Published in Cell Stem Cell on August 07, 2009
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol (2010) 4.22
Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell (2010) 3.82
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov (2014) 2.55
Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer (2010) 2.51
Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol (2015) 2.02
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell (2014) 1.83
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A (2012) 1.80
Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited. Stem Cells (2010) 1.78
Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell (2015) 1.66
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60
The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest (2011) 1.59
Emerging targeted agents in metastatic breast cancer. Nat Rev Clin Oncol (2013) 1.59
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res (2011) 1.58
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58
CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res (2010) 1.52
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
Cancer stem cells in glioblastoma--molecular signaling and therapeutic targeting. Protein Cell (2010) 1.45
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res (2013) 1.43
Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42
Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. BMC Cancer (2017) 1.38
VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38
Cancer stem cells. Int J Biochem Cell Biol (2012) 1.35
Molecular identification and targeting of colorectal cancer stem cells. Oncotarget (2010) 1.33
Patient-derived breast tumor xenografts facilitating personalized cancer therapy. Breast Cancer Res (2013) 1.23
Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell (2011) 1.20
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res (2013) 1.20
A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. Cancer Cell (2013) 1.19
Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am J Pathol (2011) 1.18
Self-renewal related signaling in myeloid leukemia stem cells. Int J Hematol (2011) 1.17
Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol (2012) 1.17
Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol (2010) 1.17
Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16
Brain tumor stem cells: Molecular characteristics and their impact on therapy. Mol Aspects Med (2013) 1.14
Patient-derived xenografts of non small cell lung cancer: resurgence of an old model for investigation of modern concepts of tailored therapy and cancer stem cells. J Biomed Biotechnol (2012) 1.14
Cancer heterogeneity--a multifaceted view. EMBO Rep (2013) 1.11
The role of microRNAs in the regulation of cancer stem cells. Front Genet (2014) 1.09
Breast cancer stem cells: Multiple capacities in tumor metastasis. Cancer Lett (2014) 1.07
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem Cells (2014) 1.07
Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med (2009) 1.07
Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models. Stem Cells Transl Med (2013) 1.04
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer. Mol Oncol (2012) 1.01
Glioblastoma multiforme therapy and mechanisms of resistance. Pharmaceuticals (Basel) (2013) 1.00
2nd PEGS Annual Symposium on Antibodies for Cancer Therapy: April 30-May 1, 2012, Boston, USA. MAbs (2012) 0.99
NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov (2014) 0.99
Therapeutic promise and challenges of targeting DLL4/NOTCH1. Vasc Cell (2011) 0.98
Regulation of breast cancer stem cell features. Contemp Oncol (Pozn) (2015) 0.97
Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon. Mol Cancer (2013) 0.97
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest (2014) 0.97
Spatially addressed combinatorial protein libraries for recombinant antibody discovery and optimization. Nat Biotechnol (2010) 0.97
Colon cancer stem cells: controversies and perspectives. World J Gastroenterol (2013) 0.95
Emerging antibody combinations in oncology. MAbs (2011) 0.94
Cancer stem cells and their role in metastasis. Pharmacol Ther (2013) 0.93
Advanced prostate cancer--a case for adjuvant differentiation therapy. Nat Rev Urol (2012) 0.93
Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93
Cancerous stem cells: deviant stem cells with cancer-causing misbehavior. Stem Cell Res Ther (2010) 0.91
Therapeutic strategies targeting cancer stem cells. Cancer Biol Ther (2013) 0.91
Regulation of cancer stem cell activities by tumor-associated macrophages. Am J Cancer Res (2012) 0.90
Cancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectives. World J Gastroenterol (2014) 0.90
Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90
Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion. PLoS One (2011) 0.89
New Approaches to Target T-ALL. Front Oncol (2014) 0.88
Notch signaling: its roles and therapeutic potential in hematological malignancies. Oncotarget (2016) 0.87
Eradicating cancer cells: struggle with a chameleon. Oncotarget (2011) 0.86
Understanding the colon cancer stem cells and perspectives on treatment. Cancer Cell Int (2015) 0.86
Dll4-Notch signaling in regulation of tumor angiogenesis. J Cancer Res Clin Oncol (2013) 0.86
Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy. Vasc Cell (2012) 0.86
Immunotargeting of cancer stem cells. Contemp Oncol (Pozn) (2015) 0.85
Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival. J Transl Med (2013) 0.84
Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations. Cancer Med (2012) 0.84
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
Tumor initiating cells and chemoresistance: which is the best strategy to target colon cancer stem cells? Biomed Res Int (2014) 0.83
Molecular targeting of cancer stem cells. Cell Stem Cell (2009) 0.83
Targeting Notch to overcome radiation resistance. Oncotarget (2016) 0.82
Delta-like ligand 4: A predictor of poor prognosis in clear cell renal cell carcinoma. Oncol Lett (2014) 0.82
Anti-DLL4, a cancer therapeutic with multiple mechanisms of action. Vasc Cell (2011) 0.82
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy? Contemp Oncol (Pozn) (2013) 0.81
Circulating tumor cells: application as a biomarker for molecular characterization and predictor of survival in an all-comer solid tumor phase I clinical study. PLoS One (2013) 0.81
Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts. PLoS One (2014) 0.81
Combining Notch inhibition with current therapies for breast cancer treatment. Ther Adv Med Oncol (2013) 0.81
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat Commun (2016) 0.81
Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells. World J Gastroenterol (2013) 0.80
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Sci Rep (2016) 0.80
Intra-tumor heterogeneity from a cancer stem cell perspective. Mol Cancer (2017) 0.80
Cancer stem cells: a systems biology view of their role in prognosis and therapy. Anticancer Drugs (2014) 0.79
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer. Int J Cancer (2015) 0.78
VEGF promotes cartilage angiogenesis by phospho-ERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats. Oncotarget (2017) 0.77
Investigational Notch and Hedgehog inhibitors--therapies for cardiovascular disease. Expert Opin Investig Drugs (2011) 0.77
In vitro models of cancer stem cells and clinical applications. BMC Cancer (2016) 0.77
Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies. Bone Marrow Res (2010) 0.77
Simultaneous blockade of VEGF and Dll4 by HD105, a bispecific antibody, inhibits tumor progression and angiogenesis. MAbs (2016) 0.76
Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy. Cytotechnology (2014) 0.76
Therapeutic targeting of cancer stem cells. Front Oncol (2011) 0.76
An alternative way to initiate Notch1 signaling in non-small cell lung cancer. Transl Lung Cancer Res (2014) 0.76
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23
Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60
Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60
Design parameters to control synthetic gene expression in Escherichia coli. PLoS One (2009) 3.38
Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J Immunol (2004) 2.65
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res (2004) 2.43
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23
Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17
Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. J Biol Chem (2002) 2.02
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A (2012) 1.80
Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69
The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat Neurosci (2003) 1.66
Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57
Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell (2007) 1.48
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43
Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41
Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res (2010) 1.32
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol (2002) 1.26
Effects of time since fire on birds: how informative are generalized fire response curves for conservation management? Ecol Appl (2012) 1.22
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. J Biol Chem (2004) 1.20
A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. J Biol Chem (2002) 1.17
Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17
Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature (2013) 1.13
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat (2012) 1.07
Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells. Clin Cancer Res (2012) 1.02
Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer. Cancer Lett (2005) 1.02
FlyGEM, a full transcriptome array platform for the Drosophila community. Genome Biol (2004) 1.00
Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A (2012) 0.99
New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther (2002) 0.99
NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J Biol Chem (2004) 0.95
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res (2007) 0.89
Remodeling of endogenous mammary epithelium by breast cancer stem cells. Stem Cells (2012) 0.88
Changes in the bispectral index and cerebral oxygen saturation during neuroendovascular intervention under general anesthesia. Korean J Anesthesiol (2012) 0.88
Optimal fire histories for biodiversity conservation. Conserv Biol (2014) 0.87
The Myc connection: ES cells and cancer. Cell (2010) 0.87
The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. J Exp Med (2003) 0.86
LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo. Endocrinology (2008) 0.83
A comparison of stream biological responses to discharge from wastewater treatment plants in high and low population density areas. Environ Toxicol Chem (2002) 0.83
Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys (2009) 0.83
Neurobiology: at the root of brain cancer. Nature (2004) 0.83
Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide. Nucl Med Biol (2002) 0.81
Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity. Cell Stem Cell (2013) 0.80
Liquid refractive index sensing independent of opacity using an optofluidic diffraction sensor. Opt Lett (2014) 0.78
Identifying the metastatic seeds of breast cancer. Nat Biotechnol (2013) 0.78
Electro-induced mechanical and thermal responses of carbon nanotube fibers. Adv Mater (2014) 0.78
The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells. Lung Cancer (2005) 0.77
SLUGging away at cell death. Cancer Cell (2002) 0.77
Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting. J Virol Methods (2011) 0.76
Large-area, uniform and low-cost dual-mode plasmonic naked-eye colorimetry and SERS sensor with handheld Raman spectrometer. Nanoscale (2016) 0.76