Published in BMJ on July 06, 2009
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol (2013) 4.29
The pathobiology of vascular dementia. Neuron (2013) 3.07
Outcome markers for clinical trials in cerebral amyloid angiopathy. Lancet Neurol (2014) 2.39
Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. BMJ (2011) 1.51
Suspected early dementia. BMJ (2011) 1.41
Ischemic stroke in the elderly: an overview of evidence. Nat Rev Neurol (2010) 1.15
Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease. Brain (2011) 1.13
Cognitive impairment in peritoneal dialysis patients. Am J Kidney Dis (2011) 1.13
Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients. PLoS One (2012) 1.01
Vulnerability: the crossroads of frailty and delirium. J Am Geriatr Soc (2011) 1.00
Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment. Stroke (2014) 0.96
Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study. J Neurol (2012) 0.94
MRI-detected white matter lesions: do they really matter? J Neural Transm (Vienna) (2011) 0.92
Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid. Cerebrospinal Fluid Res (2010) 0.92
Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res (2014) 0.91
Ischemic brain injury in cerebral amyloid angiopathy. J Cereb Blood Flow Metab (2016) 0.89
Circulating omega-3 polyunsaturated fatty acids and subclinical brain abnormalities on MRI in older adults: the Cardiovascular Health Study. J Am Heart Assoc (2013) 0.87
Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab (2016) 0.84
METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimers Dement (2016) 0.83
Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLoS One (2011) 0.83
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. Brain (2015) 0.83
White Matter Lesion Assessment in Patients with Cognitive Impairment and Healthy Controls: Reliability Comparisons between Visual Rating, a Manual, and an Automatic Volumetrical MRI Method-The Gothenburg MCI Study. J Aging Res (2013) 0.82
Depressive symptoms as a predictor of quality of life in cerebral small vessel disease, acting independently of disability; a study in both sporadic small vessel disease and CADASIL. Int J Stroke (2012) 0.82
Genetics of age-related white matter lesions from linkage to genome wide association studies. J Neurol Sci (2012) 0.82
Do eye movement impairments in patients with small vessel cerebrovascular disease depend on lesion load or on cognitive deficits? A video-oculographic and MRI study. J Neurol (2014) 0.82
Cerebral small vessel disease, cognitive reserve and cognitive dysfunction. J Neurol (2015) 0.81
Dementia: Vascular and neurodegenerative pathways-will they meet? Nat Rev Neurol (2013) 0.81
White matter dementia. Ther Adv Neurol Disord (2012) 0.81
Correlating Cognitive Decline with White Matter Lesion and Brain Atrophy Magnetic Resonance Imaging Measurements in Alzheimer's Disease. J Alzheimers Dis (2015) 0.81
The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review. Neuropsychol Rev (2016) 0.80
Prognostic implications of microvascular and macrovascular abnormalities in older adults: cardiovascular health study. J Gerontol A Biol Sci Med Sci (2014) 0.80
Imaging small vessel-associated white matter changes in aging. Neuroscience (2013) 0.80
Longitudinal change of small-vessel disease-related brain abnormalities. J Cereb Blood Flow Metab (2016) 0.80
Leukoaraiosis, Cerebral Hemorrhage, and Outcome After Intravenous Thrombolysis for Acute Ischemic Stroke: A Meta-Analysis (v1). Stroke (2016) 0.80
Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers-The VMCI-Tuscany Study: Rationale, Design, and Methodology. Int J Alzheimers Dis (2012) 0.79
The VAS-COG clinic: an out-patient service for patients with cognitive and behavioral consequences of cerebrovascular diseases. Neurol Sci (2012) 0.79
Comparison of dementia risk between end stage renal disease patients with hemodialysis and peritoneal dialysis--a population based study. Sci Rep (2015) 0.79
BIANCA (Brain Intensity AbNormality Classification Algorithm): A new tool for automated segmentation of white matter hyperintensities. Neuroimage (2016) 0.78
Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: results from a subset of the LADIS study. Am J Geriatr Psychiatry (2013) 0.78
Impact of white matter lesions on cognition in stroke patients free from pre-stroke cognitive impairment: a one-year follow-up study. Dement Geriatr Cogn Dis Extra (2012) 0.78
Progression of White Matter Lesion Volume and Health-Related Quality of Life in Patients with Symptomatic Atherosclerotic Disease: The SMART-MR Study. J Aging Res (2011) 0.78
Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study. J Am Geriatr Soc (2015) 0.77
Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study. Neurol Sci (2012) 0.77
Dementia and neuroimaging. J Neurol (2012) 0.77
Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study. J Neurol (2014) 0.77
Incidental Intracranial Findings and Their Clinical Impact; The HUNT MRI Study in a General Population of 1006 Participants between 50-66 Years. PLoS One (2016) 0.76
Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? Front Pharmacol (2016) 0.76
Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease. Mol Brain (2016) 0.76
Subjective cognitive impairment subjects in our clinical practice. Dement Geriatr Cogn Dis Extra (2014) 0.76
Morphologic and neuropsychological patterns in patients suffering from Alzheimer's disease. Neuroradiology (2016) 0.76
The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease. Medicine (Baltimore) (2016) 0.76
Effects of citicoline therapy on the network connectivity of the corpus callosum in patients with leukoaraiosis. Medicine (Baltimore) (2017) 0.75
Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment. PLoS One (2017) 0.75
Coronary artery calcium is associated with cortical thinning in cognitively normal individuals. Sci Rep (2016) 0.75
Vascular Cognitive Impairment through the Looking Glass of Transcranial Magnetic Stimulation. Behav Neurol (2017) 0.75
Concepts and opportunities for repair in cerebral microvascular disease and white matter stroke. Neural Regen Res (2016) 0.75
White matter and ageing. Osteoarthritis and protection from global functional decline. BMJ (2009) 0.75
Vascular Cognitive Impairment in a Memory Clinic Population: Rationale and Design of the "Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment" (TRACE-VCI) Study. JMIR Res Protoc (2017) 0.75
What can imaging tell us about cognitive impairment and dementia? World J Radiol (2016) 0.75
The Dementia and Disability Project in Thai Elderly: rational, design, methodology and early results. BMC Neurol (2013) 0.75
Pseudobulbar paralysis in the Renaissance: Cosimo I de' Medici case. Neurol Sci (2014) 0.75
Cystatin C, a potential marker for cerebral microvascular compliance, is associated with white-matter hyperintensities progression. PLoS One (2017) 0.75
Periventricular White Matter Lesions as a Prognostic Factor of Swallowing Function in Older Patients with Mild Stroke. Dysphagia (2017) 0.75
Thrombolysis in dementia patients with acute stroke: is it justified? Neurol Sci (2016) 0.75
Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist (1969) 45.63
Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med (1999) 9.17
Experience from a multicentre stroke register: a preliminary report. Bull World Health Organ (1976) 7.43
Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc (1983) 6.17
Pathogenesis of leukoaraiosis: a review. Stroke (1997) 4.95
Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology (1994) 3.75
Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain (2005) 3.34
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke (2006) 3.27
Cerebral white matter lesions and the risk of dementia. Arch Neurol (2004) 3.17
Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation (2005) 2.97
Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke (2005) 2.59
Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. J Am Geriatr Soc (2005) 2.31
Cerebral white matter changes and geriatric syndromes: is there a link? J Gerontol A Biol Sci Med Sci (2004) 1.92
Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology. Neuroepidemiology (2005) 1.92
Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke (2006) 1.88
The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke (1995) 1.87
Plan and operation of the NHANES I Epidemiologic Followup Study, 1992. Vital Health Stat 1 (1997) 1.61
Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study. Arch Intern Med (2007) 1.52
White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease. Neurology (2004) 1.47
Leukoaraiosis: an independent risk factor for stroke? Stroke (2003) 1.21
The Italian Longitudinal Study on Aging (ILSA): design and methods. Aging (Milano) (1994) 1.20
Subcortical white matter lesions and functional impairment in geriatric depression. Depress Anxiety (2002) 1.19
Subcortical vascular disease and functional decline: a 6-year predictor study. J Am Geriatr Soc (2002) 1.11
Clinical features of leuko-araiosis. J Neurol Neurosurg Psychiatry (1996) 1.06
White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study. AJNR Am J Neuroradiol (2008) 0.97
Methodological challenges in measurements of functional ability in gerontological research. A review. Aging (Milano) (1997) 0.87
Health data on older Americans: United States, 1992. Introduction. Background. Vital Health Stat 3 (1993) 0.82
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.26
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol (2007) 18.62
A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med (2014) 18.12
High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med (2006) 14.79
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med (2010) 13.82
Mild cognitive impairment. Lancet (2006) 10.21
Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol (2010) 8.74
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA (2009) 7.29
Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet (2015) 7.16
Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol (2006) 6.97
National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke (2006) 6.94
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol (2013) 6.18
Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet (2011) 6.09
MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol (2012) 5.91
Donepezil and memantine for moderate-to-severe Alzheimer's disease. N Engl J Med (2012) 5.64
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat Genet (2013) 5.22
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med (2006) 5.20
Cerebral venous thrombosis: an update. Lancet Neurol (2007) 5.17
Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan: Response. Radiology (2017) 4.99
The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol (2010) 4.59
Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ (2011) 4.34
Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin Chem (2004) 4.23
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study. Hum Brain Mapp (2005) 4.11
PML in a patient treated with dimethyl fumarate from a compounding pharmacy. N Engl J Med (2013) 4.02
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93
Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol (2008) 3.91
Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke (2004) 3.83
Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet (2011) 3.76
Vascular cognitive impairment. Lancet Neurol (2003) 3.73
Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev (2011) 3.71
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol (2009) 3.65
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke (2010) 3.53
MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol (2007) 3.47
Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. Lancet Neurol (2009) 3.42
Subcortical ischaemic vascular dementia. Lancet Neurol (2002) 3.32
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol (2007) 3.25
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A (2011) 3.23
Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol (2007) 3.22
Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study. Lancet Neurol (2011) 3.16
Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry. Stroke (2003) 3.15
Fast and robust multi-atlas segmentation of brain magnetic resonance images. Neuroimage (2009) 3.13
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement (2011) 3.05
Incident lacunes influence cognitive decline: the LADIS study. Neurology (2011) 2.81
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci (2008) 2.77
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch Neurol (2011) 2.75
Dementia with Lewy bodies. Lancet Neurol (2004) 2.66
Comprehensive geriatric assessment for older hospital patients. Br Med Bull (2005) 2.64
Chronic cerebrospinal venous insufficiency and multiple sclerosis. Ann Neurol (2010) 2.63
Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke (2005) 2.59
Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study. Stroke (2008) 2.57
Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke (2007) 2.56
Causes and predictors of death in cerebral venous thrombosis. Stroke (2005) 2.56
Cognitive impairment in heart failure: a systematic review of the literature. Eur J Heart Fail (2006) 2.56
Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke (2009) 2.51
Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment. Neurobiol Aging (2008) 2.51
Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology (2005) 2.47
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry (2010) 2.44
MRI and the diagnosis of multiple sclerosis: expanding the concept of "no better explanation". Lancet Neurol (2006) 2.44
Profile of cognitive impairment in chronic heart failure. J Am Geriatr Soc (2007) 2.43
Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study. Hypertension (2004) 2.43
Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology (2008) 2.41
Brain imaging in patients with diabetes: a systematic review. Diabetes Care (2006) 2.39
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37
European Stroke Initiative Recommendations for Stroke Management-update 2003. Cerebrovasc Dis (2003) 2.35
Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem (2009) 2.32
Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance. Brain (2002) 2.30
White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study. Ann Neurol (2005) 2.29
Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance. Neurobiol Aging (2010) 2.27
Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology (2012) 2.23
Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain (2003) 2.20
Magnetic resonance imaging pattern recognition in hypomyelinating disorders. Brain (2010) 2.19
Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele. Lancet Neurol (2010) 2.18