Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMC 2755706)

Published in J Biol Chem on June 15, 2009

Authors

Ming Li1, Christopher J Smith, Matthew T Walker, Thomas J Smith

Author Affiliations

1: Donald Danforth Plant Science Center, St. Louis, Missouri 63132, USA.

Associated clinical trials:

Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome | NCT03797222

Vitamin E Efficacy in HI/HA | NCT04984798

Articles citing this

Therapeutic targeting of cancer cell metabolism. J Mol Med (Berl) (2011) 1.62

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol (2011) 1.29

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication. Cell Res (2012) 1.27

Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03

Binding leverage as a molecular basis for allosteric regulation. PLoS Comput Biol (2011) 0.99

Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site. J Biol Chem (2011) 0.98

Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes. Front Endocrinol (Lausanne) (2013) 0.96

Antibacterial mechanisms identified through structural systems pharmacology. BMC Syst Biol (2013) 0.86

The structure and allosteric regulation of glutamate dehydrogenase. Neurochem Int (2010) 0.85

Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase. J Biol Chem (2011) 0.85

A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res (2012) 0.82

Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression. Neurochem Int (2011) 0.81

In silico prediction of antimalarial drug target candidates. Int J Parasitol Drugs Drug Resist (2012) 0.80

Mechanisms of amino acid-stimulated insulin secretion in congenital hyperinsulinism. Acta Biochim Biophys Sin (Shanghai) (2012) 0.80

Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia. World J Diabetes (2014) 0.78

Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase. Proc Natl Acad Sci U S A (2016) 0.78

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem (2016) 0.76

Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry). J Histochem Cytochem (2014) 0.76

Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Oncotarget (2016) 0.75

Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications. Biology (Basel) (2016) 0.75

A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J (2011) 0.75

Purification, crystallization and preliminary X-ray diffraction analysis of NADP-dependent glutamate dehydrogenase from Aspergillus niger. Acta Crystallogr F Struct Biol Commun (2014) 0.75

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening. MBio (2016) 0.75

Affordable uniform isotope labeling with (2)H, (13)C and (15)N in insect cells. J Biomol NMR (2015) 0.75

Computational design of glutamate dehydrogenase in Bacillus subtilis natto. J Mol Model (2013) 0.75

Articles cited by this

Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01

The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88

Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr D Biol Crystallogr (2004) 23.86

Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med (1998) 3.28

Glutamic dehydrogenase. I. The effect of coenzyme on the sedimentation velocity and kinetic behavior. J Biol Chem (1959) 2.96

The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Structure (1995) 2.56

The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett (2000) 2.22

Kinetic studies of glutamate dehydrogenase with glutamate and norvaline as substrates. Coenzyme activation and negative homotropic interactions in allosteric enzymes. Biochem J (1969) 2.10

Planar stacking interactions of arginine and aromatic side-chains in proteins. J Mol Biol (1994) 1.97

L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature (1980) 1.81

Conformational flexibility in glutamate dehydrogenase. Role of water in substrate recognition and catalysis. J Mol Biol (1993) 1.67

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J Biol Chem (2006) 1.64

Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. J Biol Chem (2002) 1.53

L-glutamate dehydrogenases: distribution, properties and mechanism. Comp Biochem Physiol B (1993) 1.52

Subunit assembly and active site location in the structure of glutamate dehydrogenase. Proteins (1992) 1.50

Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI/HA Contributing Investigators. Diabetes (2000) 1.46

Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome. J Pediatr (2001) 1.42

Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase. J Clin Endocrinol Metab (2001) 1.42

[Regulation of the activity of glutamate dehydrogenase by effectors GTP and ADP: study by means of "stopped flow"]. Bull Soc Chim Biol (Paris) (1967) 1.42

An effect of L-leucine and other essential amino acids on the structure and activity of glutamic dehydrogenase. Proc Natl Acad Sci U S A (1961) 1.36

A signaling role of glutamine in insulin secretion. J Biol Chem (2004) 1.33

Regulation of insulin release by factors that also modify glutamate dehydrogenase. J Biol Chem (1988) 1.29

Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation. J Mol Biol (2001) 1.29

GLUTAMATE DEHYDROGENASE. VI. SURVEY OF PURINE NUCLEOTIDE AND OTHER EFFECTS ON THE ENZYME FROM VARIOUS SOURCES. J Biol Chem (1965) 1.28

The structure of apo human glutamate dehydrogenase details subunit communication and allostery. J Mol Biol (2002) 1.27

Regulation of bovine glutamate dehydrogenase. The effects of pH and ADP. J Biol Chem (1982) 1.19

Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci U S A (1981) 1.16

Untangling the glutamate dehydrogenase allosteric nightmare. Trends Biochem Sci (2008) 1.13

The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery. Structure (1999) 1.11

Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation. Biochemistry (2003) 1.10

Evolution of glutamate dehydrogenase regulation of insulin homeostasis is an example of molecular exaptation. Biochemistry (2004) 0.99

Mechanism of hysteresis in bovine glutamate dehydrogenase: role of subunit interactions. Biochemistry (1982) 0.95

Studies of glutamate dehydrogenase. The influence of ADP, GTP, and L-glutamate on the binding of the reduced coenzyme to beef-liver glutamate dehydrogenase. Eur J Biochem (1973) 0.95

The influence of diethylstilbestrol and adenosine diphosphate on pyridine nucleotide coenzyme binding by glutamic dehydrogenase. J Biol Chem (1962) 0.94

Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys (1981) 0.91

High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors. Biochemistry (2007) 0.90

Kinetic studies on the mechanism of the action of ADP on the glutamate dehydrogenase reaction. FEBS Lett (1972) 0.84

Identification of amino acids modified by the bifunctional affinity label 5'-(p-(fluorosulfonyl)benzoyl)-8-azidoadenosine in the reduced coenzyme regulatory site of bovine liver glutamate dehydrogenase. Biochemistry (1992) 0.84

Substrate inhibition of Pediococcus acidilactici by glucose on a waste medium. Simulations and experimental results. Lett Appl Microbiol (2003) 0.83

Studies of glutamate dehydrogenase. The interaction of ADP, GTP, and NADPH in complexes with glutamate dehydrogenase. Eur J Biochem (1981) 0.83

Identification of the lysine and tyrosine peptides labeled by 5'-p-fluorosulfonylbenzoyladenosine in the NADH inhibitory site of glutamate dehydrogenase. J Biol Chem (1984) 0.82

5'-p-fluorosulfonyl)benzoyl-8-azidoadenosine: a new bifunctional affinity label for nucleotide binding sites in proteins. Arch Biochem Biophys (1989) 0.79

The mechanism of activation of glutamate dehydrogenase-catalyzed reactions by two different, cooperatively bound activators. J Biol Chem (1973) 0.78

Affinity labeling of a regulatory site of bovine liver glutamate dehydrogenase. Biochemistry (1975) 0.77

Articles by these authors

(truncated to the top 100)

The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59

American Society of Clinical Oncology identifies five key opportunities to improve care and reduce costs: the top five list for oncology. J Clin Oncol (2012) 7.16

American Society of Clinical Oncology guidance statement: the cost of cancer care. J Clin Oncol (2009) 6.77

American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol (2003) 6.66

American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol (2009) 4.95

Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med (2004) 4.84

American society of clinical oncology statement: toward individualized care for patients with advanced cancer. J Clin Oncol (2011) 4.64

American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting. J Clin Oncol (2006) 4.61

Complex glycan catabolism by the human gut microbiota: the Bacteroidetes Sus-like paradigm. J Biol Chem (2009) 4.05

Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol (2007) 3.91

Why do patients choose chemotherapy near the end of life? A review of the perspective of those facing death from cancer. J Clin Oncol (2006) 3.71

Early specialty palliative care--translating data in oncology into practice. N Engl J Med (2013) 3.58

The role of chemotherapy at the end of life: "when is enough, enough?". JAMA (2008) 3.31

2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. J Clin Oncol (2011) 3.21

Starch catabolism by a prominent human gut symbiont is directed by the recognition of amylose helices. Structure (2008) 3.02

The shortage of essential chemotherapy drugs in the United States. N Engl J Med (2011) 2.74

Palliative care and oncology partnerships in real practice. Oncology (Williston Park) (2011) 2.72

Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol (2012) 2.62

Talking with patients about dying. N Engl J Med (2012) 2.34

Hospital mortality rates: how is palliative care taken into account? J Pain Symptom Manage (2010) 2.32

Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax (2010) 2.26

Primary synovial sarcoma of the ovary: first reported case. Pathology (2005) 2.20

Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest (2009) 2.16

Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med (2003) 2.11

Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect (2004) 2.06

Heliox with inhaled nitric oxide: a novel strategy for severe localized interstitial pulmonary emphysema in preterm neonatal ventilation. Respir Care (2008) 2.04

Lung cancer and elemental carbon exposure in trucking industry workers. Environ Health Perspect (2012) 2.04

Providing pain and palliative care education internationally. J Support Oncol (2011) 2.04

Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing. J Clin Oncol (2009) 2.03

Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet (2006) 1.89

Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control (2003) 1.86

Is it time for (survivorship care) plan B? J Clin Oncol (2011) 1.84

Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure. Am J Epidemiol (2006) 1.84

Advances in microbicide vaginal rings. Antiviral Res (2010) 1.76

SPIKE$: a six-step protocol for delivering bad news about the cost of medical care. J Clin Oncol (2008) 1.76

Spatial modeling of PM10 and NO2 in the continental United States, 1985-2000. Environ Health Perspect (2009) 1.73

Fatal Loeffler's endocarditis due to hypereosinophilic syndrome. Am J Hematol (2007) 1.73

The association of particulate air metal concentrations with heart rate variability. Environ Health Perspect (2002) 1.71

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem (2010) 1.68

Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am J Med Genet B Neuropsychiatr Genet (2007) 1.65

Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J Biol Chem (2006) 1.64

Variability of familial risk of Alzheimer disease across the late life span. Arch Gen Psychiatry (2005) 1.63

Reasons why physicians do not have discussions about poor prognosis, why it matters, and what can be improved. J Clin Oncol (2012) 1.60

Assessment of optimal size and composition of the U.S. National Registry of hematopoietic stem cell donors. Transplantation (2004) 1.59

Lung cancer and vehicle exhaust in trucking industry workers. Environ Health Perspect (2008) 1.57

Structure of antibody-neutralized murine norovirus and unexpected differences from viruslike particles. J Virol (2007) 1.49

Improving the quality of cancer care: implications for palliative care. J Palliat Med (2014) 1.49

Randomized trial of long-term follow-up for early-stage breast cancer: a comparison of family physician versus specialist care. J Clin Oncol (2006) 1.48

American Society of Clinical Oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer. J Clin Oncol (2004) 1.44

A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282. Int J Radiat Oncol Biol Phys (2005) 1.43

'Futile care': what to do when your patient insists on chemotherapy that likely won't help. Oncology (Williston Park) (2008) 1.42

Advance Care Planning Discussions: Why They Should Happen, Why They Don't, and How We Can Facilitate the Process. Oncology (Williston Park) (2015) 1.40

Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Am J Psychiatry (2004) 1.40

A case of inaccurate prognostication after the ARCTIC protocol. J Pain Symptom Manage (2012) 1.39

The association between personal measurements of environmental exposure to particulates and heart rate variability. Epidemiology (2002) 1.38

Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring. Antimicrob Agents Chemother (2011) 1.38

An antibody to the putative aphid recognition site on cucumber mosaic virus recognizes pentons but not hexons. J Virol (2002) 1.35

Differential antifungal and calcium channel-blocking activity among structurally related plant defensins. Plant Physiol (2004) 1.35

Paradoxes in advance care planning: the complex relationship of oncology patients, their physicians, and advance medical directives. J Clin Oncol (2009) 1.30

Structural determinants of metal specificity in the zinc transport protein ZnuA from synechocystis 6803. J Mol Biol (2003) 1.30

Scrambler therapy may relieve chronic neuropathic pain more effectively than guideline-based drug management: results of a pilot, randomized, controlled trial. J Pain Symptom Manage (2011) 1.29

Long-term ambient multipollutant exposures and mortality. Am J Respir Crit Care Med (2010) 1.29

Historical estimation of diesel exhaust exposure in a cohort study of U.S. railroad workers and lung cancer. Cancer Causes Control (2006) 1.26

Symptom domains in autism and related conditions: evidence for familiality. Am J Med Genet (2002) 1.21

Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle. J Virol (2012) 1.21

Cause-specific mortality in the unionized U.S. trucking industry. Environ Health Perspect (2007) 1.20

SusG: a unique cell-membrane-associated alpha-amylase from a prominent human gut symbiont targets complex starch molecules. Structure (2010) 1.20

Summary of the findings from the exposure assessments for metalworking fluid mortality and morbidity studies. Appl Occup Environ Hyg (2003) 1.19

High-resolution cryo-electron microscopy structures of murine norovirus 1 and rabbit hemorrhagic disease virus reveal marked flexibility in the receptor binding domains. J Virol (2010) 1.19

An intravaginal ring for the simultaneous delivery of multiple drugs. J Pharm Sci (2012) 1.17

Cyclic nucleotides. Phytochemistry (2004) 1.17

Human rhinovirus capsid dynamics is controlled by canyon flexibility. Virology (2003) 1.14

Skin exposure to isocyanates: reasons for concern. Environ Health Perspect (2006) 1.14

High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain. J Virol (2010) 1.13

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med (2011) 1.13

Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques. Antimicrob Agents Chemother (2012) 1.11

The structure of a cyanobacterial bicarbonate transport protein, CmpA. J Biol Chem (2006) 1.11

Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation. Biochemistry (2003) 1.10

Tenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings. AIDS (2012) 1.10

Persistent trigeminal artery terminating in the posterior inferior cerebellar artery: case report. Neurosurgery (2008) 1.09

Comparison of fine particle measurements from a direct-reading instrument and a gravimetric sampling method. J Occup Environ Hyg (2004) 1.09

Wiser use of dose-dense adjuvant therapy in breast cancer. J Clin Oncol (2012) 1.09

Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations. Biochem J (2002) 1.08

Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Am J Med Genet B Neuropsychiatr Genet (2008) 1.08

Structure of a SusD homologue, BT1043, involved in mucin O-glycan utilization in a prominent human gut symbiont. Biochemistry (2009) 1.08

Cotton dust and endotoxin levels in three Shanghai textile factories: a comparison of samplers. J Occup Environ Hyg (2006) 1.07

Microbial biofilms on the surface of intravaginal rings worn in non-human primates. J Med Microbiol (2011) 1.07

Toenail arsenic concentrations, GSTT1 gene polymorphisms, and arsenic exposure from drinking water. Cancer Epidemiol Biomarkers Prev (2005) 1.06

Vehicle traffic as a source of particulate polycyclic aromatic hydrocarbon exposure in the Mexico City metropolitan area. Environ Sci Technol (2004) 1.05

Using claims-based measures to predict performance status score in patients with lung cancer. Cancer (2010) 1.05

Antibodies to the buried N terminus of rhinovirus VP4 exhibit cross-serotypic neutralization. J Virol (2009) 1.05

Evidence-based palliative care in the intensive care unit: a systematic review of interventions. J Palliat Med (2014) 1.05

Distinction between paraclinoid and cavernous sinus aneurysms with computed tomographic angiography. Neurosurgery (2003) 1.05

Palliative care consultation and hospital length of stay. J Palliat Med (2010) 1.03

Do the large benefits justify the large costs of adjuvant breast cancer trastuzumab? J Clin Oncol (2007) 1.03

The structure and allosteric regulation of mammalian glutamate dehydrogenase. Arch Biochem Biophys (2011) 1.03

Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study. Am J Epidemiol (2007) 1.02

Tracking personal exposure to particulate diesel exhaust in a diesel freight terminal using organic tracer analysis. J Expo Sci Environ Epidemiol (2008) 1.02

Pilot evaluation of Scrambler therapy for the treatment of chemotherapy-induced peripheral neuropathy. Support Care Cancer (2014) 1.02