Published in Lancet on December 08, 1990
Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. Am J Hum Genet (2011) 1.80
The first nuclear-encoded complex I mutation in a patient with Leigh syndrome. Am J Hum Genet (1998) 1.80
A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle. Am J Hum Genet (1997) 1.68
Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy. Am J Pathol (1998) 1.27
Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia. Am J Hum Genet (1996) 1.23
Metabolic cardiomyopathies. Int J Exp Pathol (2000) 1.19
Mitochondrial transfer RNAMet 4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree. Hypertension (2009) 1.10
Failures in mitochondrial tRNAMet and tRNAGln metabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese Family. Hypertension (2009) 1.09
Maternally inherited hypertrophic cardiomyopathy due to a novel T-to-C transition at nucleotide 9997 in the mitochondrial tRNA(glycine) gene. Am J Hum Genet (1994) 1.03
Electron transport chain defects in heart failure. Heart Fail Rev (2002) 0.99
Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management. Eur Heart J (2012) 0.96
Mutations in mitochondrial tRNA genes: non-linkage with syndromes of Wolfram and chronic progressive external ophthalmoplegia. Nucleic Acids Res (1992) 0.95
Congenital encephalomyopathy and adult-onset myopathy and diabetes mellitus: different phenotypic associations of a new heteroplasmic mtDNA tRNA glutamic acid mutation. Am J Hum Genet (1995) 0.93
Retinitis pigmentosa, ataxia, and mental retardation associated with mitochondrial DNA mutation in an Italian family. Br J Ophthalmol (1993) 0.92
The mitochondrial A3243G mutation presenting as severe cardiomyopathy. J Med Genet (1997) 0.87
Recurrent myoglobinuria in a sporadic patient with a novel mitochondrial DNA tRNA(Ile) mutation. J Neurol Sci (2011) 0.80
Mitochondrial leucine tRNA mutation in a mitochondrial encephalomyopathy. Lancet (1991) 0.79
Mitochondrial tRNA(Thr) mutations and lethal infantile mitochondrial myopathy. Am J Hum Genet (1992) 0.79
Mitochondrial DNA deletion diagnosed by analysis of an endomyocardial biopsy specimen from a patient with Kearns-Sayre syndrome and complete heart block. Br Heart J (1992) 0.79
Impairment of mitochondrial tRNAIle processing by a novel mutation associated with chronic progressive external ophthalmoplegia. Mitochondrion (2011) 0.78
Cardiac mitochondrial dysfunction and DNA depletion in children with hypertrophic cardiomyopathy. J Inherit Metab Dis (1997) 0.75
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression. EMBO J (1986) 19.59
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Construction of a colicin E1-R factor composite plasmid in vitro: means for amplification of deoxyribonucleic acid. J Bacteriol (1975) 13.95
Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature (1995) 10.89
Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1. DNA Res (1999) 7.39
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
The nucleotide sequence of pUB110: some salient features in relation to replication and its regulation. Plasmid (1986) 7.07
Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. J Clin Oncol (2001) 6.83
Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell (1999) 6.83
Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3. DNA Res (1998) 6.79
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity (1994) 6.18
Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med (1996) 6.01
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol (1992) 5.93
Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature (1970) 5.65
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell (2000) 5.64
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell (2000) 5.49
The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46
The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature (1989) 5.43
Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology (1992) 5.16
Syringe method for stepwise chemical synthesis of oligonucleotides. Nucleic Acids Res (1982) 4.70
Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates. Antimicrob Agents Chemother (1992) 4.43
Norwalk virus infection of volunteers: new insights based on improved assays. J Infect Dis (1994) 4.37
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
A neomycin resistance gene cassette selectable in a single copy state in the Bacillus subtilis chromosome. Nucleic Acids Res (1989) 3.87
Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology (1999) 3.83
Coding of modified body schema during tool use by macaque postcentral neurones. Neuroreport (1996) 3.78
Transcriptional sequencing: A method for DNA sequencing using RNA polymerase. Proc Natl Acad Sci U S A (1998) 3.78
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77
High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus. J Biol Chem (1984) 3.76
An endothelial receptor for oxidized low-density lipoprotein. Nature (1997) 3.76
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat Struct Biol (1995) 3.75
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem (1986) 3.64
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol (2001) 3.29
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology (1992) 3.22
Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation (1995) 3.18
A high-throughput SNP typing system for genome-wide association studies. J Hum Genet (2001) 3.18
Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release (2009) 3.08
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature (1997) 3.07
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci U S A (1981) 3.04
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7. DNA Res (2001) 2.99
Cloning of the genes for penicillinase, penP and penI, of Bacillus licheniformis in some vector plasmids and their expression in Escherichia coli, Bacillus subtilis, and Bacillus licheniformis. J Bacteriol (1981) 2.93
Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (2001) 2.89
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature (1998) 2.88
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A (1996) 2.88
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell (2000) 2.86
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol (1996) 2.80
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet (1998) 2.80
Nature of phosphorus limitation in the ultraoligotrophic eastern Mediterranean. Science (2005) 2.79
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol (1994) 2.74
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol (1990) 2.73
Finer features for functional microdevices. Nature (2001) 2.73
Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol (1999) 2.72
Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med (1990) 2.72
Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum (2000) 2.72
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet (1995) 2.65
Risk of poliomyelitis importation and re-emergence in Laos. Lancet (2000) 2.64
Solid phase synthesis of oligoribonucleotides using o-nitrobenzyl protection of 2'-hydroxyl via a phosphite triester approach. Nucleic Acids Res (1986) 2.64
Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res (1998) 2.63
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc Natl Acad Sci U S A (1975) 2.60
Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Microbiol (1991) 2.60
Isolation and characterization of four plasmids from Bacillus subtilis. J Bacteriol (1977) 2.59
Mitochondrial genotype associated with longevity. Lancet (1998) 2.58
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus. J Ethnopharmacol (1996) 2.57
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell (2001) 2.47
Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. J Clin Microbiol (1999) 2.46
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44
Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans: coronary angiographic findings within 1 week before the onset of infarction. Circulation (2000) 2.42
Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun (2000) 2.42
Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol (1994) 2.41
The biology of Stat4 and Stat6. Oncogene (2000) 2.40
Periodic emission from the gamma-ray binary 1FGL J1018.6-5856. Science (2012) 2.40
Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science (1993) 2.40
Complete physical map of the Bacillus subtilis 168 chromosome constructed by a gene-directed mutagenesis method. J Mol Biol (1991) 2.40
Hepatitis C virus infection in spouses of patients with type C chronic liver disease. Ann Intern Med (1994) 2.38
Hepatitis C virus infection in medical personnel after needlestick accident. Hepatology (1992) 2.37
Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci U S A (1998) 2.37
A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIIB fraction. Cell (1992) 2.32
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol (1990) 2.30
Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J (1997) 2.28
Failure of parturition in mice lacking the prostaglandin F receptor. Science (1997) 2.27