Intestinal mucosal inflammation leads to systemic genotoxicity in mice.

PubWeight™: 1.90‹?› | Rank: Top 3%

🔗 View Article (PMC 2709766)

Published in Cancer Res on June 01, 2009

Authors

Aya M Westbrook1, Bo Wei, Jonathan Braun, Robert H Schiestl

Author Affiliations

1: Departments of Molecular Toxicology, University of California at Los Angeles School of Medicine and School of Public Health, Los Angeles, California 90095, USA.

Articles citing this

Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2010) 2.58

Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res (2009) 1.71

Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61

Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci (2013) 1.52

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. PLoS Genet (2011) 1.27

Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res (2010) 1.17

GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One (2012) 1.13

Intestinal inflammation and colorectal cancer: a double-edged sword? World J Gastroenterol (2011) 1.09

Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res (2010) 1.06

IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals. Oncogene (2011) 1.03

DNA repair is indispensable for survival after acute inflammation. J Clin Invest (2012) 0.96

Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect. Gut (2014) 0.94

The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol (2014) 0.94

Cancer in inflammatory bowel disease: lessons from animal models. Curr Opin Gastroenterol (2012) 0.93

Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity. Cancer Res (2013) 0.90

Innate inflammation and cancer: Is it time for cancer prevention? F1000 Med Rep (2011) 0.90

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One (2011) 0.88

Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice. Int J Cancer (2011) 0.87

Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease. Dig Dis Sci (2015) 0.85

Chemistry meets biology in colitis-associated carcinogenesis. Free Radic Res (2013) 0.83

Application of liposomes in drug development--focus on gastroenterological targets. Int J Nanomedicine (2013) 0.81

The role of tumour necrosis factor-α and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity. Mutagenesis (2011) 0.81

IL-13 overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood. Mutat Res (2014) 0.80

IL-1 in Colon Inflammation, Colon Carcinogenesis and Invasiveness of Colon Cancer. Cancer Microenviron (2015) 0.80

More damaging than we think: systemic effects of intestinal inflammation. Cell Cycle (2009) 0.79

Intestinal microbiome and lymphoma development. Cancer J (2014) 0.79

Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis. Cancer Biol Ther (2010) 0.78

Effects of side-stream tobacco smoke and smoke extract on glutathione- and oxidative DNA damage repair-deficient mice and blood cells. Mutat Res (2013) 0.77

Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies. Oncotarget (2015) 0.77

Lymphoma caused by intestinal microbiota. Int J Environ Res Public Health (2014) 0.76

Can stressed blood cells tell cancer risk in inflammatory bowel diseases? Gastroenterology (2009) 0.75

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. PLoS One (2016) 0.75

Interventional effects of plumbagin on experimental ulcerative colitis in mice. J Nat Prod (2013) 0.75

[Pathogenesis of colitis-associated neoplasms]. Pathologe (2012) 0.75

Articles cited by this

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell (2004) 15.82

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology (2004) 14.78

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology (1990) 11.22

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18

Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med (1990) 6.87

Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol (1998) 5.77

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest (2008) 5.26

The comet assay: a method to measure DNA damage in individual cells. Nat Protoc (2006) 5.11

Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology (1994) 4.57

Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis (2009) 3.32

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet (1995) 3.29

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med (2007) 3.27

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest (2008) 3.17

CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol (2003) 2.70

Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites. EMBO J (1997) 2.65

Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci (1993) 2.62

Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res (2004) 2.42

Cancer in inflammatory bowel disease. World J Gastroenterol (2008) 2.12

Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies. Leukemia (2003) 2.12

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology (2008) 2.06

Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med (2006) 2.03

Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut (1990) 1.99

Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther (2001) 1.97

Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation. Carcinogenesis (2000) 1.95

Polarized immune responses differentially regulate cancer development. Immunol Rev (2008) 1.95

Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol (2001) 1.58

Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. Am J Pathol (2005) 1.51

An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells. Nat Protoc (2008) 1.44

Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase. Carcinogenesis (2004) 1.25

Chromosomal aberrations: formation, identification and distribution. Mutat Res (2002) 1.22

In vivo rodent erythrocyte micronucleus assay. Mutat Res (1994) 1.22

Changes in bacterial phagocytosis of macrophages in experimental ulcerative colitis. Digestion (1995) 1.22

hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis (2006) 1.21

Cutting edge: transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer. J Immunol (2007) 1.21

DNA mismanagement leads to immune system oversight. Cell (2007) 1.12

Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. Cancer Res (2002) 1.02

Differential response to DNA damage may explain different cancer susceptibility between small and large intestine. Exp Biol Med (Maywood) (2005) 0.97

Absence of genotoxicity of the carcinogenic sulfated polysaccharides carrageenan and dextran sulfate in mammalian DNA repair and bacterial mutagenicity assays. Nutr Cancer (1984) 0.92

Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity. DNA Repair (Amst) (2006) 0.91

Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP. Int J Cancer (2008) 0.90

Proliferative effect of dextran sulfate sodium (DSS)-pulsed macrophages on T cells from mice with DSS-induced colitis and inhibition of effect by IgG. Scand J Immunol (1997) 0.89

Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation. Am J Physiol Gastrointest Liver Physiol (2008) 0.86

Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice. Cell Biol Toxicol (1986) 0.80

Articles by these authors

High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 5.62

FSH directly regulates bone mass. Cell (2006) 4.64

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med (2007) 3.27

Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology (2002) 3.21

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33

TNFalpha blockade in human diseases: mechanisms and future directions. Clin Immunol (2007) 2.17

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology (2012) 2.11

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology (2008) 2.06

Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.89

TNFalpha blockade in human diseases: an overview of efficacy and safety. Clin Immunol (2007) 1.85

Large-scale high-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.76

Abundant and diverse fungal microbiota in the murine intestine. Appl Environ Microbiol (2006) 1.76

Radiation-induced long-lived extracellular radicals do not contribute to measurement of intracellular reactive oxygen species using the dichlorofluorescein method. Radiat Res (2008) 1.71

Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A (2005) 1.71

Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res (2009) 1.71

A model for harmonizing flow cytometry in clinical trials. Nat Immunol (2010) 1.70

Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. Mol Cell Biol (2010) 1.61

Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A (2003) 1.60

A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network. Hum Pathol (2007) 1.59

The value of vesicant 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in gastric malignancies. Nucl Med Commun (2004) 1.54

Early microbial markers of celiac disease. J Clin Gastroenterol (2014) 1.48

Frozen competent yeast cells that can be transformed with high efficiency using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 1.48

MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J Biol Chem (2005) 1.47

Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia. J Virol (2011) 1.46

TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol (2009) 1.45

Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res (2004) 1.43

Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol (2010) 1.43

Small-for-size syndrome after living donor liver transplantation: successful treatment with a transjugular intrahepatic portosystemic shunt. Liver Transpl (2012) 1.41

MiRPara: a SVM-based software tool for prediction of most probable microRNA coding regions in genome scale sequences. BMC Bioinformatics (2011) 1.38

The effects of a semiconstrained integrated artificial disc on zygapophyseal joint pressure and displacement. Spine (Phila Pa 1976) (2014) 1.38

IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J Immunol (2011) 1.38

Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol Rev (2004) 1.34

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice. DNA Repair (Amst) (2006) 1.32

B cell developmental requirement for the G alpha i2 gene. J Immunol (2003) 1.31

Pseudomonas fluorescens encodes the Crohn's disease-associated I2 sequence and T-cell superantigen. Infect Immun (2002) 1.31

Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS One (2011) 1.30

New and emerging technologies for genetic toxicity testing. Environ Mol Mutagen (2010) 1.28

Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol (2008) 1.27

Quantitation of cell number by a positron emission tomography reporter gene strategy. Mol Imaging Biol (2004) 1.26

Systemic control of plasmacytoid dendritic cells by CD8+ T cells and commensal microbiota. J Immunol (2008) 1.24

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23

Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc (2009) 1.21

Evolutionary and functional study of the CDPK gene family in wheat (Triticum aestivum L.). Plant Mol Biol (2008) 1.20

Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res (2002) 1.18

Bacteria associated with immunoregulatory cells in mice. Appl Environ Microbiol (2009) 1.18

Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Cancer (2006) 1.18

Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res (2010) 1.17

Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res (2003) 1.17

The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem (2002) 1.16

Noninvasive diagnosis of cellular and antibody-mediated rejection by perforin and granzyme B in renal allografts. Hum Immunol (2006) 1.14

TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit. Int Immunol (2003) 1.13

The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. Mol Biol Cell (2004) 1.13

A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface. PLoS One (2011) 1.12

Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. Exp Mol Pathol (2003) 1.12

Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol (2005) 1.12

Factors influencing Chinese male's willingness to undergo circumcision: a cross-sectional study in western China. PLoS One (2012) 1.11

Laparoscopic versus open gastrectomy with D2 lymph node dissection for gastric cancer: a meta-analysis. Surg Laparosc Endosc Percutan Tech (2011) 1.10

Monitoring the antitumor response of naive and memory CD8 T cells in RAG1-/- mice by positron-emission tomography. J Immunol (2006) 1.09

Commensal microbiota alter the abundance and TCR responsiveness of splenic naïve CD4+ T lymphocytes. Clin Immunol (2005) 1.09

Definitive intensity-modulated radiation therapy for nasopharyngeal carcinoma: long-term outcome of a multicenter prospective study. J Cancer Res Clin Oncol (2012) 1.08

Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice. J Nutr (2007) 1.07

Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res (2010) 1.06

FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction. Invest Ophthalmol Vis Sci (2008) 1.06

A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease. PLoS One (2013) 1.06

Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics (2006) 1.05

siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat Res (2006) 1.05

Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol (2006) 1.04

Refinement of the dichlorofluorescein assay for flow cytometric measurement of reactive oxygen species in irradiated and bystander cell populations. Radiat Res (2008) 1.04

The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol (2003) 1.04

A meta-analysis of robotic versus laparoscopic gastrectomy for gastric cancer. Surg Endosc (2014) 1.03

Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway. Exp Eye Res (2007) 1.03

Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutant. Gene (2002) 1.03

Laparoscopy-assisted D2 radical distal gastrectomy for advanced gastric cancer. Dig Surg (2010) 1.03

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Res (2010) 1.02

Epidemiology of major depressive disorder in mainland china: a systematic review. PLoS One (2013) 1.02

Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis (2005) 1.01

Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.01

Transcriptome analysis of H2O2-treated wheat seedlings reveals a H2O2-responsive fatty acid desaturase gene participating in powdery mildew resistance. PLoS One (2011) 1.00

Serum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancer. ANZ J Surg (2011) 0.99

Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells. Eur J Immunol (2008) 0.99

Involvement of homologous recombination in carcinogenesis. Adv Genet (2007) 0.99

The tetraspan protein EMP2 regulates expression of caveolin-1. J Biol Chem (2007) 0.99

Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology (2008) 0.99

Microtiter plate transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc (2007) 0.98

The prognostic role of matrix metalloproteinase 2 in gastric cancer: a systematic review with meta-analysis. J Cancer Res Clin Oncol (2014) 0.98

Eph receptors and ephrins as targets for cancer therapy. J Cell Mol Med (2012) 0.98