Influence of melanosome dynamics on melanoma drug sensitivity.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 2744727)

Published in J Natl Cancer Inst on August 24, 2009


Kevin G Chen1, Richard D Leapman, Guofeng Zhang, Barry Lai, Julio C Valencia, Carol O Cardarelli, Wilfred D Vieira, Vincent J Hearing, Michael M Gottesman

Author Affiliations

1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 2108, Bethesda, MD 20892, USA.

Articles cited by this

Cancer regression in patients after transfer of genetically engineered lymphocytes. Science (2006) 16.96

Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55

Management of cutaneous melanoma. N Engl J Med (2004) 9.52

A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res (2005) 7.86

Cell biology: autophagy and cancer. Nature (2007) 4.40

Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev (2006) 4.24

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72

Apoptosis and melanoma chemoresistance. Oncogene (2003) 3.58

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood (2001) 2.52

Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem (2003) 2.10

A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc Natl Acad Sci U S A (2001) 2.06

Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst (2004) 2.02

Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemother Pharmacol (1997) 1.73

The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis. Traffic (2002) 1.72

Biogenesis of pigment granules: a sensitive way to regulate melanocyte function. J Dermatol Sci (2004) 1.70

Normal murine melanocytes in culture. In Vitro Cell Dev Biol (1987) 1.47

Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild-type proteins. FASEB J (2001) 1.33

Pink-eyed dilution protein controls the processing of tyrosinase. Mol Biol Cell (2002) 1.29

Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines. J Biol Chem (2003) 1.27

Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin. J Invest Dermatol (2003) 1.23

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas. Proc Natl Acad Sci U S A (2006) 1.18

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection. Cancer Res (1994) 1.16

Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism. Mol Biol Cell (2002) 1.14

Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res (2005) 1.12

Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. Oncogene (2004) 1.10

Phase II multicenter study of neoadjuvant biochemotherapy for patients with stage III malignant melanoma. J Clin Oncol (2006) 1.03

Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem (2007) 1.03

A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma. Clin Cancer Res (2004) 1.02

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. J Biol Chem (1997) 0.98

Drug resistance towards etoposide and cisplatin in human melanoma cells is associated with drug-dependent apoptosis deficiency. J Invest Dermatol (2002) 0.97

Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Front Biosci (2006) 0.92

Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Exp Cell Res (2004) 0.92

TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content. Melanoma Res (2000) 0.88

Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res (2009) 0.87

Platinum in blood mononuclear cells from patients after cisplatin therapy. Ann Clin Lab Sci (1991) 0.83

Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia. Melanoma Res (2001) 0.81

Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833. J Biol Chem (2001) 0.79

Articles by these authors

A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science (2006) 15.18

Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A (2002) 9.55

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86

Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc Natl Acad Sci U S A (2008) 4.84

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72

P-glycoprotein: from genomics to mechanism. Oncogene (2003) 3.66

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science (2003) 3.41

Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS Biol (2007) 3.22

c-Type cytochrome-dependent formation of U(IV) nanoparticles by Shewanella oneidensis. PLoS Biol (2006) 2.80

Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system. J Immunol (2005) 2.80

Biology of TiO2-oligonucleotide nanocomposites. Nat Mater (2003) 2.68

Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J (2007) 2.62

Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells. Genome Biol (2003) 2.52

The protective role of melanin against UV damage in human skin. Photochem Photobiol (2008) 2.45

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano (2009) 2.39

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. Biochemistry (2002) 2.37

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci U S A (2010) 2.33

Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev (2012) 2.31

Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy. Proc Natl Acad Sci U S A (2005) 2.30

The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annu Rev Pharmacol Toxicol (2008) 2.26

Mechanisms of multidrug resistance in cancer. Methods Mol Biol (2010) 2.25

A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther (2004) 2.16

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure. Proc Natl Acad Sci U S A (2009) 2.15

X-ray fluorescence microprobe imaging in biology and medicine. J Cell Biochem (2006) 2.07

Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06

The regulation of skin pigmentation. J Biol Chem (2007) 2.02

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A (2011) 1.97

Physiological factors that regulate skin pigmentation. Biofactors (2009) 1.93

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer. Cancer Res (2007) 1.91

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics. J Natl Cancer Inst (2010) 1.89

UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. FASEB J (2003) 1.88

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database. Mol Cancer Ther (2009) 1.83

Mechanisms of gold biomineralization in the bacterium Cupriavidus metallidurans. Proc Natl Acad Sci U S A (2009) 1.81

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima. J Mol Biol (2008) 1.80

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta (2009) 1.79

Large intestine-targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection. Nat Med (2012) 1.74

The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation. J Invest Dermatol (2006) 1.72

Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface. J Virol (2002) 1.69

Mass of the postsynaptic density and enumeration of three key molecules. Proc Natl Acad Sci U S A (2005) 1.67

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. Cancer Res (2006) 1.64

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res (2006) 1.63

High resolution 3D x-ray diffraction microscopy. Phys Rev Lett (2002) 1.63

Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk. J Natl Cancer Inst (2005) 1.63

Elemental and redox analysis of single bacterial cells by x-ray microbeam analysis. Science (2004) 1.62

Silent (synonymous) SNPs: should we care about them? Methods Mol Biol (2009) 1.61

Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation. J Invest Dermatol (2005) 1.60

An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. J Cell Biol (2010) 1.59

Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol (2004) 1.56

Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J (2006) 1.55

The clinical relevance of cancer cell lines. J Natl Cancer Inst (2013) 1.54

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. J Transl Med (2008) 1.54

Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resist Updat (2012) 1.53

Migration of mercury from dental amalgam through human teeth. J Synchrotron Radiat (2008) 1.53

Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinks. PLoS One (2007) 1.52

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge. J Cell Biol (2008) 1.48

Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines. Cancer Res (2003) 1.48

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem Neurosci (2010) 1.46

The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers. J Biol Chem (2006) 1.46

Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4. J Cell Sci (2003) 1.45

Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity. Nano Lett (2007) 1.43

Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis. Biochemistry (2002) 1.43

Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes. J Invest Dermatol (2012) 1.43

Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res (2007) 1.41

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res (2009) 1.38

Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci (2009) 1.37

Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase. J Invest Dermatol (2007) 1.37

MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem (2005) 1.36

Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resist Updat (2012) 1.35

Nanoparticles for applications in cellular imaging. Nanoscale Res Lett (2007) 1.34

PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry (2007) 1.33

Nanoscale 3D cellular imaging by axial scanning transmission electron tomography. Nat Methods (2009) 1.32

SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentation. Proc Natl Acad Sci U S A (2007) 1.32

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res (2003) 1.31

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A (2004) 1.31

Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. J Comp Neurol (2010) 1.30

SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30

Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes. FASEB J (2007) 1.29

Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. J Clin Invest (2009) 1.28

Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. J Biol Chem (2003) 1.27

Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. J Invest Dermatol (2010) 1.27