Published in PLoS Genet on September 25, 2009
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The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun (2011) 1.07
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev (2011) 1.02
The segmentation clock mechanism moves up a notch. Trends Cell Biol (2010) 1.01
Somitogenesis. Development (2012) 0.95
O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS One (2015) 0.93
Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma. Oncotarget (2015) 0.92
Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci U S A (2013) 0.91
Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland. J Cell Physiol (2011) 0.90
The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites. BMC Dev Biol (2010) 0.90
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate. Dev Dyn (2009) 0.89
A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development (2015) 0.88
A spatio-temporal model of Notch signalling in the zebrafish segmentation clock: conditions for synchronised oscillatory dynamics. PLoS One (2011) 0.86
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α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One (2011) 0.84
Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis. Theor Biol Med Model (2013) 0.83
From dynamic expression patterns to boundary formation in the presomitic mesoderm. PLoS Comput Biol (2012) 0.81
Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord. Development (2010) 0.80
Multiple roles of timing in somite formation. Semin Cell Dev Biol (2015) 0.78
The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network. BMC Dev Biol (2013) 0.78
Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: a comprehensive mathematical model. Comput Intell Neurosci (2015) 0.77
Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. J Biol Chem (2015) 0.77
Characterization of the altered gene expression profile in early porcine embryos generated from parthenogenesis and somatic cell chromatin transfer. PLoS One (2014) 0.76
Anabolic actions of Notch on mature bone. Proc Natl Acad Sci U S A (2016) 0.76
Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock. Biomed Res Int (2014) 0.76
Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis. PLoS One (2014) 0.76
Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. PLoS One (2016) 0.76
Turn It Down a Notch. Front Cell Dev Biol (2017) 0.75
Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition. PLoS Comput Biol (2014) 0.75
A balance of positive and negative regulators determines the pace of the segmentation clock. Elife (2015) 0.75
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Presenilin genes are downregulated during somitogenesis in the cadmium-induced omphalocele chick model. Pediatr Surg Int (2012) 0.75
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
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Jagged: a mammalian ligand that activates Notch1. Cell (1995) 3.51
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development (1997) 3.42
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
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Notch signalling and the synchronization of the somite segmentation clock. Nature (2000) 2.84
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lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature (2003) 2.08
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Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev (1997) 1.97
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature (2005) 1.94
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev (2003) 1.93
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Noise-resistant and synchronized oscillation of the segmentation clock. Nature (2006) 1.80
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Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol (1999) 1.73
Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish. Development (2002) 1.71
Synchrony dynamics during initiation, failure, and rescue of the segmentation clock. Science (2007) 1.70
The genetics of vertebrate myogenesis. Nat Rev Genet (2008) 1.68
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The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell (2007) 1.54
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J Biol Chem (2006) 1.48
Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development (2004) 1.47
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol (2008) 1.45
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell (2002) 1.44
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Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J (2002) 1.43
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FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol (2008) 1.40
The genetics and embryology of zebrafish metamerism. Dev Dyn (2007) 1.39
Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem (2001) 1.39
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Monitoring Notch1 activity in development: evidence for a feedback regulatory loop. Dev Dyn (2007) 1.33
Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries. PLoS Genet (2008) 1.30
Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes Dev (2005) 1.29
A Notch feeling of somite segmentation and beyond. Dev Biol (2004) 1.28
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Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575). J Pharmacol Exp Ther (2004) 1.25
Oscillating signaling pathways during embryonic development. Curr Opin Cell Biol (2008) 1.23
Isolation and culture of whole postimplantation embryos and germ layer derivatives. Methods Enzymol (1993) 1.13
Oscillators and the emergence of tissue organization during zebrafish somitogenesis. Trends Cell Biol (2007) 1.06
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev (2008) 1.06
Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol (2009) 1.05
Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton. Development (2008) 1.05
A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development (2003) 1.02
Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures. J Bone Miner Metab (2006) 1.02
The vertebrate segmentation clock: the tip of the iceberg. Curr Opin Genet Dev (2008) 0.98
Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity. Dev Dyn (2007) 0.96
Understanding the somitogenesis clock: what's missing? Mech Dev (2007) 0.95
Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol (2009) 0.94
Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages. Biochemistry (2003) 0.92
Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis. J Exp Zool B Mol Dev Evol (2008) 0.91
CSL: a notch above the rest. Int J Biochem Cell Biol (2005) 0.91
Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PLoS One (2009) 0.83
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci (2012) 4.92
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov (2011) 4.24
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
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Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci (2009) 2.96
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J (2012) 2.72
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (2012) 2.65
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development (2004) 2.65
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends Genet (2003) 2.54
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther (2011) 2.51
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (2009) 2.43
Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology (2007) 2.39
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell (2002) 2.37
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (2009) 2.35
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J (2010) 2.26
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem (2005) 2.15
Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet (2004) 2.07
Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development (2002) 2.07
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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
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A cell biological perspective on Alzheimer's disease. Annu Rev Cell Dev Biol (2002) 1.79
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A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. J Cell Sci (2007) 1.70
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Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol (2004) 1.66
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A (2011) 1.60
Role of presenilins in neuronal calcium homeostasis. J Neurosci (2010) 1.59
Amyloid-beta precursor protein processing in neurodegeneration. Curr Opin Neurobiol (2004) 1.59
Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev (2003) 1.57
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Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem (2006) 1.55
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest (2010) 1.54
Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med (2013) 1.54
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. Nat Med (2012) 1.54
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The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol (2013) 1.54
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex. J Biol Chem (2006) 1.52
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Hum Gene Ther (2002) 1.50
The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis. Cardiovasc Res (2011) 1.48
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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. J Biol Chem (2003) 1.42
Molecular biology. miRNAs in neurodegeneration. Science (2007) 1.41
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem (2003) 1.41
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell (2006) 1.36
Parkin interacts with Ambra1 to induce mitophagy. J Neurosci (2011) 1.36
Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification. J Biol Chem (2004) 1.34
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem (2009) 1.33
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science (2014) 1.32
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Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem (2007) 1.27
Differential response of human lung epithelial cells to fas-induced apoptosis. Am J Pathol (2004) 1.27
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem (2004) 1.26
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene (2003) 1.24
Mitochondria dysfunction and neurodegenerative disorders: cause or consequence. J Alzheimers Dis (2010) 1.22
gamma-secretases: from cell biology to therapeutic strategies. Lancet Neurol (2010) 1.22
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Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome. Am J Respir Crit Care Med (2008) 1.17
Tuberculous retropharyngeal abscess associated with spinal tuberculosis well controlled by fine-needle aspiration and anti-tuberculous chemotherapy. Intern Med (2010) 1.16
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase. J Biol Chem (2008) 1.16
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci (2004) 1.14
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J Biol Chem (2012) 1.13
Gene profiling of hippocampal neuronal culture. J Neurochem (2003) 1.12
Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. J Biol Chem (2003) 1.11
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. EMBO Mol Med (2011) 1.11
Synchronised cycling gene oscillations in presomitic mesoderm cells require cell-cell contact. Int J Dev Biol (2005) 1.10
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09
Notch pathway is dispensable for adipocyte specification. Genesis (2004) 1.08