Published in Genes Dev on May 15, 2009
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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
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Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66
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The circadian molecular clock creates epidermal stem cell heterogeneity. Nature (2011) 2.34
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The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev (2010) 1.62
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The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05
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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS One (2012) 1.02
p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation. PLoS One (2011) 1.00
Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. Mol Pharmacol (2011) 0.99
Ras-induced senescence and its physiological relevance in cancer. Curr Cancer Drug Targets (2010) 0.99
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS One (2011) 0.98
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. Cell Cycle (2014) 0.97
Expression and significance of histone H3K27 demethylases in renal cell carcinoma. BMC Cancer (2012) 0.97
Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. PLoS Genet (2014) 0.97
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Novel ARF/p53-independent senescence pathways in cancer repression. J Mol Med (Berl) (2011) 0.95
KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet (2014) 0.95
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Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest (2013) 0.92
EBV finds a polycomb-mediated, epigenetic solution to the problem of oncogenic stress responses triggered by infection. Front Genet (2013) 0.91
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation. Nat Commun (2014) 0.91
ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. J Biol Chem (2012) 0.91
Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. Genome Biol (2014) 0.90
Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration. Hear Res (2012) 0.89
Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryot Cell (2012) 0.89
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes Dev (2014) 0.89
Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation. EMBO J (2013) 0.89
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Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape. Cell Rep (2015) 0.87
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Chromatin remodeling in cancer: a gateway to regulate gene transcription. Mol Oncol (2012) 0.86
The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res (2015) 0.86
MLL1 is essential for the senescence-associated secretory phenotype. Genes Dev (2016) 0.85
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev (2016) 0.85
A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nat Commun (2015) 0.84
The nuclear receptor NR2E1/TLX controls senescence. Oncogene (2014) 0.83
Chromatin remodeling, DNA damage repair and aging. Curr Genomics (2012) 0.82
Cell cycle progression in response to oxygen levels. Cell Mol Life Sci (2014) 0.82
DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells. J Biol Chem (2014) 0.82
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Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence. Cancer Res (2011) 0.80
The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated. Epigenetics (2014) 0.80
Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development. Epigenetics (2012) 0.79
Human papillomavirus carcinogenesis: an identity crisis in the retinoblastoma tumor suppressor pathway. J Virol (2015) 0.79
H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts. PLoS One (2013) 0.79
Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta (2014) 0.79
Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved. Oncotarget (2014) 0.79
Tumor suppression by the histone demethylase UTX. Cell Cycle (2010) 0.78
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JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein. Cell Death Differ (2015) 0.78
Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility. Semin Immunol (2011) 0.78
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers. Cancer Biol Ther (2012) 0.78
Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs. Haematologica (2016) 0.77
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging Dis (2016) 0.77
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). Aging Cell (2015) 0.77
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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell (2008) 7.65
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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
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A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature (2007) 4.33
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Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev (2008) 3.32
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A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol (2011) 1.35
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Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell (2005) 1.34
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc Natl Acad Sci U S A (2012) 1.33
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Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res (2005) 1.30
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Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J (2010) 1.28
G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. J Biol Chem (2008) 1.28
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem (2008) 1.26
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Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol (2006) 1.25
Contribution of p16(INK4a) to replicative senescence of human fibroblasts. Exp Cell Res (2004) 1.22
DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells. Mol Cell (2011) 1.21
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Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc (2005) 1.18
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18
Control of senescence by CXCR2 and its ligands. Cell Cycle (2008) 1.17
Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J Biol Chem (2004) 1.16
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. J Natl Cancer Inst (2003) 1.16
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol Cell Biol (2007) 1.16