The basics of epithelial-mesenchymal transition.

Immunity, inflammation, and cancer. Cell (2010) 28.27

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87

Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol (2014) 10.04

Biomarkers for epithelial-mesenchymal transitions. J Clin Invest (2009) 8.76

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15

Ovarian cancer development and metastasis. Am J Pathol (2010) 5.92

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell (2014) 5.87

MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol (2010) 5.44

Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44

Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med (2010) 4.88

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51

VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell (2012) 4.47

EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest (2009) 4.41

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature (2015) 4.18

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 4.11

The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? EMBO Rep (2010) 4.05

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02

Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98

Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93

New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature (2015) 3.77

Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS One (2012) 3.74

Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68

Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev (2013) 3.63

Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. Nat Med (2011) 3.60

To differentiate or not--routes towards metastasis. Nat Rev Cancer (2012) 3.59

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest (2012) 3.45

The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell (2010) 3.40

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol Cancer Res (2011) 3.25

Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell (2012) 3.19

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol (2014) 3.02

Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol (2011) 3.00

Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun (2013) 2.94

Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82

Circulating tumor cells as a window on metastasis biology in lung cancer. Am J Pathol (2011) 2.76

Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology (2010) 2.73

Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth (2013) 2.70

EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature (2013) 2.70

Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res (2014) 2.51

A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol (2011) 2.51

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev (2011) 2.48

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest (2011) 2.43

Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene (2011) 2.42

Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35

Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev (2012) 2.31

Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res (2011) 2.26

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol (2009) 2.25

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol (2009) 2.23

β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell (2011) 2.17

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer (2011) 2.14

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12

The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (2010) 2.12

Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med (2015) 2.12

ConceptGen: a gene set enrichment and gene set relation mapping tool. Bioinformatics (2009) 2.11

Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer (2011) 2.10

Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer (2014) 2.09

Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer. BJU Int (2016) 2.08

The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol (2010) 2.07

MicroRNAs in liver disease. Nat Rev Gastroenterol Hepatol (2013) 2.04

Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev (2010) 2.03

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest (2014) 2.01

Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res (2012) 2.00

Epithelial-to-mesenchymal transitions in the liver. Hepatology (2009) 1.99

The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. J Clin Invest (2010) 1.98

Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med (2011) 1.96

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria. Kidney Int (2011) 1.94

Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo. BMC Cancer (2011) 1.89

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities. Clin Cancer Res (2009) 1.88

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget (2010) 1.88

Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One (2010) 1.87

Implications and challenges of connexin connections to cancer. Nat Rev Cancer (2010) 1.85

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS One (2010) 1.83

Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 1.83

The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int (2011) 1.82

Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med (2010) 1.81

Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat Protoc (2014) 1.80

Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene (2010) 1.80

Regulated noise in the epigenetic landscape of development and disease. Cell (2012) 1.79

New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet (2012) 1.79

Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA. Cancer Discov (2014) 1.77

Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. Cell (2014) 1.76

Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res (2011) 1.74

TWIST1 promotes invasion through mesenchymal change in human glioblastoma. Mol Cancer (2010) 1.73

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res (2012) 1.73

IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res (2011) 1.73

Characterizing deformability and surface friction of cancer cells. Proc Natl Acad Sci U S A (2013) 1.72

Breast cancer - one term, many entities? J Clin Invest (2011) 1.72

MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell (2011) 1.71

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J (2011) 1.71

The hallmarks of cancer. Cell (2000) 113.05

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol (2008) 24.27

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev (2008) 15.01

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80

Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest (2003) 12.56

TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64

The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol (2006) 11.16

Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol (2003) 11.12

The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol (2002) 10.59

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell (2001) 10.02

TGF-beta and epithelial-to-mesenchymal transitions. Oncogene (2005) 10.02

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med (2007) 9.51

An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) (1995) 9.18

Biomarkers for epithelial-mesenchymal transitions. J Clin Invest (2009) 8.76

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 8.59

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A (2001) 7.99

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med (2003) 7.91

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A (2006) 7.08

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Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell (2008) 5.88

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev (1996) 5.71

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem (2007) 5.37

The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn (2005) 5.33

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24

Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med (2001) 5.22

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol (2002) 5.07

MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle (2008) 4.81

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The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64

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Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol (1998) 4.43

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20

E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04

A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol (2008) 4.00

Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96

FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell (2001) 3.73

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell (1996) 3.73

Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol (1997) 3.67

The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64

TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci (1999) 3.43

Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature (1996) 3.42

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Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell (1992) 3.37

Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int (2002) 3.16

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development (1997) 3.15

Early epochal maps of two different cell adhesion molecules. Proc Natl Acad Sci U S A (1983) 3.06

P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell (2006) 3.04

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem (2001) 3.04

Organogenesis: molecular mechanisms of tubulogenesis. Nat Rev Genet (2002) 2.94

Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell (2008) 2.78

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest (2003) 2.77

E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol (2001) 2.72

Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev (2005) 2.69

Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem (2007) 2.67

The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer (2008) 2.67

Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs (2005) 2.64

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev (2000) 2.62

Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int (2002) 2.50

TGF-beta signaling by Smad proteins. Adv Immunol (2000) 2.47

Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell (2008) 2.46

Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol (2000) 2.41

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J Cell Sci (2002) 2.32

Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol (2002) 2.31

Induction of the neural crest: a multigene process. Nat Rev Genet (2002) 2.26

Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell (2002) 2.24

Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol (2008) 2.21

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Renal Physiol (2003) 2.20

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest (2002) 2.15

Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem (2004) 2.13

Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol (2000) 2.12

Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol (2001) 2.12

Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J Cell Sci (2008) 2.09

Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs (2007) 1.95

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development (2008) 1.94

Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet (2003) 1.88

Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol (1987) 1.83

Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development. Development (1993) 1.83

Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development (2000) 1.77

Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition. Development (2004) 1.74

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. Carcinogenesis (2008) 1.69

E-cadherin gene mutations in signet ring cell carcinoma of the stomach. Jpn J Cancer Res (1996) 1.62

Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease. Inflamm Bowel Dis (2008) 1.61

The "seed and soil" hypothesis revisited. Lancet Oncol (2008) 1.60

Epithelial-mesenchymal transition during trophoblast differentiation. Acta Anat (Basel) (1996) 1.60

The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes. Oncogene (2008) 1.56

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Mesenchymal transition in kidney collecting duct epithelial cells. Am J Physiol Renal Physiol (2008) 1.49

Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis (2008) 1.45

Appearance and distribution of fibronectin during chick embryo gastrulation and neurulation. Dev Biol (1982) 1.45

Hallmarks of cancer: the next generation. Cell (2011) 140.01

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80

A perspective on cancer cell metastasis. Science (2011) 13.31

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

A progression puzzle. Nature (2002) 9.56

Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07

Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53

Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24

Cancer stem cells: mirage or reality? Nat Med (2009) 5.20

The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00

Rules for making human tumor cells. N Engl J Med (2002) 4.84

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79

Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70

Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67

EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest (2009) 4.41

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30

Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98

Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96

The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96

Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95

Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75

The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64

Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61

Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56

Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03

Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88

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Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75

Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38

When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37

A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24

Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08

Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03

Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96

Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79

Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78

Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74

Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74

MicroRNAs in malignant progression. Cell Cycle (2007) 1.74

Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66

MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59

miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51

The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41

Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40

An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36

Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36

Roles for microRNAs in the regulation of cell adhesion molecules. J Cell Sci (2011) 1.25

Heterogeneity of stromal fibroblasts in tumors. Cancer Biol Ther (2007) 1.21

Chemokine networks and breast cancer metastasis. Breast Dis (2007) 1.17

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res (2010) 1.17

Coevolution in the tumor microenvironment. Nat Genet (2008) 1.16

Senescence: does it all happen at the ends? Oncogene (2002) 0.98

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