The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.

PubWeight™: 16.06‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 1959406)

Published in Chest on December 01, 1991

Authors

W A Knaus1, D P Wagner, E A Draper, J E Zimmerman, M Bergner, P G Bastos, C A Sirio, D J Murphy, T Lotring, A Damiano

Author Affiliations

1: Department of Anesthesiology, George Washington University Medical Center, Washington, DC.

Articles citing this

(truncated to the top 100)

RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29

Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65

A randomized trial of nighttime physician staffing in an intensive care unit. N Engl J Med (2013) 4.94

SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Med (2005) 4.66

Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med (2009) 3.92

Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis (2007) 3.73

Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med (2007) 3.69

Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med (2005) 3.69

Chlorhexidine, toothbrushing, and preventing ventilator-associated pneumonia in critically ill adults. Am J Crit Care (2009) 3.47

Defining and improving data quality in medical registries: a literature review, case study, and generic framework. J Am Med Inform Assoc (2002) 3.41

Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med (2007) 3.31

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax (2008) 3.13

Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation (2008) 3.06

Chronic conditions and risk of in-hospital death. Health Serv Res (1994) 3.00

Association between ICU admission during morning rounds and mortality. Chest (2009) 2.98

Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int (2009) 2.97

Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother (2007) 2.97

SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 1: Objectives, methods and cohort description. Intensive Care Med (2005) 2.84

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79

Development of a triage protocol for critical care during an influenza pandemic. CMAJ (2006) 2.78

Clinical review: scoring systems in the critically ill. Crit Care (2010) 2.78

Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: the Intensive Care National Audit & Research Centre Case Mix Programme Database. Crit Care (2004) 2.71

Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53

Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med (2015) 2.53

Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax (2003) 2.47

Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med (2008) 2.37

Severe sepsis epidemiology: sampling, selection, and society. Crit Care (2004) 2.28

Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int (2011) 2.22

The role of infection and comorbidity: Factors that influence disparities in sepsis. Crit Care Med (2006) 2.21

Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17

Judging hospitals by severity-adjusted mortality rates: the influence of the severity-adjustment method. Am J Public Health (1996) 2.15

Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob Agents Chemother (2006) 2.07

Multicenter development and validation of a risk stratification tool for ward patients. Am J Respir Crit Care Med (2014) 2.06

Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards. J Hosp Med (2015) 2.02

Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia. J Clin Microbiol (2007) 1.99

A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med (2012) 1.92

A simple clinical predictive index for objective estimates of mortality in acute lung injury. Crit Care Med (2009) 1.91

Sex-and age-based differences in the delivery and outcomes of critical care. CMAJ (2007) 1.91

Methods of blood pressure measurement in the ICU. Crit Care Med (2013) 1.89

Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. Crit Care Med (2016) 1.88

Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc (2004) 1.85

Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia. BMC Infect Dis (2011) 1.83

Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J (2006) 1.82

Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med (2012) 1.81

Safer discharge from intensive care to hospital wards. BMJ (2001) 1.79

Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. Crit Care (2007) 1.78

Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med (2011) 1.77

Is there a July phenomenon? The effect of July admission on intensive care mortality and length of stay in teaching hospitals. J Gen Intern Med (2003) 1.77

Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg (2003) 1.77

The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest (2010) 1.75

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev (2013) 1.72

Acute neuromuscular respiratory paralysis. J Neurol Neurosurg Psychiatry (1993) 1.72

Differences in immune response may explain lower survival among older men with pneumonia. Crit Care Med (2009) 1.71

Informatics: essential infrastructure for quality assessment and improvement in nursing. J Am Med Inform Assoc (1995) 1.69

Patient-specific, time-varying predictors of post-ICU informal caregiver burden: the caregiver outcomes after ICU discharge project. Chest (2009) 1.69

Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study. Lancet Respir Med (2014) 1.68

Objective factors associated with physicians' and nurses' perceptions of intensive care unit capacity strain. Ann Am Thorac Soc (2014) 1.68

Classifying AKI by Urine Output versus Serum Creatinine Level. J Am Soc Nephrol (2015) 1.68

Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms. Antimicrob Agents Chemother (2007) 1.66

Tissue Doppler in critical illness: a retrospective cohort study. Crit Care (2007) 1.65

Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med (2006) 1.64

Accurate prognostications of death. Opportunities and challenges for clinicians. West J Med (1995) 1.62

Medical and financial risks associated with surgery in the elderly obese. Ann Surg (2012) 1.61

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med (2008) 1.61

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med (2010) 1.60

Prognostic factors in laryngotracheal injury following intubation and/or tracheotomy in ICU patients. Eur Arch Otorhinolaryngol (2005) 1.55

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med (2015) 1.55

Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care (2011) 1.55

Increased mortality with accessory gene regulator (agr) dysfunction in Staphylococcus aureus among bacteremic patients. Antimicrob Agents Chemother (2010) 1.52

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med (2011) 1.52

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma (2010) 1.51

Impact of empiric antibiotic therapy on outcomes in patients with Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother (2006) 1.50

Examining the positive effects of exercise in intubated adults in ICU: a prospective repeated measures clinical study. Intensive Crit Care Nurs (2012) 1.50

Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care (2007) 1.50

Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care (2013) 1.49

A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48

A physiological time series dynamics-based approach to patient monitoring and outcome prediction. IEEE J Biomed Health Inform (2014) 1.48

Perceptions of "futile care" among caregivers in intensive care units. CMAJ (2007) 1.48

'End-of-life' decision making within intensive care--objective, consistent, defensible? J Med Ethics (2000) 1.47

Costs of bloodstream infections caused by Escherichia coli and influence of extended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy. Antimicrob Agents Chemother (2010) 1.47

Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. Crit Care Resusc (2013) 1.45

Mortality prediction using SAPS II: an update for French intensive care units. Crit Care (2005) 1.43

Neglect of quality-of-life considerations in intensive care unit family meetings for long-stay intensive care unit patients. Crit Care Med (2012) 1.43

Acute respiratory distress syndrome ("ARDS"): no more than a severe acute lung injury? BMJ (1993) 1.43

Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care (2014) 1.42

Intensive care unit admission in multiple sclerosis: increased incidence and increased mortality. Neurology (2014) 1.42

Role of written advance directives in decision making: insights from qualitative and quantitative data. J Gen Intern Med (1998) 1.40

Long-term survival in patients with tracheostomy and prolonged mechanical ventilation in Olmsted County, Minnesota. Respir Care (2011) 1.40

Unfolding Physiological State: Mortality Modelling in Intensive Care Units. KDD (2014) 1.39

Effectiveness trial of an intensive communication structure for families of long-stay ICU patients. Chest (2010) 1.38

The Patient- And Nutrition-Derived Outcome Risk Assessment Score (PANDORA): Development of a Simple Predictive Risk Score for 30-Day In-Hospital Mortality Based on Demographics, Clinical Observation, and Nutrition. PLoS One (2015) 1.38

Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care (2005) 1.37

The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study. Crit Care (2005) 1.36

Role of disease risk scores in comparative effectiveness research with emerging therapies. Pharmacoepidemiol Drug Saf (2012) 1.32

The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies. Thorax (2010) 1.31

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med (2011) 1.31

A comparison between the APACHE II and Charlson Index Score for predicting hospital mortality in critically ill patients. BMC Health Serv Res (2009) 1.30

Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med (2012) 1.29

Preoperative antibiotics and mortality in the elderly. Ann Surg (2005) 1.28

Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Antimicrob Agents Chemother (2008) 1.27

Articles by these authors

APACHE II: a severity of disease classification system. Crit Care Med (1985) 69.83

The Sickness Impact Profile: development and final revision of a health status measure. Med Care (1981) 18.20

APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med (1981) 9.14

Variations in mortality and length of stay in intensive care units. Ann Intern Med (1993) 5.49

An evaluation of outcome from intensive care in major medical centers. Ann Intern Med (1986) 5.41

A normal sagittal spinal configuration: a desirable clinical outcome. J Manipulative Physiol Ther (1997) 4.75

The performance of intensive care units: does good management make a difference? Med Care (1994) 4.41

The sickness impact profile: conceptual formulation and methodology for the development of a health status measure. Int J Health Serv (1976) 4.39

The sickness impact profile: validation of a health status measure. Med Care (1976) 3.95

Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression. BMJ (1991) 3.74

Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA (1995) 3.45

Prognosis in acute organ-system failure. Ann Surg (1985) 3.26

The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments. Ann Intern Med (1995) 3.08

New do-not-resuscitate policies. A first step in cost control. Arch Intern Med (1993) 3.05

Comparison of the performance of two comorbidity measures, with and without information from prior hospitalizations. Med Care (2001) 2.96

Birth of a biome: insights into the assembly and maintenance of the Australian arid zone biota. Mol Ecol (2008) 2.73

Evaluation of acute physiology and chronic health evaluation III predictions of hospital mortality in an independent database. Crit Care Med (1998) 2.44

The use of intensive care: a comparison of a university and community hospital. Health Care Financ Rev (1981) 2.33

Initial development of a system-wide maternal-fetal outcomes assessment program. Am J Obstet Gynecol (2000) 2.24

The sickness impact profile. Development of an outcome measure of health care. Am J Public Health (1975) 2.21

Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study. J Am Coll Cardiol (2000) 2.14

Instrumental delivery and ultrasound : a multicentre randomised controlled trial of ultrasound assessment of the fetal head position versus standard care as an approach to prevent morbidity at instrumental delivery. BJOG (2014) 2.00

Improving intensive care: observations based on organizational case studies in nine intensive care units: a prospective, multicenter study. Crit Care Med (1993) 1.97

The Sickness Impact Profile: reliability of a health status measure. Med Care (1976) 1.88

Marginally effective medical care: ethical analysis of issues in cardiopulmonary resuscitation (CPR) J Med Ethics (1997) 1.85

An initial comparison of intensive care in Japan and the United States. Crit Care Med (1992) 1.79

Variations in the use of do-not-resuscitate orders in ICUS. Findings from a national study. Chest (1996) 1.77

Role of the proline knot motif in oleosin endoplasmic reticulum topology and oil body targeting. Plant Cell (1997) 1.76

The importance of bacterial sepsis in intensive care unit patients with acquired immunodeficiency syndrome: implications for future care in the age of increasing antiretroviral resistance. Crit Care Med (2001) 1.72

Measurement of health status in the 1990s. Annu Rev Public Health (1990) 1.70

Evaluation of definitions for sepsis. Chest (1992) 1.68

Value and cost of teaching hospitals: a prospective, multicenter, inception cohort study. Crit Care Med (1993) 1.64

Treatment modality and quality differences for black and white breast-cancer patients treated in community hospitals. Med Care (1989) 1.64

Isolation and characterization of a serine esterase from cytolytic T cell granules. Cell (1986) 1.63

Schistosomiasis mansoni in Yemeni in California: duration of infection, presence of disease, therapeutic management. Am J Trop Med Hyg (1974) 1.61

Evaluation of definitions for adult respiratory distress syndrome. Am J Respir Crit Care Med (1994) 1.60

A predictive risk model for outcomes of ischemic stroke. Stroke (2000) 1.59

Short-term mortality predictions for critically ill hospitalized adults: science and ethics. Science (1991) 1.56

Carbon dioxide embolism treated with hyperbaric oxygen. Can J Anaesth (1989) 1.56

Adolescent health status measurement: development of the Child Health and Illness Profile. Pediatrics (1993) 1.55

The range of intensive care services today. JAMA (1981) 1.49

Identification of low-risk monitor patients within a medical-surgical intensive care unit. Med Care (1983) 1.48

Maternal and neonatal morbidity in relation to the instrument used for mid-cavity rotational operative vaginal delivery: a prospective cohort study. BJOG (2013) 1.45

The use of risk predictions to identify candidates for intermediate care units. Implications for intensive care utilization and cost. Chest (1995) 1.44

Statistical validation of a severity of illness measure. Am J Public Health (1983) 1.44

Morbidity experienced by women before and after operative vaginal delivery: prospective cohort study nested within a two-centre randomised controlled trial of restrictive versus routine use of episiotomy. BJOG (2013) 1.41

Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells. Mol Cell Biol (2001) 1.41

Decision-making and outcomes of prolonged ICU stays in seriously ill patients. J Am Geriatr Soc (2000) 1.41

Risk factors and morbidity associated with suboptimal instrument placement at instrumental delivery: observational study nested within the Instrumental Delivery & Ultrasound randomised controlled trial ISRCTN 72230496. BJOG (2014) 1.40

A cross-cultural comparison of health status values. Am J Public Health (1985) 1.39

Usefulness of color-flow Doppler in diagnosing and in differentiating supracristal ventricular septal defect from right ventricular outflow tract obstruction. Am J Cardiol (1991) 1.39

The use and implications of do not resuscitate orders in intensive care units. JAMA (1986) 1.39

The importance of technology for achieving superior outcomes from intensive care. Brazil APACHE III Study Group. Intensive Care Med (1996) 1.38

Cost and outcome of care for patients with chronic obstructive lung disease. Analysis by physician specialty. Med Care (1986) 1.38

Women's experience of decision making about mode of delivery after a previous caesarean section: the role of health professionals and information about health risks. BJOG (2006) 1.35

The effect of managed care on ICU length of stay: implications for medicare. JAMA (1996) 1.35

A reinvestigation of the mixed carbonic anhydride method of peptide synthesis. J Am Chem Soc (1967) 1.35

Patient selection for intensive care: a comparison of New Zealand and United States hospitals. Crit Care Med (1988) 1.34

Caleosins: Ca2+-binding proteins associated with lipid bodies. Plant Mol Biol (2000) 1.33

Acute physiology and chronic health evaluation (APACHE II) and Medicare reimbursement. Health Care Financ Rev (1984) 1.33

Health status measures: an overview and guide for selection. Annu Rev Public Health (1987) 1.32

The origin of chloroplastic acetyl coenzyme A. Arch Biochem Biophys (1981) 1.31

Multiple systems organ failure: epidemiology and prognosis. Crit Care Clin (1989) 1.30

Reliability of a measure of severity of illness: acute physiology of chronic health evaluation--II. J Clin Epidemiol (1992) 1.29

Composition and role of tapetal lipid bodies in the biogenesis of the pollen coat of Brassica napus. Planta (1999) 1.27

Validation of an interval scaling: the sickness impact profile. Health Serv Res (1976) 1.25

National outcomes of cataract extraction. Retinal detachment and endophthalmitis after outpatient cataract surgery. Cataract Patient Outcomes Research Team. Ophthalmology (1994) 1.25

Daily prognostic estimates for critically ill adults in intensive care units: results from a prospective, multicenter, inception cohort analysis. Crit Care Med (1994) 1.25

The prevalence of pain in four cancers. Cancer (1987) 1.25