Published in Drug Metab Dispos on January 07, 2010
Regioselective glucuronidation of andrographolide and its major derivatives: metabolite identification, isozyme contribution, and species differences. AAPS J (2014) 0.78
Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Sci Rep (2015) 0.76
Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol (2017) 0.75
Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes. Int J Mol Sci (2016) 0.75
Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species. Eur J Drug Metab Pharmacokinet (2017) 0.75
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest (2011) 5.75
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell (2009) 4.56
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet (2016) 4.49
High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation (2007) 4.36
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol (2006) 3.40
The changing face of HIV in China. Nature (2008) 3.39
Nitrogen-doped graphene as efficient metal-free electrocatalyst for oxygen reduction in fuel cells. ACS Nano (2010) 3.26
Graphene at the edge: stability and dynamics. Science (2009) 3.17
Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J Bacteriol (2006) 3.14
Responsiveness to reduced dosage of rituximab in Chinese patients with neuromyelitis optica. Neurology (2013) 3.13
IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood (2009) 3.04
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A (2002) 2.94
Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet (2009) 2.93
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83
Melamine related bilateral renal calculi in 50 children: single center experience in clinical diagnosis and treatment. J Urol (2010) 2.83
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol (2009) 2.76
Long noncoding RNAs with snoRNA ends. Mol Cell (2012) 2.71
Brain anatomical network and intelligence. PLoS Comput Biol (2009) 2.68
Circular intronic long noncoding RNAs. Mol Cell (2013) 2.62
The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
Conservation of an RNA regulatory map between Drosophila and mammals. Genome Res (2010) 2.43
Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med (2006) 2.43
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med (2010) 2.41
Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med (2006) 2.37
Genome-wide analysis of promoter architecture in Drosophila melanogaster. Genome Res (2010) 2.29
Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genomics (2013) 2.27
Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J Virol (2012) 2.21
Comparative evaluation of tandem MS search algorithms using a target-decoy search strategy. Mol Cell Proteomics (2007) 2.13
Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int (2012) 2.12
Circumcision with a novel disposable device in Chinese children: a randomized controlled trial. Int J Urol (2012) 2.12
Clinical pharmacy education in China. Am J Pharm Educ (2008) 2.10
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neurosci Lett (2007) 2.10
Body mass index and mortality in China: a 15-year prospective study of 220 000 men. Int J Epidemiol (2012) 2.09
The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics (2012) 2.08
The microRNA-regulated SBP-Box transcription factor SPL3 is a direct upstream activator of LEAFY, FRUITFULL, and APETALA1. Dev Cell (2009) 2.07
Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol (2007) 2.00
Rare diseases and legislation in China. Lancet (2010) 1.96
Disparities in trends of hospitalization for potentially preventable chronic conditions among African Americans during the 1990s: implications and benchmarks. Am J Public Health (2003) 1.94
Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells (2011) 1.90
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol (2012) 1.87
A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol Biol Evol (2010) 1.86
Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res (2010) 1.83
Functional MRI in attention-deficit hyperactivity disorder: evidence for hypofrontality. Brain Dev (2005) 1.81
Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAIle gene in a large Han Chinese family. Circ Res (2011) 1.81
Application of multivariate statistical methods to water quality assessment of the watercourses in Northwestern New Territories, Hong Kong. Environ Monit Assess (2006) 1.80
Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss. Mitochondrion (2010) 1.80
KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest (2015) 1.80
MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler Thromb Vasc Biol (2011) 1.80
Highly efficient and specific genome editing in silkworm using custom TALENs. PLoS One (2012) 1.80
Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J (2014) 1.79
Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab (2007) 1.77
TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov (2013) 1.76
Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank. J Hypertens (2012) 1.74
Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia. Schizophr Res (2008) 1.72
Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells. Cell Cycle (2010) 1.71
CT-guided percutaneous chemical ablation of adrenal neoplasms. AJR Am J Roentgenol (2008) 1.70
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet (2013) 1.69
Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol (2003) 1.68
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci U S A (2003) 1.68
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci (2009) 1.65
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell (2012) 1.64
Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res (2008) 1.64
Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci (2010) 1.63
The molecular etiology of breast cancer: evidence from biomarkers of risk. Int J Cancer (2008) 1.62
Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol (2003) 1.60
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone. Genomics (2007) 1.59
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest (2014) 1.58
TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clin Cancer Res (2014) 1.58
MIPSPlantsDB--plant database resource for integrative and comparative plant genome research. Nucleic Acids Res (2007) 1.58
A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem (2011) 1.57
Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric Food Chem (2008) 1.57
Feasibility study of semiconductor sequencing for noninvasive prenatal detection of fetal aneuploidy. Clin Chem (2013) 1.57
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes (2011) 1.55
Long-term results of operation for 420 patients with early squamous cell esophageal carcinoma discovered by screening. Ann Thorac Surg (2004) 1.55
Efficacy of contrast-enhanced US and magnetic microbubbles targeted to vascular cell adhesion molecule-1 for molecular imaging of atherosclerosis. Radiology (2011) 1.55
Expression of hedgehog signaling molecules in lung cancer. Acta Histochem (2010) 1.52
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Strain-engineering the anisotropic electrical conductance of few-layer black phosphorus. Nano Lett (2014) 1.52
Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment. Gastroenterology (2011) 1.51
Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2007) 1.51
Contrast medium volume to creatinine clearance ratio: a predictor of contrast-induced nephropathy in the first 72 hours following percutaneous coronary intervention. Catheter Cardiovasc Interv (2011) 1.50
Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese. J Clin Endocrinol Metab (2008) 1.50
Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther (2011) 1.50
Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis (2006) 1.49
The first insight into the tissue specific taxus transcriptome via Illumina second generation sequencing. PLoS One (2011) 1.49
Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology (2013) 1.48
Pituicytoma presenting with atypical histological features. Pathology (2009) 1.48
A dammarane glycoside derived from ginsenoside Rb3. Chem Pharm Bull (Tokyo) (2005) 1.47
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. Cancer Res (2009) 1.46