Published in Diabetes on August 18, 2009
The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med (2012) 5.63
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity (2012) 2.80
Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice. Diabetes (2010) 2.76
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes (2015) 2.67
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28
Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology (2011) 1.94
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun (2015) 1.75
Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature (2015) 1.68
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. J Exp Med (2014) 1.63
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2013) 1.60
Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.59
Breaking patterns of environmentally influenced disease for health risk reduction: immune perspectives. Environ Health Perspect (2010) 1.58
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes (2012) 1.56
Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne) (2013) 1.47
Macrophage polarization in metabolic disorders: functions and regulation. Curr Opin Lipidol (2011) 1.42
Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care (2010) 1.37
RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab (2014) 1.28
The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol (2013) 1.25
Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes (2010) 1.21
Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care (2012) 1.16
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev (2012) 1.11
Macrophages, meta-inflammation, and immuno-metabolism. ScientificWorldJournal (2011) 1.10
Critical illness induces alternative activation of M2 macrophages in adipose tissue. Crit Care (2011) 1.09
Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol (2014) 1.08
The role of the immune system in obesity and insulin resistance. J Obes (2013) 1.08
Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters. J Lipid Res (2012) 1.08
RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice. Diabetes (2014) 1.05
Macrophages heterogeneity in atherosclerosis - implications for therapy. J Cell Mol Med (2010) 1.05
Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity. PLoS One (2013) 1.02
Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function? Front Immunol (2014) 1.02
Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes (2013) 1.02
Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obesity (Silver Spring) (2011) 1.01
The neuroinflammatory response of postoperative cognitive decline. Br Med Bull (2013) 1.01
Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes (2013) 1.00
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS One (2012) 0.99
Innate immune activation in obesity. Mol Aspects Med (2012) 0.99
Macrophage polarization in response to wear particles in vitro. Cell Mol Immunol (2013) 0.99
Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes (2013) 0.99
MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med (2014) 0.98
M2/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles. Exp Eye Res (2012) 0.98
Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm (2010) 0.97
The inflammatory changes of adipose tissue in late pregnant mice. J Mol Endocrinol (2011) 0.96
Mechanisms Linking Inflammation to Insulin Resistance. Int J Endocrinol (2015) 0.96
Vitamin D: a new player in non-alcoholic fatty liver disease? World J Gastroenterol (2015) 0.96
Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction. J Biol Chem (2014) 0.96
Involvement of inducible 6-phosphofructo-2-kinase in the anti-diabetic effect of peroxisome proliferator-activated receptor gamma activation in mice. J Biol Chem (2010) 0.94
Regulation of apoptosis and innate immune stimuli in inflammation-induced preterm labor. J Immunol (2013) 0.93
Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. Cytokine (2013) 0.93
The Macrophage Switch in Obesity Development. Front Immunol (2016) 0.93
Abnormal expression of genes involved in inflammation, lipid metabolism, and Wnt signaling in the adipose tissue of polycystic ovary syndrome. J Clin Endocrinol Metab (2012) 0.92
Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids. Int J Obes (Lond) (2012) 0.91
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front Endocrinol (Lausanne) (2016) 0.91
Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease. Pediatr Res (2014) 0.90
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b. Mol Endocrinol (2014) 0.90
PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. J Immunol (2014) 0.90
Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice. PLoS One (2013) 0.89
Characterization of human adipose tissue-resident hematopoietic cell populations reveals a novel macrophage subpopulation with CD34 expression and mesenchymal multipotency. Stem Cells Dev (2012) 0.89
Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages. Am J Cancer Res (2013) 0.89
Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages. Cancer Res (2012) 0.89
Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis. Int J Mol Sci (2013) 0.89
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. Diabetes (2012) 0.89
Emerging role of adipokines as mediators in atherosclerosis. World J Cardiol (2010) 0.89
Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK). J Biol Chem (2015) 0.87
Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. J Biol Chem (2013) 0.87
The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PLoS One (2012) 0.87
Antibodies to MHC class II molecules induce autoimmunity: critical role for macrophages in the immunopathogenesis of obliterative airway disease. PLoS One (2012) 0.86
Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J Biol Chem (2013) 0.86
Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells in vivo. Mol Ther (2011) 0.86
Altered polarization, morphology, and impaired innate immunity germane to resident peritoneal macrophages in mice with long-term type 2 diabetes. J Biomed Biotechnol (2012) 0.86
Characteristics of adipose tissue macrophages and macrophage-derived insulin-like growth factor-1 in virus-induced obesity. Int J Obes (Lond) (2015) 0.85
Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. Am J Physiol Heart Circ Physiol (2013) 0.85
Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metab (2016) 0.85
Adipose tissue remodeling as homeostatic inflammation. Int J Inflam (2011) 0.84
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes (2012) 0.84
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice. PLoS One (2012) 0.84
Insulin-independent reversal of type 1 diabetes in nonobese diabetic mice with brown adipose tissue transplant. Am J Physiol Endocrinol Metab (2015) 0.84
Adenovirus 36 and Obesity: An Overview. Viruses (2015) 0.84
Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses. Free Radic Biol Med (2015) 0.83
Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Endocrinology (2014) 0.82
The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS One (2014) 0.82
The relationship between inflammatory markers, angiogenesis, and obesity. ARYA Atheroscler (2013) 0.82
Differential effects of high-fish oil and high-lard diets on cells and cytokines involved in the inflammatory process in rat insulin-sensitive tissues. Int J Mol Sci (2014) 0.82
N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit. Biomed Res Int (2015) 0.82
Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. J Biol Chem (2014) 0.81
Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue. Adipocyte (2013) 0.81
Stress in obesity and associated metabolic and cardiovascular disorders. Scientifica (Cairo) (2012) 0.81
Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. J Lipid Res (2014) 0.81
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest (2017) 0.81
Adipose overexpression of heme oxygenase-1 does not protect against high fat diet-induced insulin resistance in mice. PLoS One (2013) 0.80
Controlled release of cytokines using silk-biomaterials for macrophage polarization. Biomaterials (2015) 0.80
A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice. J Biol Chem (2015) 0.80
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol (2016) 0.80
Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans. Mediators Inflamm (2014) 0.80
Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization. PLoS One (2013) 0.79
Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutr Diabetes (2013) 0.79
Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife (2014) 0.79
STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in rosiglitazone-treated mice. Sci Rep (2013) 0.79
Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice. Sci Rep (2016) 0.79
Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: implication in hyperglycemia. J Leukoc Biol (2014) 0.79
Immune response in the adipose tissue of lean mice infected with the protozoan parasite Neospora caninum. Immunology (2015) 0.79
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Inflammation and metabolic disorders. Nature (2006) 33.33
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53
Monocyte and macrophage heterogeneity. Nat Rev Immunol (2005) 24.36
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 19.38
Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 13.42
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 12.32
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature (1997) 10.53
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 7.50
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes (2004) 4.37
Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev (2007) 4.23
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue. J Biol Chem (2008) 1.81
Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab (2003) 1.50
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. Mol Cell Biol (2001) 1.32
Plasma interleukin-10 concentration is positively related to insulin sensitivity in young healthy individuals. Diabetes Care (2005) 1.14
Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells. Cytokine (2007) 1.07
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest (2006) 9.49
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes (2007) 3.87
Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol (2007) 3.73
Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med (2007) 3.67
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab (2005) 3.49
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab (2007) 3.43
Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor). Am J Surg Pathol (2005) 3.30
Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetes Res Clin Pract (2002) 3.30
Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol (2010) 3.26
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes (2002) 3.04
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest (2007) 2.81
IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis? Am J Surg Pathol (2004) 2.81
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med (2002) 2.61
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med (2003) 2.39
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med (2010) 2.35
Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res (2005) 2.28
Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 Japanese patients. J Thorac Oncol (2013) 2.22
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med (2008) 2.16
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev Cell (2005) 2.11
Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology (2009) 2.11
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology (2008) 2.05
Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res (2006) 1.94
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem (2006) 1.93
IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology (2006) 1.91
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int Immunol (2004) 1.91
Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital. Mod Pathol (2004) 1.90
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest (2004) 1.88
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab (2008) 1.86
Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab (2012) 1.84
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J Exp Med (2007) 1.82
Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J Exp Med (2011) 1.78
Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology (2013) 1.78
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J Exp Med (2002) 1.77
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab (2012) 1.77
Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J Exp Med (2005) 1.76
EGFR mutation of tumor and serum in gefitinib-treated patients with chemotherapy-naive non-small cell lung cancer. J Thorac Oncol (2006) 1.75
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet (2005) 1.69
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am J Physiol Endocrinol Metab (2009) 1.68
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci (2008) 1.67
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes (2002) 1.63
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int Immunol (2004) 1.63
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J Exp Med (2007) 1.62
Clinical evaluation of endoscopic bronchial occlusion with silicone spigots for the management of persistent pulmonary air leaks. Intern Med (2011) 1.61
Prevalence of albuminuria and renal insufficiency and associated clinical factors in type 2 diabetes: the Japan Diabetes Clinical Data Management study (JDDM15). Nephrol Dial Transplant (2008) 1.61
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. J Cell Sci (2007) 1.57
Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun (2008) 1.57
Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood (2008) 1.57
Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol (2011) 1.57
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. J Clin Invest (2004) 1.57
Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol (2003) 1.56
Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One (2007) 1.56
Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol (2011) 1.55
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A (2007) 1.55
Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology (2006) 1.53
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab (2006) 1.50
Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med (2009) 1.49
Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts. J Gastroenterol (2005) 1.48
Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray. J Clin Pathol (2006) 1.47
IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol (2009) 1.47
Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology (2008) 1.45
An elderly man with syncytial giant cell hepatitis successfully treated by immunosuppressants. Intern Med (2012) 1.44
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin. Diabetes (2006) 1.43
Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes. Biol Pharm Bull (2010) 1.41
A dietary restriction influences the progression but not the initiation of MSG-Induced nonalcoholic steatohepatitis. J Med Food (2014) 1.41
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res (2008) 1.38
Bone marrow lacks a transplantable progenitor for smooth muscle type alpha-actin-expressing cells. Stem Cells (2005) 1.38
Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol (2014) 1.36
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes (2013) 1.36
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. J Immunol (2005) 1.33
Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis. Hepatology (2013) 1.33
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res (2007) 1.32
Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. J Exp Med (2008) 1.31
Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol (2002) 1.30
Septic shock is associated with receptor for advanced glycation end products ligation of LPS. J Immunol (2011) 1.30
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem (2002) 1.30
Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet (2013) 1.28
Tracing the first waves of lymphopoiesis in mice. Development (2006) 1.28
SH2-B is required for both male and female reproduction. Mol Cell Biol (2002) 1.27
A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation. Am J Hum Genet (2007) 1.27
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol (2004) 1.27
Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Biochem Biophys Res Commun (2005) 1.26