Published in Clin Cancer Res on June 09, 2009
Targeting DNA methylation. Clin Cancer Res (2009) 2.45
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12
Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer (2011) 2.10
The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells. Cell Cycle (2012) 1.98
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol (2010) 1.63
Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. Cell Death Dis (2010) 1.55
Epigenetic modifications in cancer. Clin Genet (2011) 1.53
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39
Epigenetic mechanisms in inflammation. J Dent Res (2011) 1.35
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene (2012) 1.21
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology (2010) 1.20
Structural and functional profiling of the human histone methyltransferase SMYD3. PLoS One (2011) 1.20
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation. Mol Cell Biol (2011) 1.19
Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer. Oncotarget (2014) 1.19
Epigenetic imbalance and the floral developmental abnormality of the in vitro-regenerated oil palm Elaeis guineensis. Ann Bot (2011) 1.13
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest (2011) 1.10
Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse models. Circ Res (2013) 1.09
Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene (2012) 1.08
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PLoS One (2010) 1.08
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy. Mol Cancer Res (2010) 1.04
Epigenetic regulation of EMT: the Snail story. Curr Pharm Des (2014) 1.02
Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer. Cancer (2014) 1.01
Continuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth. J Exp Clin Cancer Res (2011) 1.01
Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol (2013) 1.00
Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature. Cancer Inform (2012) 1.00
LINE-1 hypomethylation in familial and sporadic cancer. J Mol Med (Berl) (2012) 1.00
DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PLoS One (2012) 0.97
CPEB1, a histone-modified hypomethylated gene, is regulated by miR-101 and involved in cell senescence in glioma. Cell Death Dis (2013) 0.94
Concise drug review: azacitidine and decitabine. Oncologist (2013) 0.93
Epigenetics and cancer. J Appl Physiol (1985) (2010) 0.93
Epigenome engineering in cancer: fairytale or a realistic path to the clinic? Front Oncol (2015) 0.92
Epigenetic changes: a common theme in acute myelogenous leukemogenesis. J Hematol Oncol (2013) 0.92
Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathol (2011) 0.91
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer. Int J Biol Sci (2010) 0.89
Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS One (2011) 0.89
Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase. PLoS One (2012) 0.87
Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets. BMC Syst Biol (2014) 0.86
Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition. BMC Genomics (2014) 0.85
Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention. Biomed Res Int (2015) 0.84
Simultaneous single-molecule mapping of protein-DNA interactions and DNA methylation by MAPit. Curr Protoc Mol Biol (2011) 0.84
Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem (2013) 0.84
ID4 is frequently downregulated and partially hypermethylated in prostate cancer. World J Urol (2011) 0.84
Smoking and microRNA dysregulation: a cancerous combination. Trends Mol Med (2013) 0.83
Digging deep into "dirty" drugs - modulation of the methylation machinery. Drug Metab Rev (2015) 0.83
A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing. J Biol Chem (2014) 0.82
p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression. PLoS One (2014) 0.81
Rap1 and its regulatory proteins: the tumor suppressor, oncogene, tumor suppressor gene axis in head and neck cancer. Small GTPases (2012) 0.81
Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis. Oncotarget (2015) 0.80
Clinical significance of epigenetic silencing and re-expression of O6-methylguanine-DNA methyltransferase using epigenetic agents in laryngeal carcinoma. Oncol Lett (2014) 0.80
Cubic regression-based degree of correction predicts the performance of whole bisulfitome amplified DNA methylation analysis. Epigenetics (2012) 0.79
Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma. Clin Epigenetics (2015) 0.79
Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia (2012) 0.79
DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth. Braz J Med Biol Res (2014) 0.79
Epigenetic and metabolic regulation of breast cancer stem cells. J Zhejiang Univ Sci B (2015) 0.79
DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas. Clin Epigenetics (2015) 0.79
RUNX3 site-specific hypermethylation predicts papillary thyroid cancer recurrence. Am J Cancer Res (2014) 0.79
Epigenetic regulation of epithelial-mesenchymal transition. Cell Mol Life Sci (2016) 0.79
Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area. Curr Psychiatry Rev (2014) 0.78
Factors affecting the persistence of drug-induced reprogramming of the cancer methylome. Epigenetics (2016) 0.77
Demethylating Agents in the Treatment of Cancer. Pharmaceuticals (Basel) (2010) 0.77
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis. Int J Clin Exp Med (2015) 0.77
Epigenetic modulation of the muscarinic type 3 receptor in salivary epithelial cells. Lab Invest (2014) 0.77
Class I HDAC inhibitor mocetinostat induces apoptosis by activation of miR-31 expression and suppression of E2F6. Cell Death Discov (2016) 0.77
Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells. Fertil Steril (2015) 0.77
Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence. Biochemistry (2013) 0.76
Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1. Genes Cancer (2012) 0.76
Insights into cancer mechanisms from genomic research on urological cancers. Genome Med (2011) 0.75
Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats. Biol Open (2016) 0.75
Gene-set Analysis with CGI Information for Differential DNA Methylation Profiling. Sci Rep (2016) 0.75
Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments. PLoS One (2016) 0.75
The ectopic expression of Snail in MDBK cells does not induce epithelial-mesenchymal transition. Int J Mol Med (2015) 0.75
Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer. Front Pharmacol (2017) 0.75
Epigenetic alteration of the purinergic type 7 receptor in salivary epithelial cells. Biochem Biophys Res Commun (2015) 0.75
Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias. Neoplasia (2014) 0.75
Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development? Front Oncol (2016) 0.75
DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study. Epigenetics (2016) 0.75
Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer. Clin Epigenetics (2014) 0.75
The effect of two nucleoside antitumor drugs on the proliferation and DNA methylation of human gastric cancer cells. Oncol Lett (2015) 0.75
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk. Biomed Res Int (2017) 0.75
Epigenetic: A missing paradigm in cellular and molecular pathways of sulfur mustard lung: a prospective and comparative study. Iran J Basic Med Sci (2015) 0.75
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice. Sci Rep (2016) 0.75
Effect of combined 5-aza-2'deoxycytidine and cisplatin treatment on the P15 lung adenocarcinoma cell line. Oncol Lett (2015) 0.75
5-Azacytidine mediated reactivation of silenced transgenes in potato (Solanum tuberosum) at the whole plant level. Plant Cell Rep (2017) 0.75
[DNA methylation. From basic research to routine diagnostics]. Pathologe (2010) 0.75
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med (2005) 29.65
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
CpG islands in vertebrate genomes. J Mol Biol (1987) 23.16
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med (2000) 12.34
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
The DNA methyltransferases of mammals. Hum Mol Genet (2000) 10.66
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47
Methylation-induced repression--belts, braces, and chromatin. Cell (1999) 9.89
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature (2002) 9.51
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell (2008) 7.68
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14
Global histone modification patterns predict risk of prostate cancer recurrence. Nature (2005) 7.03
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (2002) 6.05
Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med (2008) 5.87
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell (1985) 5.63
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet (2009) 5.52
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev (2006) 5.15
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res (2007) 5.13
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet (2008) 5.08
Evidence for an instructive mechanism of de novo methylation in cancer cells. Nat Genet (2006) 4.97
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet (2006) 4.86
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet (2002) 4.36
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A (2008) 4.20
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol (2008) 3.98
A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res (2007) 3.82
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene. J Natl Cancer Inst (2005) 3.73
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
An elaborate pathway required for Ras-mediated epigenetic silencing. Nature (2007) 3.47
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol (2009) 3.46
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet (2007) 3.39
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature (2007) 3.32
Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res (1988) 3.22
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol (2008) 3.20
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell (2007) 3.15
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res (2006) 3.05
CpG island mapping by epigenome prediction. PLoS Comput Biol (2007) 3.02
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res (2002) 3.02
The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev (2001) 2.91
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol (2005) 2.69
Clinical studies of histone deacetylase inhibitors. Clin Cancer Res (2009) 2.68
CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet (2006) 2.66
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet (2008) 2.55
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci (2004) 2.49
Targeting DNA methylation. Clin Cancer Res (2009) 2.45
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem (1997) 2.27
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol (1996) 2.26
Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A (2003) 2.25
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene (2007) 2.22
DNA methylation regulates MicroRNA expression. Cancer Biol Ther (2007) 2.21
Genome-wide analysis of DNA methylation patterns. Development (2007) 2.13
Rational combinations using HDAC inhibitors. Clin Cancer Res (2009) 2.12
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc Natl Acad Sci U S A (2007) 2.10
Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res (2008) 2.08
Histone arginine methylation and its dynamic regulation. Front Biosci (2006) 2.06
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene (2006) 2.05
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem (2006) 1.93
Characterization of histones and their post-translational modifications by mass spectrometry. Curr Opin Chem Biol (2006) 1.92
Cytosine methylation profiling of cancer cell lines. Proc Natl Acad Sci U S A (2008) 1.91
Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. J Clin Oncol (2005) 1.80
UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res (2008) 1.80
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome. J Mol Biol (2005) 1.65
Natural mutagenesis of human genomes by endogenous retrotransposons. Cell (2010) 5.50
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. Genome Res (2012) 1.63
Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma. Am J Pathol (2004) 1.58
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res (2006) 1.58
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem (2007) 1.48
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
DNA motifs associated with aberrant CpG island methylation. Genomics (2006) 1.40
Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int J Cancer (2011) 1.39
Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. Mol Cancer Res (2008) 1.30
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer Res (2008) 1.28
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res (2008) 1.26
Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report. Cancer (2010) 1.24
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation. Mol Cell Biol (2011) 1.19
LKB1 mutation in large cell carcinoma of the lung. Lung Cancer (2006) 1.19
A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Res (2009) 1.15
Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. J Biol Chem (2010) 1.08
Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity. Cancer Res (2008) 1.05
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy. Mol Cancer Res (2010) 1.04
Infrequent mutation of ATBF1 in human breast cancer. J Cancer Res Clin Oncol (2006) 1.03
Methylation matters: a new spin on maspin. Nat Genet (2002) 1.03
Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies. Clin Cancer Res (2013) 1.02
Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses. Pituitary (2008) 1.00
Effects of methylation on expression of TMS1/ASC in human breast cancer cells. Oncogene (2003) 1.00
Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. J Biol Chem (2001) 0.99
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC. Clin Cancer Res (2013) 0.99
Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1. Cancer Res (2011) 0.97
Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells. Cancer Genet Cytogenet (2010) 0.97
Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. Cancer Prev Res (Phila) (2014) 0.97
Real-world effectiveness of systemic agents approved for advanced non-small cell lung cancer: a SEER-Medicare analysis. Oncologist (2013) 0.91
Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine. Cancer Metastasis Rev (2014) 0.89
Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells. Cancer Res (2009) 0.89
Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha. J Biol Chem (2009) 0.88
Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. PLoS One (2013) 0.85
Could valproic acid be an effective anticancer agent? The evidence so far. Expert Rev Anticancer Ther (2014) 0.82
A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing. J Biol Chem (2014) 0.82
Dysregulation of mTOR activity through LKB1 inactivation. Chin J Cancer (2013) 0.81
Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene. Cancer Biol Ther (2004) 0.79
Targeted therapy of non-small-cell lung carcinoma. Ther Adv Respir Dis (2011) 0.76
p53 expression after treatment with zebularine is not due to demethylation. Cancer Res (2006) 0.75