Published in Biochemistry on August 04, 2009
Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field. Sci Rep (2013) 1.09
Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity. J Biol Chem (2011) 0.99
Ligand-induced dynamic changes in extended PDZ domains from NHERF1. J Mol Biol (2013) 0.90
The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain. J Biol Chem (2010) 0.89
Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin. J Biol Chem (2011) 0.87
Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. J Biol Chem (2010) 0.87
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. J Biol Chem (2010) 0.85
Binding free energy landscape of domain-peptide interactions. PLoS Comput Biol (2011) 0.84
Tolerance of protein folding to a circular permutation in a PDZ domain. PLoS One (2012) 0.82
Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions. Sci Rep (2016) 0.79
Some (dis)assembly required: partial unfolding in the Par-6 allosteric switch. Biophys Rev (2015) 0.77
Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus. Sci Rep (2015) 0.77
Discrimination between conformational selection and induced fit protein-ligand binding using Integrated Global Fit analysis. Eur Biophys J (2015) 0.77
Structure of the human discs large 1 PDZ2- adenomatous polyposis coli cytoskeletal polarity complex: insight into peptide engagement and PDZ clustering. PLoS One (2012) 0.76
Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop. Angew Chem Int Ed Engl (2016) 0.75
Understanding the effect of alternative splicing in the folding and function of the second PDZ from protein tyrosine phosphatase-BL. Sci Rep (2015) 0.75
Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95. Sci Rep (2017) 0.75
SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol Rev (2011) 3.03
The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors. EMBO J (2002) 2.37
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients. Arthritis Rheum (2010) 2.27
PDZ domains: folding and binding. Biochemistry (2007) 1.68
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med (2009) 1.68
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol (2005) 1.51
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem (2004) 1.49
Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248. 1981. J Immunol (2009) 1.49
Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. J Biol Chem (2009) 1.46
Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering. Structure (2006) 1.41
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci U S A (2012) 1.40
Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse. Arthritis Rheum (2002) 1.39
Reassessing a sparse energetic network within a single protein domain. Proc Natl Acad Sci U S A (2008) 1.33
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. J Biol Chem (2009) 1.33
Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. J Mol Biol (2005) 1.27
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. J Biol Chem (2009) 1.25
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A (2009) 1.23
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc Natl Acad Sci U S A (2004) 1.21
Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chem Commun (Camb) (2009) 1.21
Helical propensity in an intrinsically disordered protein accelerates ligand binding. Angew Chem Int Ed Engl (2014) 1.16
Fibroblast growth factors share binding sites in heparan sulphate. Biochem J (2005) 1.15
Nitrocellulose filter binding to assess binding of glycosaminoglycans to proteins. Methods Enzymol (2003) 1.11
Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins. Proc Natl Acad Sci U S A (2008) 1.10
Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity. Biochem J (2005) 1.10
The structure of the major transition state for folding of an FF domain from experiment and simulation. J Mol Biol (2005) 1.10
An obligatory intermediate in the folding pathway of cytochrome c552 from Hydrogenobacter thermophilus. J Biol Chem (2005) 1.10
Single molecule unfolding and stretching of protein domains inside a solid-state nanopore by electric field. Sci Rep (2013) 1.09
The kinetic pathway of folding of barnase. J Mol Biol (2003) 1.09
Fragmentation of peptides in MALDI in-source decay mediated by hydrogen radicals. Anal Chem (2005) 1.08
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol (2005) 1.07
A PDZ domain recapitulates a unifying mechanism for protein folding. Proc Natl Acad Sci U S A (2006) 1.06
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. J Biol Chem (2009) 1.06
The transition state structure for coupled binding and folding of disordered protein domains. Sci Rep (2013) 1.04
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. Proc Natl Acad Sci U S A (2011) 1.04
The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism. J Biol Chem (2005) 1.03
A conserved folding mechanism for PDZ domains. FEBS Lett (2007) 1.03
Identification and characterization of protein folding intermediates. Biophys Chem (2007) 1.03
Fast association and slow transitions in the interaction between two intrinsically disordered protein domains. J Biol Chem (2012) 1.02
Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. J Biol Chem (2012) 1.01
The binding mechanisms of intrinsically disordered proteins. Phys Chem Chem Phys (2013) 1.00
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J Med Chem (2008) 1.00
Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain. J Biol Chem (2006) 1.00
Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc Natl Acad Sci U S A (2010) 0.99
Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity. J Biol Chem (2011) 0.99
Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system. Proc Natl Acad Sci U S A (2013) 0.98
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc Natl Acad Sci U S A (2011) 0.98
A strategic protein in cytochrome c maturation: three-dimensional structure of CcmH and binding to apocytochrome c. J Biol Chem (2007) 0.97
Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. Angew Chem Int Ed Engl (2009) 0.97
Folding and misfolding in a naturally occurring circularly permuted PDZ domain. J Biol Chem (2008) 0.96
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem (2008) 0.96
Exploring the cytochrome c folding mechanism: cytochrome c552 from thermus thermophilus folds through an on-pathway intermediate. J Biol Chem (2003) 0.96
Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen. Arthritis Res Ther (2005) 0.96
An on-pathway intermediate in the folding of a PDZ domain. J Biol Chem (2007) 0.96
The denatured state dictates the topology of two proteins with almost identical sequence but different native structure and function. J Biol Chem (2010) 0.95
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem (2003) 0.95
GB1 is not a two-state folder: identification and characterization of an on-pathway intermediate. Biophys J (2011) 0.95
Chemical, thermal, and electric field induced unfolding of single protein molecules studied using nanopores. Anal Chem (2011) 0.93
A common folding mechanism in the cytochrome c family. Trends Biochem Sci (2004) 0.93
Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance. FASEB J (2009) 0.93
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis. Arthritis Rheum (2006) 0.91
Processing of macromolecular heparin by heparanase. J Biol Chem (2003) 0.91
Folding pathways of proteins with increasing degree of sequence identities but different structure and function. Proc Natl Acad Sci U S A (2012) 0.91
The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain. J Biol Chem (2010) 0.89
Single-molecule studies of intrinsically disordered proteins using solid-state nanopores. Anal Chem (2013) 0.89
Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac). Mol Pharmacol (2014) 0.89
An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes. J Mol Biol (2002) 0.89
The transition state of coupled folding and binding for a flexible β-finger. J Mol Biol (2012) 0.88
Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. J Biol Chem (2010) 0.87
Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem (2003) 0.87
Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. J Biol Chem (2009) 0.87
Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem (2011) 0.87
Interactions outside the boundaries of the canonical binding groove of a PDZ domain influence ligand binding. Biochemistry (2012) 0.86
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. J Am Chem Soc (2011) 0.86