Published in Int J Radiat Biol on December 01, 2009
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep (2014) 1.57
MicroRNAs: new players in the DNA damage response. J Mol Cell Biol (2010) 1.46
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Nucleic Acids Res (2014) 1.34
The mTOR inhibitor rapamycin suppresses DNA double-strand break repair. Radiat Res (2010) 1.25
Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Cell Cycle (2014) 1.10
MicroRNA-148b enhances the radiosensitivity of non-Hodgkin's Lymphoma cells by promoting radiation-induced apoptosis. J Radiat Res (2012) 1.09
PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest (2013) 1.06
Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05
Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells. BMC Genomics (2012) 0.98
REPAIRtoire--a database of DNA repair pathways. Nucleic Acids Res (2010) 0.97
Genetics and genomics of radiotherapy toxicity: towards prediction. Genome Med (2011) 0.95
Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst) (2011) 0.92
MicroRNA-449a enhances radiosensitivity in CL1-0 lung adenocarcinoma cells. PLoS One (2013) 0.90
Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle (2011) 0.90
Intraperitoneal injection is not always a suitable alternative to intravenous injection for radiotherapy. Cancer Biother Radiopharm (2013) 0.88
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clin Cancer Res (2011) 0.88
The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer. Br J Cancer (2011) 0.88
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways. J Biol Chem (2012) 0.88
DNA repair targeted therapy: The past or future of cancer treatment? Pharmacol Ther (2016) 0.84
53BP1 promotes microhomology-mediated end-joining in G1-phase cells. Nucleic Acids Res (2015) 0.83
DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy. Radiat Environ Biophys (2014) 0.83
Involvement of free radicals in breast cancer. Springerplus (2013) 0.80
A role for human homologous recombination factors in suppressing microhomology-mediated end joining. Nucleic Acids Res (2016) 0.80
Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition. Cell Death Dis (2015) 0.79
Combined hyperthermia and radiotherapy for the treatment of cancer. Cancers (Basel) (2011) 0.79
Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells. Int J Mol Med (2013) 0.79
Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases. Genome Integr (2010) 0.78
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS One (2015) 0.78
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst) (2016) 0.77
Strategies for targeting the DNA damage response for cancer therapeutics. Chin J Cancer (2012) 0.76
Databases and bioinformatics tools for the study of DNA repair. Mol Biol Int (2011) 0.76
The impact of ionizing radiation on placental trophoblasts. Placenta (2014) 0.75
DNA double-strand break repair: a theoretical framework and its application. J R Soc Interface (2016) 0.75
Drugging the Cancers Addicted to DNA Repair. J Natl Cancer Inst (2017) 0.75
In vivo sensitivity of the embryonic and adult neural stem cell compartments to low-dose radiation. J Radiat Res (2016) 0.75
BRCA1 recruitment to damaged DNA sites is dependent on CDK9. Cell Cycle (2017) 0.75
IER5 promotes irradiation- and cisplatin-induced apoptosis in human hepatocellular carcinoma cells. Am J Transl Res (2016) 0.75
Differences in DNA Repair Capacity, Cell Death and Transcriptional Response after Irradiation between a Radiosensitive and a Radioresistant Cell Line. Sci Rep (2016) 0.75
Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa. Mol Med Rep (2015) 0.75
Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids. Cancer Sci (2017) 0.75
Impaired Lymphocytes Development and Xenotransplantation of Gastrointestinal Tumor Cells in Prkdc-Null SCID Zebrafish Model. Neoplasia (2016) 0.75
Chromatin modifiers and remodellers in DNA repair and signalling. Philos Trans R Soc Lond B Biol Sci (2017) 0.75
ATM activation by oxidative stress. Science (2010) 5.22
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet (2002) 2.11
Involvement of novel autophosphorylation sites in ATM activation. EMBO J (2006) 1.94
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem (2007) 1.80
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res (2005) 1.65
Aprataxin, a novel protein that protects against genotoxic stress. Hum Mol Genet (2004) 1.60
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. J Cell Biol (2007) 1.59
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am J Hum Genet (2009) 1.54
Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations. Blood (2009) 1.48
Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J Biol Chem (2002) 1.44
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM. J Biol Chem (2002) 1.41
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. Biochem Biophys Res Commun (2004) 1.34
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet (2009) 1.32
Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Hum Mol Genet (2009) 1.30
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem (2003) 1.27
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. Proc Natl Acad Sci U S A (2002) 1.23
Use of multiple biomarkers for a molecular diagnosis of prostate cancer. Int J Cancer (2005) 1.22
Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities. J Biol Chem (2006) 1.19
Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice. PLoS One (2010) 1.16
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Natl Acad Sci U S A (2013) 1.12
New genomic structure for prostate cancer specific gene PCA3 within BMCC1: implications for prostate cancer detection and progression. PLoS One (2009) 1.11
Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice. J Neurosci (2003) 1.08
Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem (2010) 1.07
Ecological regulation of development: induction of marine invertebrate metamorphosis. Int J Dev Biol (2002) 1.06
Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet (2013) 1.03
The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst) (2004) 1.01
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech (2010) 0.98
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem (2011) 0.98
Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic Biol Med (2006) 0.98
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res (2009) 0.97
Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr (2010) 0.96
The diversity of bioactive proteins in Australian snake venoms. Mol Cell Proteomics (2007) 0.96
Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes? Clin Chem Lab Med (2010) 0.92
A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Mol Cancer Ther (2012) 0.91
Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis. Mol Cell Proteomics (2005) 0.90
Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription. Hum Mol Genet (2006) 0.90
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet (2010) 0.90
Metabolomics: a novel approach to early and noninvasive prostate cancer detection. Korean J Urol (2011) 0.88
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS J (2009) 0.87
Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation. Genes Chromosomes Cancer (2003) 0.87
Gene expression during early ascidian metamorphosis requires signalling by Hemps, an EGF-like protein. Development (2004) 0.87
Diagnostic performance of expression of PCA3, Hepsin and miR biomarkers inejaculate in combination with serum PSA for the detection of prostate cancer. Prostate (2015) 0.86
A novel role for hSMG-1 in stress granule formation. Mol Cell Biol (2011) 0.86
ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia. Hum Mutat (2005) 0.85
Comparative analysis of prothrombin activators from the venom of Australian elapids. Mol Biol Evol (2005) 0.85
A family of textilinin genes, two of which encode proteins with antihaemorrhagic properties. Br J Haematol (2002) 0.84
Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss. Br J Haematol (2009) 0.83
One-step site-directed mutagenesis of ATM cDNA in large (20kb) plasmid constructs. Hum Mutat (2002) 0.83
A randomised trial of robotic and open prostatectomy in men with localised prostate cancer. BMC Cancer (2012) 0.82
Markers for detection of prostate cancer. Cancers (Basel) (2010) 0.82
Regulation of the Atm promoter in vivo. Genes Chromosomes Cancer (2006) 0.82
Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms. Biochimie (2011) 0.82
BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. PLoS One (2013) 0.81
Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch™ (Q8009) and CoVase™ (V0801). Toxicon (2010) 0.81
A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment. Free Radic Biol Med (2010) 0.81
Evidence of aberrant DNA damage response signalling but normal rates of DNA repair in dividing lymphoblasts from patients with schizophrenia. World J Biol Psychiatry (2011) 0.80
Resistance of porcine blood clots to lysis relates to poor activation of porcine plasminogen by tissue plasminogen activator. Blood Coagul Fibrinolysis (2006) 0.80
Smg1 haploinsufficiency predisposes to tumor formation and inflammation. Proc Natl Acad Sci U S A (2012) 0.80
Cloning and characterisation of novel cystatins from elapid snake venom glands. Biochimie (2010) 0.79
Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie (2006) 0.79
Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin. PLoS One (2011) 0.78
Cloning and functional expression of venom prothrombin activator protease from Pseudonaja textilis with whole blood procoagulant activity. Br J Haematol (2005) 0.78
Diversity of toxic components from the venom of the evolutionarily distinct black whip snake, Demansia vestigiata. J Proteome Res (2007) 0.78
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Hum Mol Genet (2013) 0.78
Differential expression of PCA3 and BMCC1 in prostate cancer. Prostate (2009) 0.78
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res (2006) 0.78
Characterisation of a mannose-binding C-type lectin from Oxyuranus scutellatus snake venom. Biochimie (2010) 0.77
Genotoxicity of hydroquinone in A549 cells. Cell Biol Toxicol (2013) 0.77
Post-translational modification accounts for the presence of varied forms of nerve growth factor in Australian elapid snake venoms. Proteomics (2006) 0.76
Prothrombinase complexes with different physiological roles. Thromb Haemost (2009) 0.76
Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype. Oncogene (2004) 0.76
Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB J (2013) 0.76
The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One (2013) 0.76
Correction: AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation. PLoS One (2016) 0.75
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion (2012) 0.75
Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.75
Calcium prevents retinoic acid-induced disruption of the spectrin-based cytoskeleton in keratinocytes through the Src/PI3K-p85α/AKT/PKCδ/β-adducin pathways. Cell Calcium (2013) 0.75
Realizing the potential of ejaculate/seminal fluid in detecting and predicting natural history. Methods Mol Med (2003) 0.75