Published in Cell on June 26, 2009
Niemann-Pick disease type C. Orphanet J Rare Dis (2010) 4.86
Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J (2012) 2.08
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proc Natl Acad Sci U S A (2010) 1.89
Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. J Neurochem (2011) 1.80
Role of the gut in lipid homeostasis. Physiol Rev (2012) 1.73
Early steps in steroidogenesis: intracellular cholesterol trafficking. J Lipid Res (2011) 1.71
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc Natl Acad Sci U S A (2009) 1.69
Autophagy in lysosomal storage disorders. Autophagy (2012) 1.59
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat Methods (2013) 1.59
Cholesterol, the central lipid of mammalian cells. Curr Opin Cell Biol (2010) 1.54
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. J Cell Biol (2011) 1.48
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc Natl Acad Sci U S A (2011) 1.46
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. Cell Metab (2010) 1.44
Structure and function of ER membrane contact sites with other organelles. Nat Rev Mol Cell Biol (2015) 1.44
Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding. Proc Natl Acad Sci U S A (2011) 1.35
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. Cell Rep (2013) 1.28
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. Annu Rev Physiol (2011) 1.28
Cell cholesterol homeostasis: mediation by active cholesterol. Trends Cell Biol (2010) 1.26
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem (2012) 1.23
New therapies in the management of Niemann-Pick type C disease: clinical utility of miglustat. Ther Clin Risk Manag (2009) 1.23
Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res (2010) 1.22
High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets. Genet Med (2015) 1.22
Complex lipid trafficking in Niemann-Pick disease type C. J Inherit Metab Dis (2014) 1.20
NPC1L1 and cholesterol transport. FEBS Lett (2010) 1.19
Lipid trafficking sans vesicles: where, why, how? Cell (2010) 1.19
Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet (2009) 1.18
Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. J Biol Chem (2011) 1.18
Oxidative stress in Niemann-Pick disease, type C. Mol Genet Metab (2010) 1.18
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife (2013) 1.15
Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. Sci Transl Med (2015) 1.14
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Hum Mol Genet (2012) 1.14
Scavenger receptor class B type I is a plasma membrane cholesterol sensor. Circ Res (2012) 1.13
Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease. J Biol Chem (2010) 1.12
The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes. J Lipid Res (2009) 1.12
Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep (2012) 1.11
Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1. Hum Mol Genet (2012) 1.10
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations. J Lipid Res (2011) 1.09
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection. Elife (2015) 1.08
Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream. J Lipid Res (2012) 1.07
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem (2011) 1.07
Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage. J Lipid Res (2011) 1.07
Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease. Semin Liver Dis (2013) 1.05
ECOD: an evolutionary classification of protein domains. PLoS Comput Biol (2014) 1.04
Treatment of Niemann--pick type C disease by histone deacetylase inhibitors. Neurotherapeutics (2013) 1.02
Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion. J Lipid Res (2010) 1.01
Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress. PLoS One (2011) 1.00
An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. J Biol Chem (2011) 0.99
Lipid sorting and multivesicular endosome biogenesis. Cold Spring Harb Perspect Biol (2013) 0.98
Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes. Curr Biol (2016) 0.98
Cholesterol as a co-solvent and a ligand for membrane proteins. Protein Sci (2013) 0.97
Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc Natl Acad Sci U S A (2011) 0.97
Genetic and laboratory diagnostic approach in Niemann Pick disease type C. J Neurol (2014) 0.97
Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C. Am J Pathol (2011) 0.97
Structural architecture and functional evolution of Wnts. Dev Cell (2012) 0.97
Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin. J Lipid Res (2014) 0.96
Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration. Hum Mol Genet (2011) 0.96
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res (2011) 0.96
Synthesis of 2-hydroxypropyl-β-cyclodextrin/pluronic-based polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics. Biomacromolecules (2013) 0.93
Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C. Dis Model Mech (2013) 0.91
Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease. Clin Lipidol (2012) 0.91
The structure of the NPC1L1 N-terminal domain in a closed conformation. PLoS One (2011) 0.90
Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish. J Lipid Res (2011) 0.90
Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease. Oxid Med Cell Longev (2012) 0.90
Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells. Proc Natl Acad Sci U S A (2015) 0.90
A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. J Neurosci (2015) 0.89
Structure of human Niemann-Pick C1 protein. Proc Natl Acad Sci U S A (2016) 0.89
Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation. PLoS One (2010) 0.88
Loss of Niemann-Pick C1 or C2 protein results in similar biochemical changes suggesting that these proteins function in a common lysosomal pathway. PLoS One (2011) 0.88
Cholesterol in brain disease: sometimes determinant and frequently implicated. EMBO Rep (2014) 0.88
A cholesterol recognition amino acid consensus domain in GP64 fusion protein facilitates anchoring of baculovirus to mammalian cells. J Virol (2013) 0.88
Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2. J Lipid Res (2014) 0.88
Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol Cell Biol (2011) 0.86
Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin. PLoS Genet (2013) 0.86
Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism. Front Cell Dev Biol (2015) 0.86
Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. PLoS One (2012) 0.86
Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung. Am J Physiol Lung Cell Mol Physiol (2012) 0.85
Misdiagnosis of Niemann-Pick disease type C as Gaucher disease. J Inherit Metab Dis (2010) 0.85
Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS One (2013) 0.85
Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. PLoS Pathog (2011) 0.85
Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions. FEBS Lett (2016) 0.85
Intestinal and hepatic niemann-pick c1-like 1. Diabetes Metab J (2013) 0.85
Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks. Orphanet J Rare Dis (2013) 0.85
Altered vitamin E status in Niemann-Pick type C disease. J Lipid Res (2011) 0.84
Cysteine-rich domains related to Frizzled receptors and Hedgehog-interacting proteins. Protein Sci (2012) 0.84
Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain. Proteomics (2012) 0.84
Reduced VLDL clearance in Apoe(-/-)Npc1(-/-) mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels. J Lipid Res (2010) 0.83
Sterols and sphingolipids: dynamic duo or partners in crime? Prog Lipid Res (2010) 0.83
Role of endosomes and lysosomes in human disease. Cold Spring Harb Perspect Biol (2014) 0.83
Generation of a human neuronal stable cell model for niemann-pick C disease by RNA interference. JIMD Rep (2011) 0.82
A novel baculovirus vector for the production of nonfucosylated recombinant glycoproteins in insect cells. Glycobiology (2013) 0.82
Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts. PLoS One (2012) 0.82
The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic (2013) 0.82
STARTing to understand MLN64 function in cholesterol transport. J Lipid Res (2010) 0.82
Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2. Proc Natl Acad Sci U S A (2016) 0.82
Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes. Biophys J (2015) 0.82
The formation and function of ER-endosome membrane contact sites. Biochim Biophys Acta (2016) 0.82
Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. J Biol Chem (2015) 0.81
A marked paucity of granule cells in the developing cerebellum of the Npc1(-/-) mouse is corrected by a single injection of hydroxypropyl-β-cyclodextrin. Neurobiol Dis (2014) 0.81
Links between copper and cholesterol in Alzheimer's disease. Front Physiol (2013) 0.81
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
The gel-filtration behaviour of proteins related to their molecular weights over a wide range. Biochem J (1965) 30.51
Substructure solution with SHELXD. Acta Crystallogr D Biol Crystallogr (2002) 27.16
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
A receptor-mediated pathway for cholesterol homeostasis. Science (1986) 19.28
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell (1997) 17.78
Protein sensors for membrane sterols. Cell (2006) 8.62
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (1997) 6.66
The function of sterols in membranes. Biochim Biophys Acta (1976) 5.93
How cells handle cholesterol. Science (2000) 5.56
Identification of HE1 as the second gene of Niemann-Pick C disease. Science (2000) 5.08
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell (1999) 3.23
Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell (2004) 3.07
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc Natl Acad Sci U S A (2008) 2.81
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. J Biol Chem (1975) 2.55
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu Rev Cell Dev Biol (2005) 2.41
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem (2007) 2.34
Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc Natl Acad Sci U S A (2004) 2.32
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem (2007) 2.29
Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease. Proc Natl Acad Sci U S A (2003) 2.21
Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport. J Biol Chem (2006) 1.92
Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type C fibroblasts. J Biol Chem (1987) 1.92
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A (2003) 1.86
Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease. J Biol Chem (2007) 1.83
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. J Biol Chem (1987) 1.60
The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus. Protein Expr Purif (2009) 1.50
A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol. Biochim Biophys Acta (1999) 1.47
Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation. Biochim Biophys Acta (2008) 1.46
Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization. Proc Natl Acad Sci U S A (1999) 1.30
Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. J Biol Chem (1992) 1.30
Niemann-Pick C research from mouse to gene. Biochim Biophys Acta (2004) 1.26
Development of an assay for the intermembrane transfer of cholesterol by Niemann-Pick C2 protein. Biol Chem (2007) 1.25
Regulation of sterol transport between membranes and NPC2. Biochemistry (2008) 1.23
A coat of glycoconjugates on the inner surface of the lysosomal membrane in the rat kidney. Histochemistry (1984) 1.08
Clathrin-mediated endocytosis before fluorescent proteins. Nat Rev Mol Cell Biol (2006) 1.03
NPC1/NPC2 function as a tag team duo to mobilize cholesterol. Proc Natl Acad Sci U S A (2008) 1.00
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest (2002) 21.08
Protein sensors for membrane sterols. Cell (2006) 8.62
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A (2003) 8.20
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem (2002) 5.89
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell (2002) 5.70
Selective versus total insulin resistance: a pathogenic paradox. Cell Metab (2008) 5.25
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell (2008) 5.10
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A (2010) 4.40
Structure of the LDL receptor extracellular domain at endosomal pH. Science (2002) 4.06
The LDL receptor. Arterioscler Thromb Vasc Biol (2009) 3.78
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A (2004) 3.73
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A (2002) 3.51
Structural basis of gating by the outer membrane transporter FecA. Science (2002) 3.40
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci U S A (2003) 3.38
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab (2008) 3.33
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res (2008) 3.31
Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell (2004) 3.07
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A (2007) 3.01
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem (2004) 2.82
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc Natl Acad Sci U S A (2008) 2.81
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell (2002) 2.80
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell (2005) 2.78
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science (2002) 2.72
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest (2004) 2.66
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys (2002) 2.57
History of science. A golden era of Nobel laureates. Science (2012) 2.55
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A (2003) 2.49
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 2.48
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci U S A (2007) 2.46
Molecular basis for LDL receptor recognition by PCSK9. Proc Natl Acad Sci U S A (2008) 2.42
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell (2003) 2.40
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem (2007) 2.34
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem (2007) 2.29
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A (2010) 2.06
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem (2003) 2.05
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest (2005) 2.03
The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell (2002) 2.01
Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem (2005) 1.91
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab (2012) 1.79
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metab (2006) 1.74
Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science (2006) 1.74
Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc Natl Acad Sci U S A (2009) 1.69
Metal import through microbial membranes. Cell (2004) 1.60
Motion regularization for matting motion blurred objects. IEEE Trans Pattern Anal Mach Intell (2011) 1.56
Biomedicine. Lowering LDL--not only how low, but how long? Science (2006) 1.54
TonB-dependent receptors-structural perspectives. Biochim Biophys Acta (2002) 1.53
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A (2002) 1.53
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. Cell Metab (2010) 1.44
Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proc Natl Acad Sci U S A (2003) 1.42
Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Proc Natl Acad Sci U S A (2007) 1.42
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc Natl Acad Sci U S A (2012) 1.37
Membrane topology of human insig-1, a protein regulator of lipid synthesis. J Biol Chem (2003) 1.36
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A (2008) 1.36
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metab (2005) 1.34