Published in J Biol Chem on September 08, 2009
Heme enzyme structure and function. Chem Rev (2014) 1.58
Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase. J Am Chem Soc (2010) 1.45
Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc Natl Acad Sci U S A (2013) 1.00
NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. Arch Biochem Biophys (2012) 1.00
Calmodulin-induced structural changes in endothelial nitric oxide synthase. FEBS Lett (2012) 0.98
Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions. Coord Chem Rev (2011) 0.97
Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase. J Biol Chem (2010) 0.97
A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. J Biol Chem (2010) 0.96
Calmodulin wraps around its binding domain in the plasma membrane Ca2+ pump anchored by a novel 18-1 motif. J Biol Chem (2009) 0.94
Molecular architecture of mammalian nitric oxide synthases. Proc Natl Acad Sci U S A (2014) 0.93
Effect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthase. FEBS Lett (2011) 0.92
Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain. J Biol Chem (2014) 0.92
Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J Mol Biol (2012) 0.89
Pulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective. J Phys Chem A (2014) 0.85
Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases. J Inorg Biochem (2013) 0.84
Glycation of calmodulin binding domain of iNOS may increase the chance of occurrence of tuberculosis in chronic diabetic state. Bioinformation (2011) 0.83
Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase. Inorg Chem (2013) 0.83
Mutation in the flavin mononucleotide domain modulates magnetic circular dichroism spectra of the iNOS ferric cyano complex in a substrate-specific manner. Inorg Chem (2011) 0.82
Pulsed ENDOR determination of the arginine location in the ferrous-NO form of neuronal NOS. J Phys Chem A (2012) 0.81
Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer. J Struct Biol (2014) 0.81
Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. Comp Immunol Microbiol Infect Dis (2011) 0.81
Binding kinetics of calmodulin with target peptides of three nitric oxide synthase isozymes. J Inorg Biochem (2011) 0.80
Role of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase. J Biol Inorg Chem (2012) 0.80
Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis. FEBS J (2013) 0.79
The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177. Biosci Rep (2014) 0.79
Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS. J Phys Chem A (2011) 0.78
Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation. PLoS One (2012) 0.77
Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding. Arch Biochem Biophys (2013) 0.77
The C-terminal domain of 4-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii is an autoinhibitory domain. J Biol Chem (2012) 0.76
Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study. J Inorg Biochem (2015) 0.76
Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap. ACS Catal (2016) 0.76
Elucidating nitric oxide synthase domain interactions by molecular dynamics. Protein Sci (2015) 0.75
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery. FEBS J (2016) 0.75
A perspective on conformational control of electron transfer in nitric oxide synthases. Nitric Oxide (2016) 0.75
Solving Kinetic Equations for the Laser Flash Photolysis Experiment on Nitric Oxide Synthases: Effect of Conformational Dynamics on the Interdomain Electron Transfer. J Phys Chem A (2015) 0.75
Inducible nitric oxide synthase gene polymorphisms are associated with a risk of nephritis in Henoch-Schönlein purpura children. Eur J Pediatr (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Version 1.2 of the Crystallography and NMR system. Nat Protoc (2007) 13.01
Nitric oxide and macrophage function. Annu Rev Immunol (1997) 12.77
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (1991) 8.41
Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science (1992) 4.89
GRAMM-X public web server for protein-protein docking. Nucleic Acids Res (2006) 3.71
Calmodulin target database. J Struct Funct Genomics (2000) 3.20
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell (1998) 3.20
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proc Natl Acad Sci U S A (1997) 3.15
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (1998) 2.75
Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med (1992) 2.55
Update on mechanism and catalytic regulation in the NO synthases. J Biol Chem (2004) 2.55
Nitric oxide: a physiologic messenger. Ann Intern Med (1994) 2.50
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. J Biol Chem (2004) 2.28
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Nat Struct Biol (1999) 1.93
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer. J Biol Chem (1994) 1.70
Structure-function studies on nitric oxide synthases. J Inorg Biochem (2005) 1.69
Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer. J Biol Chem (2001) 1.68
Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem (2009) 1.54
Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains. Proc Natl Acad Sci U S A (1994) 1.51
Intrinsic and extrinsic modulation of nitric oxide synthase activity. Chem Rev (2002) 1.51
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation. J Biol Chem (1996) 1.43
Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase. J Biol Chem (2001) 1.39
Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J (2003) 1.37
Electron transfer by neuronal nitric-oxide synthase is regulated by concerted interaction of calmodulin and two intrinsic regulatory elements. J Biol Chem (2006) 1.32
A connecting hinge represses the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 1.32
NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J Biol Chem (2001) 1.31
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer. J Biol Chem (1998) 1.24
Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock. J Biol Chem (2002) 1.22
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase. J Biol Chem (2006) 1.22
Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry (2009) 1.22
The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin. J Biol Chem (2000) 1.20
Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem (1996) 1.15
Importance of the domain-domain interface to the catalytic action of the NO synthase reductase domain. Biochemistry (2008) 1.13
Nitric oxide in health and disease of the nervous system. Antioxid Redox Signal (2009) 1.13
Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. J Biol Inorg Chem (2008) 1.09
Autoinhibition of endothelial nitric-oxide synthase. Identification of an electron transfer control element. J Biol Chem (1999) 1.08
Recruitment of governing elements for electron transfer in the nitric oxide synthase family. Proc Natl Acad Sci U S A (2005) 1.06
Intra-subunit and inter-subunit electron transfer in neuronal nitric-oxide synthase: effect of calmodulin on heterodimer catalysis. J Biol Chem (2001) 1.06
Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric Oxide (2002) 1.04
Calmodulin activates intramolecular electron transfer between the two flavins of neuronal nitric oxide synthase flavin domain. Biochim Biophys Acta (1999) 1.03
Structure of the calmodulin alphaII-spectrin complex provides insight into the regulation of cell plasticity. J Biol Chem (2006) 1.00
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains. J Biol Chem (1996) 1.00
Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail. Biochemistry (2007) 1.00
Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J Biol Chem (2003) 0.99
Calmodulin-dependent regulation of mammalian nitric oxide synthase. Biochem Soc Trans (2003) 0.98
The C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain. J Biol Chem (2000) 0.97
Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs. FEBS J (2006) 0.96
Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. J Biol Chem (1998) 0.92
Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase. Biochemistry (1995) 0.90
Target recognition of apocalmodulin by nitric oxide synthase I peptides. Biochemistry (2002) 0.89
Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase. Arch Biochem Biophys (2003) 0.88
Calcium-deficient calmodulin binding and activation of neuronal and inducible nitric oxide synthases. Biochim Biophys Acta (2007) 0.87
Regulation of expression of the endothelial cell nitric oxide synthase. Clin Exp Pharmacol Physiol (1996) 0.87
Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry (2007) 0.85
Thermodynamics of apocalmodulin and nitric oxide synthase II peptide interaction. FEBS Lett (2004) 0.83
The function of the small insertion in the hinge subdomain in the control of constitutive mammalian nitric-oxide synthases. J Biol Chem (2004) 0.82
Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase. Biochemistry (2005) 0.82
Vascular endothelium summary statement I: Health promotion and chronic disease prevention. Vascul Pharmacol (2006) 0.78
Interflavin one-electron transfer in the inducible nitric oxide synthase reductase domain and NADPH-cytochrome P450 reductase. Arch Biochem Biophys (2005) 0.78
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics (2005) 2.98
Crystal structure of the interferon-induced ubiquitin-like protein ISG15. J Biol Chem (2005) 1.93
Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem (2009) 1.54
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. Proc Natl Acad Sci U S A (2006) 1.49
Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. Biochemistry (2009) 1.41
The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem (2002) 1.37
Mechanism of substrate recognition by botulinum neurotoxin serotype A. J Biol Chem (2007) 1.30
Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A (2011) 1.21
Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases. J Biol Chem (2002) 1.19
Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions. Biochemistry (2004) 1.16
Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding. J Biol Chem (2011) 1.15
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase. J Biol Chem (2008) 1.12
Gangliosides as high affinity receptors for tetanus neurotoxin. J Biol Chem (2009) 1.12
Strategies for carbohydrate recognition by the mannose 6-phosphate receptors. Glycobiology (2008) 1.11
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys (2008) 1.07
Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor. EMBO J (2004) 1.05
Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry (2006) 1.04
How bacterial ADP-ribosylating toxins recognize substrates. Nat Struct Mol Biol (2004) 1.04
Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases. J Biol Chem (2004) 1.02
The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. J Biol Chem (2004) 1.01
Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA . Biochemistry (2010) 1.01
NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. Arch Biochem Biophys (2012) 1.00
3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time". Proc Natl Acad Sci U S A (2004) 0.99
Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. J Biol Chem (2005) 0.95
Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. Nat Struct Mol Biol (2007) 0.93
Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes. J Biol Chem (2010) 0.93
The crystal structure and reaction mechanism of Escherichia coli 2,4-dienoyl-CoA reductase. J Biol Chem (2003) 0.92
Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. J Biol Chem (2008) 0.91
Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor. J Biol Chem (2002) 0.90
Unique ganglioside recognition strategies for clostridial neurotoxins. J Biol Chem (2011) 0.90
Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons. J Biol Chem (2011) 0.89
Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. J Biol Chem (2005) 0.88
Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry. J Biol Chem (2012) 0.88
Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase. Arch Biochem Biophys (2003) 0.88
High-level expression of porcine liver cytochrome P-450 reductase catalytic domain in Escherichia coli by modulating the predicted local secondary structure of mRNA. J Biochem (2003) 0.87
Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains. J Biol Chem (2003) 0.86
Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Arch Biochem Biophys (2002) 0.85
Two distinct proton donors at the active site of Escherichia coli 2,4-dienoyl-CoA reductase are responsible for the formation of different products. Biochemistry (2008) 0.83
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry (2008) 0.83
Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry (2010) 0.83
NADPH-cytochrome P450 oxidoreductase from the mosquito Anopheles minimus: kinetic studies and the influence of Leu86 and Leu219 on cofactor binding and protein stability. Arch Biochem Biophys (2008) 0.81
Enhancing the protective immune response against botulism. Infect Immun (2013) 0.81
Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human endothelial NOS reductase domain. Arch Biochem Biophys (2007) 0.80
Transcriptional enhancement of UDP-glucuronosyltransferase form 1A2 (UGT1A2) by nuclear factor I-A (NFI-A) in rat hepatocytes. J Biochem (2005) 0.79
The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate. Biochemistry (2007) 0.79
Role of Thr(66) in porcine NADH-cytochrome b5 reductase in catalysis and control of the rate-limiting step in electron transfer. J Biol Chem (2002) 0.79
Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Biochemistry (2002) 0.79
Two-cistronic expression plasmids for high-level gene expression in Escherichia coli preventing translational initiation inhibition caused by the intramolecular local secondary structure of mRNA. J Biochem (2005) 0.78
Unique ganglioside binding by botulinum neurotoxins C and D-SA. FEBS J (2011) 0.78
Metabolism of 26,26,26,27,27,27-F6-1 alpha,23S,25-trihydroxyvitamin D3 by human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos (2004) 0.78
Interflavin one-electron transfer in the inducible nitric oxide synthase reductase domain and NADPH-cytochrome P450 reductase. Arch Biochem Biophys (2005) 0.78
Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDP-glucuronosyltransferase in human liver microsomes. Drug Metab Dispos (2004) 0.77
Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes. Biochim Biophys Acta (2004) 0.77
Human neuronal nitric oxide synthase can catalyze one-electron reduction of adriamycin: role of flavin domain. Arch Biochem Biophys (2004) 0.76
Utility of acetyldithio-CoA in detecting the influence of active site residues on substrate enolization by 3-hydroxyl-3-methylglutaryl-CoA synthase. J Biol Chem (2004) 0.76
Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Biochem Biophys Res Commun (2008) 0.76
Picomolar analysis of flavins in biological samples by dynamic pH junction-sweeping capillary electrophoresis with laser-induced fluorescence detection. Anal Biochem (2003) 0.76
Effect of spironolactone on the expression of rat hepatic UDP-glucuronosyltransferase. Biochem Pharmacol (2003) 0.76
Domain swapping in the low-similarity isomerase/hydratase superfamily: the crystal structure of rat mitochondrial Delta3, Delta2-enoyl-CoA isomerase. Protein Sci (2005) 0.75
[Foreword]. Seikagaku (2015) 0.75