 0.87
Association of LIN28B with adult adiposity-related traits in females. PLoS One (2012) 0.87
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun (2015) 0.87
Reproductive aging-associated common genetic variants and the risk of breast cancer. Breast Cancer Res (2012) 0.87
A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals. Front Endocrinol (Lausanne) (2012) 0.87
ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure. Orphanet J Rare Dis (2012) 0.86
Interactions between genetic variants in AMH and AMHR2 may modify age at natural menopause. PLoS One (2013) 0.86
Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study. Front Genet (2014) 0.86
Genome wide association study of age at menarche in the Japanese population. PLoS One (2013) 0.85
Genome-wide association study of age at menarche in African-American women. Hum Mol Genet (2013) 0.85
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk. Gynecol Oncol (2010) 0.84
Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr (2012) 0.84
A new pathway in the control of the initiation of puberty: the MKRN3 gene. J Mol Endocrinol (2015) 0.83
Investigating the role of X chromosome breakpoints in premature ovarian failure. Mol Cytogenet (2012) 0.83
The Biodemography of Fertility: A Review and Future Research Frontiers. Kolner Z Soz Sozpsychol (2015) 0.83
LIN28A expression reduces sickling of cultured human erythrocytes. PLoS One (2014) 0.82
A LIN28B polymorphism predicts for colon cancer survival. Cancer Biol Ther (2012) 0.82
Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency. Mol Cell Endocrinol (2012) 0.82
Neuroendocrine control of the onset of puberty. Front Neuroendocrinol (2015) 0.81
The future for genetic studies in reproduction. Mol Hum Reprod (2013) 0.81
ApoE genotypes are associated with age at natural menopause in Chinese females. Age (Dordr) (2011) 0.81
Evaluating GWAS-identified SNPs for age at natural menopause among chinese women. PLoS One (2013) 0.81
Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts. PLoS One (2015) 0.80
Evaluation of GWAS-identified genetic variants for age at menarche among Chinese women. Hum Reprod (2013) 0.80
Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins. Immunol Rev (2013) 0.80
A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates. Horm Behav (2013) 0.80
Age at menarche and risk of colorectal cancer: a meta-analysis. PLoS One (2013) 0.80
Digit ratio and autism spectrum disorders in the Avon Longitudinal Study of Parents and Children: a birth cohort study. BMJ Open (2015) 0.80
Associations between menarche-related genetic variants and pubertal growth in male and female adolescents. J Adolesc Health (2014) 0.79
A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates. Endocrinology (2011) 0.79
Ovarian aging and premature ovarian failure. J Turk Ger Gynecol Assoc (2014) 0.79
LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls. Korean J Pediatr (2012) 0.79
Pubertal development and regulation. Lancet Diabetes Endocrinol (2016) 0.79
Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Eur J Cancer (2014) 0.78
Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice. Biol Reprod (2013) 0.78
Replication of LIN28B SNP association with age of menarche in young Filipino women. Pediatr Obes (2013) 0.78
Migraine and the menopausal transition. Neurol Sci (2014) 0.78
Molecular insights into the aetiology of female reproductive ageing. Nat Rev Endocrinol (2015) 0.78
Dynamics of the ovarian reserve and impact of genetic and epidemiological factors on age of menopause. Biol Reprod (2015) 0.78
Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. J Pediatr Endocrinol Metab (2012) 0.78
Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women. BMC Womens Health (2015) 0.78
The genetics of premature ovarian failure: current perspectives. Int J Womens Health (2015) 0.77
Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan. Cancer Epidemiol (2013) 0.77
Genome-wide copy number variation association analyses for age at menarche. J Clin Endocrinol Metab (2012) 0.77
Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice. Mol Cell Endocrinol (2012) 0.77
Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell (2016) 0.76
Testicular expression of the Lin28/let-7 system: Hormonal regulation and changes during postnatal maturation and after manipulations of puberty. Sci Rep (2015) 0.76
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume. Hum Reprod (2015) 0.76
No relationship between most polymorphisms of steroidogenic acute regulatory (StAR) gene with polycystic ovarian syndrome. Int J Reprod Biomed (Yazd) (2015) 0.76
Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk. Sci Rep (2015) 0.76
Transcript specificity in BDNF-regulated protein synthesis. Neuropharmacology (2013) 0.76
Differential Effects of Alcohol on Excitatory and Inhibitory Puberty-Related Peptides in the Basal Hypothalamus of the Female Rat. Alcohol Clin Exp Res (2015) 0.75
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Quantifying heterogeneity in a meta-analysis. Stat Med (2002) 83.16
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet (2006) 17.36
Replicating genotype-phenotype associations. Nature (2007) 16.11
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev (2002) 5.34
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet (2008) 4.31
The variability of female reproductive ageing. Hum Reprod Update (2002) 3.52
The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Cancer Res (2007) 2.43
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Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol (2006) 1.60
SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron (2006) 1.46
Relationships of age at menarche and menopause, and reproductive year with mortality from cardiovascular disease in Japanese postmenopausal women: the JACC study. J Epidemiol (2006) 1.38
A genome-wide linkage scan for age at menarche in three populations of European descent. J Clin Endocrinol Metab (2008) 1.19
Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche. J Clin Endocrinol Metab (2006) 1.16
Genetic basis of human female pelvic morphology: a twin study. Am J Phys Anthropol (2002) 1.11
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Genome-wide linkage analysis to age at natural menopause in a community-based sample: the Framingham Heart Study. Fertil Steril (2005) 1.08
Reproductive factors in breast cancer epidemiology. Acta Oncol (1992) 1.07
Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative trait loci influencing variation in human menopausal age. Am J Hum Genet (2004) 1.04
Weight-adjusted genome scan analysis for mapping quantitative trait Loci for menarchal age. J Clin Endocrinol Metab (2006) 1.03
Menstrual and reproductive factors and fracture risk: the Leisure World Cohort Study. J Womens Health (Larchmt) (2005) 0.97
Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. J Genet (2007) 0.95
Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. Microsc Res Tech (2008) 0.93
Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. Hum Genet (2008) 0.91
Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. Clin Endocrinol (Oxf) (2007) 0.83
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Inflammation and atherosclerosis. Circulation (2002) 20.77
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68
Progress and challenges in translating the biology of atherosclerosis. Nature (2011) 9.41
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet (2010) 9.07
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61
Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med (2008) 8.40
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
The Nurses' Health Study: lifestyle and health among women. Nat Rev Cancer (2005) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med (2009) 7.62
Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32
Genetic risk prediction--are we there yet? N Engl J Med (2009) 7.30
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
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Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Insulin-like growth factors and neoplasia. Nat Rev Cancer (2004) 6.29
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16