Published in Mol Divers on August 15, 2009
Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch Pharmacol (2013) 1.39
Structure-based virtual screening for drug discovery: principles, applications and recent advances. Curr Top Med Chem (2014) 0.84
Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol (2013) 0.83
IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening. PLoS One (2012) 0.81
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments. Nat Commun (2016) 0.76
Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction. Angew Chem Int Ed Engl (2017) 0.75
High-throughput screening and whole genome sequencing identifies an antimicrobially active inhibitor of Vibrio cholerae. BMC Microbiol (2014) 0.75
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J Biol Chem (2016) 0.75
Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. PLoS Biol (2017) 0.75
Public knowledge of benefits of breast and prostate cancer screening in Europe. J Natl Cancer Inst (2009) 3.45
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell (2011) 2.56
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem (2004) 2.29
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell (2012) 2.15
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell (2008) 2.12
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science (2010) 2.03
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe (2009) 2.01
Longitudinal trajectories of depression and anxiety in a prospective community study: the Zurich Cohort Study. Arch Gen Psychiatry (2003) 1.94
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. EMBO J (2004) 1.73
Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae. Mol Microbiol (2003) 1.72
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res (2012) 1.70
Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. J Biol Chem (2005) 1.68
The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol (2002) 1.65
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc Natl Acad Sci U S A (2008) 1.54
Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers. Nat Struct Mol Biol (2010) 1.53
A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites. Mol Microbiol (2002) 1.52
Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. J Biol Chem (2003) 1.50
Peptide-mediated interference with influenza A virus polymerase. J Virol (2007) 1.48
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J (2006) 1.45
Small-molecule screening identifies modulators of aquaporin-2 trafficking. J Am Soc Nephrol (2013) 1.41
Recognition of proline-rich motifs by protein-protein-interaction domains. Angew Chem Int Ed Engl (2005) 1.39
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res (2011) 1.38
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem (2004) 1.25
Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J Biol Chem (2003) 1.23
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Antimicrob Agents Chemother (2007) 1.20
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
Prevalence of mental disorders in the Zurich Cohort Study: a twenty year prospective study. Epidemiol Psichiatr Soc (2005) 1.16
Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. PLoS One (2009) 1.13
Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association. Angew Chem Int Ed Engl (2010) 1.13
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity. Antiviral Res (2010) 1.12
Inference of genetic regulatory networks with recurrent neural network models using particle swarm optimization. IEEE/ACM Trans Comput Biol Bioinform (2007) 1.11
A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics (2009) 1.11
Minimum information about a protein affinity reagent (MIAPAR). Nat Biotechnol (2010) 1.10
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA (2006) 1.09
High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins. Biol Psychiatry (2002) 1.08
Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin. J Biol Chem (2003) 1.08
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc Natl Acad Sci U S A (2006) 1.06
The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. J Immunol (2007) 1.06
Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosis. Proc Natl Acad Sci U S A (2011) 1.06
Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor. Angew Chem Int Ed Engl (2009) 1.05
Rubredoxins involved in alkane oxidation. J Bacteriol (2002) 1.05
Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine. Infect Immun (2007) 1.04
Anchor side chains of short peptide fragments trigger ligand-exchange of class II MHC molecules. PLoS One (2008) 1.03
The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters. J Virol (2009) 1.01
Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket. J Biol Chem (2006) 1.00
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J (2006) 1.00
Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology (2006) 1.00
Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymerase. Antimicrob Agents Chemother (2010) 0.99
14-3-3 proteins are constituents of the insoluble glycoprotein framework of the chlamydomonas cell wall. Plant Cell (2003) 0.99
Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. J Biol Chem (2004) 0.99
Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS One (2009) 0.98
Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids. Chemistry (2006) 0.98
An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Front Cell Infect Microbiol (2012) 0.98
Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha. Mol Biol Cell (2006) 0.97
N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus. J Hepatol (2010) 0.97
Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach. Chembiochem (2005) 0.96
Neurofilaments bind tubulin and modulate its polymerization. J Neurosci (2009) 0.96
The structures of the active center in dark-adapted bacteriorhodopsin by solution-state NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 0.96
Metabolic engineering of a genetic selection system with tunable stringency. Proc Natl Acad Sci U S A (2007) 0.95
Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. EMBO J (2002) 0.94
Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells. Exp Cell Res (2005) 0.94
Identification and characterization of the Cdc42-binding site of IQGAP1. Biochem Biophys Res Commun (2003) 0.94
The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.94
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization. Biol Chem (2006) 0.94
Systematic delineation of a calmodulin peptide interaction. J Mol Biol (2004) 0.94
MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism. FASEB J (2010) 0.92
Borna disease virus matrix protein is an integral component of the viral ribonucleoprotein complex that does not interfere with polymerase activity. J Virol (2006) 0.92
Redox-regulated conformational changes in an SH3 domain. Biochemistry (2007) 0.91
Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1. Biochemistry (2004) 0.91
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. Chembiochem (2012) 0.91
Characterization of structural features controlling the receptiveness of empty class II MHC molecules. PLoS One (2011) 0.90
The oxidized subunit B8 from human complex I adopts a thioredoxin fold. Structure (2004) 0.90
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties. J Med Chem (2012) 0.89
Solution-state (15)N NMR spectroscopic study of alpha-C-phycocyanin: implications for the structure of the chromophore-binding pocket of the cyanobacterial phytochrome Cph1. Chembiochem (2007) 0.89
Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis. J Biol Chem (2011) 0.88
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl (2013) 0.88
Peptide-mediated disruption of NFkappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori. J Immunol (2007) 0.88
Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the Universität Tübingen, and Merck KGaA, Darmstadt, Germany. Angew Chem Int Ed Engl (2001) 0.87
Impact of aromatic residues within transmembrane helix 6 of the human gonadotropin-releasing hormone receptor upon agonist and antagonist binding. Biochemistry (2002) 0.87
Isolation of scFv fragments specific to OmpD of Salmonella Typhimurium. Vet Microbiol (2010) 0.86
The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium. Mol Microbiol (2013) 0.86
The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains. FEBS Lett (2004) 0.86
Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun (2005) 0.86
Structural investigations of a GYF domain covalently linked to a proline-rich peptide. J Biomol NMR (2003) 0.85
Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma. Hum Gene Ther (2010) 0.85
High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination. Mol Med (2013) 0.84
Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2003) 0.84
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. EMBO J (2015) 0.84
Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays. Adv Biochem Eng Biotechnol (2008) 0.84
C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids. Org Lett (2007) 0.84
Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate. J Biol Chem (2012) 0.84