Correlation of CXCL12 expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer.

PubWeight™: 1.06‹?› | Rank: Top 15%

🔗 View Article (PMC 2751549)

Published in Am J Pathol on October 01, 2009

Authors

Fatimah Jaafar1, Elda Righi, Victoria Lindstrom, Christine Linton, Mahrokh Nohadani, Susan Van Noorden, Tyler Lloyd, Joshua Poznansky, Gordon Stamp, Roberto Dina, Dulcie V Coleman, Mark C Poznansky

Author Affiliations

1: Department of Histopathology and Cytology, Imperial College, Hammersmith Hospital, London, United Kingdom.

Articles citing this

CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. Cancer Res (2011) 1.42

Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast Cancer Res (2011) 1.18

Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance. Cancer Microenviron (2012) 1.15

Natural and induced T regulatory cells in cancer. Front Immunol (2013) 1.15

Therapy of human papillomavirus-related disease. Vaccine (2012) 1.11

Effector CD4 and CD8 T cells and their role in the tumor microenvironment. Cancer Microenviron (2012) 1.05

The immune response to papillomavirus during infection persistence and regression. Open Virol J (2012) 1.02

Home sweet home: the tumor microenvironment as a haven for regulatory T cells. Front Immunol (2013) 0.99

Roles of regulatory T cells in cancer immunity. Int Immunol (2016) 0.95

The "Trojan Horse" approach to tumor immunotherapy: targeting the tumor microenvironment. J Immunol Res (2014) 0.88

Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes in cervical intraepithelial neoplasia and cervical cancer. Chin J Cancer (2012) 0.83

Immunotherapy of human papilloma virus induced disease. Open Virol J (2012) 0.83

Enhancement of T cell recruitment and infiltration into tumours. Clin Exp Immunol (2014) 0.83

Epithelium Expressing the E7 Oncoprotein of HPV16 Attracts Immune-Modulatory Dendritic Cells to the Skin and Suppresses Their Antigen-Processing Capacity. PLoS One (2016) 0.80

Candidate Soluble Immune Mediators in Young Women with High-Risk Human Papillomavirus Infection: High Expression of Chemokines Promoting Angiogenesis and Cell Proliferation. PLoS One (2016) 0.77

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. Immunol Rev (2017) 0.77

FOXP3 autoantibody as a potential early prognostic serum biomarker in patients with cervical cancer. Int J Clin Oncol (2015) 0.77

Premetastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation. Cell Mol Immunol (2010) 0.75

Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy. Immunotargets Ther (2014) 0.75

Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine. Sci Rep (2017) 0.75

HPV16-E7-Specific Activated CD8 T Cells in E7 Transgenic Skin and Skin Grafts. Front Immunol (2017) 0.75

Gene expression changes in residual advanced cervical cancer after radiotherapy: indicators of poor prognosis and radioresistance? Med Sci Monit (2015) 0.75

Angiotensin II induces calcium/calcineurin signaling and podocyte injury by downregulating microRNA-30 family members. J Mol Med (Berl) (2017) 0.75

CXCL12 is a key regulator in tumor microenvironment of cervical cancer: an in vitro study. Clin Exp Metastasis (2016) 0.75

Articles cited by this

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 40.46

Involvement of chemokine receptors in breast cancer metastasis. Nature (2001) 26.07

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 22.96

Chemokines and leukocyte traffic. Nature (1998) 9.79

The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol (2004) 4.09

Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med (2001) 3.81

Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res (2002) 2.71

Human papillomavirus and cancer: the epidemiological evidence. J Clin Virol (2000) 2.63

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis. Am J Physiol Cell Physiol (2006) 2.36

Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res (2004) 2.31

Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Int J Cancer (2008) 2.06

Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod Pathol (2008) 1.90

Active movement of T cells away from a chemokine. Nat Med (2000) 1.87

Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol (2008) 1.83

Chemokines in tumor angiogenesis and metastasis. Cancer Metastasis Rev (2007) 1.63

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. J Clin Invest (2008) 1.41

CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia. Int J Cancer (2007) 1.31

Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer. Eur J Cancer (2008) 1.27

Effective cancer therapy through immunomodulation. Annu Rev Med (2006) 1.26

Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol (2006) 1.20

Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer. Cancer Res (2007) 1.17

Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses. Blood (2002) 1.10

Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best Pract Res Clin Obstet Gynaecol (2005) 1.07

Fugetaxis: active movement of leukocytes away from a chemokinetic agent. J Mol Med (Berl) (2005) 1.02

Study on CXCR4/SDF-1alpha axis in lymph node metastasis of cervical squamous cell carcinoma. Int J Gynecol Cancer (2007) 0.95

The cell-mediated immune response to human papillomavirus-induced cervical cancer: implications for immunotherapy. Adv Cancer Res (2002) 0.95

SDF-1 alone and in co-operation with HGF regulates biology of human cervical carcinoma cells. Folia Histochem Cytobiol (2006) 0.91

Immune concept of human papillomaviruses and related antigens in local cancer milieu of human cervical neoplasia. J Obstet Gynaecol Res (2007) 0.88

CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma. Int J Gynecol Cancer (2007) 0.88

Immunological treatment of ovarian cancer. Curr Opin Obstet Gynecol (2004) 0.84

The T-cell response in patients with cancer. Adv Cancer Res (2002) 0.80

Novel immunotherapeutic strategies in gynecologic oncology. Dendritic cell-based immunotherapy for ovarian cancer. Minerva Ginecol (2002) 0.78

Articles by these authors

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell (2007) 6.44

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature (2005) 5.54

A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med (2014) 3.56

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol (2004) 3.19

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell (2012) 3.10

RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell (2005) 3.09

Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res (2002) 2.71

Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission. J Clin Oncol (2006) 2.57

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A (2012) 2.50

Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears. Cancer Epidemiol Biomarkers Prev (2008) 2.20

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene (2003) 2.02

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet (2008) 2.00

Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance. Cancer Cell (2013) 1.95

Whole genome sequencing of matched primary and metastatic acral melanomas. Genome Res (2011) 1.90

Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis (2006) 1.89

Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip (2005) 1.86

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5. Gut (2010) 1.84

HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection. J Infect Dis (2009) 1.82

Time-domain fluorescence lifetime imaging applied to biological tissue. Photochem Photobiol Sci (2004) 1.75

A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts. Intensive Care Med (2013) 1.74

Inflammation-based prognostic indices in malignant pleural mesothelioma. J Thorac Oncol (2012) 1.70

Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene (2002) 1.67

E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas. Am J Surg Pathol (2008) 1.60

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell (2013) 1.60

Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells (2007) 1.59

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis. Nature (2013) 1.57

A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med (2015) 1.54

Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions. J Leukoc Biol (2009) 1.53

Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol (2005) 1.53

Drug treatment for multidrug-resistant Acinetobacter baumannii infections. Future Microbiol (2008) 1.38

R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One (2010) 1.29

The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology (2009) 1.28

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res (2011) 1.28

Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith study. Int J Cancer (2008) 1.27

Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol (2002) 1.22

Novel beta-lactam antibiotics and inhibitor combinations. Expert Opin Investig Drugs (2008) 1.21

Reverse leukocyte migration can be attractive or repulsive. Trends Cell Biol (2008) 1.21

Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol (2006) 1.20

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. Cancer Res (2004) 1.19

Novel zinc-based fixative for high quality DNA, RNA and protein analysis. Nucleic Acids Res (2007) 1.18

Incidence, risk factors, and predictors of outcome of candidemia. Survey in 2 Italian university hospitals. Diagn Microbiol Infect Dis (2007) 1.17

Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One (2009) 1.15

Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol (2012) 1.15

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target. J Pathol (2012) 1.14

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma. J Pathol (2013) 1.12

Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis (2010) 1.12

Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. Genome Med (2010) 1.12

Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia across five sites in Italy and Spain. J Clin Microbiol (2013) 1.10

Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol Microbiol (2010) 1.09

Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology (2006) 1.08

FLIM FRET technology for drug discovery: automated multiwell-plate high-content analysis, multiplexed readouts and application in situ. Chemphyschem (2011) 1.08

Performance of the Abbott RealTime high-risk HPV test in women with abnormal cervical cytology smears. J Med Virol (2010) 1.07

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. Cancer Res (2010) 1.05

Retroperitoneal myolipoma. World J Surg Oncol (2005) 1.05

Tigecycline use in serious nosocomial infections: a drug use evaluation. BMC Infect Dis (2010) 1.02

Fugetaxis: active movement of leukocytes away from a chemokinetic agent. J Mol Med (Berl) (2005) 1.02

Concordant F-18 FDG PET and Y-90 Bremsstrahlung scans depict selective delivery of Y-90-microspheres to liver tumors: confirmation with histopathology. Clin Nucl Med (2007) 1.01

Linezolid in the treatment of Gram-positive prosthetic joint infections. J Antimicrob Chemother (2005) 1.00

Phosphorylation of both EGFR and ErbB2 is a reliable predictor of prostate cancer cell proliferation in response to EGF. Neoplasia (2005) 0.99

Evaluation of germline BMP4 mutation as a cause of colorectal cancer. Hum Mutat (2010) 0.98

Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer. Int J Cancer (2007) 0.97

A CXCR4-dependent chemorepellent signal contributes to the emigration of mature single-positive CD4 cells from the fetal thymus. J Immunol (2005) 0.97

Detection of Wilms' tumor antigen--specific CTL in tumor-draining lymph nodes of patients with early breast cancer. Clin Cancer Res (2006) 0.97

A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. J Biol Chem (2007) 0.97

Current status of newer carbapenems. Curr Med Chem (2009) 0.95

The mutational burden of acral melanoma revealed by whole-genome sequencing and comparative analysis. Pigment Cell Melanoma Res (2014) 0.95

The genomic landscape of oesophagogastric junctional adenocarcinoma. J Pathol (2013) 0.95

STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis. Am J Respir Cell Mol Biol (2009) 0.95

The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours. Cytokine (2009) 0.94

Tissue characterization using dimensionality reduction and fluorescence imaging. Med Image Comput Comput Assist Interv (2006) 0.93

Multidrug-resistant bacteria: what is the threat? Hematology Am Soc Hematol Educ Program (2013) 0.93

Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution. Genome Biol (2014) 0.92

Androgen-dependent regulation of human MUC1 mucin expression. Neoplasia (2002) 0.91

Needle versus loop diathermy excision of the transformation zone for the treatment of cervical intraepithelial neoplasia: a randomised controlled trial. BJOG (2004) 0.90

Androgen-independent prostate cancer: potential role of androgen and ErbB receptor signal transduction crosstalk. Neoplasia (2003) 0.90

Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J Immunol (2007) 0.89

Characterization of adnexal masses with MRI. AJR Am J Roentgenol (2005) 0.89

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol (2011) 0.89

How to manage aspergillosis in non-neutropenic intensive care unit patients. Crit Care (2014) 0.89

Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood (2002) 0.89

Pretreatment tumour volume measurement on high-resolution magnetic resonance imaging as a predictor of survival in cervical cancer. BJOG (2004) 0.89

The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer. Ann Surg (2015) 0.88

Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J Virol (2004) 0.88

Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors. Cancer Immunol Immunother (2007) 0.88

Pseudomonas aeruginosa serious infections: mono or combination antimicrobial therapy? Curr Med Chem (2008) 0.88

Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction. JACC Cardiovasc Interv (2009) 0.88

Castleman's disease associated with myasthenia gravis. Ann Thorac Surg (2003) 0.88

Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha induced hepatic apoptosis. Am J Respir Crit Care Med (2007) 0.88

RAS interaction with PI3K p110α is required for tumor-induced angiogenesis. J Clin Invest (2014) 0.87

X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens. J Virol (2009) 0.87

Borderline tumors of the ovary: CT and MRI features and tumor markers in differentiation from stage I disease. AJR Am J Roentgenol (2005) 0.87

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation. BMC Clin Pathol (2003) 0.87

Expression of lymphotoxin-beta (LT-beta) in chronic inflammatory conditions. J Pathol (2003) 0.87

Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy. BMJ Case Rep (2011) 0.86