Molecular replacement with MOLREP.

Overview of the CCP4 suite and current developments. Acta Crystallogr D Biol Crystallogr (2011) 67.55

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease. Nature (2014) 3.72

Highly conserved protective epitopes on influenza B viruses. Science (2012) 3.47

Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER. Acta Crystallogr D Biol Crystallogr (2012) 3.05

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog (2013) 2.66

How insulin engages its primary binding site on the insulin receptor. Nature (2013) 2.52

Elongation factor G bound to the ribosome in an intermediate state of translocation. Science (2013) 2.12

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat Commun (2012) 2.01

In situ macromolecular crystallography using microbeams. Acta Crystallogr D Biol Crystallogr (2012) 1.94

Structure and flexibility of the complete periplasmic domain of BamA: the protein insertion machine of the outer membrane. Structure (2010) 1.92

Structure and function of Zucchini endoribonuclease in piRNA biogenesis. Nature (2012) 1.90

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions. Acta Crystallogr D Biol Crystallogr (2015) 1.89

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol (2011) 1.87

Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature (2013) 1.85

The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70

Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature (2011) 1.67

Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A (2010) 1.66

Improvement of molecular-replacement models with Sculptor. Acta Crystallogr D Biol Crystallogr (2011) 1.61

Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron (2015) 1.58

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist. Nat Neurosci (2011) 1.58

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers. J Virol (2013) 1.54

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48

A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature. Dev Cell (2014) 1.47

AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell (2014) 1.43

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nat Struct Mol Biol (2014) 1.40

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation. EMBO J (2012) 1.39

Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors. Acta Crystallogr D Biol Crystallogr (2014) 1.39

Structural basis for catalytic activation of a serine recombinase. Structure (2011) 1.39

Retracted Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of aspartyl aminopeptidase from the apeB gene of Pseudomonas aeruginosa. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 1.38

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs. PLoS One (2016) 1.38

Loss of T cell antigen recognition arising from changes in peptide and major histocompatibility complex protein flexibility: implications for vaccine design. J Biol Chem (2011) 1.37

Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein. Nat Methods (2014) 1.36

Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat Struct Mol Biol (2010) 1.33

Room-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposure. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 1.33

Experience with exchange and archiving of raw data: comparison of data from two diffractometers and four software packages on a series of lysozyme crystals. J Appl Crystallogr (2012) 1.32

ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature (2014) 1.32

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood (2012) 1.31

Crystal structures of a double-barrelled fluoride ion channel. Nature (2015) 1.28

Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature (2015) 1.27

Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures. Nature (2013) 1.26

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2011) 1.26

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics (2012) 1.25

Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol (2012) 1.24

Comparative structural analysis of human DEAD-box RNA helicases. PLoS One (2010) 1.21

Phaser.MRage: automated molecular replacement. Acta Crystallogr D Biol Crystallogr (2013) 1.20

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP. Nat Struct Mol Biol (2014) 1.20

Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation. Nat Struct Mol Biol (2012) 1.20

Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein. J Biol Chem (2012) 1.19

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus. Nucleic Acids Res (2010) 1.19

Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase. PLoS One (2011) 1.19

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature (2014) 1.19

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein. J Biol Chem (2010) 1.18

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc Natl Acad Sci U S A (2011) 1.18

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease. J Biol Chem (2010) 1.17

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers. Proc Natl Acad Sci U S A (2011) 1.17

Crystal structure of bacteriophage SPP1 distal tail protein (gp19.1): a baseplate hub paradigm in gram-positive infecting phages. J Biol Chem (2010) 1.16

Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody. Structure (2010) 1.15

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nat Struct Mol Biol (2011) 1.14

Crystal structure of the eukaryotic origin recognition complex. Nature (2015) 1.14

Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14

Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. J Biol Chem (2014) 1.14

Structure and molecular assignment of lactococcal phage TP901-1 baseplate. J Biol Chem (2010) 1.13

Biogenesis and structure of a type VI secretion membrane core complex. Nature (2015) 1.12

INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis. Proc Natl Acad Sci U S A (2012) 1.11

Oligomycin frames a common drug-binding site in the ATP synthase. Proc Natl Acad Sci U S A (2012) 1.10

Structure and mechanism of the mammalian fructose transporter GLUT5. Nature (2015) 1.09

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol (2010) 1.07

A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes. J Virol (2011) 1.07

Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell (2012) 1.06

Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface. PLoS One (2012) 1.06

Structure-based modification of a Clostridium difficile-targeting endolysin affects activity and host range. J Bacteriol (2011) 1.05

Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth. PLoS Pathog (2013) 1.05

Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump. Nature (2015) 1.05

Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J Biol Chem (2012) 1.04

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody. MAbs (2015) 1.04

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature (2012) 1.04

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB. Elife (2014) 1.04

Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography. J Biol Chem (2014) 1.04

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage. Retrovirology (2013) 1.04

Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. Acta Crystallogr D Biol Crystallogr (2010) 1.04

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. Acta Crystallogr D Biol Crystallogr (2011) 1.04

Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site. Nat Struct Mol Biol (2013) 1.04

The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosine. Nucleic Acids Res (2012) 1.03

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature (2015) 1.03

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature (2013) 1.02

Evaluating the solution from MrBUMP and BALBES. Acta Crystallogr D Biol Crystallogr (2011) 1.02

Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. Nucleic Acids Res (2010) 1.01

Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J Biol Chem (2011) 1.01

CryoEM and molecular dynamics of the circadian KaiB-KaiC complex indicates that KaiB monomers interact with KaiC and block ATP binding clefts. J Mol Biol (2013) 1.00

The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases. Nat Chem Biol (2016) 1.00

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains. Acta Crystallogr D Biol Crystallogr (2013) 1.00

Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep (2014) 1.00

Structure and organization of heteromeric AMPA-type glutamate receptors. Science (2016) 1.00

Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork. Nucleic Acids Res (2015) 1.00

Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proc Natl Acad Sci U S A (2012) 0.99

Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism. Plant Cell (2012) 0.99

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. J Med Chem (2014) 0.99

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Sci Signal (2013) 0.99

Complex between α-bungarotoxin and an α7 nicotinic receptor ligand-binding domain chimaera. Biochem J (2013) 0.98

Structure-kinetic relationship study of CDK8/CycC specific compounds. Proc Natl Acad Sci U S A (2013) 0.98