Gadd45b and Gadd45g are important for anti-tumor immune responses.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3025293)

Published in Eur J Immunol on November 01, 2009

Authors

Songguang Ju1, Yibei Zhu, Lin Liu, Shao Dai, Changyou Li, Elizabeth Chen, Yukai He, Xueguang Zhang, Binfeng Lu

Author Affiliations

1: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Articles citing this

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol (2011) 1.32

Gadd45 proteins: relevance to aging, longevity and age-related pathologies. Ageing Res Rev (2011) 1.19

Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest. Cancer Res (2010) 0.94

Glucocorticoids regulate gene expression and repress cellular proliferation in human uterine leiomyoma cells. Horm Cancer (2012) 0.84

GADD45γ induces G2/M arrest in human pharynx and nasopharyngeal carcinoma cells by cucurbitacin E. Sci Rep (2014) 0.81

Hepatic gene expression profiling of 5'-AMP-induced hypometabolism in mice. Physiol Genomics (2011) 0.81

Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice. Arthritis Rheum (2011) 0.81

Abnormal expression of GADD45B in human colorectal carcinoma. J Transl Med (2012) 0.81

Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes. J Immunol (2015) 0.80

GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment. Cell Death Dis (2013) 0.79

Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways. Nucleic Acids Res (2013) 0.79

Analysis of the genome-wide DNA methylation profile of side population cells in hepatocellular carcinoma. Dig Dis Sci (2013) 0.78

Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer Res (2016) 0.77

GADD45β, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens. Oncotarget (2016) 0.77

Induction of innate immune gene expression following methyl methanesulfonate-induced DNA damage in sea urchins. Biol Lett (2016) 0.75

Articles cited by this

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 24.54

A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61

Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol (2002) 14.75

Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (2003) 7.75

Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol (2007) 4.75

Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol (2006) 3.73

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med (2005) 3.13

Interleukin-12: biological properties and clinical application. Clin Cancer Res (2007) 3.00

L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. J Immunol (2003) 2.91

Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol (1994) 2.83

Immune resistance orchestrated by the tumor microenvironment. Immunol Rev (2006) 2.83

IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production. Nat Immunol (2001) 2.81

The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res (2005) 2.79

GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol (2002) 2.41

Gamma delta T cells provide an early source of interferon gamma in tumor immunity. J Exp Med (2003) 1.99

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. J Exp Med (2002) 1.95

GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity (2001) 1.73

Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol (2003) 1.52

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50

Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer. Clin Cancer Res (1999) 1.20

Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Am J Pathol (2003) 1.17

T-bet regulates metastasis rate in a murine model of primary prostate cancer. Cancer Res (2004) 1.14

The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. Gut (2007) 1.03

Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. J Exp Med (2005) 0.99

Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol (2005) 0.95

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res (2013) 6.89

Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (2009) 5.24

Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66

Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology (2010) 3.57

Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity (2010) 3.35

Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem (2006) 3.24

Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci U S A (2008) 3.07

Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (2013) 2.90

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. Blood (2009) 2.88

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med (2004) 2.84

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31

MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell (2013) 2.28

Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis (2006) 2.26

Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology (2009) 2.24

Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits. Behav Genet (2004) 2.14

Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis (2008) 2.08

Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Am J Surg Pathol (2011) 2.03

Crop diversity for yield increase. PLoS One (2009) 2.02

Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int (2006) 2.01

Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res (2012) 1.89

MicroRNA: past and present. Front Biosci (2007) 1.79

High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J Immunol (2008) 1.79

B7-H3 over expression in prostate cancer promotes tumor cell progression. J Urol (2011) 1.71

MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68

Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics (2005) 1.68

Oncolytic viruses as therapeutic cancer vaccines. Mol Cancer (2013) 1.64

MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol (2010) 1.61

Application of nonlinear dynamics analysis in assessing unconsciousness: a preliminary study. Clin Neurophysiol (2010) 1.59

An expedited code stroke protocol is feasible and safe. Stroke (2006) 1.57

3D in vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror. Opt Express (2010) 1.55

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem (2003) 1.54

NIHSS training and certification using a new digital video disk is reliable. Stroke (2005) 1.53

Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum. Immunology (2008) 1.52

Isolation of highly pure alveolar epithelial type I and type II cells from rat lungs. Lab Invest (2004) 1.51

GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50

microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. Carcinogenesis (2011) 1.48

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res (2013) 1.48

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits. Cell Res (2010) 1.48

Germline stem cells and neo-oogenesis in the adult human ovary. Dev Biol (2007) 1.48

National Institutes of Health Stroke Scale certification is reliable across multiple venues. Stroke (2009) 1.45

TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One (2012) 1.44

Retracted A meta-analysis of external fixator versus intramedullary nails for open tibial fracture fixation. J Orthop Surg Res (2014) 1.42

Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension. J Cardiovasc Med (Hagerstown) (2011) 1.41

The consumption of low-mineral bottled water increases the risk of cardiovascular disease: an experimental study of rabbits and young men. Int J Cardiol (2013) 1.41

A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain. Pain (2011) 1.41

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Res (2012) 1.39

T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol (2010) 1.36

Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo. Nucleic Acids Res (2004) 1.33

Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. Mol Cancer Ther (2004) 1.33

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol (2011) 1.32

Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol (2013) 1.30

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis (2009) 1.30

A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30

miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. Mol Cancer Ther (2012) 1.29

ASAP1, a gene at 8q24, is associated with prostate cancer metastasis. Cancer Res (2008) 1.29

Identifying functional miRNA-mRNA regulatory modules with correspondence latent dirichlet allocation. Bioinformatics (2010) 1.28

SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell (2011) 1.27

Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics (2007) 1.27

Improved orange and red Ca²± indicators and photophysical considerations for optogenetic applications. ACS Chem Neurosci (2013) 1.26

Identification of two novel markers for alveolar epithelial type I and II cells. Biochem Biophys Res Commun (2004) 1.24

Diagnosis value of serum B7-H3 expression in non-small cell lung cancer. Lung Cancer (2009) 1.23

Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother (2010) 1.23

Effect of cholesterol depletion on exocytosis of alveolar type II cells. Am J Respir Cell Mol Biol (2006) 1.23

Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res (2011) 1.22

Coevolutionary patterns in plasminogen activation. Proc Natl Acad Sci U S A (2003) 1.22

T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract. Immunol Res (2011) 1.21

Primer extension-based method for the generation of a siRNA/miRNA expression vector. Physiol Genomics (2007) 1.21

A novel approach for the construction of multiple shRNA expression vectors. J Gene Med (2007) 1.21

Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women. Am J Obstet Gynecol (2005) 1.20

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol (2002) 1.20

Factor V Leiden and risk of ischemic stroke in nonvalvular atrial fibrillation: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. J Thromb Thrombolysis (2003) 1.20

Piglets cloned from induced pluripotent stem cells. Cell Res (2012) 1.19

Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest (2010) 1.19

Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res (2011) 1.18

Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway. J Biol Chem (2006) 1.17

Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. J Biol Chem (2009) 1.17

The Methods Behind PH WINS. J Public Health Manag Pract (2015) 1.17

Alveolar type I cells protect rat lung epithelium from oxidative injury. J Physiol (2006) 1.17