Published in Bioessays on October 01, 2009
The therapeutic promise of the cancer stem cell concept. J Clin Invest (2010) 3.26
Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res (2010) 1.83
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62
Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine (Lond) (2012) 1.54
Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest (2012) 1.53
Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia (2010) 1.11
Stacking the DEK: from chromatin topology to cancer stem cells. Cell Cycle (2012) 1.01
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application? J Hematol Oncol (2015) 0.96
Colon cancer stem cells: controversies and perspectives. World J Gastroenterol (2013) 0.95
Cancer stem cells and chemoresistance: The smartest survives the raid. Pharmacol Ther (2016) 0.93
Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking? Lab Invest (2013) 0.92
Challenges in the development of future treatments for breast cancer stem cells. Breast Cancer (Dove Med Press) (2010) 0.89
Tumor initiation in human malignant melanoma and potential cancer therapies. Anticancer Agents Med Chem (2010) 0.88
CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS Lett (2011) 0.88
Can nanomedicines kill cancer stem cells? Adv Drug Deliv Rev (2013) 0.86
Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer. Oncotarget (2015) 0.84
Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts. J Exp Clin Cancer Res (2013) 0.82
Cancer stem cells: a systems biology view of their role in prognosis and therapy. Anticancer Drugs (2014) 0.79
Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells. PLoS One (2015) 0.79
Sarcoma stem cells: do we know what we are looking for? Sarcoma (2012) 0.79
Transient TNF regulates the self-renewing capacity of stem-like label-retaining cells in sphere and skin equivalent models of melanoma. Cell Commun Signal (2014) 0.79
Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance. Oncol Lett (2016) 0.78
In vitro models of cancer stem cells and clinical applications. BMC Cancer (2016) 0.77
Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4(+) cells with tumor-initiating capability. Cancer Biol Ther (2013) 0.77
A quest for initiating cells of head and neck cancer and their treatment. Cancers (Basel) (2010) 0.77
Cancer stem cells (CSCs), cervical CSCs and targeted therapies. Oncotarget (2017) 0.75
Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma. Ocul Oncol Pathol (2015) 0.75
Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae (2016) 0.75
Biliary tract cancer stem cells - translational options and challenges. World J Gastroenterol (2017) 0.75
Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models. Gene Ther (2016) 0.75
A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer. Chin J Cancer (2012) 0.75
11R-P53 and GM-CSF Expressing Oncolytic Adenovirus Target Cancer Stem Cells with Enhanced Synergistic Activity. J Cancer (2017) 0.75
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol (2017) 0.75
The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig (2014) 0.75
Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells. PLoS One (2014) 0.75
Highlights from the Gynecologic Oncology Track at the 2017 Annual Meeting of the American Society of Clinical Oncology. J Gynecol Oncol (2017) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
Identification of human brain tumour initiating cells. Nature (2004) 38.87
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52
Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44
The clonal evolution of tumor cell populations. Science (1976) 24.39
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer (2002) 15.72
Tumour stem cells and drug resistance. Nat Rev Cancer (2005) 15.21
Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell (2005) 15.06
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell (2007) 14.87
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res (2004) 14.73
let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med (2001) 11.94
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst (2008) 11.93
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet (2004) 11.77
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
A perivascular niche for brain tumor stem cells. Cancer Cell (2007) 11.55
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med (2004) 11.29
Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst (2006) 10.06
Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer (2008) 9.82
Primary bioassay of human tumor stem cells. Science (1977) 9.69
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer (2006) 8.50
Identification of cells initiating human melanomas. Nature (2008) 8.28
A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res (2005) 7.86
The stem-cell niche as an entity of action. Nature (2006) 7.73
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature (2006) 7.69
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell (2007) 7.05
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res (2006) 6.77
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood (2002) 6.64
Dynamics of chronic myeloid leukaemia. Nature (2005) 6.63
Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell (2008) 6.48
Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res (2008) 6.38
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell (2004) 5.98
Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med (2006) 5.92
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature (2008) 5.59
Characterization of clonogenic multiple myeloma cells. Blood (2003) 5.35
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol (2007) 5.21
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol (2004) 5.10
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature (2009) 4.99
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A (2007) 4.97
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood (2006) 4.41
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Biological diversity in metastatic neoplasms: origins and implications. Science (1982) 3.95
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood (2001) 3.90
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res (2006) 3.81
Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer (2007) 3.80
PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood (2008) 3.67
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res (2005) 3.52
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature (2009) 3.37
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood (1999) 3.33
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood (2008) 3.19
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
Preferential induction of apoptosis for primary human leukemic stem cells. Proc Natl Acad Sci U S A (2002) 3.12
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood (2001) 2.71
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood (2007) 2.68
Characterization of acute lymphoblastic leukemia progenitor cells. Blood (2004) 2.65
Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood (2002) 2.44
Comment on "Tumor growth need not be driven by rare cancer stem cells". Science (2007) 2.41
In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst (2009) 2.39
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med (2005) 2.36
Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst (2007) 2.23
Mouse myeloma tumor stem cells: a primary cell culture assay. J Natl Cancer Inst (1971) 2.17
Identification of cancer stem cells in Ewing's sarcoma. Cancer Res (2009) 2.15
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood (2007) 2.14
Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem (2003) 2.10
Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res (2004) 2.10
A QUANTITATIVE ASSAY FOR THE NUMBER OF MURINE LYMPHOMA CELLS CAPABLE OF PROLIFERATION IN VIVO. Nature (1963) 1.96
Human acute myeloid leukemia CD34+/CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. Cancer Res (2000) 1.94
Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol (2004) 1.87
Circumventing resistance to kinase-inhibitor therapy. N Engl J Med (2006) 1.75
The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells (2008) 1.70
Oncolytic adenoviruses kill breast cancer initiating CD44+CD24-/low cells. Mol Ther (2007) 1.68
Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65
Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood (2007) 1.60
Mechanisms controlling pathogenesis and survival of leukemic stem cells. Oncogene (2004) 1.58
Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood (2007) 1.52
A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer. PLoS One (2006) 1.48
BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood (2007) 1.40
Antitumor immunity and cancer stem cells. Ann N Y Acad Sci (2009) 1.36
Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res (2008) 1.34
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. Blood (2006) 1.33
Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38- cells. Leukemia (2006) 1.17
Identification of cells initiating human melanomas. Nature (2008) 8.28
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res (2005) 3.52
The therapeutic promise of the cancer stem cell concept. J Clin Invest (2010) 3.26
Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem (2003) 2.10
Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res (2010) 1.83
Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62
The in vitro spheroid melanoma cell culture assay: cues on tumor initiation? J Invest Dermatol (2010) 1.53
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol (2006) 1.42
Antitumor immunity and cancer stem cells. Ann N Y Acad Sci (2009) 1.36
The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol (2011) 1.27
ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res (2011) 1.23
Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun (2010) 1.13
Synergy of photoacoustic and fluorescence flow cytometry of circulating cells with negative and positive contrasts. J Biophotonics (2012) 1.05
SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol (2011) 1.01
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol (2011) 0.96
Myogenic potential of muscle side and main population cells after intravenous injection into sub-lethally irradiated mdx mice. J Histochem Cytochem (2005) 0.92
Tumor initiation in human malignant melanoma and potential cancer therapies. Anticancer Agents Med Chem (2010) 0.88
CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island. Am J Physiol Renal Physiol (2004) 0.87
Colorectal Cancer Stem Cells: Biology and Therapeutic Implications. Curr Colorectal Cancer Rep (2011) 0.87
A novel in vivo regulatory role of P-glycoprotein in alloimmunity. Biochem Biophys Res Commun (2010) 0.86
Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Biochem Biophys Res Commun (2013) 0.86
ABCB5 gene amplification in human leukemia cells. Leuk Res (2009) 0.84
Restoring the cornea from limbal stem cells. Regen Med (2015) 0.81
The multidrug-resistance transporter ABCB5 is expressed in human placenta. Int J Gynecol Pathol (2014) 0.78
Novel double heterozygous mutations in MEFV and NLRP3 genes in a patient with familial Mediterranean fever. J Clin Rheumatol (2013) 0.77
P-glycoprotein and alloimmune T-cell activation. Clin Appl Immunol Rev (2003) 0.76
Dissecting a Case of Abdominal Pain. N Engl J Med (2016) 0.75