Published in J Physiol on June 02, 2009
Up-regulation of the fetal baboon hypothalamo-pituitary-adrenal axis in intrauterine growth restriction: coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation. Endocrinology (2013) 1.51
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem (2013) 1.00
Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs). BMC Res Notes (2013) 0.93
Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. PLoS One (2011) 0.91
New pharmacological perspectives for the leptin receptor in the treatment of obesity. Front Endocrinol (Lausanne) (2014) 0.86
A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. J Pharmacol Exp Ther (2014) 0.86
Proteomic analysis of multiple primary cilia reveals a novel mode of ciliary development in mammals. Biol Open (2012) 0.85
Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech (2013) 0.83
The endocrinology of taste receptors. Nat Rev Endocrinol (2015) 0.80
Leptin receptor signaling inhibits ovarian follicle development and egg laying in chicken hens. Reprod Biol Endocrinol (2014) 0.79
Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity. Front Physiol (2015) 0.78
Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP. Mol Metab (2014) 0.78
Long-term changes in the ghrelin-CB1R axis associated with the maintenance of lower body weight after sleeve gastrectomy. Nutr Diabetes (2014) 0.76
The Leptin Receptor Complex: Heavier Than Expected? Front Endocrinol (Lausanne) (2017) 0.75
Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes. Fish Physiol Biochem (2015) 0.75
Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals. Front Endocrinol (Lausanne) (2017) 0.75
Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57
Weight-reducing effects of the plasma protein encoded by the obese gene. Science (1995) 13.05
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science (1995) 9.09
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med (1995) 5.45
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology (2004) 4.10
Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest (1997) 3.56
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest (2000) 3.50
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab (2007) 3.43
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med (2004) 2.98
Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98
The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem (1999) 2.63
Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes (2004) 2.33
Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett (1996) 2.28
Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) (2001) 1.74
Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol (2004) 1.58
C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis (1998) 1.46
The role of leptin in leptin resistance and obesity. Physiol Behav (2006) 1.41
Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am J Physiol (1997) 1.39
Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology (1998) 1.36
Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res (2000) 1.32
Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci (2001) 1.28
Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology (2006) 1.26
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes (1999) 1.26
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol (2007) 1.24
Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes (1998) 1.21
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci U S A (2005) 1.17
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia (2005) 1.16
Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes (2004) 1.11
Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol (2003) 1.00
Photoperiod regulates growth, puberty and hypothalamic neuropeptide and receptor gene expression in female Siberian hamsters. Endocrinology (2000) 0.98
Cyclical variations in the abundance of leptin receptors, but not in circulating leptin, correlate with NPY expression during the oestrous cycle. Neuroendocrinology (1999) 0.97
Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus. Am J Physiol Regul Integr Comp Physiol (2000) 0.96
Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology (2005) 0.95
Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett (1997) 0.94
Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen. Neuroendocrinology (1998) 0.94
Leptin binding in the arcuate nucleus is increased during fasting. Brain Res (1999) 0.93
Hypothalamic bHLH transcription factors are novel candidates in the regulation of energy balance. Eur J Neurosci (2002) 0.93
Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression. Endocrinology (2003) 0.92
Fasting, but not adrenalectomy, reduces transport of leptin into the brain. Peptides (2000) 0.91
Directional secretion and transport of leptin and expression of leptin receptor isoforms in human placental BeWo cells. Mol Cell Endocrinol (2005) 0.89
Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet. J Endocrinol (2004) 0.87
Leptin modulates the expression of its receptors in the hypothalamic-pituitary-ovarian axis in a differential way. J Endocrinol (2008) 0.86
Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain. Neurosci Lett (2005) 0.86
Interleukin 8 in the cervix of non-pregnant ewes. Reproduction (2002) 0.85
Effects of neuropeptides and leptin on nutrient partitioning: dysregulations in obesity. Annu Rev Med (2001) 0.84
Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain. Brain Res (2003) 0.81
Rapid inhibition of leptin signaling by glucocorticoids in vitro and in vivo. J Biol Chem (2004) 0.81
Choroid plexus epithelial cells co-express the long and short form of the leptin receptor. Neurosci Lett (2005) 0.80
Differential regulation of leptin receptor but not orexin in the hypothalamus of the lactating rat. J Neuroendocrinol (2000) 0.80
Effects of leptin and dexamethasone on long and short leptin receptor mRNA. Pediatr Int (2004) 0.78
Leptin action is modified by an interaction between dietary fat content and ambient temperature. Am J Physiol Regul Integr Comp Physiol (2004) 0.77
Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats. Regul Pept (2000) 0.77
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab (2008) 2.89
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol (2007) 2.42
Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest (2006) 2.03
Leptin, from fat to inflammation: old questions and new insights. FEBS Lett (2005) 1.92
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem (2005) 1.83
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79
Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev (2012) 1.76
The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev (2007) 1.66
Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology (2012) 1.58
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol (2007) 1.51
The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci (2008) 1.49
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab (2010) 1.49
Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes (2006) 1.46
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep (2010) 1.40
A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS One (2009) 1.31
Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes (2006) 1.26
Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis (2011) 1.25
Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci (2010) 1.25
Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology (2003) 1.24
Adipokines as novel modulators of lipid metabolism. Trends Biochem Sci (2009) 1.22
Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology (2006) 1.21
The cannabinoid receptor 2 is critical for the host response to sepsis. J Immunol (2009) 1.18
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes (2011) 1.16
Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine. Eur J Endocrinol (2002) 1.13
Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab (2011) 1.11
Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes (2004) 1.11
Regulation of pituitary cell function by adiponectin. Endocrinology (2006) 1.11
Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun (2004) 1.10
Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab (2005) 1.09
Exendin-4 potently decreases ghrelin levels in fasting rats. Diabetes (2007) 1.07
Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J (2009) 1.07
One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Mol Cell Endocrinol (2006) 1.05
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab (2010) 1.04
Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease. Eur J Endocrinol (2004) 1.04
CNS leptin action modulates immune response and survival in sepsis. J Neurosci (2010) 1.01
Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab (2008) 1.01
Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. an ex vivo organ culture study. Endocrinology (2007) 1.01
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. J Endocrinol (2011) 1.00
Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action. FEBS Lett (2003) 1.00
Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins. Neuroendocrinology (2011) 0.98
Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology (2008) 0.98
The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake. PLoS One (2013) 0.96
The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity. Diabetes (2011) 0.96
The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Genes Nutr (2008) 0.96
GOAT: the master switch for the ghrelin system? Eur J Endocrinol (2010) 0.95
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. J Mol Endocrinol (2009) 0.95
Prevalence of hypopituitarism and growth hormone deficiency in adults long-term after severe traumatic brain injury. Clin Endocrinol (Oxf) (2005) 0.95
A pilot study of buprenorphine-naloxone combination tablet (Suboxone) in treatment of opioid dependence. Drug Alcohol Rev (2004) 0.94
Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiol Behav (2011) 0.94
Mice lacking δ-opioid receptors resist the development of diet-induced obesity. FASEB J (2012) 0.93
kappa-Opioid receptors control the metabolic response to a high-energy diet in mice. FASEB J (2009) 0.93
Introducing GOAT: a target for obesity and anti-diabetic drugs? Trends Pharmacol Sci (2008) 0.92
Using gene expression to predict differences in the secretome of human omental vs. subcutaneous adipose tissue. Obesity (Silver Spring) (2012) 0.92
Ghrelin: new molecular pathways modulating appetite and adiposity. Obes Facts (2010) 0.92
Melatonin receptors in human fetal brain: 2-[(125)I]iodomelatonin binding and MT1 gene expression. J Pineal Res (2002) 0.92
Regulation of ghrelin secretion and action. Endocrine (2003) 0.92
The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. EMBO J (2007) 0.91
Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patients. Eur J Endocrinol (2003) 0.90
Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. Obesity (Silver Spring) (2008) 0.90
Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes. Arthritis Rheum (2009) 0.90
Oleoylethanolamide: effects on hypothalamic transmitters and gut peptides regulating food intake. Neuropharmacology (2010) 0.90
Cysteine-induced modifications of zero-valent silver nanomaterials: implications for particle surface chemistry, aggregation, dissolution, and silver speciation. Environ Sci Technol (2012) 0.89
Peripheral tissue-brain interactions in the regulation of food intake. Proc Nutr Soc (2007) 0.89
Central administration of resistin promotes short-term satiety in rats. Eur J Endocrinol (2005) 0.88
Leptin up-regulates pro-inflammatory cytokines in discrete cells within mouse colon. J Cell Physiol (2011) 0.88
High-fat diet alters gene expression in the liver and colon: links to increased development of aberrant crypt foci. Dig Dis Sci (2012) 0.88
Solid and liquid obesogenic diets induce obesity and counter-regulatory changes in hypothalamic gene expression in juvenile Sprague-Dawley rats. J Nutr (2007) 0.88
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech (2013) 0.88
Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet. Obes Res (2003) 0.87
Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure. Peptides (2010) 0.86
Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms. J Cell Physiol (2007) 0.86
Food addiction in a Spanish sample of eating disorders: DSM-5 diagnostic subtype differentiation and validation data. Eur Eat Disord Rev (2014) 0.86
Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors. J Clin Endocrinol Metab (2011) 0.86
Changes in neuroendocrine and metabolic hormones induced by atypical antipsychotics in normal-weight patients with schizophrenia. Neuroendocrinology (2007) 0.85
The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin Endocrinol (Oxf) (2002) 0.85
The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus. Br J Nutr (2005) 0.84
Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus. Eur J Neurosci (2004) 0.84
Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland. Proc Natl Acad Sci U S A (2003) 0.83
The GHRH/GHRP-6 test for the diagnosis of GH deficiency in elderly or severely obese men. Eur J Endocrinol (2005) 0.83
Resistin: regulation of food intake, glucose homeostasis and lipid metabolism. Endocr Dev (2009) 0.83
Ghrelin, the same peptide for different functions: player or bystander? Vitam Horm (2005) 0.82
Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH + GHRP-6 test. Clin Endocrinol (Oxf) (2006) 0.82
Early developmental expression of leptin receptor gene and [125I]leptin binding in the rat forebrain. J Chem Neuroanat (2007) 0.82
Ghrelin: the link connecting growth with metabolism and energy homeostasis. Rev Endocr Metab Disord (2002) 0.82
Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis. J Endocrinol (2006) 0.82