Published in AAPS J on May 20, 2009
International Conference on Harmonisation; guidance on Q6A specifications: test procedures and acceptance criteria for new drug substances and new drug products: chemical substances. Notice. Fed Regist (2000) 2.45
Predicting the impact of physiological and biochemical processes on oral drug bioavailability. Adv Drug Deliv Rev (2001) 1.90
A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol (2002) 1.85
Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities. J Pharm Sci (2004) 1.43
Application of the biopharmaceutical classification system in clinical drug development--an industrial view. AAPS J (2008) 1.31
Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds. AAPS J (2008) 1.05
Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine. Clin Pharmacokinet (2006) 0.95
A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer), a new intravenous iron preparation and its clinical implications. Eur J Pharm Biopharm (2011) 1.61
Determination of cell survival after irradiation via clonogenic assay versus multiple MTT Assay--a comparative study. Radiat Oncol (2012) 1.20
Transfer of lipophilic markers from PLGA and polystyrene nanoparticles to caco-2 monolayers mimics particle uptake. Pharm Res (2002) 1.12
Application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds. AAPS J (2008) 1.05
Influence of mechanical activation on the physical stability of salbutamol sulphate. Eur J Pharm Biopharm (2003) 1.01
Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther (2009) 0.92
Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability. Biopharm Drug Dispos (2008) 0.91
Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol (2004) 0.90
Caki-1 cells as a model system for the interaction of renally secreted drugs with OCT3. Nephron Physiol (2008) 0.88
In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect. Pharm Res (2006) 0.87
Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation. Mol Pharm (2009) 0.87
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT? Eur J Pharm Sci (2005) 0.86
UV exposure boosts transcutaneous immunization and improves tumor immunity: cytotoxic T-cell priming through the skin. J Invest Dermatol (2010) 0.85
Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. Br J Nutr (2011) 0.84
Regulatory T cells and IL-10 independently counterregulate cytotoxic T lymphocyte responses induced by transcutaneous immunization. PLoS One (2011) 0.84
Effects of controlled-release on the pharmacokinetics and absorption characteristics of a compound undergoing intestinal efflux in humans. Eur J Pharm Sci (2006) 0.83
Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). Pharm Res (2008) 0.83
In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen. Biopharm Drug Dispos (2012) 0.82
Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs. Eur J Pharm Sci (2009) 0.82
IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system. J Pharm Sci (2009) 0.81
Iron oxide/hydroxide nanoparticles with negatively charged shells show increased uptake in Caco-2 cells. Mol Pharm (2012) 0.80
Caki-1 cells represent an in vitro model system for studying the human proximal tubule epithelium. Nephron Exp Nephrol (2007) 0.80
High-performance liquid chromatography of lactose with evaporative light scattering detection, applied to determine fine particle dose of carrier in dry powder inhalation products. J Chromatogr A (2006) 0.80
Conditioning following powder micronization: influence on particle growth of salbutamol sulfate. Drug Dev Ind Pharm (2003) 0.79
Bidirectional membrane transport: simulations of transport inhibition in uptake studies explain data obtained with flavonoids. Eur J Pharm Sci (2006) 0.79
IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics. J Pharm Sci (2010) 0.79
Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport. Drug Metab Pharmacokinet (2006) 0.79
Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. Pharm Res (2008) 0.79
Force control and powder dispersibility of spray dried particles for inhalation. J Pharm Sci (2010) 0.79
Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen. J Pharm Sci (2012) 0.79
Investigation of various shellac grades: additional analysis for identity. Drug Dev Ind Pharm (2009) 0.79
How does the benzamide antipsychotic amisulpride get into the brain?--An in vitro approach comparing amisulpride with clozapine. Neuropsychopharmacology (2003) 0.78
Hemin-coupled iron(III)-hydroxide nanoparticles show increased uptake in Caco-2 cells. J Pharm Pharmacol (2011) 0.78
Hyperbranched polyglycerol-based lipids via oxyanionic polymerization: toward multifunctional stealth liposomes. Biomacromolecules (2010) 0.78
Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride. Mol Pharm (2013) 0.78
Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. Planta Med (2006) 0.78
Biowaiver monographs for immediate release solid oral dosage forms: efavirenz. J Pharm Sci (2012) 0.78
Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Biopharm Drug Dispos (2012) 0.78
Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms. Mol Pharm (2013) 0.78
Transport processes of radiopharmaceuticals and -modulators. Radiat Oncol (2011) 0.78
Lipophilicities of baclofen ester prodrugs correlate with affinities to the ATP-dependent efflux pump P-glycoprotein: relevance for their permeation across the blood-brain barrier? Pharm Res (2003) 0.78
OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol Pharm (2007) 0.78
Comparative toxicity and cell-tissue distribution study on nanoparticular iron complexes using avian embryos and HepG2-cells. Transl Res (2007) 0.77
Comparative transcutaneous immunization with imiquimod-containing ointments and potential of in vitro methods to predict effects. Biopharm Drug Dispos (2012) 0.77
CE characterization of potential toxic labile iron in colloidal parenteral iron formulations using off-capillary and on-capillary complexation with EDTA. Electrophoresis (2007) 0.77
Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport. Mol Pharm (2005) 0.77
Liposome formation from bile salt-lipid micelles in the digestion and drug delivery model FaSSIF(mod) estimated by combined time-resolved neutron and dynamic light scattering. Mol Pharm (2011) 0.77
Different dissolution media lead to different crystal structures of talinolol with impact on its dissolution and solubility. Drug Dev Ind Pharm (2003) 0.77
Influence of blister package design on usability among older adults. Int J Clin Pharm (2012) 0.77
Predicting the in vivo release from a liposomal formulation by IVIVC and non-invasive positron emission tomography imaging. Eur J Pharm Sci (2010) 0.77
The impact of the EMA change in definition of "dose" on the BCS dose-solubility ratio: a review of the biowaiver monographs. J Pharm Sci (2013) 0.77
Effect of interactive ternary mixtures on dispersion characteristics of ipratropium bromide in dry powder inhaler formulations. AAPS PharmSciTech (2007) 0.76
The Influence of Chitosan on the Oral Bioavailability of Acyclovir--a Comparative Bioavailability Study in Humans. Pharm Res (2015) 0.75
Risk analysis in bioequivalence and biowaiver decisions. Biopharm Drug Dispos (2013) 0.75
"Incorporation of mRNA in lamellar lipid matrices for parenteral administration". Mol Pharm (2017) 0.75
Biowaiver monograph for immediate-release solid oral dosage forms: fluconazole. J Pharm Sci (2014) 0.75
Quantitation of talinolol in rat plasma by LC-MS-MS. J Chromatogr Sci (2010) 0.75
In vitro assessment of intestinal IGF-I stability. J Pharm Sci (2002) 0.75
Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid. J Pharm Sci (2012) 0.75
Dose determination using alanine detectors in a mixed neutron and gamma field for boron neutron capture therapy of liver malignancies. Acta Oncol (2011) 0.75
Role of continuous moisture profile monitoring by inline NIR spectroscopy during fluid bed granulation of an Enalapril formulation. Drug Dev Ind Pharm (2010) 0.75
Relationships between in vitro drug dissolution and in vivo response. Biopharm Drug Dispos (2012) 0.75
Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate. J Pharm Sci (2014) 0.75
Partially quarternized amino functional poly(methacrylate) terpolymers: versatile drug permeability modifiers. Biomacromolecules (2010) 0.75
Comparison of quantitative analysis techniques for the determination of heat seal lacquer layers on aluminum blister foils. Eur J Pharm Sci (2010) 0.75
Improvement of trospium-specific absorption models for fasted and fed states in humans. Biopharm Drug Dispos (2014) 0.75
Influences of heat seal lacquer thickness on the quality of blister packages. Eur J Pharm Sci (2011) 0.75
Biowaiver monographs for immediate release solid oral dosage forms: piroxicam. J Pharm Sci (2013) 0.75
Improvement of the wettability and dissolution of fenofibrate compacts by plasma treatment. Int J Pharm (2011) 0.75
Biowaiver monographs for immediate-release solid oral dosage forms: Zidovudine (azidothymidine). J Pharm Sci (2013) 0.75
In vivo predictive release methods for medicated chewing gums. Biopharm Drug Dispos (2012) 0.75
Editorial: in memoriam Dr. Marcus Brewster. J Pharm Sci (2014) 0.75
Compromised integrity of excised porcine intestinal epithelium obtained from the abattoir affects the outcome of in vitro particle uptake studies. Eur J Pharm Sci (2002) 0.75
dsRNA-functionalized multifunctional gamma-Fe2O3 nanocrystals: a tool for targeting cell surface receptors. Angew Chem Int Ed Engl (2008) 0.75
Biowaiver monograph for immediate-release solid oral dosage forms: bisoprolol fumarate. J Pharm Sci (2013) 0.75
Evaluation of drug-polymer solubility curves through formal statistical analysis: comparison of preparation techniques. J Pharm Sci (2014) 0.75
Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration. Xenobiotica (2011) 0.75
Characterization of the epithelial permeation enhancing effect of basic butylated methacrylate copolymer--in vitro studies. Biomacromolecules (2008) 0.75