Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares?

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 19950271)

Published in Arthritis Rheum on December 01, 2009

Authors

Helena Enocsson1, Christopher Sjöwall, Thomas Skogh, Maija-Leena Eloranta, Lars Rönnblom, Jonas Wetterö

Author Affiliations

1: Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. helena.enocsson@liu.se

Articles citing this

Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis (2011) 2.88

Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol (2011) 1.24

Elevated interleukin 8 and T-helper 1 and T-helper 17 cytokine levels prior to antiretroviral therapy in participants who developed immune reconstitution inflammatory syndrome during ACTG A5164. J Infect Dis (2012) 1.12

A novel pathogenetic concept-antiviral immunity in lupus nephritis. Nat Rev Nephrol (2012) 1.01

CRP/anti-CRP antibodies assembly on the surfaces of cell remnants switches their phagocytic clearance toward inflammation. Front Immunol (2011) 0.95

Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE. Front Immunol (2016) 0.91

The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus. Arthritis Res Ther (2011) 0.90

Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. PLoS One (2011) 0.90

Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis. Arthritis Res Ther (2009) 0.90

C-reactive protein inhibits plasmacytoid dendritic cell interferon responses to autoantibody immune complexes. Arthritis Rheum (2013) 0.82

Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes. Mediators Inflamm (2015) 0.80

Pulmonary impairment, not muscle injury, is associated with elevated ESR in the idiopathic inflammatory myopathies. Rheumatology (Oxford) (2013) 0.78

Interferon-α coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 in vitro. Clin Exp Immunol (2017) 0.75

The relationship between the presence of autoantibodies, indicators of local and systemic inflammation, the serum concentration of B-cell activating factor (BAFF) and the intensity of salivary gland infiltration in patients with primary Sjögren's syndrome - a preliminary study. Reumatologia (2016) 0.75

Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up. Arthritis Res Ther (2015) 0.75

C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels. Clin Rheumatol (2017) 0.75

Articles by these authors

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med (2008) 9.61

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet (2005) 4.80

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci U S A (2007) 4.71

Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG. Arthritis Rheum (2004) 3.57

Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J Immunol (2003) 2.45

Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum (2005) 2.42

The type I interferon system in systemic lupus erythematosus. Arthritis Rheum (2006) 2.25

Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Rheum (2003) 2.16

B lymphocytes enhance interferon-α production by plasmacytoid dendritic cells. Arthritis Rheum (2012) 2.09

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet (2008) 1.98

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet (2007) 1.95

Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. Arthritis Rheum (2006) 1.86

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med (2009) 1.85

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology (2014) 1.85

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum (2007) 1.72

Abnormal antinuclear antibody titers are less common than generally assumed in established cases of systemic lupus erythematosus. J Rheumatol (2008) 1.66

Infections preceding early arthritis in southern Sweden: a prospective population-based study. J Rheumatol (2003) 1.59

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet (2011) 1.59

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol (2013) 1.57

The interferon signature in autoimmune diseases. Curr Opin Rheumatol (2013) 1.46

Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system. Nucleic Acids Res (2002) 1.44

[Burdensome rules for clinical trials are not in proportion to benefits for the patient]. Lakartidningen (2005) 1.38

C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis. Arthritis Rheum (2009) 1.37

Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE. Eur J Immunol (2009) 1.37

Type I interferon system activation and association with disease manifestations in systemic sclerosis. Ann Rheum Dis (2010) 1.35

The type I interferon system in the development of lupus. Semin Immunol (2011) 1.35

Type I interferon and lupus. Curr Opin Rheumatol (2009) 1.32

A possible mechanism for endogenous activation of the type I interferon system in myositis patients with anti-Jo-1 or anti-Ro 52/anti-Ro 60 autoantibodies. Arthritis Rheum (2007) 1.31

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus. Arthritis Rheum (2010) 1.27

Role of natural interferon-alpha producing cells (plasmacytoid dendritic cells) in autoimmunity. Autoimmunity (2003) 1.20

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. J Clin Immunol (2008) 1.20

Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system. Nat Clin Pract Rheumatol (2006) 1.18

NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. Sci Transl Med (2013) 1.12

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J Biol Chem (2005) 1.09

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells. Arthritis Rheum (2009) 1.09

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. Eur J Hum Genet (2012) 1.09

Systemic lupus erythematosus prevalence in Sweden in 2010: what do national registers say? Arthritis Care Res (Hoboken) (2014) 1.03

Presence and utility of IgA-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis: the Swedish TIRA project. Arthritis Res Ther (2008) 1.02

Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis. Arthritis Rheum (2007) 1.01

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE. Eur J Hum Genet (2010) 1.01

Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP) in relation to collagen fibrils in the equine tendon. Matrix Biol (2005) 1.00

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis. PLoS One (2013) 1.00

Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. Arthritis Res Ther (2003) 1.00

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons. Arthritis Rheum (2012) 1.00

Associations between antinuclear antibody staining patterns and clinical features of systemic lupus erythematosus: analysis of a regional Swedish register. BMJ Open (2013) 0.98

Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus. Immunology (2008) 0.98

IFN-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1β and LFA-1. J Immunol (2011) 0.98

Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins. Clin Chim Acta (2006) 0.96

Role of the actin cytoskeleton during respiratory burst in chemoattractant-stimulated neutrophils. Cell Biol Int (2006) 0.94

Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils. PLoS One (2012) 0.94

Type I interferons in Sjögren's syndrome. Autoimmun Rev (2012) 0.94

Autoantibodies to C-reactive protein is a common finding in SLE, but not in primary Sjögren's syndrome, rheumatoid arthritis or inflammatory bowel disease. J Autoimmun (2002) 0.94

A comparison between IgG- and IgA-class antibodies to cyclic citrullinated peptides and to modified citrullinated vimentin in early rheumatoid arthritis and very early arthritis. J Rheumatol (2011) 0.93

Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern. Ann Rheum Dis (2011) 0.93

28-Joint count disease activity score at 3 months after diagnosis of early rheumatoid arthritis is strongly associated with direct and indirect costs over the following 4 years: the Swedish TIRA project. Rheumatology (Oxford) (2011) 0.93

Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays. Rheumatology (Oxford) (2012) 0.93

Antinuclear antibodies in the oldest-old women and men. J Autoimmun (2006) 0.92

Methods of choice for diagnostic antinuclear antibody (ANA) screening: benefit of adding antigen-specific assays to immunofluorescence microscopy. J Autoimmun (2004) 0.92

IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: a possible new treatment? Arthritis Rheum (2012) 0.92

Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis. Arthritis Res Ther (2009) 0.90

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus. Ann Rheum Dis (2009) 0.90

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus. Transl Res (2013) 0.90

Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples. Ann Rheum Dis (2012) 0.90

Intracellular oxidative activation in synovial fluid neutrophils from patients with rheumatoid arthritis but not from other arthritis patients. J Rheumatol (2007) 0.89

Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. Br J Haematol (2004) 0.88

Survey of the use and effect of assistive devices in patients with early rheumatoid arthritis: a two-year followup of women and men. Arthritis Rheum (2004) 0.88

Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4. Ann Rheum Dis (2012) 0.87

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Arthritis Res Ther (2011) 0.87

Primary Sjögren's syndrome and the type I interferon system. Curr Pharm Biotechnol (2012) 0.87

RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE. PLoS One (2013) 0.87