Mechanisms of acetaminophen-induced liver necrosis.

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Published in Handb Exp Pharmacol on January 01, 2010

Authors

Jack A Hinson1, Dean W Roberts, Laura P James

Author Affiliations

1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. hinsonjacka@uams.edu

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Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther (1973) 5.23

Acute liver necrosis following overdose of paracetamol. Br Med J (1966) 4.75

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Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40

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Liver necrosis from paracetamol. Br J Pharmacol Chemother (1966) 3.77

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Role of metals in oxygen radical reactions. J Free Radic Biol Med (1985) 3.22

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Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem (2008) 3.08

Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet (1977) 3.00

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Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol (2001) 2.18

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Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut (2006) 1.82

Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics (1978) 1.80

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Role of neutrophils in acute inflammatory liver injury. Liver Int (2006) 1.72

Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J (1992) 1.72

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Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol (1991) 1.57

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The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. Drug Metab Dispos (2006) 1.54

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The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol (1983) 1.24

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Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture. J Biol Chem (1993) 1.24

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol Appl Pharmacol (2002) 1.23

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NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver Physiol (2004) 1.23

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Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha. Toxicol Pathol (1997) 1.22

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Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptosis. Int J Mol Epidemiol Genet (2010) 0.84

Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med (2011) 0.83

Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines. Chem Res Toxicol (2004) 0.83

Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity. Chem Biol Interact (2010) 0.82

Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther (2012) 0.82

Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Toxicol Environ Health A (2007) 0.81

Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J (2012) 0.80

Coma in a 20-month-old child from an ingestion of a toy containing 1,4-butanediol, a precursor of gamma-hydroxybutyrate. Pediatr Emerg Care (2009) 0.80

Complications and outcomes of brown recluse spider bites in children. Clin Pediatr (Phila) (2011) 0.80

Accuracy of the Spacelabs 90217 ambulatory blood pressure monitor in a pediatric population. Blood Press Monit (2015) 0.80

Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr (2015) 0.80

A multicenter, randomized, open-label, pharmacokinetics and safety study of pantoprazole tablets in children and adolescents aged 6 through 16 years with gastroesophageal reflux disease. J Clin Pharmacol (2010) 0.79

Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging (2011) 0.79

Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity. Neurotoxicology (2013) 0.79

Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol (2011) 0.78

Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology. Anal Chem (2013) 0.78

Sulfaphenazole and α-naphthoflavone attenuate the metabolism of the synthetic cannabinoids JWH-018 and AM2201 found in K2/spice. Drug Metab Lett (2013) 0.78

Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS. Anal Chem (2014) 0.78

Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol (2012) 0.77

Pharmacokinetics of famotidine in infants. Clin Pharmacokinet (2005) 0.76

Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. Pediatr Infect Dis J (2017) 0.75

Famotidine disposition in children and adolescents with chronic renal insufficiency. J Clin Pharmacol (2003) 0.75

Methamphetamine exposure presenting as caustic ingestions in children. Ann Emerg Med (2006) 0.75

Digital radiography in the diagnosis of Toddler's fracture. South Med J (2003) 0.75

The use and tolerability of Crotalidae Polyvalent Immune FAB (Ovine) in pediatric envenomations. Clin Pediatr (Phila) (2012) 0.75

Methemoglobinemia associated with metoclopramide therapy in a neonate. J Pediatr Pharmacol Ther (2004) 0.75