Published in EMBO J on September 17, 2009
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet (2010) 4.26
Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science (2010) 2.23
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol (2010) 1.69
Functional interaction between telomere protein TPP1 and telomerase. Genes Dev (2010) 1.60
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res (2011) 1.56
A two-step mechanism for TRF2-mediated chromosome-end protection. Nature (2013) 1.55
Telomere dysfunction and chromosome instability. Mutat Res (2011) 1.51
TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Genomic instability and telomere fusion of canine osteosarcoma cells. PLoS One (2012) 1.05
A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Biol (2012) 1.04
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection. Mol Cell (2016) 1.02
Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J Biol Chem (2012) 0.98
Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol (2015) 0.97
Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase. Nucleic Acids Res (2010) 0.97
TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Rep (2014) 0.94
Stop pulling my strings - what telomeres taught us about the DNA damage response. Nat Rev Mol Cell Biol (2016) 0.93
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. Curr Opin Genet Dev (2014) 0.93
Dicentric breakage at telomere fusions. Genes Dev (2010) 0.92
End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1. EMBO J (2013) 0.92
Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One (2014) 0.88
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres. Cell Rep (2013) 0.87
Defending the end zone: studying the players involved in protecting chromosome ends. FEBS Lett (2010) 0.86
Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle (2010) 0.86
Cellular senescence and protein degradation: breaking down cancer. Cell Cycle (2014) 0.85
The role of telomeres and telomerase in cancer research. Cancer Res (2010) 0.82
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation. J Clin Invest (2013) 0.81
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutat Res Rev Mutat Res (2014) 0.78
Trapping Rap1 at the telomere to prevent chromosome end fusions. EMBO J (2009) 0.77
Minishelterins separate telomere length regulation and end protection in fission yeast. Genes Dev (2015) 0.76
Mammalian Rap1 widens its impact. Nat Cell Biol (2010) 0.75
The shelterin complex and hematopoiesis. J Clin Invest (2016) 0.75
A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance. Aging Cell (2016) 0.75
Telomere protein RAP1 levels are affected by cellular aging and oxidative stress. Biomed Rep (2016) 0.75
DNA Replication Origins and Fork Progression at Mammalian Telomeres. Genes (Basel) (2017) 0.75
Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells. Open Biol (2017) 0.75
How do telomeres and NHEJ coexist? Mol Cell Oncol (2014) 0.75
Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction. Front Genet (2017) 0.75
The mre11 A470 alleles influence the hereditability and the segregation of telosomes in Saccharomyces cerevisiae. PLoS One (2017) 0.75
The Stability of Broken Ends of Chromosomes in Zea Mays. Genetics (1941) 16.95
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Mammalian telomeres end in a large duplex loop. Cell (1999) 12.12
How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08
Pot1, the putative telomere end-binding protein in fission yeast and humans. Science (2001) 6.95
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol (2005) 5.49
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature (2008) 5.11
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet (1997) 4.95
Homologous recombination generates T-loop-sized deletions at human telomeres. Cell (2004) 4.85
A human telomeric protein. Science (1995) 4.77
Identification of human Rap1: implications for telomere evolution. Cell (2000) 4.06
DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol (2002) 3.95
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. EMBO J (2001) 3.28
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell (2007) 2.67
spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol (2001) 2.64
TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem (2004) 2.52
The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell (1996) 2.42
Ku is associated with the telomere in mammals. Proc Natl Acad Sci U S A (1999) 2.36
Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol (2001) 2.21
Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell (2001) 1.93
t-loops at trypanosome telomeres. EMBO J (2001) 1.91
Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr Biol (2001) 1.89
The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88
Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J (2005) 1.87
Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J (2005) 1.83
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev (2008) 1.80
DNA damage response at functional and dysfunctional telomeres. Genes Dev (2008) 1.75
Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J (2004) 1.72
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol (2004) 1.71
Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell (2003) 1.59
Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc Natl Acad Sci U S A (1999) 1.57
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol (2009) 1.51
Closed chromatin loops at the ends of chromosomes. J Cell Biol (2004) 1.47
Multiple pathways inhibit NHEJ at telomeres. Genes Dev (2008) 1.40
The human Rap1 protein complex and modulation of telomere length. J Biol Chem (2004) 1.38
Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities. Protein Sci (2005) 1.36
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol (2008) 1.14
Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures. J Biol Chem (2004) 1.11
Proteins that bind to double-stranded regions of telomeric DNA. Trends Cell Biol (1997) 1.10
Quantitative fluorescence in situ hybridization (Q-FISH). Curr Protoc Cell Biol (2001) 1.02
Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences. Nucleic Acids Res (1999) 1.02
Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA. Nucleic Acids Res (2000) 1.02
The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. Gene (2003) 0.89
Comparative functional genomics of the fission yeasts. Science (2011) 6.00
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell (2007) 2.67
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature (2003) 2.08
Spliceosomal cleavage generates the 3' end of telomerase RNA. Nature (2008) 1.93
TER1, the RNA subunit of fission yeast telomerase. Nat Struct Mol Biol (2007) 1.92
Smoking in pregnancy revisited: findings from a large population-based study. Am J Obstet Gynecol (2005) 1.75
Human POT1 facilitates telomere elongation by telomerase. Curr Biol (2003) 1.64
The severity of cognitive deficits predicts return to work after a first-ever ischaemic stroke. J Neurol Neurosurg Psychiatry (2012) 1.42
Unisexual reproduction among vertebrates. Trends Genet (2011) 1.41
Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry (2002) 1.38
Chromosome fusions following telomere loss are mediated by single-strand annealing. Mol Cell (2008) 1.25
Extended DNA binding site in Pot1 broadens sequence specificity to allow recognition of heterogeneous fission yeast telomeres. J Biol Chem (2005) 1.20
A flexible template boundary element in the RNA subunit of fission yeast telomerase. J Biol Chem (2008) 1.15
Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes. Nature (2012) 1.12
Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards. Nature (2010) 1.11
Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability. Mol Cell Biol (2005) 1.07
Role of SUMO in the dynamics of telomere maintenance in fission yeast. Proc Natl Acad Sci U S A (2007) 1.06
A Geographically Diverse Collection of Schizosaccharomyces pombe Isolates Shows Limited Phenotypic Variation but Extensive Karyotypic Diversity. G3 (Bethesda) (2011) 1.03
Laboratory synthesis of an independently reproducing vertebrate species. Proc Natl Acad Sci U S A (2011) 1.01
The role of maternal body mass index in outcomes of vaginal births after cesarean. Am J Obstet Gynecol (2005) 0.94
Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast. Genes Dev (2013) 0.87
G-quadruplexes: from guanine gels to chemotherapeutics. Mol Biotechnol (2011) 0.87
In situ and operando atomic force microscopy of high-capacity nano-silicon based electrodes for lithium-ion batteries. Nanoscale (2016) 0.83
G-quadruplexes: from guanine gels to chemotherapeutics. Methods Mol Biol (2010) 0.81
Schizosaccharomyces cryophilus sp. nov., a new species of fission yeast. FEMS Yeast Res (2010) 0.79
Cortical and cerebellar modulation of autonomic responses to loud sounds. Psychophysiology (2013) 0.78
Apollo-taking the lead in telomere protection. Mol Cell (2010) 0.77
Taking control of G-quadruplexes. Nat Struct Mol Biol (2005) 0.76
The cognitive burden of stroke emerges even with an intact NIH Stroke Scale Score: a cohort study. J Neurol Neurosurg Psychiatry (2013) 0.76
Mediastinal metastasis of glioblastoma multiforme evolving from anaplastic astrocytoma. J Neurooncol (2005) 0.76
TERRA -a calling card for telomerase. Mol Cell (2013) 0.76
[Treatment of stroke in Finland]. Duodecim (2002) 0.75
[Hyperkalemic periodic paralysis]. Duodecim (2002) 0.75