Published in Cancer Res on November 10, 2009
MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78
The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol (2010) 2.20
Dysregulation of miR-15a and miR-214 in human pancreatic cancer. J Hematol Oncol (2010) 1.51
NHERF-2 maintains endothelial homeostasis. Blood (2012) 1.47
Massively parallel high-order combinatorial genetics in human cells. Nat Biotechnol (2015) 1.43
MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PLoS One (2012) 1.27
miRNA profiling along tumour progression in ovarian carcinoma. J Cell Mol Med (2011) 1.21
Epigenetic alterations in aging. J Appl Physiol (1985) (2010) 1.20
hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations. Br J Cancer (2010) 1.19
Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. Breast Cancer Res (2012) 1.14
miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Am J Pathol (2012) 1.13
Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells. J Oncol (2010) 1.13
miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies. Oncotarget (2015) 1.08
BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. Mol Cancer (2010) 1.08
NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08
Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. Br J Cancer (2011) 1.05
Clinically relevant microRNAs in ovarian cancer. Mol Cancer Res (2014) 1.01
Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer. PLoS One (2011) 1.01
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Mol Cell Biol (2011) 1.00
Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma. Mol Cancer (2015) 0.99
Bmi-1: At the crossroads of physiological and pathological biology. Genes Dis (2015) 0.95
MicroRNAs in human embryonic and cancer stem cells. Yonsei Med J (2010) 0.93
Minireview: The roles of small RNA pathways in reproductive medicine. Mol Endocrinol (2011) 0.92
microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts. Cell Cycle (2013) 0.90
A microRNA code for prostate cancer metastasis. Oncogene (2015) 0.89
miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways. Oncotarget (2016) 0.89
Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. PLoS One (2011) 0.88
Cancer stem cells: biological functions and therapeutically targeting. Int J Mol Sci (2014) 0.87
Identifying dysfunctional miRNA-mRNA regulatory modules by inverse activation, cofunction, and high interconnection of target genes: a case study of glioblastoma. Neuro Oncol (2013) 0.87
Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion. Pharm Res (2015) 0.86
Epigenetic regulation of cancer-associated genes in ovarian cancer. Int J Mol Sci (2011) 0.85
Non-coding RNAs and cancer. Int J Mol Sci (2013) 0.85
Role of TGF-β signaling in uterine carcinosarcoma. Oncotarget (2015) 0.84
Aberrant Expression of MicroRNA-15a and MicroRNA-16 Synergistically Associates with Tumor Progression and Prognosis in Patients with Colorectal Cancer. Gastroenterol Res Pract (2014) 0.84
MicroRNA Regulation of Human Breast Cancer Stem Cells. J Clin Med (2015) 0.84
Targeting FoxM1 effectively retards p53-null lymphoma and sarcoma. Mol Cancer Ther (2013) 0.83
Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens. J Cancer Prev (2013) 0.83
Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways. Biomed Res Int (2014) 0.82
Up-regulation of microRNAs, miR21 and miR23a in human liver cancer cells treated with Coptidis rhizoma aqueous extract. Exp Ther Med (2010) 0.82
Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy (2016) 0.81
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. Oncogene (2016) 0.80
Identification of miRNA-mediated core gene module for glioma patient prediction by integrating high-throughput miRNA, mRNA expression and pathway structure. PLoS One (2014) 0.80
An overview of long non-coding RNAs in ovarian cancers. Oncotarget (2016) 0.80
Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation. Oncotarget (2016) 0.79
Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs. Front Genet (2015) 0.79
MicroRNA expression profiling of mature ovarian teratomas. Oncol Lett (2011) 0.79
WNT7A Regulation by miR-15b in Ovarian Cancer. PLoS One (2016) 0.78
PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster. J Biol Chem (2014) 0.78
miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors. Cell Death Dis (2015) 0.77
BMI1: A Biomarker of Hematologic Malignancies. Biomark Cancer (2016) 0.77
MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. PLoS One (2012) 0.77
MicroRNAs in Gynecological Cancers: Small molecules with big implications. Cancer Lett (2017) 0.76
Mitochondrial BMI1 maintains bioenergetic homeostasis in cells. FASEB J (2016) 0.76
Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer. PLoS One (2015) 0.76
miR-30e-5p and miR-15a Synergistically Regulate Fatty Acid Metabolism in Goat Mammary Epithelial Cells via LRP6 and YAP1. Int J Mol Sci (2016) 0.76
B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer. Onco Targets Ther (2016) 0.75
BMI1, a new target of CK2α. Mol Cancer (2017) 0.75
Circulating biomarkers in renal cell carcinoma: the link between microRNAs and extracellular vesicles, where are we now? J Kidney Cancer VHL (2014) 0.75
Prioritizing cancer-related microRNAs by integrating microRNA and mRNA datasets. Sci Rep (2016) 0.75
BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin. Physiol Rep (2016) 0.75
Therapeutic evaluation of microRNA-15a and microRNA-16 in ovarian cancer. Oncotarget (2016) 0.75
Tumor suppressor p53 induces miR-15a processing to inhibit neuronal apoptosis inhibitory protein (NAIP) in the apoptotic response DNA damage in breast cancer cell. Am J Transl Res (2017) 0.75
Negative regulation of Bmi-1 by AMPK and implication in cancer progression. Oncotarget (2016) 0.75
MDR1 mediated chemoresistance: BMI1 and TIP60 in action. Biochim Biophys Acta (2016) 0.75
Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer. Onco Targets Ther (2014) 0.75
Determination of absolute expression profiles using multiplexed miRNA analysis. PLoS One (2017) 0.75
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell (2006) 23.59
miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature (2003) 12.06
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA (2007) 9.97
MicroRNA signatures in human ovarian cancer. Cancer Res (2007) 9.45
Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst (2005) 8.36
microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci U S A (2006) 8.24
MicroRNA expression profiling in prostate cancer. Cancer Res (2007) 8.04
MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res (2008) 7.45
MicroRNA-cancer connection: the beginning of a new tale. Cancer Res (2006) 7.38
Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res (2008) 6.38
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest (2005) 5.90
MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res (2008) 5.54
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell (2007) 5.40
miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res (2006) 4.91
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A (2008) 4.79
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res (2008) 4.64
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res (2002) 3.16
MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun (2007) 2.75
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer (2001) 2.67
2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004). Ann Oncol (2005) 2.33
bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis. Oncogene (1993) 2.25
MicroRNA-143 and -145 in colon cancer. DNA Cell Biol (2007) 2.24
Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene (1997) 1.98
Relapsed ovarian cancer: challenges and management strategies for a chronic disease. Oncologist (2002) 1.93
miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol (2005) 1.93
Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1. Trends Immunol (2003) 1.55
Role of hedgehog signaling in ovarian cancer. Clin Cancer Res (2008) 1.36
Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues. Exp Oncol (2008) 1.02
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA (2008) 12.26
miRNAs, cancer, and stem cell division. Cell (2005) 12.15
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
MicroRNA signatures in human ovarian cancer. Cancer Res (2007) 9.45
MicroRNAs in Cancer. Annu Rev Med (2009) 9.37
The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2005) 8.60
A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24
A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14
MicroRNA expression and function in cancer. Trends Mol Med (2006) 7.02
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res (2006) 5.72
Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol (2009) 5.56
MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47
MicroRNAs in body fluids--the mix of hormones and biomarkers. Nat Rev Clin Oncol (2011) 5.46
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell (2007) 5.40
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res (2007) 5.40
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood (2008) 5.23
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res (2008) 5.16
Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A (2002) 4.86
Micro-RNA profiling in kidney and bladder cancers. Urol Oncol (2007) 4.35
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell (2010) 4.07
CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A (2007) 4.06
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell (2008) 4.01
Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88
MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A (2006) 3.80
RNA interference in the clinic: challenges and future directions. Nat Rev Cancer (2010) 3.43
MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov (2013) 3.33
MicroRNA 29b functions in acute myeloid leukemia. Blood (2009) 3.19
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA (2011) 3.16
Regulation of tumor angiogenesis by EZH2. Cancer Cell (2010) 3.10
miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res (2009) 3.07
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell (2010) 2.78
Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65
Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome (2006) 2.64
Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J (2008) 2.58
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57
Concern Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci U S A (2003) 2.52
mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Mol Cancer (2007) 2.40
Biological properties of "naked" metal nanoparticles. Adv Drug Deliv Rev (2008) 2.33
MicroRNAs. Cancer J (2008) 2.28
microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood (2010) 2.25
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21
Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res (2008) 2.20
Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. Carcinogenesis (2008) 2.12
MicroRNAs and cancer: profile, profile, profile. Int J Cancer (2008) 2.10
SnapShot: MicroRNAs in Cancer. Cell (2009) 2.10
MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One (2009) 1.97
MicroRNAs and cancer--new paradigms in molecular oncology. Curr Opin Cell Biol (2009) 1.96
Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis. Proc Natl Acad Sci U S A (2010) 1.95
MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci U S A (2007) 1.90
An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem (2009) 1.90
Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood (2013) 1.87
Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood (2008) 1.87
Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer. Prostate (2008) 1.86
The use of microorganisms for the formation of metal nanoparticles and their application. Appl Microbiol Biotechnol (2005) 1.81
Effect of nanoparticle surface charge at the plasma membrane and beyond. Nano Lett (2010) 1.77
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res (2006) 1.71
MicroRNA history: discovery, recent applications, and next frontiers. Mutat Res (2011) 1.66
Noninvasive radiofrequency field-induced hyperthermic cytotoxicity in human cancer cells using cetuximab-targeted gold nanoparticles. J Exp Ther Oncol (2008) 1.59
Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther (2007) 1.57
Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells. J Nanobiotechnology (2008) 1.56
Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. Blood (2010) 1.55
Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future. Chem Soc Rev (2012) 1.55
Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. Adv Drug Deliv Rev (2009) 1.54
Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues. Immunology (2008) 1.54
Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patients. Cancer (2011) 1.53
Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles. PLoS One (2011) 1.53
Cytogenetic and molecular evaluation of 241 small supernumerary marker chromosomes: cooperative study of 19 Italian laboratories. Genet Med (2005) 1.53
Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer. ACS Chem Biol (2012) 1.50
Regulation of microRNA expression: the hypoxic component. Cell Cycle (2007) 1.49
MicroRNA profiling in cancer. Clin Sci (Lond) (2011) 1.49
CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget (2013) 1.48
NHERF-2 maintains endothelial homeostasis. Blood (2012) 1.47
miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer Res (2013) 1.46
Advanced glycation end products and bone loss during aging. Ann N Y Acad Sci (2005) 1.45
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
MicroRNA involvement in brain tumors: from bench to bedside. Brain Pathol (2008) 1.40
MicroRNAome genome: a treasure for cancer diagnosis and therapy. CA Cancer J Clin (2014) 1.40
Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology (2012) 1.38
Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas. J Cell Physiol (2007) 1.37
Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. FASEB J (2005) 1.37
Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab (2011) 1.36
Role of hedgehog signaling in ovarian cancer. Clin Cancer Res (2008) 1.36
Retracted Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J Biol Chem (2009) 1.33
Gold nanoparticles: opportunities and challenges in nanomedicine. Expert Opin Drug Deliv (2010) 1.32