| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
Science
|
2007
|
43.16
|
|
2
|
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
Nat Genet
|
2008
|
35.06
|
|
3
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
Nature
|
2010
|
28.21
|
|
4
|
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
Nat Genet
|
2008
|
25.83
|
|
5
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
|
6
|
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|
Nat Genet
|
2008
|
22.35
|
|
7
|
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
Nat Genet
|
2008
|
20.66
|
|
8
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
|
9
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
10
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
|
11
|
Identification of ten loci associated with height highlights new biological pathways in human growth.
|
Nat Genet
|
2008
|
16.25
|
|
12
|
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
|
Nat Genet
|
2008
|
15.94
|
|
13
|
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
|
14
|
Genome-wide association study identifies eight loci associated with blood pressure.
|
Nat Genet
|
2009
|
12.44
|
|
15
|
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
|
Lancet
|
2012
|
12.10
|
|
16
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
|
17
|
Variants in MTNR1B influence fasting glucose levels.
|
Nat Genet
|
2008
|
10.85
|
|
18
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
|
19
|
Common variants in the GDF5-UQCC region are associated with variation in human height.
|
Nat Genet
|
2008
|
7.31
|
|
20
|
A map of open chromatin in human pancreatic islets.
|
Nat Genet
|
2010
|
6.75
|
|
21
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
|
22
|
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
|
PLoS Genet
|
2009
|
5.81
|
|
23
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
|
24
|
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
|
Nat Genet
|
2011
|
4.50
|
|
25
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
|
26
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
|
27
|
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
Arterioscler Thromb Vasc Biol
|
2010
|
4.08
|
|
28
|
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
|
Diabetes
|
2010
|
4.07
|
|
29
|
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
|
PLoS Med
|
2011
|
3.94
|
|
30
|
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
|
J Clin Invest
|
2008
|
3.51
|
|
31
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
|
32
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
33
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
|
34
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
|
35
|
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
|
PLoS One
|
2009
|
2.77
|
|
36
|
FTO genotype is associated with phenotypic variability of body mass index.
|
Nature
|
2012
|
2.77
|
|
37
|
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
|
Diabetes
|
2006
|
2.58
|
|
38
|
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.
|
Nat Genet
|
2012
|
2.55
|
|
39
|
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14.
|
Diabetes
|
2004
|
2.46
|
|
40
|
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
|
Diabetes
|
2010
|
2.44
|
|
41
|
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
|
Diabetes
|
2004
|
2.43
|
|
42
|
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
PLoS Genet
|
2012
|
2.34
|
|
43
|
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
|
Nat Genet
|
2010
|
2.30
|
|
44
|
Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.
|
Diabetes
|
2006
|
2.03
|
|
45
|
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.
|
Diabetes
|
2008
|
2.01
|
|
46
|
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
|
Nat Genet
|
2012
|
1.90
|
|
47
|
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.
|
Diabetes
|
2007
|
1.74
|
|
48
|
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database.
|
Genet Epidemiol
|
2006
|
1.74
|
|
49
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
50
|
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.
|
PLoS One
|
2012
|
1.65
|
|
51
|
A computational system to select candidate genes for complex human traits.
|
Bioinformatics
|
2007
|
1.60
|
|
52
|
Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
|
PLoS Genet
|
2013
|
1.57
|
|
53
|
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
|
PLoS Genet
|
2013
|
1.51
|
|
54
|
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.
|
Hum Mol Genet
|
2010
|
1.38
|
|
55
|
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults.
|
Hum Mol Genet
|
2010
|
1.35
|
|
56
|
Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
|
Diabetes
|
2008
|
1.26
|
|
57
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
|
58
|
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
|
PLoS Genet
|
2009
|
1.18
|
|
59
|
Comparison of ENCODE region SNPs between Cebu Filipino and Asian HapMap samples.
|
J Hum Genet
|
2007
|
1.08
|
|
60
|
Finding genes and variants for lipid levels after genome-wide association analysis.
|
Curr Opin Lipidol
|
2012
|
1.08
|
|
61
|
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
|
Obesity (Silver Spring)
|
2010
|
1.05
|
|
62
|
Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK.
|
Hum Mol Genet
|
2010
|
1.05
|
|
63
|
Population-specific coding variant underlies genome-wide association with adiponectin level.
|
Hum Mol Genet
|
2011
|
1.04
|
|
64
|
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|
Inflammation
|
2012
|
0.97
|
|
65
|
Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.
|
Diabetes
|
2013
|
0.94
|
|
66
|
Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort.
|
Diabetes
|
2002
|
0.92
|
|
67
|
Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.
|
Diabetes
|
2013
|
0.92
|
|
68
|
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
|
Hum Mol Genet
|
2013
|
0.91
|
|
69
|
A comprehensive SNP and indel imputability database.
|
Bioinformatics
|
2013
|
0.90
|
|
70
|
Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.
|
Proc Natl Acad Sci U S A
|
2010
|
0.87
|
|
71
|
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
|
J Lipid Res
|
2013
|
0.87
|
|
72
|
Fine-mapping and initial characterization of QT interval loci in African Americans.
|
PLoS Genet
|
2012
|
0.86
|
|
73
|
Obesity genes: so close and yet so far...
|
J Biol
|
2008
|
0.84
|
|
74
|
Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.
|
J Hum Genet
|
2011
|
0.83
|
|
75
|
Nonsynonymous variants and fatty liver disease.
|
Nat Genet
|
2008
|
0.83
|
|
76
|
Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis.
|
Clin Endocrinol (Oxf)
|
2014
|
0.81
|
|
77
|
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
|
PLoS Genet
|
2016
|
0.75
|
|
78
|
ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.
|
medRxiv
|
2020
|
0.75
|
|
79
|
Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
PLoS Genet
|
2017
|
0.75
|
|
80
|
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
|
Circ Cardiovasc Genet
|
2017
|
0.75
|