Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 2788253)

Published in Br J Cancer on November 03, 2009

Authors

S Darby1, T Murphy, H Thomas, C N Robson, H Y Leung, M E Mathers, V J Gnanapragasam

Author Affiliations

1: Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK.

Articles cited by this

Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev (2005) 3.91

Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol (2005) 3.14

Functions and regulations of fibroblast growth factor signaling during embryonic development. Dev Biol (2005) 2.92

Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell (2004) 2.04

The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer (2004) 1.86

Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol (2002) 1.75

Signal transduction in prostate cancer progression. Clin Sci (Lond) (2005) 1.64

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat Cell Biol (2002) 1.61

Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma. Cancer Res (2006) 1.52

Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer. J Pathol (2007) 1.46

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer (2001) 1.37

Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. Oncogene (2006) 1.34

Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer. Oncogene (2005) 1.33

Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J Biol Chem (2003) 1.22

A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. J Biol Chem (2003) 1.20

Getting a first clue about SPRED functions. Bioessays (2007) 1.13

Aberrant fibroblast growth factor receptor signaling in bladder and other cancers. Differentiation (2007) 1.08

hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. J Biol Chem (2003) 1.04

FGF8 isoform b expression in human prostate cancer. Br J Cancer (2003) 1.01

Loss of Sef (similar expression to FGF) expression is associated with high grade and metastatic prostate cancer. Oncogene (2006) 1.00

Critical tumor-suppressor gene regions on chromosome 3P in major human epithelial malignancies: allelotyping and quantitative real-time PCR. Int J Cancer (2002) 0.96

Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proc Natl Acad Sci U S A (2004) 0.94

Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene (2007) 0.92

Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells. Oncogene (2001) 0.91

A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. Cell Signal (2006) 0.89

Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling. Biochem Biophys Res Commun (2007) 0.87

hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cell Signal (2007) 0.87

The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate. J Biol Chem (2006) 0.86

hSef co-localizes and interacts with Ras in the inhibition of Ras/MAPK signaling pathway. Biochem Biophys Res Commun (2006) 0.84

Sef-S, an alternative splice isoform of sef gene, inhibits NIH3T3 cell proliferation via a mitogen-activated protein kinases p42 and p44 (ERK1/2)-independent mechanism. Cell Signal (2006) 0.81

Articles by these authors

The measurement of satisfaction with healthcare: implications for practice from a systematic review of the literature. Health Technol Assess (2002) 6.37

Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science (1996) 5.55

Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology (1997) 5.53

Clinical evaluation of difco ESP culture system II for growth and detection of mycobacteria. J Clin Microbiol (1997) 3.26

Collecting morbidity data in general practice: the Somerset morbidity project. BMJ (1996) 3.08

Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol (2001) 2.95

Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ Res (2000) 2.93

The role of expectancies in the placebo effect and their use in the delivery of health care: a systematic review. Health Technol Assess (1999) 2.83

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol (1993) 2.73

Measurement of breast tumours. Histopathology (2003) 2.67

Should women carry their antenatal records? Br Med J (Clin Res Ed) (1986) 2.17

Postoperative pulmonary complications. Epidural analgesia using bupivacaine and opioids versus parenteral opioids. Anesthesiology (1993) 2.14

A simple physicochemical micromethod for determining fixed anionic groups in connective tissue. Biochim Biophys Acta (1970) 1.98

Induction of remission in hepatocellular carcinoma with doxorubicin. Lancet (1978) 1.86

MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene (2003) 1.83

A randomized controlled trial of the provision of a social support service during pregnancy: the South Manchester Family Worker Project. Br J Obstet Gynaecol (1989) 1.81

Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study. J Hepatol (1996) 1.73

The HIV information project for transfusion recipients a decade after transfusion. Arch Pediatr Adolesc Med (1995) 1.70

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1. Nat Struct Biol (1995) 1.68

Retrotransposon evolution in diverse plant genomes. Genetics (2000) 1.68

Tip60 is a nuclear hormone receptor coactivator. J Biol Chem (1999) 1.67

Risk factors for postthyroidectomy hypocalcemia. Surgery (1994) 1.62

Catabolites of chlorophyll in senescing barley leaves are localized in the vacuoles of mesophyll cells. Proc Natl Acad Sci U S A (1988) 1.61

AphidBase: a centralized bioinformatic resource for annotation of the pea aphid genome. Insect Mol Biol (2010) 1.57

Nitric oxide activates skeletal and cardiac ryanodine receptors. Cell Calcium (1997) 1.56

Skin carriage of acinetobacters in Hong Kong. J Clin Microbiol (1999) 1.53

A rational approach to shift work in emergency medicine. Ann Emerg Med (1992) 1.53

Protective effect of cephalothin against gentamincin-induced nephrotoxicity in rats. Antimicrob Agents Chemother (1976) 1.47

Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer. J Pathol (2007) 1.46

Effect of cephalothin on renal cortical concentrations of gentamicin in rats. Antimicrob Agents Chemother (1976) 1.45

Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract. J Urol (2000) 1.45

Evidence in support of a role for plant-mediated proteolysis in the rumens of grazing animals. Br J Nutr (2005) 1.44

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc Natl Acad Sci U S A (1988) 1.43

Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins. J Biol Chem (1988) 1.43

Praziquantel. Med Res Rev (1983) 1.41

On changing Indian eligibility for health care. Am J Public Health (1987) 1.40

What proportion of isotope injected does the child receive in dynamic renal scanning? Nucl Med Commun (1992) 1.38

Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin. Mol Endocrinol (2000) 1.38

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer (2001) 1.37

Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: association with increased infusion-related side effects and rapid blood tumor clearance. J Clin Oncol (1999) 1.36

Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity. Nucleic Acids Res (1995) 1.34

Hepatitis B variant in Europe. Lancet (1988) 1.31

Cleft lip and palate care in the United Kingdom--the Clinical Standards Advisory Group (CSAG) Study. Part 2: dentofacial outcomes and patient satisfaction. Cleft Palate Craniofac J (2001) 1.29

Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media. Infect Immun (1992) 1.28

Recent advances: oncology. BMJ (1999) 1.26

The efficacy of praziquantel against cestodes in animals. Z Parasitenkd (1977) 1.26

Cost effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C. Gut (2005) 1.24

De novo evolution of satellite DNA on the rye B chromosome. Genetics (2000) 1.24

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia (2003) 1.23

Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut (2003) 1.23

Validation of a simple model for predicting liver fibrosis in HIV/hepatitis C virus-coinfected patients. HIV Med (2005) 1.22

The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor. J Pathol (2008) 1.22

Docetaxel and cisplatin in combination as first-line chemotherapy for advanced epithelial ovarian cancer. Scottish Gynaecological Cancer Trials Group. J Clin Oncol (1999) 1.22

Long-term follow-up of the hepatitis C HENCORE cohort: response to therapy and occurrence of liver-related complications. J Viral Hepat (2007) 1.21

Cleft lip and palate care in the United Kingdom--the Clinical Standards Advisory Group (CSAG) Study. Part 3: speech outcomes. Cleft Palate Craniofac J (2001) 1.21

FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease. Oncogene (1999) 1.21

Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer. Br J Cancer (2005) 1.20

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene (2010) 1.20

Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer (2006) 1.19

Chemotherapy for ovarian cancer--a consensus statement on standard practice. Br J Cancer (1998) 1.19

A dynamic posturography study of balance in healthy elderly. Neurology (1992) 1.17

Chronic cough in a hospital population; its relationship to atopy and defects in host defence. Arch Dis Child (1989) 1.16

Reconstitution of RecBC DNase activity from purified Escherichia coli RecB and RecC proteins. J Biol Chem (1985) 1.16

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death Dis (2011) 1.15

Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer. Oncogene (2006) 1.14

Nuclear accumulation of histone deacetylase 4 (HDAC4) coincides with the loss of androgen sensitivity in hormone refractory cancer of the prostate. Eur Urol (2004) 1.14

Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene (2007) 1.13

Evaluation of an integrated community antenatal clinic. J R Coll Gen Pract (1987) 1.13

Cleft lip and palate care in the United Kingdom--the Clinical Standards Advisory Group (CSAG) Study. Part 4: outcome comparisons, training, and conclusions. Cleft Palate Craniofac J (2001) 1.12

Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study. Gut (2003) 1.11

Action of caffeine on calcium transport by isolated fractions of myofibrils, mitochondria, and sarcoplasmic reticulum from rabbit heart. Circ Res (1978) 1.11

Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol Cell Physiol (2000) 1.11

The ACE gene and Alzheimer's disease susceptibility. J Med Genet (2000) 1.11

Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Clin Cancer Res (1999) 1.10

The state of hepatitis B and C in the Mediterranean and Balkan countries: report from a summit conference. J Viral Hepat (2013) 1.10

ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer (2011) 1.10

Effectiveness of interferon alfa on incidence of hepatocellular carcinoma and decompensation in cirrhosis type C. European Concerted Action on Viral Hepatitis (EUROHEP). J Hepatol (1997) 1.09

Preparation of insoluble collagen from human cartilage. Biochem J (1973) 1.09

Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients. Eur J Immunol (2001) 1.08

BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. J Pathol (2008) 1.07

A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis. J Neurol Neurosurg Psychiatry (2006) 1.07

Induction of FGF receptor 2-IIIb expression and response to its ligands in epithelial ovarian cancer. Oncogene (2001) 1.07

Tip60 is a co-activator specific for class I nuclear hormone receptors. J Biol Chem (2001) 1.07

Utilization of ammonia for tryptophan synthesis. Biochem Biophys Res Commun (1975) 1.06

Demonstration of the ascending aorta in infective endocarditis by intravenous digital subtraction angiography. Br Heart J (1988) 1.06

Multistep ionization of argon clusters in intense femtosecond extreme ultraviolet pulses. Phys Rev Lett (2008) 1.06

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study. Magn Reson Med (2011) 1.05

Autoantibodies found after thymectomy in a patient later developing myasthenia gravis. J Neurol Neurosurg Psychiatry (1965) 1.04

Atypical thyroglossal duct cyst: a rare cause for a solitary cold thyroid nodule in childhood. Am Surg (1993) 1.04