Plasticity of CD4+ T cell lineage differentiation.

PubWeight™: 8.08‹?› | Rank: Top 0.1%

🔗 View Article (PMID 19464987)

Published in Immunity on May 01, 2009

Authors

Liang Zhou1, Mark M W Chong, Dan R Littman

Author Affiliations

1: The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

Articles citing this

(truncated to the top 100)

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50

Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10

Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science (2010) 6.06

Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98

Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature (2014) 5.22

Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med (2011) 4.83

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97

Diversity and dialogue in immunity to helminths. Nat Rev Immunol (2011) 3.72

Organization of immunological memory by bone marrow stroma. Nat Rev Immunol (2010) 3.57

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity (2009) 3.51

IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest (2009) 3.30

Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity (2010) 3.27

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol (2009) 3.19

Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol (2010) 3.12

Biology of interleukin-22. Semin Immunopathol (2010) 2.92

Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A (2010) 2.88

Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One (2011) 2.84

High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci U S A (2010) 2.74

Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70

Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol (2009) 2.65

In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol (2010) 2.63

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med (2012) 2.62

Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity (2009) 2.51

Metabolic checkpoints in activated T cells. Nat Immunol (2012) 2.47

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity. Cancer Metastasis Rev (2010) 2.41

The immune system and the gut microbiota: friends or foes? Nat Rev Immunol (2010) 2.38

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol (2012) 2.37

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study. Am J Clin Nutr (2013) 2.20

The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol (2010) 2.11

Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat Biotechnol (2014) 2.10

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation. Nat Med (2010) 2.10

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol (2017) 2.02

Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A (2011) 2.00

Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99

Regulation of human Th9 differentiation by type I interferons and IL-21. Immunol Cell Biol (2010) 1.99

New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol (2009) 1.92

Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med (2010) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions. MAbs (2010) 1.86

Dry eye as a mucosal autoimmune disease. Int Rev Immunol (2013) 1.85

Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol (2015) 1.82

MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75

The functional plasticity of T cell subsets. Nat Rev Immunol (2009) 1.74

Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity (2011) 1.72

Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol (2013) 1.71

Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J Exp Med (2010) 1.70

Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol (2010) 1.67

Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal (2010) 1.66

Targeting regulatory T cells in cancer. Cancer Res (2011) 1.66

CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. J Immunol (2010) 1.62

Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res (2011) 1.62

Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol (2014) 1.61

STAT6-dependent regulation of Th9 development. J Immunol (2011) 1.60

The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med (2011) 1.60

Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol (2015) 1.57

Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets. Nat Rev Cardiol (2011) 1.57

Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol (2009) 1.52

Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunity. Front Immunol (2012) 1.51

Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J Immunol (2010) 1.48

CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J Mol Cell Biol (2011) 1.45

TOR in the immune system. Curr Opin Cell Biol (2011) 1.44

Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges. AIDS (2014) 1.41

The potential of CD4 T-cell memory. Immunology (2010) 1.40

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest (2010) 1.40

Harnessing CD4⁺ T cell responses in HIV vaccine development. Nat Med (2013) 1.39

Pathogenesis of chagas' disease: parasite persistence and autoimmunity. Clin Microbiol Rev (2011) 1.38

Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36

Immunopathology of inflammatory bowel disease. World J Gastroenterol (2014) 1.36

CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol (2011) 1.36

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proc Natl Acad Sci U S A (2010) 1.36

Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol (2009) 1.33

Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol (2011) 1.32

Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype. J Exp Med (2012) 1.32

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A (2012) 1.30

Role of regulatory T cells during virus infection. Immunol Rev (2013) 1.28

Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer (2010) 1.28

Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity (2013) 1.27

Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells. J Exp Med (2011) 1.27

Metabolic control of the Treg/Th17 axis. Immunol Rev (2013) 1.26

Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.26

Biomimetic delivery with micro- and nanoparticles. Adv Mater (2012) 1.25

Plasticity of human CD4 T cell subsets. Front Immunol (2014) 1.25

The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol (2013) 1.24

Intestinal effector T cells in health and disease. Immunity (2009) 1.24

Peripherally induced tregs - role in immune homeostasis and autoimmunity. Front Immunol (2013) 1.24

Clinical perspectives for regulatory T cells in transplantation tolerance. Semin Immunol (2011) 1.23

Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biol (2010) 1.22

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease. Cell Mol Immunol (2010) 1.21

Phenotypic and functional characteristics of CD4+ CD39+ FOXP3+ and CD4+ CD39+ FOXP3neg T-cell subsets in cancer patients. Eur J Immunol (2012) 1.21

IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol (2012) 1.21

Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. J Biomed Sci (2011) 1.20

Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation. Immunity (2009) 1.20

Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis. PLoS One (2012) 1.20

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.20

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood (2015) 1.18

Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol (2010) 1.18

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol (2012) 1.18

IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol (2010) 1.17

Articles by these authors

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08

Interactions between the microbiota and the immune system. Science (2012) 10.45

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med (2006) 6.86

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity (2002) 4.62

Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A (2009) 4.10

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86

PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86

The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology (2008) 3.13

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature (2013) 2.95

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol (2008) 2.93

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84

Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity (2005) 2.72

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med (2008) 2.60

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (2004) 2.54

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54

Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol (2003) 2.51

Nuclear hormone receptors in T lymphocytes. Cell (2002) 2.51

RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol (2009) 2.49

Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39

The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol (2015) 2.26

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol (2008) 2.19

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity (2009) 2.15

The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med (2004) 2.14

Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell (2010) 2.09

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (2013) 2.03

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology (2010) 1.92

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J Exp Med (2004) 1.88

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem (2004) 1.85

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82

The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev (2003) 1.82

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. J Exp Med (2011) 1.82

Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev (2010) 1.67

A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. J Neurosci (2003) 1.61

Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. Gastroenterology (2011) 1.61

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med (2009) 1.57

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol (2005) 1.57

Modulation of immune homeostasis by commensal bacteria. Curr Opin Microbiol (2011) 1.57

Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection. J Infect Dis (2010) 1.52

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion. J Biol Chem (2004) 1.49

Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J Immunol (2005) 1.48

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. J Leukoc Biol (2012) 1.47

Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev (2005) 1.46

Species-specific restriction of apobec3-mediated hypermutation. J Virol (2007) 1.46

Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity (2002) 1.44

CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol (2005) 1.44

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell (2002) 1.43

CXCR4 acts as a costimulator during thymic beta-selection. Nat Immunol (2009) 1.42

Harnessing CD4⁺ T cell responses in HIV vaccine development. Nat Med (2013) 1.39

Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN. J Virol (2006) 1.38

Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev (2010) 1.37

Hiding in plain sight: how HIV evades innate immune responses. Cell (2011) 1.37

Myd88 is required for an antibody response to retroviral infection. PLoS Pathog (2009) 1.35