Published in Biochemistry on January 10, 1978
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem J (1988) 8.02
Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc Natl Acad Sci U S A (1979) 3.33
Purification of a calmodulin-binding protein from chicken gizzard that interacts with F-actin. Proc Natl Acad Sci U S A (1981) 3.14
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein. Mol Cell Biol (1984) 2.98
Calmodulin activation of plant microsomal Ca uptake. Proc Natl Acad Sci U S A (1980) 2.94
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity. Proc Natl Acad Sci U S A (1979) 2.14
Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. Proc Natl Acad Sci U S A (1985) 2.00
Activation of calcineurin by limited proteolysis. Proc Natl Acad Sci U S A (1983) 1.85
Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol (2010) 1.84
Immunocytochemical localization of calmodulin and a heat-labile calmodulin-binding protein (CaM-BP80) in basal ganglia of mouse brain. J Cell Biol (1980) 1.78
Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin-dependent protein kinase. J Cell Biol (1984) 1.61
Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography. Proc Natl Acad Sci U S A (1979) 1.46
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun (2010) 1.40
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell (2008) 1.37
Purification of bovine brain inositol 1,4,5-trisphosphate 3-kinase. Identification of the enzyme by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. Biochem J (1989) 1.30
A rapid and sensitive method for detection and quantification of calcineurin and calmodulin-binding proteins using biotinylated calmodulin. Proc Natl Acad Sci U S A (1985) 1.22
Calmodulin-binding proteins from brain and other tissues. Biochem J (1979) 1.19
The effects of calcium ions, ionophore A23187 and inhibition of energy metabolism on protein degradation in the rat diaphragm and epitrochlearis muscles in vitro. Biochem J (1980) 1.19
Isolation and characterization of calmodulin from an insulin-secreting tumour. Biochem J (1981) 1.12
Calmodulin-binding proteins that interact with actin filaments in a Ca2+-dependent flip-flop manner: survey in brain and secretory tissues. Proc Natl Acad Sci U S A (1983) 1.11
Evidence for the participation of calmodulin in stimulus-secretion coupling in the pancreatic beta-cell. Biochem J (1980) 1.08
Calmodulin isoforms differentially enhance the binding of cauliflower nuclear proteins and recombinant TGA3 to a region derived from the Arabidopsis Cam-3 promoter. Plant Cell (1996) 1.08
Analysis of the state of posttranslational calmodulin methylation in developing pea plants. Plant Physiol (1990) 1.07
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal (2009) 1.06
The preparation of calmodulins from barley (Hordeum sp.) and basidiomycete fungi. Biochem J (1980) 1.06
Calcium-binding modulator protein from the unfertilized egg of the sea urchin Arbacia punctulata. J Cell Biol (1979) 1.05
The binding of calmodulin to myelin basic protein and histone H2B. Biochem J (1980) 1.05
Purification of myosin light chain kinase from bovine cardiac muscle. Proc Natl Acad Sci U S A (1980) 1.03
Preparation of azidocalmodulin: a photoaffinity label for calmodulin-binding proteins. Proc Natl Acad Sci U S A (1981) 1.01
Identification of calmodulin-binding proteins in chicken embryo fibroblasts. J Cell Biol (1984) 0.99
Purification and characterization of caldesmon77: a calmodulin-binding protein that interacts with actin filaments from bovine adrenal medulla. Proc Natl Acad Sci U S A (1985) 0.97
A role for calcineurin in Alzheimer's disease. Curr Neuropharmacol (2011) 0.97
Interactions of basic polypeptides and proteins with calmodulin. Biochem J (1980) 0.95
Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol Rev (2009) 0.93
Structural basis for activation of calcineurin by calmodulin. J Mol Biol (2011) 0.92
Function of calmodulin in postsynaptic densities. I. Presence of a calmodulin-activatable cyclic nucleotide phosphodiesterase activity. J Cell Biol (1981) 0.91
Ca2+-dependent phosphorylation of tyrosine hydroxylase in PC12 cells. J Cell Biol (1985) 0.91
Sequential adsorption-electrophoresis: combined procedure for purification of calcium-dependent cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A (1979) 0.87
Chinese hamster ovary cell population density affects intracellular concentrations of calcium-dependent regulator and ability of regulator to inhibit adenylate cyclase activity. Proc Natl Acad Sci U S A (1979) 0.87
Recognition of β-calcineurin by the domains of calmodulin: thermodynamic and structural evidence for distinct roles. Proteins (2010) 0.86
Calmodulin triggers the resumption of meiosis in amphibian oocytes. J Cell Biol (1981) 0.85
Cytosynalin: a Mr 35,000 cytoskeleton-interacting and calmodulin-binding protein. Proc Natl Acad Sci U S A (1987) 0.84
Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity. Biochem J (1983) 0.84
A novel target recognition revealed by calmodulin in complex with the basic helix--loop--helix transcription factor SEF2-1/E2-2. Protein Sci (2001) 0.83
Identification and characterization of a Ca2+-calmodulin-sensitive cyclic nucleotide phosphodiesterase in a human lymphoblastoid cell line. Biochem J (1987) 0.82
The cytoskeletal system of nucleated erythrocytes. II. presence of a high molecular weight calmodulin-binding protein. J Cell Biol (1982) 0.82
Telokin (kinase-related protein) modulates the oligomeric state of smooth-muscle myosin light-chain kinase and its interaction with myosin filaments. Biochem J (1997) 0.81
Neuroimmunomodulation by calcineurin in aging and Alzheimer's disease. Aging Dis (2010) 0.81
Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase. Biochem J (1992) 0.81
Effects of dehydrouramil on protein phosphorylation and insulin secretion in rat islets of Langerhans. Biochem J (1986) 0.80
Isolation of two myosin light-chain kinases from bovine carotid artery and their regulation by phosphorylation mediated by cyclic AMP-dependent protein kinase. Biochem J (1982) 0.79
Human salivary gustin is a potent activator of calmodulin-dependent brain phosphodiesterase. Proc Natl Acad Sci U S A (1987) 0.78
The metabolism and hormonal responses of human eccrine sweat glands isolated by collagenase digestion. Biochem J (1983) 0.77
Studies on rat parotid-cell actomyosin. Biochem J (1984) 0.77
Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes. J Physiol (2015) 0.77
Kinase-related protein (telokin) is phosphorylated by smooth-muscle myosin light-chain kinase and modulates the kinase activity. Biochem J (1997) 0.77
Calmodulin-binding proteins and calmodulin-regulated enzymes in dog pancreas. Biochem J (1986) 0.76
Purification and characterization of the 27,000 Da calcium-binding protein of bovine brain. Biochem J (1987) 0.75
Calcineurin β protects brain after injury by activating the unfolded protein response. Neurobiol Dis (2016) 0.75
Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci (2017) 0.75
Preliminary crystallization studies of calmodulin-dependent protein phosphatase (calcineurin) from bovine brain. Mol Cell Biochem (1996) 0.75
Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science (1992) 6.16
Calmodulin. Annu Rev Biochem (1980) 4.22
Calmodulin. Adv Protein Chem (1982) 3.89
Identification of the NH2-terminal blocking group of calcineurin B as myristic acid. FEBS Lett (1982) 3.42
Solution structure of calcium-free calmodulin. Nat Struct Biol (1995) 3.36
Calcineurin: a calcium- and calmodulin-binding protein of the nervous system. Proc Natl Acad Sci U S A (1979) 3.33
Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. Nat Struct Biol (2001) 3.18
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry (1992) 3.05
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A (1992) 2.98
Purification and characterization of smooth muscle myosin light chain kinase. J Biol Chem (1981) 2.84
Discovery of a Ca2+- and calmodulin-dependent protein phosphatase: probable identity with calcineurin (CaM-BP80). FEBS Lett (1982) 2.75
Changes in D(--)-beta-hydroxybutyric dehydrogenase activity during brain maturation in the rat. J Biol Chem (1967) 2.55
Conformational transition accompanying the binding of Ca2+ to the protein activator of 3',5'-cyclic adenosine monophosphate phosphodiesterase. Biochemistry (1977) 2.34
Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase. J Biol Chem (1978) 2.33
Calcineurin: from structure to function. Curr Top Cell Regul (2000) 2.10
Positive cooperative binding of calcium to bovine brain calmodulin. Biochemistry (1980) 2.08
Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B. Biochemistry (1994) 2.02
Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Biochemistry (1981) 1.87
Functional domain structure of calcineurin A: mapping by limited proteolysis. Biochemistry (1989) 1.86
Activation of calcineurin by limited proteolysis. Proc Natl Acad Sci U S A (1983) 1.85
Calmodulin. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 1.65
Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin. J Biol Chem (1992) 1.64
Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. Science (1992) 1.53
Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proc Natl Acad Sci U S A (1989) 1.52
Superoxide dismutase protects calcineurin from inactivation. Nature (1996) 1.32
Subunit structure and catalytic properties of bovine brain Ca2+-dependent cyclic nucleotide phosphodiesterase. Biochemistry (1979) 1.29
The processive degradation of individual polyribonucleotide chains. II. Micrococcus lysodeikticus polynucleotide phosphorylase. J Biol Chem (1968) 1.26
Isolation and characterization of bovine brain calcineurin: a calmodulin-stimulated protein phosphatase. Methods Enzymol (1983) 1.23
Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B). Eur J Biochem (1994) 1.23
Calmodulin binding by calcineurin. Ligand-induced renaturation of protein immobilized on nitrocellulose. J Biol Chem (1987) 1.22
Purification of smooth muscle myosin light-chain kinase. Methods Enzymol (1982) 1.21
Interaction of calmodulin with myosin light chain kinase and cAMP-dependent protein kinase in bovine brain. J Biol Chem (1981) 1.21
Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm. J Cell Biol (1988) 1.19
Calcium modulation of inositol 1,4,5-trisphosphate-induced calcium release from neuroblastoma x glioma hybrid (NG108-15) microsomes. J Biol Chem (1986) 1.17
The effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding. J Biol Chem (1989) 1.16
Phosphorylase kinase from rabbit skeletal muscle: identification of the calmodulin-binding subunits. Eur J Biochem (1980) 1.16
A convenient method for the preparation of primer-dependent polynucleotide phosphorylase from Micrococcus lysodeikticus. Biochem Biophys Res Commun (1967) 1.14
Agonist and antagonist properties of calmodulin fragments. J Biol Chem (1984) 1.13
Ultrastructural immunocytochemical localization of calmodulin in cultured cells. J Histochem Cytochem (1983) 1.13
Isotope-edited multidimensional NMR of calcineurin B in the presence of the non-deuterated detergent CHAPS. J Biomol NMR (1993) 1.11
The role of alpha-lactalbumin in lactose synthetase. Biochem Biophys Res Commun (1970) 1.10
The structure of the B subunit of calcineurin. Eur J Biochem (1984) 1.09
Calmodulin activates the isolated catalytic unit of brain adenylate cyclase. J Biol Chem (1981) 1.08
The proteolytic conversion of polynucleotide phosphorylase to a primer-dependent form. J Biol Chem (1969) 1.06
Interaction of 125I-labeled Ca2+-dependent regulator protein with cyclic nucleotide phosphodiesterase and its inhibitory protein. J Biol Chem (1978) 1.04
Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A. Biochemistry (2000) 1.04
Activation of phosphorylase kinase from rabbit skeletal muscle by calmodulin and troponin. FEBS Lett (1979) 1.03
Exocytosis induction in Paramecium tetraurelia cells by exogenous phosphoprotein phosphatase in vivo and in vitro: possible involvement of calcineurin in exocytotic membrane fusion. J Cell Biol (1987) 1.03
Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. Cytogenet Cell Genet (1996) 0.99
Serine/threonine phosphatases in the nervous system. Curr Opin Neurobiol (1991) 0.98
Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem (1986) 0.98
1H, 13C, 15N nuclear magnetic resonance backbone assignments and secondary structure of human calcineurin B. Biochemistry (1994) 0.97
Reversible and irreversible activation of cyclic nucleotide phosphodiesterase: separation of the regulatory and catalytic domains by limited proteolysis. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 0.97
Specific perturbation by Ca2+ of tyrosyl residue 138 of calmodulin. J Biol Chem (1979) 0.94
Solution structure of calmodulin and its complex with a myosin light chain kinase fragment. Cell Calcium (1992) 0.94
Identification and quantification of calcium-binding proteins in squid axoplasm. J Neurosci (1988) 0.94
Polynucleotide phosphorylase of Micrococcus luteus (Micrococcus lysodeikticus). The effect of sulfhydryl compounds on the ability to catalyze the polymerization reaction. J Biol Chem (1968) 0.93
The interaction of -lactalbumin and the A protein of lactose synthetase. J Biol Chem (1972) 0.92
Reversible polymerization of histidine ammonia lyase. The role of sulfhydryl groups in the activity and polymeric state of the enzyme. J Biol Chem (1970) 0.90
Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. Biochem Biophys Res Commun (1994) 0.89
Regulation of the calcium signal by calmodulin. Ciba Found Symp (1986) 0.88
Characterization of the lanthanide ion-binding properties of calcineurin-B using laser-induced luminescence spectroscopy. Biochemistry (1994) 0.87
Purification and characterization of a novel Ca2+-binding protein (CBP-18) from bovine brain. J Biol Chem (1984) 0.86
Spurious protein activators of Bordetella pertussis adenylate cyclase. Eur J Biochem (1981) 0.86
Heteronuclear 3D NMR and isotopic labeling of calmodulin. Towards the complete assignment of the 1H NMR spectrum. Biochem Pharmacol (1990) 0.86
Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin. J Biol Chem (1992) 0.86
Domain II of calmodulin is involved in activation of calcineurin. FEBS Lett (1988) 0.86
Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. DNA (1989) 0.86
Conformation-dependent nitration of the protein activator of cyclic adenosine 3',5'-monophosphate phosphodiesterase. Biochemistry (1978) 0.85
Calcium-induced sensitization of the central helix of calmodulin to proteolysis. Biochemistry (1991) 0.85
Calcium ion dependent covalent modification of calmodulin with norchlorpromazine isothiocyanate. Biochemistry (1983) 0.84
Identification of the calmodulin-regulated protein phosphatase, calcineurin, in rat pancreatic islets. Biochim Biophys Acta (1991) 0.84
Isolation of a cysteine-peptide at the active site of histidine ammonia-lyase. J Biol Chem (1972) 0.84
Metal activation of histidine ammonia-lyase. Metal ion-sulfhydryl group relationship. J Biol Chem (1972) 0.82
Concerted role of calmodulin and calcineurin in calcium regulation. Ann N Y Acad Sci (1980) 0.81
Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. Ann N Y Acad Sci (1980) 0.81
Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A. Eur J Biochem (1989) 0.80
Phenothiazine-binding and attachment sites of CAPP1-calmodulin. Biochemistry (1989) 0.80
Affinity selection of chemically modified proteins: role of lysyl residues in the binding of calmodulin to calcineurin. Biochemistry (1987) 0.80
Activation of enzymes by calmodulins containing intramolecular cross-links. Biochim Biophys Acta (1993) 0.79
The regulation of muscle phosphorylase kinase by calcium ions, calmodulin and troponin-C. Cell Calcium (1981) 0.79
The phosphorylation of calmodulin and calmodulin fragments by kinase fractions from bovine brain. Biochim Biophys Acta (1988) 0.79
Selective affinity chromatography with calmodulin fragments coupled to sepharose. J Biol Chem (1985) 0.79
A deoxyadenylate kinase activity associated with polynucleotide phosphorylase from Micrococcus luteus. Nucleic Acids Res (1976) 0.78
Histidine ammonia-lyase. The use of 4-fluorohistidine in identification of the rate-determining step. J Biol Chem (1975) 0.78
The effect of thyroid on protein synthesis in brain and other organs. Res Publ Assoc Res Nerv Ment Dis (1966) 0.78
There is communication between all four Ca(2+)-bindings sites of calcineurin B. Biochemistry (2001) 0.78
4-Nitro-L-histidine as a substrate for histidine ammonia-lyase: the role of beta-hydrogen acidity in the rate-limiting step. Biochem Biophys Res Commun (1979) 0.78
Large scale preparation of calmodulin. Prep Biochem (1988) 0.78
Stereospecific irreversible inhibition of histidine ammonia-lyase by L-cysteine. Biochemistry (1974) 0.76
Activation of Bordetella pertussis adenylate cyclase by the carboxyl-terminal tryptic fragment of calmodulin. Biochemistry (1986) 0.76