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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 5.22

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SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73

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STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47

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Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11

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PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06

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NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02

TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96

Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91

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Homer proteins regulate sensitivity to cocaine. Neuron (2004) 1.83

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development (2012) 1.81

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RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58

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Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56

XTRPC1-dependent chemotropic guidance of neuronal growth cones. Nat Neurosci (2005) 1.55

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci (2010) 1.54

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene (2002) 1.54

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell (2011) 1.52

Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50

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Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron (2011) 1.49

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci (2012) 1.49

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47

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Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36