Published in FEBS Lett on October 27, 2009
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes. J Biol Chem (2011) 1.22
Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2010) 1.10
Cross-platform comparison of glycan microarray formats. Glycobiology (2014) 1.08
Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. Proc Natl Acad Sci U S A (2013) 1.06
Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance. Adv Cancer Res (2013) 0.99
Sialidase significance for cancer progression. Glycoconj J (2012) 0.94
Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells. J Biol Chem (2012) 0.92
Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer. Front Oncol (2015) 0.91
Ganglioside biochemistry. ISRN Biochem (2012) 0.89
Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS One (2011) 0.89
Increase of O-glycosylated oncofetal fibronectin in high glucose-induced epithelial-mesenchymal transition of cultured human epithelial cells. PLoS One (2013) 0.87
Ganglioside-Lipid and Ganglioside-Protein Interactions Revealed by Coarse-Grained and Atomistic Molecular Dynamics Simulations. J Phys Chem B (2016) 0.87
Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance. Int J Mol Sci (2014) 0.84
GM3 and cancer. Glycoconj J (2015) 0.83
The glycosphingolipid P₁ is an ovarian cancer-associated carbohydrate antigen involved in migration. Br J Cancer (2014) 0.81
Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells. J Lipid Res (2012) 0.81
Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation. PLoS One (2015) 0.80
Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacol Sin (2012) 0.80
Lipids and membrane lateral organization. Front Physiol (2010) 0.80
Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells. Cell Adh Migr (2013) 0.80
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9. J Biol Chem (2013) 0.78
Human glycolipid transfer protein (GLTP) expression modulates cell shape. PLoS One (2011) 0.78
An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells. Oncotarget (2015) 0.77
Glycolipid dynamics in generation and differentiation of induced pluripotent stem cells. Sci Rep (2015) 0.77
A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells. Glycoconj J (2013) 0.77
Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression. ACS Med Chem Lett (2015) 0.75
I-branching N-acetylglucosaminyltransferase regulates prostate cancer invasiveness by enhancing α5β1 integrin signaling. Cancer Sci (2016) 0.75
Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum. Cancer Sci (2015) 0.75
Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane. Biophys J (2016) 0.75
Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells. Biomed Res Int (2015) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Siglecs and their roles in the immune system. Nat Rev Immunol (2007) 7.98
The caveolae membrane system. Annu Rev Biochem (1998) 7.54
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn (2005) 5.33
Selective solubilization of proteins and phospholipids from red blood cell membranes by nonionic detergents. J Supramol Struct (1973) 4.95
The immunological synapse. Annu Rev Immunol (2001) 4.45
Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem Biophys Res Commun (1997) 3.67
Selectin ligands. Proc Natl Acad Sci U S A (1994) 3.66
Normal stem cells and cancer stem cells: the niche matters. Cancer Res (2006) 3.60
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell (1998) 3.56
Sorting of an apical plasma membrane glycoprotein occurs before it reaches the cell surface in cultured epithelial cells. J Cell Biol (1984) 3.48
Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP-GalNAc 4-epimerase deficient mutant. Cell (1986) 3.25
Isolation of brain strandin, a new type of large molecule tissue component. J Biol Chem (1951) 3.13
Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol (2009) 3.09
Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol (1982) 2.90
Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A (2003) 2.56
The glycosynapse. Proc Natl Acad Sci U S A (2002) 2.46
Response of basal epithelial cell surface and Cytoskeleton to solubilized extracellular matrix molecules. J Cell Biol (1981) 2.45
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J Biol Chem (1986) 2.00
Specific interaction between Lex and Lex determinants. A possible basis for cell recognition in preimplantation embryos and in embryonal carcinoma cells. J Biol Chem (1989) 1.88
Saccharide orientation at the cell surface affects glycolipid receptor function. Proc Natl Acad Sci U S A (1991) 1.69
Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling. J Biol Chem (1998) 1.69
Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol (2001) 1.67
Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj J (1997) 1.54
Regulation of growth factor receptors by gangliosides. Sci STKE (2002) 1.54
Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res (1996) 1.50
Specific glycosphingolipids mediate epithelial-to-mesenchymal transition of human and mouse epithelial cell lines. Proc Natl Acad Sci U S A (2009) 1.49
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. J Biol Chem (2007) 1.40
Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells. Cancer Res (1997) 1.39
New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules,involved in cell adhesion coupled with signaling. Glycobiology (1998) 1.34
Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor. J Biol Chem (2005) 1.31
The effect of hydrogen bonds on the conformation of glycosphingolipids. Methylated and unmethylated cerebroside studied by X-ray single crystal analysis and model calculations. Chem Phys Lipids (1990) 1.31
A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9. J Biol Chem (2005) 1.28
GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells. J Biol Chem (1998) 1.27
Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. Cancer Res (1999) 1.26
GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy. Biochemistry (2001) 1.26
Gold glyconanoparticles as new tools in antiadhesive therapy. Chembiochem (2004) 1.25
Gold Glyconanoparticles as Water-Soluble Polyvalent Models To Study Carbohydrate Interactions This work was supported by the DGICYT (PB96-0820), J.M.F. thanks the MEC for a predoctoral fellowship. A.G.B. thanks CSIC for financial support. We thank Prof. Martín-Lomas for his scientific and financial support. Angew Chem Int Ed Engl (2001) 1.21
Cell adhesion, spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction. J Biol Chem (1991) 1.19
Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Proc Natl Acad Sci U S A (2008) 1.17
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
Tetraspanin CD9 is a "proteolipid," and its interaction with alpha 3 integrin in microdomain is promoted by GM3 ganglioside, leading to inhibition of laminin-5-dependent cell motility. J Biol Chem (2002) 1.15
Further studies on cell adhesion based on Le(x)-Le(x) interaction, with new approaches: embryoglycan aggregation of F9 teratocarcinoma cells, and adhesion of various tumour cells based on Le(x) expression. Glycoconj J (1994) 1.13
Glycosphingolipid behaviour in complex membranes. Biochim Biophys Acta (2008) 1.10
Cell growth regulation through GM3-enriched microdomain (glycosynapse) in human lung embryonal fibroblast WI38 and its oncogenic transformant VA13. J Biol Chem (2004) 1.08
Adhesion Forces between Lewis(X) Determinant Antigens as Measured by Atomic Force Microscopy. Angew Chem Int Ed Engl (2001) 1.02
A carbohydrate-carbohydrate interaction between galactosylceramide-containing liposomes and cerebroside sulfate-containing liposomes: dependence on the glycolipid ceramide composition. Biochemistry (1993) 1.02
Organization of glycosphingolipids in phosphatidylcholine bilayers: use of antibody molecules and Fab fragments as morphologic markers. Biochemistry (1990) 1.01
Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside). Proc Natl Acad Sci U S A (2004) 1.01
Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling. An Acad Bras Cienc (2004) 0.99
Plasma membrane and mucosal glycosphingolipids in the rat intestine. Biochim Biophys Acta (1973) 0.99
Glycosphingolipids in detergent-insoluble substrate attachment matrix (DISAM) prepared from substrate attachment material (SAM). Their possible role in regulating cell adhesion. Exp Cell Res (1984) 0.98
Localization of globoside and Forssman glycolipids on erythrocyte membranes. Biochim Biophys Acta (1983) 0.98
Specific interaction between gangliotriaosylceramide (Gg3) and sialosyllactosylceramide (GM3) as a basis for specific cellular recognition between lymphoma and melanoma cells. J Biol Chem (1989) 0.97
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells. Glycobiology (2009) 0.96
Simultaneous expression of caveolin-1 and E-cadherin in ovarian carcinoma cells stabilizes adherens junctions through inhibition of src-related kinases. Am J Pathol (2005) 0.95
Sphingolipids and membrane environments for caveolin. FEBS Lett (2009) 0.92
Glycolipids of chick embryo fibroblasts infected with temperature-sensitive mutants of avian sarcoma viruses. Virology (1977) 0.89
Natural ligands for CD33-related Siglecs? Glycobiology (2009) 0.89
The natural LewisX-bearing lipids promote membrane adhesion: influence of ceramide on carbohydrate-carbohydrate recognition. Angew Chem Int Ed Engl (2005) 0.88
Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note. Biochem Biophys Res Commun (2007) 0.85
Novel fucolipids of human adenocarcinoma: monoclonal antibody specific for trifucosyl Ley (III3FucV3FucVI2FucnLc6) and a possible three-dimensional epitope structure. J Biol Chem (1986) 0.85
Signal transduction pathways involved in interaction of galactosylceramide/sulfatide-containing liposomes with cultured oligodendrocytes and requirement for myelin basic protein and glycosphingolipids. J Neurosci Res (2008) 0.82
Probing specificity in carbohydrate-carbohydrate interactions with micelles and Langmuir monolayers. Angew Chem Int Ed Engl (2003) 0.81
Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim Biophys Acta (2007) 1.62