Utility of adiponectin as a biomarker predictive of glycemic efficacy is demonstrated by collaborative pooling of data from clinical trials conducted by multiple sponsors.

PubWeight™: 2.60‹?› | Rank: Top 1%

🔗 View Article (PMID 19553931)

Published in Clin Pharmacol Ther on June 24, 2009

Authors

J A Wagner1, E C Wright, M M Ennis, M Prince, J Kochan, D J R Nunez, B Schneider, M-D Wang, Y Chen, S Ghosh, B J Musser, M T Vassileva

Author Affiliations

1: Department of Clinical Pharmacology, Merck Research Laboratories, Rahway, New Jersey, USA.

Articles by these authors

(truncated to the top 100)

The Ensembl genome database project. Nucleic Acids Res (2002) 40.87

Gene-expression profiles in hereditary breast cancer. N Engl J Med (2001) 29.80

Ensembl 2009. Nucleic Acids Res (2008) 25.38

Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21

The nucleic acid database. A comprehensive relational database of three-dimensional structures of nucleic acids. Biophys J (1992) 21.67

Ensembl 2008. Nucleic Acids Res (2007) 20.67

Ensembl 2007. Nucleic Acids Res (2006) 20.10

Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet (1996) 15.73

Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature (2000) 15.53

Ensembl 2005. Nucleic Acids Res (2005) 15.13

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35

Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26

Ensembl 2004. Nucleic Acids Res (2004) 11.88

Ensembl 2006. Nucleic Acids Res (2006) 11.66

Expression profiling using cDNA microarrays. Nat Genet (1999) 11.58

Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature (1999) 10.97

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14

Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci U S A (2006) 9.26

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73

Data management and analysis for gene expression arrays. Nat Genet (1998) 8.60

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res (2001) 8.34

Ratio-based decisions and the quantitative analysis of cDNA microarray images. J Biomed Opt (1997) 8.32

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (2001) 7.66

Inhibition of NF-kappa B by sodium salicylate and aspirin. Science (1994) 7.60

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell (1998) 7.03

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (1999) 5.95

NF-kappaB and the immune response. Oncogene (2006) 5.62

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A (2001) 5.48

Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study. Diabetologia (2005) 5.47

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (1997) 5.45

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J (1998) 5.34

Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 5.20

A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet (2001) 5.06

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 5.04

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99

Cross-bridge model of muscle contraction. Quantitative analysis. Biophys J (1980) 4.91

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78

Prevention of fat-induced insulin resistance by salicylate. J Clin Invest (2001) 4.74

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res (1998) 4.68

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature (2000) 4.66

NICE guidance on CardioQ(TM) oesophageal Doppler monitoring. Anaesthesia (2011) 4.63

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol (1996) 4.56

Signal transduction through NF-kappa B. Immunol Today (1998) 4.54

Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling. Cancer Res (2001) 4.51

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet (2001) 4.48

Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature (1991) 4.27

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology (1998) 4.13

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science (2000) 4.04

Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99

Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science (1994) 3.96

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem (2000) 3.90

Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Res (2000) 3.83

Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76

The PDB data uniformity project. Nucleic Acids Res (2001) 3.65

A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1. J Virol (1998) 3.65

Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study. Proc Natl Acad Sci U S A (1984) 3.63

Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature (1995) 3.59

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev (1992) 3.47

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science (1999) 3.47

High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol Motil (2004) 3.44

Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature (1996) 3.37

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev (1996) 3.32

Cooperative effects in models of steady-state transport across membranes. 3. Simulation of potassium ion transport in nerve. Proc Natl Acad Sci U S A (1970) 3.30

Mechanism of the cardiotoxic actions of terfenadine. JAMA (1993) 3.27

Long-term treatment of pulmonary hypertension with aerosolized iloprost. Eur Respir J (2001) 3.27

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci U S A (1998) 3.27

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science (1998) 3.26

Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae. Mol Biol Cell (1996) 3.23

Concern Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up. BMJ (1992) 3.14

Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol (2000) 3.08

Scanning two-photon fluctuation correlation spectroscopy: particle counting measurements for detection of molecular aggregation. Biophys J (1996) 3.04

Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest (2001) 3.04

Prognosis in chronic obstructive pulmonary disease. Am Rev Respir Dis (1986) 3.03

Ageing and mental health in a developing country: who cares? Qualitative studies from Goa, India. Psychol Med (2001) 3.02

Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med (1992) 3.01

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res (2000) 3.01

An SNP map of human chromosome 22. Nature (2000) 2.99

Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect Immun (2001) 2.98

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol (1998) 2.97

TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene (2008) 2.94

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc Natl Acad Sci U S A (1998) 2.92

Comparison of the ABI 7700 system (TaqMan) and competitive PCR for quantification of IS6110 DNA in sputum during treatment of tuberculosis. J Clin Microbiol (1998) 2.91

Quantitative quality control in microarray image processing and data acquisition. Nucleic Acids Res (2001) 2.91

Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science (1986) 2.89

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation. Science (1995) 2.87

Phase changes at the end of a microtubule with a GTP cap. Proc Natl Acad Sci U S A (1984) 2.87

High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N Engl J Med (2000) 2.86

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci U S A (1998) 2.85

Structural and magnetic phase diagram of CeFeAsO(1- x)F(x) and its relation to high-temperature superconductivity. Nat Mater (2008) 2.83

Airways obstruction and the risk for lung cancer. Ann Intern Med (1987) 2.77

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut (2008) 2.77

Predictors of aspiration pneumonia: how important is dysphagia? Dysphagia (1998) 2.76

Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes (1997) 2.76