Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 3378134)

Published in EMBO Mol Med on July 01, 2009

Authors

Marie Littmann1, Barbara Albiger, Anne Frentzen, Staffan Normark, Birgitta Henriques-Normark, Laura Plant

Author Affiliations

1: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 16, Stockholm SE-171 77, Sweden.

Articles citing this

The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73

Regulation of inflammasome signaling. Nat Immunol (2012) 4.10

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice. J Clin Invest (2011) 1.53

Inflammasome inhibition as a pathogenic stealth mechanism. Cell Host Microbe (2010) 1.47

Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. J Immunol (2011) 1.33

The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med (2013) 1.21

Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease. Mediators Inflamm (2013) 1.01

Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias. J Infect Dis (2011) 0.96

Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun (2011) 0.96

Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood. Infect Immun (2011) 0.94

Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem (2012) 0.92

Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia. Front Cell Infect Microbiol (2013) 0.87

Alcohol abuse and Streptococcus pneumoniae infections: consideration of virulence factors and impaired immune responses. Alcohol (2011) 0.87

Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function. BMC Infect Dis (2011) 0.87

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation. MBio (2014) 0.86

The β-hemolysin and intracellular survival of Streptococcus agalactiae in human macrophages. PLoS One (2013) 0.84

The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice. PLoS One (2015) 0.83

Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. BMC Infect Dis (2013) 0.82

Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae. Cell Microbiol (2013) 0.81

Roles of virulence genes (PsaA and CpsA) on the invasion of Streptococcus pneumoniae into blood system. Eur J Med Res (2013) 0.80

Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan) (2016) 0.79

The influence of infectious factors on dendritic cell apoptosis. Arch Med Sci (2015) 0.78

Toll-Like Receptor 3/TRIF-Dependent IL-12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells. MBio (2016) 0.78

Inflammasome/IL-1β Responses to Streptococcal Pathogens. Front Immunol (2015) 0.78

An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner. J Infect Dis (2014) 0.78

Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner. PLoS One (2015) 0.77

Fatal infection in adults by pneumolysin & autolysin producing, non-vaccine serotype Streptococcus pneumonia. Indian J Med Res (2016) 0.75

Articles cited by this

Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med (1994) 21.52

Role of hemolysin for the intracellular growth of Listeria monocytogenes. J Exp Med (1988) 12.95

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07

Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes. Infect Immun (1986) 10.02

Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae. Infect Immun (1987) 4.92

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A (2003) 4.56

Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infect Immun (1983) 3.85

Activation of human complement by the pneumococcal toxin pneumolysin. Infect Immun (1984) 3.47

Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun (2005) 3.39

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci U S A (1993) 3.25

Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen. Clin Infect Dis (2006) 3.01

An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis (2002) 2.94

Host cellular immune response to pneumococcal lung infection in mice. Infect Immun (2000) 2.74

Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50

Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates. J Clin Microbiol (2003) 2.17

Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infect Immun (1984) 2.12

Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics (2002) 2.08

Epithelial cells are sensitive detectors of bacterial pore-forming toxins. J Biol Chem (2006) 1.90

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature (2008) 1.89

Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (2003) 1.88

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86

CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun (2004) 1.70

Intracellular trafficking and killing of Streptococcus pneumoniae by human alveolar macrophages are influenced by opsonins. Infect Immun (2000) 1.48

Pediatric parapneumonic empyema, Spain. Emerg Infect Dis (2008) 1.48

Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32

Critical involvement of pneumolysin in production of interleukin-1alpha and caspase-1-dependent cytokines in infection with Streptococcus pneumoniae in vitro: a novel function of pneumolysin in caspase-1 activation. Infect Immun (2008) 1.30

Pneumolysin localizes to the cell wall of Streptococcus pneumoniae. J Bacteriol (2009) 1.28

Culture-negative childhood empyema is usually due to penicillin-sensitive Streptococcus pneumoniae capsular serotype 1. J Clin Microbiol (2003) 1.28

Antigen presentation in the lung. Am J Respir Crit Care Med (2000) 1.23

Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J Immunol (2003) 1.18

Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin. J Clin Microbiol (2006) 1.18

Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance. J Infect Dis (2003) 1.18

Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks. J Infect Dis (2007) 1.16

Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis (2004) 1.11

FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells. J Immunol (2007) 1.06

Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infect Immun (2004) 0.94

Characterization of dendritic cell populations in the respiratory tract. J Aerosol Med (2000) 0.93

Host cell responses of Salmonella typhimurium infected human dendritic cells. Immunol Cell Biol (2006) 0.81

Articles by these authors

Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (2002) 5.58

An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps. Curr Biol (2006) 3.69

Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06

Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2009) 2.80

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A (2014) 2.63

Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med (2002) 2.53

Bacterial adhesins in host-microbe interactions. Cell Host Microbe (2009) 2.43

Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol (2002) 2.33

The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells. Res Microbiol (2002) 2.18

Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med (2007) 2.11

Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. J Exp Med (2003) 2.05

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis. Proc Natl Acad Sci U S A (2006) 2.01

Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps. Cell Microbiol (2007) 1.99

Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics (2014) 1.86

CD46 in meningococcal disease. Science (2003) 1.84

Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children. J Infect Dis (2013) 1.84

Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica. Proc Natl Acad Sci U S A (2002) 1.83

Epidemiology of severe Streptococcus pyogenes disease in Europe. J Clin Microbiol (2008) 1.81

Neutrophil extracellular traps: casting the NET over pathogenesis. Curr Opin Microbiol (2007) 1.80

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut (2014) 1.70

Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol (2006) 1.62

Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans. J Infect Dis (2014) 1.62

Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol (2005) 1.59

Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging. Cell Microbiol (2005) 1.53

Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle. FEBS Lett (2007) 1.50

Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related. J Infect Dis (2008) 1.49

The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources. J Bacteriol (2003) 1.44

ETosis: a novel cell death pathway. Sci Signal (2008) 1.41

Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4. J Infect Dis (2003) 1.39

Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy. BMC Microbiol (2007) 1.33

The rise and fall of bacterial clones: Streptococcus pneumoniae. Nat Rev Microbiol (2008) 1.32

Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease. Infect Immun (2003) 1.32

Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications. Microbes Infect (2003) 1.30

High abundance of virulence gene homologues in marine bacteria. Environ Microbiol (2009) 1.27

Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci. J Infect Dis (2008) 1.24

LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan. J Biol Chem (2012) 1.23

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol (2009) 1.23

Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22

Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37. Cell Microbiol (2005) 1.22

hepatitis c Virus p7 is critical for capsid assembly and envelopment. PLoS Pathog (2013) 1.20

Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology. J Clin Microbiol (2007) 1.20

Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance. J Infect Dis (2003) 1.18

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol (2009) 1.18

Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet (2013) 1.17

Molecular characterization of the acid-inducible asr gene of Escherichia coli and its role in acid stress response. J Bacteriol (2003) 1.16

Developmental switch of intestinal antimicrobial peptide expression. J Exp Med (2008) 1.11

Disulfide bond formation and cysteine exclusion in gram-positive bacteria. J Biol Chem (2009) 1.09

Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly. J Virol (2013) 1.09

An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection. Proc Natl Acad Sci U S A (2006) 1.09

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. MBio (2012) 1.07

MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. PLoS Pathog (2012) 1.07

Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05

The ScpC protease of Streptococcus pyogenes affects the outcome of sepsis in a murine model. Infect Immun (2008) 1.02

Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases. PLoS One (2008) 1.02

Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS One (2009) 1.02

C-terminal peptides of tissue factor pathway inhibitor are novel host defense molecules. J Biol Chem (2010) 1.02

Components of the peptidoglycan-recycling pathway modulate invasion and intracellular survival of Salmonella enterica serovar Typhimurium. Cell Microbiol (2005) 1.00

Studies on the antibacterial effects of statins--in vitro and in vivo. PLoS One (2011) 1.00

Human-like immune responses in CD46 transgenic mice. J Immunol (2005) 1.00

TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14. Cell Microbiol (2002) 0.99

The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol Rev (2006) 0.99

Fimbriae, pili, flagella and bacterial virulence. Contrib Microbiol (2005) 0.99

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun (2010) 0.96

Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae. Infect Immun (2011) 0.96

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells. BMC Microbiol (2009) 0.94

Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype. J Bacteriol (2005) 0.94

Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae. Infect Immun (2010) 0.93

The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract. BMC Microbiol (2006) 0.93

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis. Proc Natl Acad Sci U S A (2013) 0.93

Characterization of hepatitis C virus intra- and intergenotypic chimeras reveals a role of the glycoproteins in virus envelopment. J Virol (2013) 0.92

A changing gastric environment leads to adaptation of lipopolysaccharide variants in Helicobacter pylori populations during colonization. PLoS One (2009) 0.91

Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes. FEMS Microbiol Lett (2009) 0.90

Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae. MBio (2014) 0.90

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. J Bacteriol (2013) 0.90