Published in J Infect Dis on January 15, 2010
A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. MBio (2013) 2.48
Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71
Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection. PLoS One (2010) 1.64
The bicomponent pore-forming leucocidins of Staphylococcus aureus. Microbiol Mol Biol Rev (2014) 1.32
A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe (2013) 1.31
Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). FEMS Immunol Med Microbiol (2012) 1.19
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18
The WalKR system controls major staphylococcal virulence genes and is involved in triggering the host inflammatory response. Infect Immun (2012) 1.09
Identification of the P3 promoter and distinct roles of the two promoters of the SaeRS two-component system in Staphylococcus aureus. J Bacteriol (2011) 1.08
Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06
Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother (2013) 1.06
The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection. PLoS One (2011) 1.05
From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? Nat Rev Microbiol (2012) 1.03
Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. PLoS Pathog (2013) 1.02
Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol (2012) 1.00
Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Mol Microbiol (2011) 0.99
Local inflammation exacerbates the severity of Staphylococcus aureus skin infection. PLoS One (2013) 0.99
Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30. Front Cell Infect Microbiol (2012) 0.95
Temporal and stochastic control of Staphylococcus aureus biofilm development. MBio (2014) 0.94
The δ subunit of RNA polymerase guides promoter selectivity and virulence in Staphylococcus aureus. Infect Immun (2014) 0.94
CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300. Infect Immun (2012) 0.92
Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils. Infect Immun (2014) 0.91
Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli. Proc Natl Acad Sci U S A (2014) 0.90
Fur is required for the activation of virulence gene expression through the induction of the sae regulatory system in Staphylococcus aureus. Int J Med Microbiol (2010) 0.89
The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. J Innate Immun (2013) 0.89
The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300. J Leukoc Biol (2013) 0.88
18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob Agents Chemother (2012) 0.88
SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One (2015) 0.88
Organizational requirements of the SaeR binding sites for a functional P1 promoter of the sae operon in Staphylococcus aureus. J Bacteriol (2012) 0.86
Dual RNA regulatory control of a Staphylococcus aureus virulence factor. Nucleic Acids Res (2014) 0.85
Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils. J Innate Immun (2013) 0.84
Impaired respiration elicits SrrAB-dependent programmed cell lysis and biofilm formation in Staphylococcus aureus. Elife (2017) 0.83
Ketamine inhibits tumor necrosis factor secretion by RAW264.7 murine macrophages stimulated with antibiotic-exposed strains of community-associated, methicillin-resistant Staphylococcus aureus. BMC Immunol (2011) 0.81
Haemin represses the haemolytic activity of Staphylococcus aureus in an Sae-dependent manner. Microbiology (2012) 0.80
Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease. PLoS One (2014) 0.80
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection. PLoS One (2015) 0.79
CodY, a master integrator of metabolism and virulence in Gram-positive bacteria. Curr Genet (2016) 0.79
Staphylococcus aureus Inhibits Neutrophil-derived IL-8 to Promote Cell Death. J Infect Dis (2015) 0.79
The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiol Spectr (2016) 0.79
Staphylococcus aureus SaeR/S-regulated factors reduce human neutrophil reactive oxygen species production. J Leukoc Biol (2016) 0.78
Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc. MBio (2016) 0.78
Using Quantitative Spectrometry to Understand the Influence of Genetics and Nutritional Perturbations On the Virulence Potential of Staphylococcus aureus. Mol Cell Proteomics (2017) 0.78
Resistance to Acute Macrophage Killing Promotes Airway Fitness of Prevalent Community-Acquired Staphylococcus aureus Strains. J Immunol (2016) 0.77
Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection. Infect Immun (2015) 0.77
Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins. Infect Immun (2015) 0.77
The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. PLoS Pathog (2016) 0.76
TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens. BMC Genomics (2016) 0.76
Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia. Cell Microbiol (2016) 0.76
The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus. J Bacteriol (2016) 0.76
Staphylococcus aureus pathogenesis in diverse host environments. Pathog Dis (2017) 0.75
Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus. Nat Commun (2017) 0.75
The SaeRS Two-Component System of Staphylococcus aureus. Genes (Basel) (2016) 0.75
An in vivo reporter assay for sRNA-directed gene control in Gram-positive bacteria: identifying a novel sRNA target in Staphylococcus aureus. Nucleic Acids Res (2017) 0.75
The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. mSphere (2016) 0.75
Interaction of Staphylococci with Human B cells. PLoS One (2016) 0.75
Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. PLoS Pathog (2017) 0.75
Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus. Sci Rep (2017) 0.75
Epic Immune Battles of History: Neutrophils vs. Staphylococcus aureus. Front Cell Infect Microbiol (2017) 0.75
Regulatory mechanism of the three-component system HptRSA in glucose-6-phosphate uptake in Staphylococcus aureus. Med Microbiol Immunol (2015) 0.75
Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases. Biochem Res Int (2017) 0.75
The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function. PLoS Pathog (2017) 0.75
Immune evasion by a staphylococcal inhibitor of myeloperoxidase. Proc Natl Acad Sci U S A (2017) 0.75
Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus. MBio (2017) 0.75
Downstream element determines RNase Y cleavage of the saePQRS operon in Staphylococcus aureus. Nucleic Acids Res (2017) 0.75
SaeRS Is Responsive to Cellular Respiratory Status and Regulates Fermentative Biofilm Formation in Staphylococcus aureus. Infect Immun (2017) 0.75
Staphylococcus aureus infections. N Engl J Med (1998) 36.39
Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA (2007) 26.98
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet (2006) 15.99
Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol (2003) 10.68
Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med (2005) 8.39
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75
Immune evasion by staphylococci. Nat Rev Microbiol (2005) 7.22
Evolutionary genomics of Staphylococcus aureus: insights into the origin of methicillin-resistant strains and the toxic shock syndrome epidemic. Proc Natl Acad Sci U S A (2001) 6.22
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol (2005) 5.18
Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus. FEMS Microbiol Lett (1997) 5.02
Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol (2007) 4.83
Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun (2002) 4.62
Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis (2008) 4.16
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A (2009) 3.89
Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol Med Microbiol (2004) 3.88
Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc (2007) 3.31
SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J Biol Chem (1999) 3.11
Global regulation of Staphylococcus aureus genes by Rot. J Bacteriol (2003) 3.02
Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev (2004) 3.01
Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. N Engl J Med (2005) 2.91
The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol (2008) 2.78
The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus. Mol Microbiol (2001) 2.57
Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis (2008) 2.41
Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci U S A (2005) 2.30
Purpura fulminans due to Staphylococcus aureus. Clin Infect Dis (2005) 2.27
Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol (2007) 2.24
The sae locus of Staphylococcus aureus encodes a two-component regulatory system. FEMS Microbiol Lett (1999) 2.00
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing. Microbiology (2003) 1.98
A structural basis for complement inhibition by Staphylococcus aureus. Nat Immunol (2007) 1.95
Staphylococcus aureus AgrA binding to the RNAIII-agr regulatory region. J Bacteriol (2004) 1.85
Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages. Emerg Infect Dis (2004) 1.84
The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus. J Bacteriol (2004) 1.81
5' end cDNA amplification using classic RACE. Nat Protoc (2006) 1.77
Influence of the two-component system SaeRS on global gene expression in two different Staphylococcus aureus strains. J Bacteriol (2006) 1.76
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background. Microbiology (2009) 1.66
The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals. J Bacteriol (2008) 1.58
Subinhibitory concentrations of beta-lactam induce haemolytic activity in Staphylococcus aureus through the SaeRS two-component system. FEMS Microbiol Lett (2007) 1.52
Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases teicoplanin resistance in Staphylococcus aureus. Biochim Biophys Acta (2000) 1.49
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus. J Biol Chem (2008) 1.42
TcaR, a putative MarR-like regulator of sarS expression. J Bacteriol (2004) 1.36
Fatal brain abscess due to community-associated methicillin-resistant Staphylococcus aureus strain USA300. Clin Infect Dis (2007) 1.20
Repression of hla by rot is dependent on sae in Staphylococcus aureus. Infect Immun (2008) 1.14
Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors. Curr Opin Infect Dis (2008) 1.00
Regulation of Rot expression in Staphylococcus aureus. J Bacteriol (2007) 0.87
Analysis of Staphylococcus aureus gene expression during PMN phagocytosis. Methods Mol Biol (2008) 0.84
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell Microbiol (2004) 3.26
A crucial role for exopolysaccharide modification in bacterial biofilm formation, immune evasion, and virulence. J Biol Chem (2004) 3.05
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils. Proc Natl Acad Sci U S A (2003) 2.54
Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain. J Infect Dis (2004) 2.29
Staphylococcus quorum sensing in biofilm formation and infection. Int J Med Microbiol (2006) 2.25
Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression. Proc Natl Acad Sci U S A (2002) 1.85
Identification and characterization of a novel heme-associated cell surface protein made by Streptococcus pyogenes. Infect Immun (2002) 1.79
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis. Mol Microbiol (2010) 1.71
Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One (2011) 1.71
Identification and characterization of HtsA, a second heme-binding protein made by Streptococcus pyogenes. Infect Immun (2003) 1.68
An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation. J Leukoc Biol (2003) 1.66
Key role of poly-gamma-DL-glutamic acid in immune evasion and virulence of Staphylococcus epidermidis. J Clin Invest (2005) 1.64
Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease. J Immunol (2004) 1.63
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J Immunol (2005) 1.53
Role of the luxS quorum-sensing system in biofilm formation and virulence of Staphylococcus epidermidis. Infect Immun (2006) 1.51
Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz) (2006) 1.42
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells. Proc Natl Acad Sci U S A (2002) 1.42
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor. J Leukoc Biol (2005) 1.28
Characterization of the Staphylococcus epidermidis accessory-gene regulator response: quorum-sensing regulation of resistance to human innate host defense. J Infect Dis (2006) 1.25
Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J Immunol (2003) 1.24
Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. PLoS One (2012) 1.18
Engagement of the pathogen survival response used by group A Streptococcus to avert destruction by innate host defense. J Immunol (2004) 1.17
Opsonophagocytosis-inhibiting mac protein of group a streptococcus: identification and characteristics of two genetic complexes. Infect Immun (2002) 1.16
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol (2002) 1.14
Regulation of the neutrophil-mediated inflammatory response to infection. Microbes Infect (2003) 1.08
Conversion of Staphylococcus epidermidis strains from commensal to invasive by expression of the ica locus encoding production of biofilm exopolysaccharide. Infect Immun (2005) 1.06
Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins. J Bacteriol (2012) 1.06
Characterization of an extracellular virulence factor made by group A Streptococcus with homology to the Listeria monocytogenes internalin family of proteins. Infect Immun (2003) 1.05
The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection. PLoS One (2011) 1.05
Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infect Immun (2013) 1.01
Community-associated methicillin-resistant Staphylococcus aureus skin infections: advances toward identifying the key virulence factors. Curr Opin Infect Dis (2008) 1.00
SarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis. J Infect Dis (2008) 0.95
The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. J Innate Immun (2013) 0.89
The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300. J Leukoc Biol (2013) 0.88
18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob Agents Chemother (2012) 0.88
Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics. ACS Chem Biol (2013) 0.84
SpyA, a C3-like ADP-ribosyltransferase, contributes to virulence in a mouse subcutaneous model of Streptococcus pyogenes infection. Infect Immun (2011) 0.81
The SaeR/S two-component system induces interferon-gamma production in neutrophils during invasive Staphylococcus aureus infection. Microbes Infect (2013) 0.79