Published in Angew Chem Int Ed Engl on January 01, 2009
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev (2010) 3.89
Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics. Mol Cell Proteomics (2010) 3.44
Copper-free click chemistry in living animals. Proc Natl Acad Sci U S A (2010) 2.76
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc (2010) 2.74
From mechanism to mouse: a tale of two bioorthogonal reactions. Acc Chem Res (2011) 2.50
Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions. Nat Chem (2011) 2.04
Organelle-targetable fluorescent probes for imaging hydrogen peroxide in living cells via SNAP-Tag protein labeling. J Am Chem Soc (2010) 1.99
Biocompatible copper(I) catalysts for in vivo imaging of glycans. J Am Chem Soc (2010) 1.98
Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics. Chem Biol (2010) 1.91
Design and synthesis of highly reactive dienophiles for the tetrazine-trans-cyclooctene ligation. J Am Chem Soc (2011) 1.90
Labeling live cells by copper-catalyzed alkyne--azide click chemistry. Bioconjug Chem (2010) 1.86
Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation. Angew Chem Int Ed Engl (2013) 1.85
Choosing an effective protein bioconjugation strategy. Nat Chem Biol (2011) 1.82
Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging. Nat Methods (2012) 1.80
Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation. Bioconjug Chem (2011) 1.78
Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc (2010) 1.71
Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chem Commun (Camb) (2010) 1.69
Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes. J Am Chem Soc (2012) 1.67
Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. Proc Natl Acad Sci U S A (2011) 1.65
Direct identification of ligand-receptor interactions on living cells and tissues. Nat Biotechnol (2012) 1.64
Highly fluorescent semiconducting polymer dots for biology and medicine. Angew Chem Int Ed Engl (2013) 1.63
In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria. Nat Med (2015) 1.62
Ultrabright and bioorthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry. Angew Chem Int Ed Engl (2010) 1.59
Bioorthogonal chemistry: recent progress and future directions. Chem Commun (Camb) (2010) 1.58
Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions. Angew Chem Int Ed Engl (2012) 1.55
A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. Nat Chem (2011) 1.54
A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry. J Nucl Med (2013) 1.52
A streptavidin variant with slower biotin dissociation and increased mechanostability. Nat Methods (2010) 1.46
Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry. Bioconjug Chem (2011) 1.45
Bringing chemistry to life. Nat Methods (2011) 1.45
Noncanonical amino acids in the interrogation of cellular protein synthesis. Acc Chem Res (2011) 1.44
Tandem fluorescence imaging of dynamic S-acylation and protein turnover. Proc Natl Acad Sci U S A (2010) 1.44
Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants. Mol Cell Proteomics (2010) 1.43
Click chemistry in complex mixtures: bioorthogonal bioconjugation. Chem Biol (2014) 1.40
Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc (2012) 1.40
(D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. ACS Chem Biol (2013) 1.29
Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J Am Chem Soc (2010) 1.29
Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Acc Chem Res (2011) 1.28
Genetically encoded cyclopropene directs rapid, photoclick-chemistry-mediated protein labeling in mammalian cells. Angew Chem Int Ed Engl (2012) 1.28
Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc (2010) 1.28
A metabolic alkene reporter for spatiotemporally controlled imaging of newly synthesized proteins in Mammalian cells. ACS Chem Biol (2010) 1.27
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl (2012) 1.25
trans-Cyclooctene--a stable, voracious dienophile for bioorthogonal labeling. Curr Opin Chem Biol (2013) 1.25
Reactivity of biarylazacyclooctynones in copper-free click chemistry. J Am Chem Soc (2012) 1.24
Photoinducible bioorthogonal chemistry: a spatiotemporally controllable tool to visualize and perturb proteins in live cells. Acc Chem Res (2011) 1.22
Bioorthogonal chemistry: strategies and recent developments. Chem Commun (Camb) (2013) 1.19
Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease. ACS Chem Biol (2012) 1.17
Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc Natl Acad Sci U S A (2014) 1.14
Protein glycoengineering enabled by the versatile synthesis of aminooxy glycans and the genetically encoded aldehyde tag. J Am Chem Soc (2011) 1.13
A genetically encoded acrylamide functionality. ACS Chem Biol (2013) 1.12
Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation. Chem Biol Drug Des (2010) 1.12
Exploring bacterial cell biology with single-molecule tracking and super-resolution imaging. Nat Rev Microbiol (2014) 1.10
Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. Chembiochem (2011) 1.10
Glycan evolution in response to collaboration, conflict, and constraint. J Biol Chem (2013) 1.10
Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition. Chem Asian J (2011) 1.09
Copper-free Sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells. J Am Chem Soc (2011) 1.08
Thiacycloalkynes for copper-free click chemistry. Angew Chem Int Ed Engl (2012) 1.08
Water-soluble organocatalysts for hydrazone and oxime formation. J Org Chem (2013) 1.08
Selective, rapid and optically switchable regulation of protein function in live mammalian cells. Nat Chem (2015) 1.08
π-Clamp-mediated cysteine conjugation. Nat Chem (2015) 1.06
Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem (2011) 1.06
Probing the mycobacterial trehalome with bioorthogonal chemistry. J Am Chem Soc (2012) 1.06
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes. Bioconjug Chem (2014) 1.05
Glycotherapy: new advances inspire a reemergence of glycans in medicine. Chem Biol (2013) 1.04
Fluorogenic azidofluoresceins for biological imaging. J Am Chem Soc (2012) 1.04
In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry. Environ Microbiol (2014) 1.04
Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J Am Chem Soc (2013) 1.03
Synthesis of functionalized dialkyl ketones from carboxylic acid derivatives and alkyl halides. Org Lett (2012) 1.03
Importance of ortho proton donors in catalysis of hydrazone formation. Org Lett (2013) 1.03
Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell Culture Scaffolds. ACS Macro Lett (2012) 1.02
Supramolecular host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed Engl (2011) 1.02
Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells. J Am Chem Soc (2012) 1.01
A chemical reporter for protein AMPylation. J Am Chem Soc (2011) 1.01
Methods for site-specific drug conjugation to antibodies. MAbs (2014) 1.00
Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification. Mol Pharm (2010) 1.00
A Pictet-Spengler ligation for protein chemical modification. Proc Natl Acad Sci U S A (2012) 0.99
Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. Chem Sci (2014) 0.99
A fluorogenic probe for the catalyst-free detection of azide-tagged molecules. J Am Chem Soc (2012) 0.98
Synthetically defined glycoprotein vaccines: current status and future directions. Chem Sci (2013) 0.97
Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry. Bioconjug Chem (2013) 0.97
Site-selective protein-modification chemistry for basic biology and drug development. Nat Chem (2015) 0.96
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proc Natl Acad Sci U S A (2016) 0.96
A general method for artificial metalloenzyme formation through strain-promoted azide-alkyne cycloaddition. Chembiochem (2013) 0.96
Transition metal photoredox catalysis of radical thiol-ene reactions. J Org Chem (2012) 0.96
A Mild, Large-Scale Synthesis of 1,3-Cyclooctanedione: Expanding Access to Difluorinated Cyclooctyne for Copper-Free Click Chemistry. Tetrahedron Lett (2011) 0.96
The inverse electron demand Diels-Alder click reaction in radiochemistry. J Labelled Comp Radiopharm (2013) 0.96
Imaging beyond the proteome. Chem Commun (Camb) (2012) 0.95
Superglue from bacteria: unbreakable bridges for protein nanotechnology. Trends Biotechnol (2014) 0.95
Plug-and-play pairing via defined divalent streptavidins. J Mol Biol (2013) 0.94
4-aminophenylalanine as a biocompatible nucleophilic catalyst for hydrazone ligations at low temperature and neutral pH. Bioconjug Chem (2011) 0.94
Proline editing: a general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4-substituted prolines on conformation within peptides. J Am Chem Soc (2013) 0.94
Site-specific protein modifications through pyrroline-carboxy-lysine residues. Proc Natl Acad Sci U S A (2011) 0.94
2'-Azido RNA, a versatile tool for chemical biology: synthesis, X-ray structure, siRNA applications, click labeling. ACS Chem Biol (2012) 0.93
Synthesis of macrocyclic tetrazoles for rapid photoinduced bioorthogonal 1,3-dipolar cycloaddition reactions. Chemistry (2010) 0.93
A DOTA-peptide conjugate by copper-free click chemistry. Bioorg Med Chem Lett (2010) 0.93
Real-time bioluminescence imaging of glycans on live cells. J Am Chem Soc (2010) 0.92
Azirine ligation: fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition. Chem Commun (Camb) (2010) 0.92
Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols. J Am Chem Soc (2011) 0.91
The green fluorescent protein. Annu Rev Biochem (1998) 34.17
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew Chem Int Ed Engl (2002) 24.12
A guide to choosing fluorescent proteins. Nat Methods (2005) 18.55
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J Org Chem (2002) 13.76
Synthesis of proteins by native chemical ligation. Science (1994) 10.98
Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science (1982) 10.61
A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A (2008) 10.09
Specific covalent labeling of recombinant protein molecules inside live cells. Science (1998) 9.32
Copper-free click chemistry for dynamic in vivo imaging. Proc Natl Acad Sci U S A (2007) 8.50
Cell surface engineering by a modified Staudinger reaction. Science (2000) 8.09
Chemistry in living systems. Nat Chem Biol (2005) 7.55
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems. J Am Chem Soc (2004) 7.51
Metals, toxicity and oxidative stress. Curr Med Chem (2005) 7.48
The growing impact of click chemistry on drug discovery. Drug Discov Today (2003) 6.79
A general method for the covalent labeling of fusion proteins with small molecules in vivo. Nat Biotechnol (2002) 6.77
Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 5.98
Profiling enzyme activities in vivo using click chemistry methods. Chem Biol (2004) 5.97
Advances in fluorescent protein technology. J Cell Sci (2007) 5.91
Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions. Angew Chem Int Ed Engl (2008) 5.90
New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. J Am Chem Soc (2002) 5.83
Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol (2005) 5.80
Multicolor and electron microscopic imaging of connexin trafficking. Science (2002) 5.60
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J Am Chem Soc (2008) 5.52
Polytriazoles as copper(I)-stabilizing ligands in catalysis. Org Lett (2004) 5.49
Development and use of fluorescent protein markers in living cells. Science (2003) 5.47
In vivo imaging of membrane-associated glycans in developing zebrafish. Science (2008) 5.45
Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 5.34
Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase. Nat Methods (2005) 5.21
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 4.92
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev (2006) 4.88
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci U S A (2001) 4.88
Chemical remodelling of cell surfaces in living animals. Nature (2004) 4.86
An expanded eukaryotic genetic code. Science (2003) 4.66
PEGylation, successful approach to drug delivery. Drug Discov Today (2005) 4.56
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc Natl Acad Sci U S A (2006) 4.44
Site-specific labeling of proteins with small molecules in live cells. Curr Opin Biotechnol (2005) 4.39
A comparative study of bioorthogonal reactions with azides. ACS Chem Biol (2006) 4.26
Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems. Appl Microbiol Biotechnol (2002) 4.22
Targeting quantum dots to surface proteins in living cells with biotin ligase. Proc Natl Acad Sci U S A (2005) 4.15
A general method for site-specific incorporation of unnatural amino acids into proteins. Science (1989) 4.15
Trafficking and signaling by fatty-acylated and prenylated proteins. Nat Chem Biol (2006) 4.11
Expressed protein ligation: a general method for protein engineering. Proc Natl Acad Sci U S A (1998) 4.01
Tetrazine-based cycloadditions: application to pretargeted live cell imaging. Bioconjug Chem (2008) 3.93
An engineered protein tag for multiprotein labeling in living cells. Chem Biol (2008) 3.92
Synthesis of native proteins by chemical ligation. Annu Rev Biochem (2000) 3.81
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc (2008) 3.65
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Semisynthesis of proteins by expressed protein ligation. Annu Rev Biochem (2003) 3.44
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat Biotechnol (2007) 3.41
Sortagging: a versatile method for protein labeling. Nat Chem Biol (2007) 3.39
Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis. Science (1997) 3.34
Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A (2008) 3.34
Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat Biotechnol (2005) 3.28
Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant. Cell (1986) 3.25
Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition. J Am Chem Soc (2003) 3.25
Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nat Methods (2006) 3.24
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature (2005) 3.18
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods (2005) 3.11
Labeling of fusion proteins with synthetic fluorophores in live cells. Proc Natl Acad Sci U S A (2004) 3.11
Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res (2000) 3.05
A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A (2003) 2.97
Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl (2006) 2.96
Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Cell (2003) 2.93
Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells. Proc Natl Acad Sci U S A (2007) 2.78
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates. J Am Chem Soc (2005) 2.75
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A (2004) 2.74
A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins. Angew Chem Int Ed Engl (2008) 2.72
Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo. Proc Natl Acad Sci U S A (2006) 2.70
Nucleophilic catalysis of oxime ligation. Angew Chem Int Ed Engl (2006) 2.69
Mechanism-based profiling of enzyme families. Chem Rev (2006) 2.66
Introducing genetically encoded aldehydes into proteins. Nat Chem Biol (2007) 2.65
Protein ligation: an enabling technology for the biophysical analysis of proteins. Nat Methods (2006) 2.60
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A (2003) 2.56
Reversible site-selective labeling of membrane proteins in live cells. Nat Biotechnol (2004) 2.55
Biosynthesis by Escherichia coli of active altered proteins containing selenium instead of sulfur. Biochim Biophys Acta (1957) 2.47
High-efficiency labeling of sialylated glycoproteins on living cells. Nat Methods (2009) 2.46
Production of cyclic peptides and proteins in vivo. Proc Natl Acad Sci U S A (1999) 2.42
Ruthenium-catalyzed cycloaddition of alkynes and organic azides. J Am Chem Soc (2005) 2.35
Selective functionalization of a genetically encoded alkene-containing protein via "photoclick chemistry" in bacterial cells. J Am Chem Soc (2008) 2.33
Recombinant expression of selectively sulfated proteins in Escherichia coli. Nat Biotechnol (2006) 2.31
1,3-dipolar cycloadditions of azides and alkynes: a universal ligation tool in polymer and materials science. Angew Chem Int Ed Engl (2007) 2.28
Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase. Proc Natl Acad Sci U S A (1991) 2.27
Specific labeling of cell surface proteins with chemically diverse compounds. J Am Chem Soc (2004) 2.27
Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J Am Chem Soc (2002) 2.26
Fluorescent labeling of recombinant proteins in living cells with FlAsH. Methods Enzymol (2000) 2.24
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proc Natl Acad Sci U S A (2006) 2.23
Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking. Nat Chem Biol (2005) 2.22
Nicotine binding to brain receptors requires a strong cation-pi interaction. Nature (2009) 2.21
Mechanistic investigation of the staudinger ligation. J Am Chem Soc (2005) 2.19
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc (2007) 2.10
Site-specific incorporation of fluorescent probes into protein: hexahistidine-tag-mediated fluorescent labeling with (Ni(2+):nitrilotriacetic Acid (n)-fluorochrome conjugates. J Am Chem Soc (2001) 2.08
High-affinity adaptors for switchable recognition of histidine-tagged proteins. J Am Chem Soc (2005) 2.06
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
Visualization of mRNA translation in living cells. J Cell Biol (2006) 2.03
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes. Med Res Rev (2008) 2.02
Control of protein phosphorylation with a genetically encoded photocaged amino acid. Nat Chem Biol (2007) 1.99
Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology. Nat Chem Biol (2006) 1.98
Copper-free click chemistry for dynamic in vivo imaging. Proc Natl Acad Sci U S A (2007) 8.50
Chemistry in living systems. Nat Chem Biol (2005) 7.55
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems. J Am Chem Soc (2004) 7.51
Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov (2005) 6.14
In vivo imaging of membrane-associated glycans in developing zebrafish. Science (2008) 5.45
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci U S A (2001) 4.88
Chemical remodelling of cell surfaces in living animals. Nature (2004) 4.86
A comparative study of bioorthogonal reactions with azides. ACS Chem Biol (2006) 4.26
Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev (2010) 3.89
Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc (2008) 3.65
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat Biotechnol (2007) 3.41
A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A (2003) 2.97
Copper-free click chemistry in living animals. Proc Natl Acad Sci U S A (2010) 2.76
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc (2010) 2.74
Introducing genetically encoded aldehydes into proteins. Nat Chem Biol (2007) 2.65
Imaging the glycome. Proc Natl Acad Sci U S A (2008) 2.62
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci U S A (2003) 2.62
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A (2003) 2.56
From mechanism to mouse: a tale of two bioorthogonal reactions. Acc Chem Res (2011) 2.50
The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Biochemistry (2008) 2.40
Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J Am Chem Soc (2002) 2.26
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proc Natl Acad Sci U S A (2006) 2.23
Mechanistic investigation of the staudinger ligation. J Am Chem Soc (2005) 2.19
Chemical technologies for probing glycans. Cell (2006) 2.04
A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci U S A (2007) 2.00
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci U S A (2007) 1.98
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics. Methods Enzymol (2006) 1.93
Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A (2006) 1.85
A hydrophilic azacyclooctyne for Cu-free click chemistry. Org Lett (2008) 1.84
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A (2009) 1.83
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A (2009) 1.83
Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol (2012) 1.79
A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl (2008) 1.79
The chemistry and biology of mucin-type O-linked glycosylation. Bioorg Med Chem (2005) 1.78
Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling. Chem Biol (2004) 1.78
Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc Natl Acad Sci U S A (2010) 1.74
Sulfotransferases and sulfatases in mycobacteria. Chem Biol (2002) 1.74
Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A (2008) 1.73
Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat Protoc (2007) 1.73
Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc (2007) 1.65
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc Natl Acad Sci U S A (2010) 1.63
Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A (2011) 1.61
5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice. Mol Microbiol (2006) 1.59
Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug Chem (2015) 1.58
Symbol nomenclature for glycan representation. Proteomics (2009) 1.56
Sulfate metabolism in mycobacteria. Chembiochem (2006) 1.55
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55
Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew Chem Int Ed Engl (2009) 1.53
Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem Commun (Camb) (2008) 1.52
In vivo imaging of Caenorhabditis elegans glycans. ACS Chem Biol (2009) 1.48
Bringing chemistry to life. Nat Methods (2011) 1.45
Trehalose is required for growth of Mycobacterium smegmatis. J Biol Chem (2004) 1.44
Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase. J Mol Biol (2006) 1.42
Noncovalent cell surface engineering: incorporation of bioactive synthetic glycopolymers into cellular membranes. J Am Chem Soc (2008) 1.41
Metabolic oligosaccharide engineering as a tool for glycobiology. Curr Opin Chem Biol (2003) 1.41
Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc (2012) 1.40
Programmable cell adhesion encoded by DNA hybridization. Angew Chem Int Ed Engl (2006) 1.39
Selective enrichment of azide-containing peptides from complex mixtures. J Proteome Res (2009) 1.38
A chemical reporter strategy to probe glycoprotein fucosylation. J Am Chem Soc (2006) 1.35
Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology (2005) 1.35
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
A conserved mechanism for sulfonucleotide reduction. PLoS Biol (2005) 1.34
Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A (2008) 1.34
Chemical approaches to perturb, profile, and perceive glycans. Acc Chem Res (2009) 1.33
A decade of bioorthogonal chemistry. Acc Chem Res (2011) 1.32
Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc (2009) 1.31
Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J (2007) 1.31
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir (2009) 1.30
(D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. ACS Chem Biol (2013) 1.29
Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J Am Chem Soc (2010) 1.29
Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl Environ Microbiol (2010) 1.29
A fluorogenic dye activated by the staudinger ligation. J Am Chem Soc (2003) 1.29
Expanding the diversity of unnatural cell-surface sialic acids. Chembiochem (2004) 1.29
5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria. J Biol Chem (2002) 1.27
Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach. Proc Natl Acad Sci U S A (2002) 1.26
Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem Biol (2011) 1.25
Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl (2012) 1.25
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci U S A (2007) 1.25
Interfacing carbon nanotubes with living cells. J Am Chem Soc (2006) 1.25
Reactivity of biarylazacyclooctynones in copper-free click chemistry. J Am Chem Soc (2012) 1.24
An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation. Chem Biol (2002) 1.22
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20
Synthesis, characterization, and theory of [9]-, [12]-, and [18]cycloparaphenylene: carbon nanohoop structures. J Am Chem Soc (2008) 1.19
Metabolic functionalization of recombinant glycoproteins. Biochemistry (2004) 1.19
A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc (2003) 1.18
Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications. Angew Chem Int Ed Engl (2009) 1.18
A chemical method for labeling lysine methyltransferase substrates. Chembiochem (2010) 1.18
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 1.16
Synthetic glycopeptides and glycoproteins as tools for biology. Chem Soc Rev (2004) 1.16
Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc (2012) 1.15
Probing glycosyltransferase activities with the Staudinger ligation. J Am Chem Soc (2004) 1.15
The regulation of sulfur metabolism in Mycobacterium tuberculosis. PLoS Pathog (2011) 1.15
The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus. Curr Opin Cell Biol (2004) 1.15
Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library. Antimicrob Agents Chemother (2003) 1.14
Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc Natl Acad Sci U S A (2014) 1.14
Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. Chembiochem (2010) 1.14
A strategy for functional proteomic analysis of glycosidase activity from cell lysates. Angew Chem Int Ed Engl (2004) 1.14
Azido sialic acids can modulate cell-surface interactions. Chembiochem (2004) 1.14
Protein glycoengineering enabled by the versatile synthesis of aminooxy glycans and the genetically encoded aldehyde tag. J Am Chem Soc (2011) 1.13