Published in Biochem Soc Trans on December 01, 2009
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci (2011) 5.64
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci (2010) 5.27
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol (2010) 1.54
Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci (2010) 1.40
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.32
Calcium dysregulation and homeostasis of neural calcium in the molecular mechanisms of neurodegenerative diseases provide multiple targets for neuroprotection. Antioxid Redox Signal (2010) 1.27
Calcium signaling in synapse-to-nucleus communication. Cold Spring Harb Perspect Biol (2011) 1.12
Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions. Blood (2011) 1.04
Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics (2012) 0.98
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun (2014) 0.96
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol (2012) 0.96
Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci (2010) 0.93
Mechanisms of calpain mediated proteolysis of voltage gated sodium channel α-subunits following in vitro dynamic stretch injury. J Neurochem (2012) 0.93
Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal (2011) 0.92
NMDA Receptors in Glial Cells: Pending Questions. Curr Neuropharmacol (2013) 0.92
The influence of synaptic activity on neuronal health. Curr Opin Neurobiol (2011) 0.92
Regulation of Ras proteins by reactive nitrogen species. Free Radic Biol Med (2011) 0.90
Glutamate transporters in the biology of malignant gliomas. Cell Mol Life Sci (2013) 0.90
A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Syst Biol (2013) 0.90
C-terminal domains of N-methyl-D-aspartic acid receptor modulate unitary channel conductance and gating. J Biol Chem (2012) 0.90
Developmental localization of NMDA receptors, Src and MAP kinases in mouse brain. Neurosci Lett (2011) 0.89
Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity. Front Cell Dev Biol (2014) 0.87
Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. J Neuroinflammation (2011) 0.87
The impact of biosampling procedures on molecular data interpretation. Mol Cell Proteomics (2013) 0.87
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia (2013) 0.85
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma. J Biol Chem (2012) 0.84
Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption. J Neurochem (2010) 0.84
Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission. PLoS Comput Biol (2011) 0.84
The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects. J Cereb Blood Flow Metab (2014) 0.83
Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors. J Neurosci (2011) 0.83
Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload. J Neurosci (2014) 0.83
Identification of an N-methyl-D-aspartate receptor in isolated nervous system mitochondria. J Biol Chem (2012) 0.82
Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics. J Neurotrauma (2012) 0.82
Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function. ASN Neuro (2011) 0.82
N-methyl D-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori Infection. Gastroenterology (2011) 0.81
Neuroprotective effects of a novel single compound 1-methoxyoctadecan-1-ol isolated from Uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model. PLoS One (2014) 0.81
Stretch injury selectively enhances extrasynaptic, GluN2B-containing NMDA receptor function in cortical neurons. J Neurophysiol (2013) 0.81
Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus. Int J Physiol Pathophysiol Pharmacol (2010) 0.80
Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem (2012) 0.80
Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling. J Neurochem (2014) 0.80
Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice. PLoS One (2011) 0.79
Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. J Neurosci Res (2013) 0.79
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. Exp Neurol (2010) 0.78
Scaffolding protein Homer1a protects against NMDA-induced neuronal injury. Cell Death Dis (2015) 0.78
Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci (2015) 0.78
Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders. Neuropsychopharmacology (2016) 0.78
XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia. Med Gas Res (2013) 0.78
The Role of NMDA Receptors in the Development of Brain Resistance through Pre- and Postconditioning. Aging Dis (2014) 0.77
Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival. Front Oncol (2014) 0.76
Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience (2012) 0.76
Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain disease. Cell Death Discov (2015) 0.76
Mechanisms responsible for the effect of median nerve electrical stimulation on traumatic brain injury-induced coma: orexin-A-mediated N-methyl-D-aspartate receptor subunit NR1 upregulation. Neural Regen Res (2016) 0.75
Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain. Pharmaceuticals (Basel) (2010) 0.75
Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity. Biochim Biophys Acta (2016) 0.75
The Effect of Noscapine on Oxygen-Glucose Deprivation on Primary Murine Cortical Neurons in High Glucose Condition. Iran J Pharm Res (2016) 0.75
An Immunological Approach to Increase the Brain's Resilience to Insults. ISRN Neurosci (2014) 0.75
Selected gene profiles of stressed NSC-34 cells and rat spinal cord following peripheral nerve reconstruction and minocycline treatment. Exp Ther Med (2016) 0.75
Synthesis and Biological Evaluation of Novel Multi-target-Directed Benzazepines Against Excitotoxicity. Mol Neurobiol (2016) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol (2001) 10.69
Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci (1999) 10.61
PDZ domain proteins of synapses. Nat Rev Neurosci (2004) 8.14
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci (2002) 7.57
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science (1999) 7.37
Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med (1994) 6.77
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science (1999) 6.37
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science (2004) 5.88
Oxidative stress and neurodegeneration: where are we now? J Neurochem (2006) 5.44
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
Excitotoxic cell death. J Neurobiol (1992) 4.76
Viability thresholds and the penumbra of focal ischemia. Ann Neurol (1994) 4.49
A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature (2003) 4.45
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol (2001) 4.09
Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature (2006) 4.01
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science (2002) 3.98
Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem (2006) 3.67
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov (2006) 3.58
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med (2003) 3.45
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci (2007) 3.44
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol (2002) 3.30
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science (1999) 3.13
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature (1998) 3.13
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci (1988) 3.13
Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem (2000) 3.12
N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist (2005) 3.11
Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science (1969) 3.08
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci (2004) 3.01
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature (1997) 2.93
The changing landscape of ischaemic brain injury mechanisms. Nature (1999) 2.91
The Yin and Yang of NMDA receptor signalling. Trends Neurosci (2003) 2.83
Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron (1998) 2.82
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat Neurosci (2001) 2.79
Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature (2000) 2.78
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci (2009) 2.71
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell (2005) 2.63
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron (2002) 2.45
Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial. JAMA (2001) 2.40
Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J Biol Chem (2004) 2.32
Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J Physiol (2006) 2.27
Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron (2002) 2.17
Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci (2006) 2.16
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J Neurosci (2005) 2.16
Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci (1998) 2.14
NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol (2008) 2.13
Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron (2007) 2.08
Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2001) 2.04
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem (1997) 2.02
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels. Neuron (1999) 2.00
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci (2006) 1.94
NMDA receptor function: subunit composition versus spatial distribution. Cell Tissue Res (2006) 1.93
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neurosci (2009) 1.87
Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 1.86
Drug-induced apoptotic neurodegeneration in the developing brain. Brain Pathol (2002) 1.85
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci (2001) 1.81
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett (2002) 1.79
Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biol (2008) 1.79
Pathologically activated therapeutics for neuroprotection. Nat Rev Neurosci (2007) 1.77
Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J Neurosci (2001) 1.72
Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol (2005) 1.71
Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr Mol Med (2004) 1.66
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated. Biochim Biophys Acta (2002) 1.66
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J (2008) 1.62
Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann N Y Acad Sci (2008) 1.62
Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron (2007) 1.61
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. J Neurosci (2008) 1.58
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione. J Neurochem (2008) 1.58
Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons. J Neurosci (2000) 1.57
Oxidative stress and energy crises in neuronal dysfunction. Ann N Y Acad Sci (2008) 1.54
TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc Natl Acad Sci U S A (2007) 1.52
Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J Neurosci (2005) 1.51
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neurosci (2003) 1.50
Is CREB a key to neuronal survival? Trends Neurosci (2000) 1.48
How BAD phosphorylation is good for survival. Nat Cell Biol (1999) 1.45
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology (2007) 1.44
Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. J Neurosci Res (2007) 1.44
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins. Antioxid Redox Signal (2009) 1.39
Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem (2006) 1.38
Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death. J Neurosci (2007) 1.38
Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. Nat Neurosci (2007) 1.36
Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem (2000) 1.36
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience (2008) 1.36
Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis. Cell Death Differ (2002) 1.36
Nuclear calcium/calmodulin regulates memory consolidation. J Neurosci (2004) 1.34
NMDA Receptors in glia. Neuroscientist (2007) 1.33