Published in Exp Hematol on May 27, 2009
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood (2012) 1.00
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem (2011) 0.95
Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. J Biol Chem (2012) 0.94
BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget (2015) 0.85
Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PLoS One (2012) 0.85
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. Blood (2016) 0.84
FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia. Oncotarget (2016) 0.81
Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML. Oncogene (2016) 0.78
Disease diversity and FLT3 mutations. Proc Natl Acad Sci U S A (2013) 0.78
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases. Sci Signal (2015) 0.77
Expression of GADS enhances FLT3-induced mitogenic signaling. Oncotarget (2016) 0.77
Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. Oncotarget (2016) 0.77
A review of new agents evaluated against pediatric acute lymphoblastic leukemia by the Pediatric Preclinical Testing Program. Leukemia (2016) 0.76
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58
Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev (2012) 2.13
A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood (2009) 1.58
The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate. Eur Urol (2007) 1.46
p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med (2004) 1.42
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3. Cell Signal (2009) 1.40
Protein kinase C expression is deregulated in chronic lymphocytic leukemia. Leuk Lymphoma (2013) 1.40
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem (2004) 1.33
Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J (2006) 1.12
Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. Biochem Biophys Res Commun (2008) 1.10
Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J (2003) 1.10
Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy. Br J Haematol (2010) 1.09
Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res (2003) 1.09
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A (2012) 1.06
Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection. Plant Cell (2003) 1.06
Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome. Clin Cancer Res (2007) 1.06
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol (2002) 1.04
Src family kinases are involved in the differential signaling from two splice forms of c-Kit. J Biol Chem (2003) 1.02
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood (2012) 1.00
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem (2008) 0.99
Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem (2010) 0.98
Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res (2007) 0.97
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene (2002) 0.96
SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML. Blood (2012) 0.95
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem (2011) 0.95
Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. J Biol Chem (2012) 0.94
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation. Blood (2011) 0.94
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem (2004) 0.94
SOCS proteins in regulation of receptor tyrosine kinase signaling. Cell Mol Life Sci (2014) 0.93
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Mol Oncol (2012) 0.90
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Br J Haematol (2009) 0.90
Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem Biophys Res Commun (2011) 0.89
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. Biochim Biophys Acta (2003) 0.89
Identification of protein tyrosine phosphatases associating with the PDGF receptor. Biochemistry (2003) 0.89
SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. Tumour Biol (2014) 0.88
The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cell Signal (2013) 0.88
C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One (2011) 0.88
The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome. Exp Hematol (2013) 0.88
Ezrin is a substrate for Lck in T cells. FEBS Lett (2003) 0.88
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J (2003) 0.88
Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. Mol Oncol (2013) 0.87
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett (2012) 0.87
Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin. Exp Cell Res (2003) 0.87
Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res (2003) 0.86
Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PLoS One (2012) 0.85
Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling. J Cell Sci (2013) 0.84
The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem (2009) 0.84
HIF-2α expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1α is repressed. Am J Pathol (2011) 0.83
Enhanced SOX10 and KIT expression in cutaneous melanoma. Med Oncol (2013) 0.82
Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia. Med Oncol (2013) 0.82
FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL). Med Oncol (2013) 0.81
Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor. J Cell Physiol (2006) 0.81
Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cell Mol Life Sci (2015) 0.81
Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation. J Biol Chem (2013) 0.79
3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells. Ann Hematol (2011) 0.79
Keratin 19 expression correlates with poor prognosis in breast cancer. Mol Biol Rep (2014) 0.77
Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length. Cell Signal (2013) 0.77
Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice. Br J Haematol (2011) 0.77
The basic helix-loop-helix (bHLH) proteins in breast cancer progression. Med Oncol (2013) 0.77
Deregulation of protein phosphatase expression in acute myeloid leukemia. Med Oncol (2013) 0.76
Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes. Cell Signal (2002) 0.75
Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Br J Haematol (2006) 0.75
EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor. Int J Mol Med (2002) 0.75