Published in Analyst on July 30, 2009
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol (2010) 2.17
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults. Diabetes Care (2012) 1.98
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet (2012) 1.97
Metabolic signatures of insulin resistance in 7,098 young adults. Diabetes (2012) 1.80
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med (2014) 1.60
Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care (2012) 1.57
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol (2016) 1.49
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Metabolic effects of albumin therapy in acute lung injury measured by proton nuclear magnetic resonance spectroscopy of plasma: a pilot study. Crit Care Med (2011) 1.42
Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study. PLoS Genet (2016) 1.38
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A network perspective on metabolism and aging. Integr Comp Biol (2010) 1.10
Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study. Diabetologia (2015) 1.07
Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. Diabetes (2011) 0.99
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genet (2011) 0.97
Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease. PLoS One (2015) 0.95
Physical activity versus sedentary behavior: associations with lipoprotein particle subclass concentrations in healthy adults. PLoS One (2013) 0.93
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes (2013) 0.92
Multi-omic signature of body weight change: results from a population-based cohort study. BMC Med (2015) 0.89
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals. PLoS One (2013) 0.89
Lipoprotein subclass metabolism in nonalcoholic steatohepatitis. J Lipid Res (2014) 0.88
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun (2016) 0.88
Ratio analysis nuclear magnetic resonance spectroscopy for selective metabolite identification in complex samples. Anal Chem (2011) 0.88
Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men. Diabetes Care (2013) 0.88
Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study. PLoS One (2012) 0.87
A differential network approach to exploring differences between biological states: an application to prediabetes. PLoS One (2011) 0.87
Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet). PLoS One (2014) 0.86
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. Lipids (2012) 0.86
NMRbot: Python scripts enable high-throughput data collection on current Bruker BioSpin NMR spectrometers. Metabolomics (2013) 0.86
Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles. Arterioscler Thromb Vasc Biol (2011) 0.84
Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study. Aging (Albany NY) (2016) 0.83
The emergence of proton nuclear magnetic resonance metabolomics in the cardiovascular arena as viewed from a clinical perspective. Atherosclerosis (2014) 0.83
A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs. Front Endocrinol (Lausanne) (2014) 0.83
Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. Bioinformatics (2014) 0.82
A family based tailored counselling to increase non-exercise physical activity in adults with a sedentary job and physical activity in their young children: design and methods of a year-long randomized controlled trial. BMC Public Health (2011) 0.81
Quantitative high-throughput metabolomics: a new era in epidemiology and genetics. Genome Med (2012) 0.81
Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy. J Lipid Res (2015) 0.81
Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity. J R Soc Interface (2014) 0.81
Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up. Lipids Health Dis (2014) 0.81
The future of NMR metabolomics in cancer therapy: towards personalizing treatment and developing targeted drugs? Metabolites (2013) 0.81
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis. Bioinformatics (2016) 0.81
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol (2016) 0.81
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep (2016) 0.81
Metabolic profiling of fatty liver in young and middle-aged adults - cross-sectional and prospective analyses of the Young Finns Study. Hepatology (2016) 0.80
Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque. Sci Rep (2014) 0.80
Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals. Nutr Metab (Lond) (2014) 0.80
Lipoprotein subclass profiles in young adults born preterm at very low birth weight. Lipids Health Dis (2013) 0.79
An epidemiological perspective of personalized medicine: the Estonian experience. J Intern Med (2015) 0.78
Multifractal analysis for nutritional assessment. PLoS One (2013) 0.78
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
1H NMR-based metabolite profiling of plasma in a rat model of chronic kidney disease. PLoS One (2014) 0.78
Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors. Atherosclerosis (2014) 0.77
Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. Am J Hum Genet (2015) 0.77
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects. Circ Cardiovasc Genet (2016) 0.77
Metabolomics in the studies of islet autoimmunity and type 1 diabetes. Rev Diabet Stud (2012) 0.77
Association of height and pubertal timing with lipoprotein subclass profile: exploring the role of genetic and environmental effects. Am J Hum Biol (2013) 0.76
Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial. Am J Clin Nutr (2013) 0.76
NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins. PLoS One (2013) 0.76
Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women. Sci Rep (2016) 0.76
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med (2016) 0.76
Metabonomic Evaluation of Chronic Unpredictable Mild Stress-Induced Changes in Rats by Intervention of Fluoxetine by HILIC-UHPLC/MS. PLoS One (2015) 0.75
Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men. Front Med (Lausanne) (2016) 0.75
Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? Int J Epidemiol (2016) 0.75
Active Smarter Kids (ASK): Rationale and design of a cluster-randomized controlled trial investigating the effects of daily physical activity on children's academic performance and risk factors for non-communicable diseases. BMC Public Health (2015) 0.75
Perspectives on the design and methodology of periconceptional nutrient supplementation trials. Trials (2016) 0.75
Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. Sci Rep (2017) 0.75
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Cardiovasc Diabetol (2016) 0.75
Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. Int J Epidemiol (2016) 0.75
Lipidomics in vascular health: current perspectives. Vasc Health Risk Manag (2015) 0.75
Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study. Sci Rep (2016) 0.75
NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study. Metabolomics (2011) 0.75
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biol (2017) 0.75
Low level activity thresholds for changes in NMR biomarkers and genes in high risk subjects for Type 2 Diabetes. Sci Rep (2017) 0.75
Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity. Int J Obes (Lond) (2017) 0.75
NMR analysis reveals significant differences in the plasma metabolic profiles of Niemann Pick C1 patients, heterozygous carriers, and healthy controls. Sci Rep (2017) 0.75
Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity. Int J Obes (Lond) (2017) 0.75
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med (2011) 7.16
Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA (2003) 6.60
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Physical activity from childhood to adulthood: a 21-year tracking study. Am J Prev Med (2005) 5.28
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Bacterial signatures in thrombus aspirates of patients with myocardial infarction. Circulation (2013) 2.81
The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet (2008) 2.79
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation (2004) 2.72
Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod (2002) 2.70
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol (2008) 2.51
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36
T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J (2007) 2.36
Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation (2013) 2.33