Published in Antioxid Redox Signal on February 01, 2010
Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood (2012) 2.10
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood (2013) 2.05
Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Blood (2010) 1.51
Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2010) 1.41
Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome. Crit Care (2012) 1.33
Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. Am J Physiol Heart Circ Physiol (2012) 1.23
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes. Front Pharmacol (2014) 1.20
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development. Front Physiol (2014) 1.10
Vasculature and kidney complications in sickle cell disease. J Am Soc Nephrol (2012) 1.08
The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1. Antioxid Redox Signal (2014) 1.01
Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. J Biol Chem (2011) 1.00
Age sensitizes the kidney to heme protein-induced acute kidney injury. Am J Physiol Renal Physiol (2012) 0.98
The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging. Oxid Med Cell Longev (2013) 0.95
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood (2013) 0.95
Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration. J Biol Chem (2012) 0.94
Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease. Am J Physiol Renal Physiol (2010) 0.92
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol (2011) 0.92
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. Transl Res (2015) 0.90
Haptoglobin genotype and its role in determining heme-iron mediated vascular disease. Pharmacol Res (2012) 0.89
Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice. Blood (2014) 0.88
Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses. ISRN Oxidative Med (2013) 0.87
Redox homeostasis: The Golden Mean of healthy living. Redox Biol (2016) 0.86
Signaling function of heme oxygenase proteins. Antioxid Redox Signal (2014) 0.85
Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Br J Haematol (2011) 0.85
Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema. Funct Integr Genomics (2011) 0.85
Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis. Oxid Med Cell Longev (2013) 0.84
Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection. Front Microbiol (2015) 0.83
Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model. PLoS One (2014) 0.83
Iron overload in diabetic retinopathy: a cause or a consequence of impaired mechanisms? Exp Diabetes Res (2010) 0.83
Extracellular heme uptake and the challenges of bacterial cell membranes. Curr Top Membr (2012) 0.83
A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. Am J Physiol Heart Circ Physiol (2012) 0.81
The influence of hydroxyurea on oxidative stress in sickle cell anemia. Rev Bras Hematol Hemoter (2012) 0.81
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice. Front Pharmacol (2014) 0.81
Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men. PLoS One (2013) 0.80
A review on hemeoxygenase-2: focus on cellular protection and oxygen response. Oxid Med Cell Longev (2014) 0.80
Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid. Mol Aspects Med (2016) 0.79
Complement, oxidants, and endothelial injury: how a bedside observation opened a door to vascular biology. J Clin Invest (2012) 0.79
Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest (2017) 0.78
Disruption of heme-peptide covalent cross-linking in mammalian peroxidases by hypochlorous acid. J Inorg Biochem (2014) 0.78
Association of heme oxygenase 1 with the restoration of liver function after damage in murine malaria by Plasmodium yoelii. Infect Immun (2014) 0.78
Patient selection and vitamin E treatment in diabetes mellitus. Expert Rev Cardiovasc Ther (2013) 0.78
Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation (2016) 0.77
Oxidative stress in sickle cell disease. Rev Bras Hematol Hemoter (2013) 0.77
Transformation of membrane nanosurface of red blood cells under hemin action. Sci Rep (2014) 0.77
Mechanisms of sickle cell alloimmunization. Transfus Clin Biol (2015) 0.76
Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. Redox Biol (2013) 0.75
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. PLoS Negl Trop Dis (2017) 0.75
Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology. Oncol Lett (2016) 0.75
Lipopolysaccharide-induced hemolysis: Evidence for direct membrane interactions. Sci Rep (2016) 0.75
The clinical characteristics of posterior reversible encephalopathy syndrome in patients with chronic renal failure. Exp Ther Med (2017) 0.75
Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J (1984) 13.20
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell (1997) 8.68
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev (2006) 7.76
The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol (1997) 7.50
Identification of the haemoglobin scavenger receptor. Nature (2001) 7.05
Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol (2003) 5.34
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest (1999) 4.66
Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci U S A (1989) 4.57
Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem (1992) 4.22
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol (1996) 3.72
High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease. N Engl J Med (1994) 3.10
Exchange of heme among hemoglobins and between hemoglobin and albumin. J Biol Chem (1968) 3.09
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A (1993) 2.77
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest (2005) 2.75
Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol Rev (2005) 2.73
Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A (2002) 2.72
Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol (2001) 2.72
Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. Circ Res (2006) 2.68
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem (1997) 2.58
Free heme toxicity and its detoxification systems in human. Toxicol Lett (2005) 2.54
Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev (2003) 2.52
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci U S A (2001) 2.48
Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J Clin Invest (2000) 2.47
Cell and tissue responses to oxidative damage. Lab Invest (1993) 2.45
Pro-oxidant and cytotoxic effects of circulating heme. Blood (2002) 2.45
Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res (2006) 2.39
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Ferritin, iron homeostasis, and oxidative damage. Free Radic Biol Med (2002) 2.26
Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion. Blood (2000) 2.10
Transgenic sickle mice have vascular inflammation. Blood (2003) 2.03
Methemoglobin--it's not just blue: a concise review. Am J Hematol (2007) 2.02
Identification of the receptor scavenging hemopexin-heme complexes. Blood (2005) 1.97
Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J Biol Chem (2000) 1.95
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci U S A (2004) 1.92
Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. J Clin Invest (2006) 1.91
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood (2001) 1.88
CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood (2005) 1.86
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A (1994) 1.85
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood (1968) 1.81
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases. Cell Res (2006) 1.79
Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem (1991) 1.77
Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species. Lab Invest (1991) 1.77
Hemopexin: structure, function, and regulation. DNA Cell Biol (2002) 1.75
Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer. J Biol Chem (1995) 1.75
Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal (2007) 1.66
Reperfusion injury pathophysiology in sickle transgenic mice. Blood (2000) 1.65
Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Am J Pathol (2001) 1.61
Metal-induced oxidative stress and signal transduction. Free Radic Biol Med (2004) 1.59
NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol (1996) 1.58
Beneficial effect of intravenous dexamethasone in children with mild to moderately severe acute chest syndrome complicating sickle cell disease. Blood (1998) 1.57
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice. Am J Physiol Heart Circ Physiol (2005) 1.57
Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal (2007) 1.55
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc Natl Acad Sci U S A (1992) 1.54
Heme oxygenase-1 deficiency: the first autopsy case. Hum Pathol (2002) 1.53
Ferritin and superoxide-dependent lipid peroxidation. J Biol Chem (1985) 1.51
Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb (1991) 1.49
Neutrophil activation by heme: implications for inflammatory processes. Blood (2002) 1.49
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J Biol Chem (2003) 1.47
Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood (2009) 1.46
Modulation of nitric oxide bioavailability by erythrocytes. Proc Natl Acad Sci U S A (2001) 1.45
Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions. J Biol Chem (1997) 1.45
Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects. Pharmacol Ther (2006) 1.44
Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains. Nat Struct Biol (1999) 1.42
Stimulation by nitroxides of catalase-like activity of hemeproteins. Kinetics and mechanism. J Biol Chem (1996) 1.33
Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants. Br J Haematol (2006) 1.33
Reactive species in sickle cell disease. Ann N Y Acad Sci (2000) 1.32
Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst. Blood (1996) 1.31
Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein. Biochem J (1979) 1.31
Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice. Am J Physiol Heart Circ Physiol (2004) 1.30
Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. J Biol Chem (1992) 1.28
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. Am J Pathol (2008) 1.26
Crystal structure of rat heme oxygenase-1 in complex with heme. FEBS Lett (2000) 1.25
Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood (1996) 1.23
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells. J Biol Chem (2003) 1.22
Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. J Biol Chem (2004) 1.22
Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro. Am J Pathol (1995) 1.22
Mitochondrial ferritin. Int J Biochem Cell Biol (2004) 1.21
Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy. Am J Hematol (2004) 1.21
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol (2002) 1.21
Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL. Biochemistry (2004) 1.19
Neutrophil activation in sickle cell disease. J Leukoc Biol (1999) 1.19
Multiple elements within the 5' distal enhancer of the mouse heme oxygenase-1 gene mediate induction by heavy metals. J Biol Chem (1994) 1.17
Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. J Biol Chem (2003) 1.16
Hepatic subcellular metabolism of heme from heme-hemopexin: incorporation of iron into ferritin. Biochem Biophys Res Commun (1979) 1.16
Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest (1988) 1.15
Iron loading of endothelial cells augments oxidant damage. J Lab Clin Med (1990) 1.15
The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood (2004) 1.15
The ferritin family of iron storage proteins. Adv Enzymol Relat Areas Mol Biol (1990) 1.15
Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences. Cell Mol Biol (Noisy-le-grand) (2004) 1.15
Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol (2002) 1.14
Redox regulation of the transcriptional repressor Bach1. Free Radic Biol Med (2005) 1.13
Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. J Biol Chem (1998) 1.13
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis (2001) 1.11
TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am J Physiol (1999) 1.10
Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. Blood (2002) 1.09
Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal (2007) 1.09
The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. Br J Cancer (1991) 1.08
Iron incorporation into apoferritin. The role of apoferritin as a ferroxidase. J Biol Chem (1986) 1.06
Efficacy of methylprednisolone in children with severe community acquired pneumonia. Pediatr Pulmonol (2012) 2.04
Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury. J Clin Invest (2013) 1.73
Once-monthly subcutaneous C.E.R.A. maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly. Clin J Am Soc Nephrol (2007) 1.40
Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease. J Mol Med (Berl) (2010) 1.23
Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-Hodgkin lymphomas. Biol Blood Marrow Transplant (2010) 1.21
Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells. J Biol Chem (2009) 1.19
Heme oxygenase-1-related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium. FASEB J (2003) 1.08
Pre-conditioning cryosurgery: cellular and molecular mechanisms and dynamics of TNF-α enhanced cryotherapy in an in vivo prostate cancer model system. Cryobiology (2010) 0.94
Dietary self-efficacy: determinant of compliance behaviours and biochemical outcomes in haemodialysis patients. Nephrol Dial Transplant (2003) 0.91
Inflammation and resistance to erythropoiesis-stimulating agents--what do we know and what needs to be clarified? Nephrol Dial Transplant (2005) 0.91
The cellular autophagy markers Beclin-1 and LC3B-II are increased during reperfusion in fibrillated mouse hearts. Curr Pharm Des (2013) 0.87
Cardioprotective effects of sour cherry seed extract (SCSE) on the hypercholesterolemic rabbit heart. Curr Pharm Des (2013) 0.83
Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells. Atherosclerosis (2006) 0.82
Adverse impact of diet-induced hypercholesterolemia on cardiovascular tissue homeostasis in a rabbit model: time-dependent changes in cardiac parameters. Int J Mol Sci (2013) 0.81
Histamine and H1 -histamine receptors faster venous circulation. J Cell Mol Med (2011) 0.80
Relationship between serum nickel and homocysteine concentration in hemodialysis patients. Biol Trace Elem Res (2008) 0.78
Quantitative real-time polymerase chain reaction (qRT-PCR) restriction fragment length polymorphism (RFLP) method for monitoring highly conserved transgene expression during gene therapy. Transl Res (2008) 0.78
Homocysteine metabolism in peripheral blood mononuclear cells: evidence for cystathionine beta-synthase activity in resting state. Amino Acids (2011) 0.78
Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils. J Nutr Biochem (2007) 0.78
Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cells. J Cell Mol Med (2012) 0.75
Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients. Nephron Clin Pract (2006) 0.75
In utero incarceration of congenital diaphragmatic hernia. J Pediatr Surg (2011) 0.75
Orally delivered sour cherry seed extract (SCSE) affects cardiovascular and hematological parameters in humans. Phytother Res (2015) 0.75