Published in J Clin Invest on December 14, 2009
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J (2011) 1.67
Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq. Circ Res (2010) 1.61
Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy. PLoS Genet (2010) 1.37
Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. Proc Natl Acad Sci U S A (2011) 1.33
A human 3' miR-499 mutation alters cardiac mRNA targeting and function. Circ Res (2012) 1.29
Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases. Circ Res (2013) 1.01
Small heat shock proteins in redox metabolism: implications for cardiovascular diseases. Int J Biochem Cell Biol (2012) 0.99
The sarcomeric Z-disc and Z-discopathies. J Biomed Biotechnol (2011) 0.99
The genomic architecture of sporadic heart failure. Circ Res (2011) 0.95
A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum Genet (2012) 0.86
Clinical considerations of heritable factors in common heart failure. Circ Cardiovasc Genet (2011) 0.84
Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells. Diabetes (2015) 0.82
Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish. Dev Biol (2013) 0.81
Microarray analysis of port wine stains before and after pulsed dye laser treatment. Lasers Surg Med (2013) 0.81
Linking Genes to Cardiovascular Diseases: Gene Action and Gene-Environment Interactions. J Cardiovasc Transl Res (2015) 0.80
Polymorphism of ZBTB17 gene is associated with idiopathic dilated cardiomyopathy: a case control study in a Han Chinese population. Eur J Med Res (2013) 0.79
Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation. Int J Oncol (2014) 0.77
Association of an intronic, but not any exonic, FRMD4B sequence variant and heart failure. Clin Transl Sci (2010) 0.76
Common Variants for Heart Failure. Curr Genomics (2015) 0.75
Common variant rs7597774 in ADD2 is associated with dilated cardiomyopathy in Chinese Han population. Int J Clin Exp Med (2015) 0.75
Genetic polymorphisms associated with heart failure: A literature review. J Int Med Res (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Genetic mapping in human disease. Science (2008) 15.12
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet (2004) 14.76
Accounting for human polymorphisms predicted to affect protein function. Genome Res (2002) 14.10
The UCSC Genome Browser Database: update 2009. Nucleic Acids Res (2008) 10.31
Advanced sequencing technologies: methods and goals. Nat Rev Genet (2004) 9.31
Positive and negative selection on the human genome. Genetics (2001) 7.25
Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78
Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol (2004) 6.45
A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol (2008) 5.07
Translating insights from the cancer genome into clinical practice. Nature (2008) 4.37
Next-generation sequencing: from basic research to diagnostics. Clin Chem (2009) 4.18
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (2003) 3.71
The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet (2003) 3.67
Quantification of rare allelic variants from pooled genomic DNA. Nat Methods (2009) 3.66
Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA (2005) 3.16
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
Race, quality of care, and outcomes of elderly patients hospitalized with heart failure. JAMA (2003) 2.77
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A (2006) 2.05
Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation (2006) 2.00
Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest (2006) 1.81
Genetics of essential hypertension. Am J Med (1993) 1.70
The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. J Clin Invest (1998) 1.65
Clinical and genetic modifiers of long-term survival in heart failure. J Am Coll Cardiol (2009) 1.42
Phospholamban and cardiac contractile function. J Mol Cell Cardiol (2000) 1.32
Simple method to analyze SNP-based association studies using DNA pools. Genet Epidemiol (2003) 1.29
Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA. Proc Natl Acad Sci U S A (2003) 1.27
Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues. J Biol Chem (1999) 1.26
Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol Ther (2007) 1.26
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nat Clin Pract Cardiovasc Med (2008) 1.21
Molecular genetics of atrial fibrillation. J Am Coll Cardiol (2008) 1.15
Phospholamban R14 deletion results in late-onset, mild, hereditary dilated cardiomyopathy. J Am Coll Cardiol (2006) 1.04
Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. J Biol Chem (2008) 0.94
Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension. J Hypertens (2006) 0.94
The natural history, epidemiology, and prognosis of heart failure in African Americans. Congest Heart Fail (2004) 0.93
Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation. J Transl Med (2008) 0.86
Alpha- and beta-adrenergic receptor polymorphisms in hypertensive and normotensive offspring. J Cardiovasc Med (Hagerstown) (2006) 0.84
Low sequence variation in the gene encoding the human beta-myosin heavy chain. Genomics (2001) 0.81
Polymorphisms of beta-adrenergic receptors in heart failure. Am J Med (2004) 0.80
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
Advanced sequencing technologies: methods and goals. Nat Rev Genet (2004) 9.31
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
Identifying genetic determinants needed to establish a human gut symbiont in its habitat. Cell Host Microbe (2009) 6.67
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (2010) 5.31
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med (2010) 4.31
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature (2002) 3.92
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Quantification of rare allelic variants from pooled genomic DNA. Nat Methods (2009) 3.66
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. N Engl J Med (2016) 3.40
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation (2005) 3.25
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation (2003) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS One (2012) 3.11
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res (2011) 2.99
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. J Card Fail (2009) 2.89
Inflammation impairs reverse cholesterol transport in vivo. Circulation (2009) 2.86
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat Med (2003) 2.83
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab (2003) 2.72
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation (2009) 2.70
Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation (2003) 2.70
Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res (2005) 2.67
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51
Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab (2007) 2.48
Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol (2008) 2.42
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res (2009) 2.40
Phenotyping hypertrophy: eschew obfuscation. Circ Res (2003) 2.32
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res (2011) 2.32
Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res (2011) 2.27
Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes (2009) 2.27
Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25
Genetically determined height and coronary artery disease. N Engl J Med (2015) 2.24
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest (2007) 2.23
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res (2008) 2.22
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation (2008) 2.21
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
BET bromodomains mediate transcriptional pause release in heart failure. Cell (2013) 2.17
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure. J Am Coll Cardiol (2011) 2.09
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res (2006) 2.08
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med (2002) 2.05
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A (2006) 2.05
Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation (2006) 2.00
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure. Circ Heart Fail (2010) 1.96
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol (2007) 1.87
Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. J Am Coll Cardiol (2013) 1.86
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86
Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A (2010) 1.85
Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev (2003) 1.84
High-throughput discovery of rare insertions and deletions in large cohorts. Genome Res (2010) 1.83
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest (2009) 1.83
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet (2010) 1.79
Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy. Circ Res (2012) 1.79
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Physiology (Bethesda) (2007) 1.78