Leukaemogenesis: more than mutant genes.

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Published in Nat Rev Cancer on January 01, 2010

Authors

Jianjun Chen1, Olatoyosi Odenike, Janet D Rowley

Author Affiliations

1: Department of Medicine, University of Chicago, IL 60637, USA.

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature (1973) 15.28

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Selective blockade of microRNA processing by Lin28. Science (2008) 14.39

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Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A (1982) 10.50

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Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol (2002) 9.83

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell (1991) 9.40

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell (1991) 8.98

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MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer (2007) 8.17

MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17

Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14

Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell (1984) 6.78

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Acute promyelocytic leukemia: from highly fatal to highly curable. Blood (2008) 5.35

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature (1998) 5.30

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature (1990) 5.24

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An E2F/miR-20a autoregulatory feedback loop. J Biol Chem (2006) 5.20

FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist (2007) 4.95

MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med (2008) 4.91

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Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem (2006) 4.57

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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A (2008) 4.26

Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell (2008) 4.20

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CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A (2007) 4.06

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MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci U S A (2006) 3.80

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Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J (1993) 3.58

Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med (1991) 3.52

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood (2008) 3.50

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood (2009) 3.35

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science (1990) 3.34

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Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood (2007) 3.27

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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13

HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood (2008) 3.12

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol (1998) 3.06

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02

Chromosome translocations: dangerous liaisons revisited. Nat Rev Cancer (2001) 3.01

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 3.00

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Emerging role of the histone deacetylase inhibitor romidepsin in hematologic malignancies. Expert Opin Pharmacother (2010) 0.78

Targeting mutations predictably. Blood (2011) 0.77

Chronic myeloid leukemia: current perspectives. Clin Lab Med (2011) 0.77

Comparative gene mapping in cattle, Indian muntjac, and Chinese muntjac by fluorescence in situ hybridization. Genetica (2008) 0.77

Generation of longer cDNA fragments from SAGE tags for gene identification. Methods Mol Biol (2003) 0.77

Harmful moratorium on stem cell research. Science (2002) 0.77

Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia. Blood Cells Mol Dis (2012) 0.77

Late-phase investigational approaches for the treatment of relapsed/refractory acute myeloid leukemia. Expert Opin Pharmacother (2012) 0.76

Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. Leuk Lymphoma (2010) 0.76

High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML). Leuk Lymphoma (2012) 0.76

Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale. Cancer Genet Cytogenet (2007) 0.75

Myelofibrosis with myeloid metaplasia: where is the biology leading us? Semin Oncol (2005) 0.75

Screening poly [dA/dT(-)] cDNA for gene identification. Methods Mol Biol (2003) 0.75

Molecular cytogenetic characterization of breakpoints in 19 patients with hematologic malignancies and 12p unbalanced translocations. Cancer Genet Cytogenet (2003) 0.75

Prognostic significance of the AML1-ETO fusion transcript expression in children and young adults with t(8;21) acute myeloid leukemia. Haematologica (2003) 0.75

A 32-year-old man with persistent cough, shortness of breath, eosinophilic pneumonia, and peripheral blood eosinophilia. Myeloid neoplasm associated with eosinophilia and platelet-derived growth factor receptor-alpha rearrangement. Chest (2012) 0.75

t(1;3)(p36;p21) is a recurring therapy-related translocation. Genes Chromosomes Cancer (2002) 0.75