Published in Am J Clin Nutr on September 02, 2009
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med (2010) 2.25
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A (2010) 2.12
Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ (2014) 2.06
The genetics of obesity: FTO leads the way. Trends Genet (2010) 1.90
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One (2010) 1.89
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
The bigger picture of FTO: the first GWAS-identified obesity gene. Nat Rev Endocrinol (2013) 1.73
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
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From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry (2010) 1.49
Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women. Diabetes Care (2011) 1.44
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet (2010) 1.38
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr (2013) 1.35
Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation (2012) 1.33
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Measured parental weight status and familial socio-economic status correlates with childhood overweight and obesity at age 9. PLoS One (2012) 1.28
Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients (2013) 1.20
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr (2011) 1.20
Health behavior change: can genomics improve behavioral adherence? Am J Public Health (2012) 1.20
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FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial. Diabetes (2012) 1.16
Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exerc (2011) 1.12
FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet (2014) 1.11
Increasing genetic variance of body mass index during the Swedish obesity epidemic. PLoS One (2011) 1.10
Increased genetic variance of BMI with a higher prevalence of obesity. PLoS One (2011) 1.00
Beyond the fourth wave of genome-wide obesity association studies. Nutr Diabetes (2012) 0.98
Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. Am J Epidemiol (2013) 0.94
Common genetic variants and central adiposity among Asian-Indians. Obesity (Silver Spring) (2011) 0.91
Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study. Genes Nutr (2013) 0.90
Invited commentary: Gene X lifestyle interactions and complex disease traits--inferring cause and effect from observational data, sine qua non. Am J Epidemiol (2010) 0.89
Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption. PLoS One (2012) 0.89
The complex interplay of genetic and lifestyle risk factors in type 2 diabetes: an overview. Scientifica (Cairo) (2012) 0.89
Gene-diet interactions in childhood obesity. Curr Genomics (2011) 0.86
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. Diabetes (2015) 0.85
Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children. PLoS One (2012) 0.85
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet (2015) 0.84
Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction. J Clin Lipidol (2012) 0.84
Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults. Food Nutr Res (2013) 0.84
Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children. BMC Med Genet (2013) 0.83
Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk. Nutr Res Pract (2012) 0.82
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index. Nat Commun (2016) 0.82
Genomic insights into early-onset obesity. Genome Med (2010) 0.81
Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations. J Acad Nutr Diet (2014) 0.81
Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort. BMC Med Genet (2015) 0.80
Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. Sci Rep (2016) 0.80
Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key? J Pharmacol Exp Ther (2012) 0.79
Longitudinal effects of physical inactivity and obesity on gait speed in older adults with frequent knee pain: data from the Osteoarthritis Initiative. Int J Environ Res Public Health (2015) 0.78
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet (2017) 0.78
The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents. PLoS One (2014) 0.78
Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial. Clin Gastroenterol Hepatol (2015) 0.77
Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity. Hum Genet (2015) 0.77
A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake. Genes Nutr (2014) 0.77
Obesity: interactions of genome and nutrients intake. Prev Nutr Food Sci (2015) 0.77
FTO polymorphisms moderate the association of food reinforcement with energy intake. Physiol Behav (2014) 0.76
Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study. Behav Genet (2015) 0.76
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. J Hum Genet (2016) 0.75
Associations Between Fast-Food Consumption and Body Mass Index: A Cross-Sectional Study in Adult Twins. Twin Res Hum Genet (2015) 0.75
FTO gene variation, macronutrient intake and coronary heart disease risk: a gene-diet interaction analysis. Eur J Nutr (2015) 0.75
Association of Fat Mass and Obesity-associated Gene Variant with Lifestyle Factors and Body Fat in Indian Children. Indian J Endocrinol Metab (2017) 0.75
The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? Health Place (2016) 0.75
Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population. Nutr Metab (Lond) (2016) 0.75
FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits. Appetite (2017) 0.75
The Interplay of Genetics and Environmental Factors in the Development of Obesity. Cureus (2017) 0.75
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Testing for an unusual distribution of rare variants. PLoS Genet (2011) 9.28
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet (2010) 6.07
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. BMC Med Genet (2007) 5.64
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes (2006) 4.36
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
The validity of obesity based on self-reported weight and height: Implications for population studies. Obesity (Silver Spring) (2007) 3.78
Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology (2009) 3.67
Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med (2007) 3.58
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet (2009) 3.07
Consumption of vegetables and fruits and risk of breast cancer. JAMA (2005) 3.02
Genetic prediction of future type 2 diabetes. PLoS Med (2005) 2.98
Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer (2004) 2.96
Meat consumption and prospective weight change in participants of the EPIC-PANACEA study. Am J Clin Nutr (2010) 2.87
High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort. Am J Clin Nutr (2007) 2.38
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models. Int J Epidemiol (2008) 2.11
[Time to tidy up the diet debate: scientific evidence--who knows the truth?]. Lakartidningen (2008) 2.03
Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. Am J Clin Nutr (2012) 1.98
Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study1,4. Am J Clin Nutr (2013) 1.84
Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol (2009) 1.83
The role of smoking and diet in explaining educational inequalities in lung cancer incidence. J Natl Cancer Inst (2009) 1.81
Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects. Arterioscler Thromb Vasc Biol (2011) 1.78
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2012) 1.67
Dietary patterns as identified by factor analysis and colorectal cancer among middle-aged Americans. Am J Clin Nutr (2008) 1.65
Defining the spectrum of alleles that contribute to blood lipid concentrations in humans. Curr Opin Lipidol (2008) 1.59
Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2008) 1.57
Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr (2011) 1.56
No association of consumption of animal foods with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.55
Breast cancer risk in relation to abortion: Results from the EPIC study. Int J Cancer (2006) 1.51
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
Comparing 3 dietary pattern methods--cluster analysis, factor analysis, and index analysis--With colorectal cancer risk: The NIH-AARP Diet and Health Study. Am J Epidemiol (2009) 1.50
Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population. J Nutr (2008) 1.49
A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J (2012) 1.47
Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr (2009) 1.45
Plasma copeptin and the risk of diabetes mellitus. Circulation (2010) 1.44
The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels. Genes Nutr (2014) 1.42
[Time to change continuing medical education!]. Lakartidningen (2009) 1.40
Physical activity and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev (2006) 1.38
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr (2013) 1.35
A prospective study of adiposity and all-cause mortality: the Malmö Diet and Cancer Study. Obes Res (2002) 1.34
Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control (2007) 1.33
Dietary patterns among older Europeans: the EPIC-Elderly study. Br J Nutr (2005) 1.33
Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. Diabetes (2004) 1.32
Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2008) 1.30
Dietary patterns and survival of older Europeans: the EPIC-Elderly Study (European Prospective Investigation into Cancer and Nutrition). Public Health Nutr (2007) 1.28
Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2008) 1.27
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J Hepatol (2012) 1.22
Fruit and vegetable consumption and mortality: European prospective investigation into cancer and nutrition. Am J Epidemiol (2013) 1.22
Adherence to the Mediterranean diet is associated with lower abdominal adiposity in European men and women. J Nutr (2009) 1.22
Dairy products and its association with incidence of cardiovascular disease: the Malmö diet and cancer cohort. Eur J Epidemiol (2011) 1.20
Mediterranean dietary patterns and prospective weight change in participants of the EPIC-PANACEA project. Am J Clin Nutr (2010) 1.18
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. Cancer Epidemiol Biomarkers Prev (2010) 1.18
Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One (2012) 1.17
Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer (2006) 1.15
Salivary cortisol differs with age and sex and shows inverse associations with WHR in Swedish women: a cross-sectional study. BMC Endocr Disord (2009) 1.15
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab (2006) 1.14
Misreporting of energy: prevalence, characteristics of misreporters and influence on observed risk estimates in the Malmö Diet and Cancer cohort. Br J Nutr (2005) 1.13
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes (2011) 1.13
A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study. Int J Cancer (2003) 1.12
Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev (2008) 1.11
Incidence and prevalence of primary sclerosing cholangitis in a defined adult population in Sweden. Hepatology (2010) 1.09
A methodological report from the Malmö Diet and Cancer study: development and evaluation of altered routines in dietary data processing. Nutr J (2002) 1.09
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J Lipid Res (2008) 1.09
Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes (2011) 1.08
Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. Eur J Endocrinol (2009) 1.06
A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden). Cancer Causes Control (2007) 1.05
Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.05
Postmenopausal breast cancer is associated with high intakes of omega6 fatty acids (Sweden). Cancer Causes Control (2002) 1.05
Variety in fruit and vegetable consumption and the risk of lung cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev (2010) 1.05
Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the Malmö Diet and Cancer Cohort: a prospective study. PLoS One (2012) 1.04