Published in Genet Epidemiol on February 01, 2010
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The influence of genetics on response to treatment with ranibizumab (Lucentis) for age-related macular degeneration: the Lucentis Genotype Study (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2011) 1.18
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A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. Biol Psychol (2010) 1.12
Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genet Epidemiol (2011) 1.11
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Sequence kernel association test for survival traits. Genet Epidemiol (2014) 1.09
Estimating genetic effects and quantifying missing heritability explained by identified rare-variant associations. Am J Hum Genet (2012) 1.07
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Assessing the impact of non-differential genotyping errors on rare variant tests of association. Hum Hered (2011) 1.03
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Meta-analysis of sequencing studies with heterogeneous genetic associations. Genet Epidemiol (2014) 1.00
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SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases. Genet Epidemiol (2013) 0.99
Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol (2014) 0.99
Evaluating methods for combining rare variant data in pathway-based tests of genetic association. BMC Proc (2011) 0.99
Power of family-based association designs to detect rare variants in large pedigrees using imputed genotypes. Genet Epidemiol (2013) 0.98
A LASSO-based approach to analyzing rare variants in genetic association studies. BMC Proc (2011) 0.98
Region-based association analysis of human quantitative traits in related individuals. PLoS One (2013) 0.97
A robust model-free approach for rare variants association studies incorporating gene-gene and gene-environmental interactions. PLoS One (2013) 0.96
Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. PLoS One (2012) 0.95
A data-driven method for identifying rare variants with heterogeneous trait effects. Genet Epidemiol (2011) 0.95
Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. Am J Hum Genet (2014) 0.93
Statistical analysis of genetic interactions. Genet Res (Camb) (2010) 0.92
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Effect of population stratification analysis on false-positive rates for common and rare variants. BMC Proc (2011) 0.92
A variational Bayes discrete mixture test for rare variant association. Genet Epidemiol (2014) 0.92
Gene Level Meta-Analysis of Quantitative Traits by Functional Linear Models. Genetics (2015) 0.91
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A haplotype map of the human genome. Nature (2005) 105.70
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Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics (2002) 34.50
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol (1995) 30.55
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
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Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum Genet (2008) 4.28
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets. Nat Genet (2005) 2.66
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Rare variant association analysis methods for complex traits. Annu Rev Genet (2010) 5.59
Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet (2004) 4.76
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med (2006) 3.75
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes (2006) 3.51
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes (2007) 2.73
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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
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Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis (2012) 1.62
Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol (2009) 1.60
A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet (2011) 1.60
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The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Ann Rheum Dis (2013) 0.92
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No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis (2012) 0.86
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Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. J Rheumatol (2002) 0.76
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2016) 0.75
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Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure. BMC Genet (2003) 0.75
Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nat Commun (2015) 0.75
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