Published in PLoS Genet on November 26, 2009
Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. PLoS Biol (2013) 1.68
Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice. PLoS Genet (2011) 1.13
The physiology of protein S-acylation. Physiol Rev (2015) 1.03
Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circ Res (2012) 1.00
Fat chance! Getting a grip on a slippery modification. ACS Chem Biol (2012) 0.98
Role of fatty acid transporters in epidermis: Implications for health and disease. Dermatoendocrinol (2011) 0.91
Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells. Cell Death Differ (2014) 0.87
Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biol (2014) 0.86
Specificity of transmembrane protein palmitoylation in yeast. PLoS One (2011) 0.85
Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. PLoS One (2014) 0.82
Fatty acid transporters in skin development, function and disease. Biochim Biophys Acta (2013) 0.82
Fatty acylation of proteins: The long and the short of it. Prog Lipid Res (2016) 0.81
Evidence for additional FREM1 heterogeneity in Manitoba oculotrichoanal syndrome. Mol Vis (2012) 0.81
Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol (2015) 0.80
Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. J Invest Dermatol (2015) 0.80
Palmitoylation and depalmitoylation defects. J Inherit Metab Dis (2014) 0.80
Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. J Biol Chem (2016) 0.78
Role for the epidermal growth factor receptor in chemotherapy-induced alopecia. PLoS One (2013) 0.78
Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome. Nat Commun (2016) 0.77
Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A (2015) 0.76
The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arterioscler Thromb Vasc Biol (2015) 0.76
Protein post-translational modifications: In silico prediction tools and molecular modeling. Comput Struct Biotechnol J (2017) 0.75
A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC Mol Biol (2016) 0.75
Slippery signaling: Palmitoylation-dependent control of neuronal kinase localization and activity. Mol Membr Biol (2016) 0.75
Progress toward Understanding Protein S-acylation: Prospective in Plants. Front Plant Sci (2017) 0.75
Protein S-palmitoylation in cellular differentiation. Biochem Soc Trans (2017) 0.75
FOXN1 transcription factor in epithelial growth and wound healing. Mol Cell Biol (2017) 0.75
Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
A single type of progenitor cell maintains normal epidermis. Nature (2007) 6.32
A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12
Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1996) 5.94
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Scratching the surface of skin development. Nature (2007) 4.61
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature (2008) 4.52
Global analysis of protein palmitoylation in yeast. Cell (2006) 4.43
Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37
Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem (2004) 4.34
Synaptic strength regulated by palmitate cycling on PSD-95. Cell (2002) 4.15
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell (2006) 4.09
Patterned acquisition of skin barrier function during development. Development (1998) 3.88
Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev (2001) 3.52
The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol (2002) 3.48
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem (2002) 3.27
CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein Eng Des Sel (2008) 2.86
Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development (2002) 2.79
Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat Genet (2004) 2.77
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
Long-term renewal of hair follicles from clonogenic multipotent stem cells. Proc Natl Acad Sci U S A (2005) 2.67
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron (2005) 2.16
The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. J Neurosci (2004) 2.07
Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci (2008) 1.92
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev (1996) 1.87
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus. Am J Hum Genet (2007) 1.73
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A (2008) 1.66
Bone morphogenetic proteins and their antagonists in skin and hair follicle biology. J Invest Dermatol (2003) 1.60
fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev (1995) 1.51
Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB J (2000) 1.48
Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A (2004) 1.41
Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Methods (2006) 1.40
The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Curr Biol (2008) 1.40
Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene (2004) 1.37
Barrier function regulates epidermal DNA synthesis. J Clin Invest (1991) 1.35
p63 is upstream of IKK alpha in epidermal development. J Cell Sci (2006) 1.35
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Development (2006) 1.32
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest (2001) 1.31
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. J Cell Biol (2000) 1.23
Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis (2000) 1.20
A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells. J Cell Biol (2002) 1.19
Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity. Mol Biol Cell (2008) 1.18
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development (2004) 1.18
Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Eur J Hum Genet (2005) 1.17
Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. Genes Chromosomes Cancer (2000) 1.16
Palmitoylation controls recycling in lysosomal sorting and trafficking. Traffic (2008) 1.12
Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A (2006) 1.07
A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. Mol Cell (2000) 1.01
Depilated (dep), a mutant gene that affects the coat of the mouse and acts in the epidermis. Genetics (1976) 0.92
The cerberus-related gene, Cerr1, is not essential for mouse head formation. Genesis (2000) 0.92
Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. Genesis (2000) 0.90
ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies. BMC Psychiatry (2005) 0.86
Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. PLoS One (2009) 0.86
Molecular genetics of the brown (b)-locus region of mouse chromosome 4. II. Complementation analyses of lethal brown deletions. Genetics (1994) 0.85
Skin abnormality in aged fyn-/- fak+/- mice. Carcinogenesis (1997) 0.81
A comparative transcript map and candidates for mutant phenotypes in the Tyrp1 (brown) deletion complex homologous to human 9p21-23. Mamm Genome (2000) 0.81
Differential expression of nitric oxide synthases in human scalp epidermal and hair follicle pigmentary units: implications for regulation of melanogenesis. Br J Dermatol (2005) 0.77
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2001) 5.49
Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05
Dominant role of the niche in melanocyte stem-cell fate determination. Nature (2002) 4.05
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science (2006) 3.52
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A (2002) 3.50
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Protein palmitoylation in neuronal development and synaptic plasticity. Nat Rev Neurosci (2010) 2.66
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell (2012) 2.62
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A (2010) 2.07
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem (2004) 2.01
PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science (2004) 1.97
Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol (2009) 1.91
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol (2003) 1.80
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol (2006) 1.79
Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology (2006) 1.77
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity (2006) 1.75
Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet (2006) 1.74
Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci (2009) 1.74
GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci (2006) 1.68
Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J Hum Genet (2011) 1.66
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development. J Invest Dermatol (2012) 1.56
Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem (2008) 1.55
Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet (2005) 1.51
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci (2013) 1.48
Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol (2008) 1.45
Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res (2009) 1.42
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci U S A (2007) 1.41
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A (2004) 1.41
Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet (2002) 1.41
Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Methods (2006) 1.40
Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med (2006) 1.40
Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell (2003) 1.39
Role of CRMP-2 in neuronal polarity. J Neurobiol (2004) 1.37
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34
Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Hum Mol Genet (2005) 1.33
Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci (2005) 1.31
Molecular constituents of neuronal AMPA receptors. J Cell Biol (2005) 1.31
Patched 1 conditional null allele in mice. Genesis (2003) 1.31
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol (2013) 1.30
Discovery of protein-palmitoylating enzymes. Pflugers Arch (2008) 1.30
Signatures of diversifying selection in European pig breeds. PLoS Genet (2013) 1.30
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
Local palmitoylation cycles define activity-regulated postsynaptic subdomains. J Cell Biol (2013) 1.26
Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur J Immunol (2010) 1.26
Regulation of pigmentation in zebrafish melanophores. Pigment Cell Res (2006) 1.25
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci (2007) 1.24
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol (2005) 1.21
Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. Hum Mutat (2013) 1.17
Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome (2004) 1.16
Presence of visual head tracking differentiates normal sighted from retinal degenerate mice. Neurosci Lett (2002) 1.15
LGI2 truncation causes a remitting focal epilepsy in dogs. PLoS Genet (2011) 1.14
Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice. PLoS Genet (2011) 1.13
Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology (2006) 1.13
The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases. Mol Biol Cell (2009) 1.13
Characterization of early assembly intermediates of recombinant human keratins. J Struct Biol (2002) 1.12
Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. J Med Genet (2011) 1.11
Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem (2003) 1.10
Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. J Invest Dermatol (2010) 1.09
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. J Cell Sci (2008) 1.08
Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol (2011) 1.08
Neural crest progenitors of the melanocyte lineage: coat colour patterns revisited. Development (2002) 1.08
Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A (2006) 1.07
Spatial mapping and quantification of developmental branching morphogenesis. Development (2012) 1.07
SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol Cell (2011) 1.03
Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci (2004) 1.03
The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics (2003) 1.03
Ex vivo live imaging of melanoblast migration in embryonic mouse skin. Pigment Cell Melanoma Res (2010) 1.02
2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases. J Am Chem Soc (2013) 1.01
Loss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and mice. PLoS Genet (2011) 1.01
Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J (2009) 1.00