Published in Am J Physiol Cell Physiol on November 11, 2009
Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol (2010) 1.81
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem (2011) 1.76
Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal (2012) 1.49
Purinergic signalling and cancer. Purinergic Signal (2013) 1.18
Imaging exocytosis of ATP-containing vesicles with TIRF microscopy in lung epithelial A549 cells. Purinergic Signal (2011) 1.06
Receptor regulation of osmolyte homeostasis in neural cells. J Physiol (2010) 0.91
Extracellular nucleotides and apyrases regulate stomatal aperture in Arabidopsis. Plant Physiol (2011) 0.89
Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR). Pflugers Arch (2016) 0.84
Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells. Am J Physiol Cell Physiol (2012) 0.83
RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. PLoS One (2012) 0.79
Volume-regulated anion channel-a frenemy within the brain. Pflugers Arch (2015) 0.79
Astrocytic vesicle mobility in health and disease. Int J Mol Sci (2013) 0.78
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther (2013) 0.78
Cell culture: complications due to mechanical release of ATP and activation of purinoceptors. Cell Tissue Res (2017) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Physiology of cell volume regulation in vertebrates. Physiol Rev (2009) 5.11
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett (2005) 3.89
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87
Purine and pyrimidine receptors. Cell Mol Life Sci (2007) 3.79
Cellular and molecular physiology of volume-sensitive anion channels. Am J Physiol (1996) 3.57
Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol (2003) 3.47
Ischemia opens neuronal gap junction hemichannels. Science (2006) 3.00
Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79
Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J (2007) 2.51
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Connexin 43 hemichannels are permeable to ATP. J Neurosci (2008) 2.46
Amazing chloride channels: an overview. Acta Physiol Scand (2003) 2.42
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther (2008) 2.42
Functional connexin "hemichannels": a critical appraisal. Glia (2006) 2.21
ATP released from astrocytes during swelling activates chloride channels. J Neurophysiol (2003) 2.05
Pannexin: to gap or not to gap, is that a question? IUBMB Life (2006) 2.05
Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Natl Acad Sci U S A (1996) 2.04
Physiological regulation of ATP release at the apical surface of human airway epithelia. J Biol Chem (2006) 2.04
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
Activation of a Cl- current by hypotonic volume increase in human endothelial cells. J Gen Physiol (1994) 1.81
Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem (2003) 1.79
Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release. J Gen Physiol (2001) 1.78
Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med (2006) 1.70
The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem (2003) 1.69
A central role of connexin 43 in hypoxic preconditioning. J Neurosci (2008) 1.56
Inhibition of gap junction hemichannels by chloride channel blockers. J Membr Biol (2002) 1.50
Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel. J Physiol (2009) 1.50
Connexins are mechanosensitive. Am J Physiol Cell Physiol (2004) 1.46
Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A (2005) 1.44
ATP release via anion channels. Purinergic Signal (2005) 1.43
Volume-regulated anion channels serve as an auto/paracrine nucleotide release pathway in aortic endothelial cells. J Gen Physiol (2002) 1.41
Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells. J Physiol (2001) 1.39
Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior. Neuropharmacology (2009) 1.35
Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes. J Physiol (2006) 1.29
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem (2009) 1.27
Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia. Am J Physiol (1992) 1.21
Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture. Cell Res (2008) 1.20
Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions. J Physiol (2004) 1.18
Inhibition of amiloride-sensitive epithelial Na(+) absorption by extracellular nucleotides in human normal and cystic fibrosis airways. Am J Respir Cell Mol Biol (2000) 1.17
Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. Glia (2009) 1.16
ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms. Am J Physiol Cell Physiol (2004) 1.15
ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes. Am J Physiol Cell Physiol (2002) 1.15
Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes. Am J Physiol Cell Physiol (2008) 1.13
Noradrenergic modulation of electrical coupling in GABAergic networks of the hippocampus. J Neurosci (2008) 1.12
Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides. J Physiol (2007) 1.10
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07
Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia. Channels (Austin) (2009) 1.04
Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors. J Cell Physiol (2008) 1.04
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. Mol Biol Cell (1996) 1.04
Oxygen-glucose deprivation induces ATP release via maxi-anion channels in astrocytes. Purinergic Signal (2007) 1.04
Hypothermia therapy for brain injury. Annu Rev Biomed Eng (2009) 1.03
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells. Purinergic Signal (2007) 0.99
Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels. J Physiol (2009) 0.99
The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity. J Physiol Sci (2008) 0.95
Thrombin potently enhances swelling-sensitive glutamate efflux from cultured astrocytes. Glia (2007) 0.94
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci U S A (1994) 0.90
Potentiation of the osmosensitive release of taurine and D-aspartate from SH-SY5Y neuroblastoma cells after activation of M3 muscarinic cholinergic receptors. J Pharmacol Exp Ther (2004) 0.90
Sulphonic acid derivatives as probes of pore properties of volume-regulated anion channels in endothelial cells. Br J Pharmacol (1999) 0.89
Multiple actions of dimethylsphingosine in 1321N1 astrocytes. Mol Cells (2007) 0.86
Two conventional protein kinase C isoforms, alpha and beta I, are involved in the ATP-induced activation of volume-regulated anion channel and glutamate release in cultured astrocytes. J Neurochem (2008) 0.86
Role of phosphoinositide hydrolysis in astrocyte volume regulation. J Neurochem (1993) 0.85
Subnanomolar concentrations of thrombin enhance the volume-sensitive efflux of taurine from human 1321N1 astrocytoma cells. J Pharmacol Exp Ther (2005) 0.85
Receptor regulation of the volume-sensitive efflux of taurine and iodide from human SH-SY5Y neuroblastoma cells: differential requirements for Ca(2+) and protein kinase C. J Pharmacol Exp Ther (2006) 0.85
Cl channel blockers inhibit the volume-activated efflux of Cl and taurine in cultured neurons. Am J Physiol (1996) 0.83
Extracellular ATP activates chloride and taurine conductances in cultured hippocampal neurons. Neurochem Res (2004) 0.81
Lack of coupling between membrane stretching and pannexin-1 hemichannels. Biochem Biophys Res Commun (2009) 0.80
Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin. Am J Physiol Cell Physiol (2006) 0.80
Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons. Am J Physiol Cell Physiol (2008) 0.79
Inhibition of ATP-induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes. Pharmacology (2008) 0.79
Pitfalls when examining gap junction hemichannels: interference from volume-regulated anion channels. Pflugers Arch (2006) 0.77
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem (2007) 4.27
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity (2008) 3.36
Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol (2007) 3.06
Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol (2011) 2.67
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol (2003) 2.61
Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol (2005) 2.49
Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem (2003) 1.79
Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J (2005) 1.69
Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4. J Immunol (2006) 1.67
P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release. J Immunol (2003) 1.52
Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol (2003) 1.45
Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells. J Immunol (2013) 1.28
Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol (2003) 1.25
P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol (2009) 1.25
Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol (2005) 1.14
Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes. Am J Physiol Cell Physiol (2008) 1.13
Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation. Br J Pharmacol (2004) 1.11
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol (2003) 1.10
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle. Am J Physiol Heart Circ Physiol (2011) 1.05
Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. J Leukoc Biol (2004) 1.04
P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways. Purinergic Signal (2009) 1.02
Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells. J Neurochem (2005) 1.02
Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. Infect Immun (2010) 0.99
Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: synergistic modulation by cyclic AMP and hyperphosphatemia. Am J Physiol Cell Physiol (2009) 0.98
Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages. Mol Pharmacol (2004) 0.98
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun (2009) 0.97
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells. J Immunol (2009) 0.95
Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages. J Immunol (2007) 0.94
Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells. Am J Physiol Cell Physiol (2009) 0.93
Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis. Carcinogenesis (2005) 0.90
ATP and control of intracellular growth of mycobacteria by T cells. Infect Immun (2002) 0.88
The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation. Purinergic Signal (2008) 0.87
Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans. J Biol Chem (2006) 0.84
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1. Am J Physiol Cell Physiol (2011) 0.83
Functionalized congeners of tyrosine-based P2X(7) receptor antagonists: probing multiple sites for linking and dimerization. Bioconjug Chem (2002) 0.83
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther (2013) 0.78
Human β-defensin-3 structure motifs that are important in CXCR4 antagonism. FEBS J (2013) 0.77
Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes. Purinergic Signal (2009) 0.77
Focus on "extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells". Am J Physiol Cell Physiol (2002) 0.76
Function without form: an ongoing search for maxi-anion channel proteins. Focus on "Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells". Am J Physiol Cell Physiol (2012) 0.76
Dueling nucleosides: cross-regulation of extracellular adenosine by guanosine. Focus on "Extracellular guanosine regulates extracellular adenosine levels". Am J Physiol Cell Physiol (2013) 0.76
Charge of the mito brigade. Focus on "Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis". Am J Physiol Cell Physiol (2010) 0.75