|
1
|
The ToxCast program for prioritizing toxicity testing of environmental chemicals.
|
Toxicol Sci
|
2006
|
4.85
|
|
2
|
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.
|
Environ Health Perspect
|
2010
|
3.84
|
|
3
|
Improving the human hazard characterization of chemicals: a Tox21 update.
|
Environ Health Perspect
|
2013
|
2.95
|
|
4
|
Uncertainties for endocrine disrupters: our view on progress.
|
Toxicol Sci
|
2003
|
2.36
|
|
5
|
Endocrine profiling and prioritization of environmental chemicals using ToxCast data.
|
Environ Health Perspect
|
2010
|
2.06
|
|
6
|
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.
|
Toxicol Sci
|
2011
|
2.03
|
|
7
|
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
|
Environ Health Perspect
|
2011
|
1.57
|
|
8
|
Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential.
|
Environ Health Perspect
|
2011
|
1.57
|
|
9
|
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.
|
Environ Sci Technol
|
2010
|
1.54
|
|
10
|
Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database.
|
Environ Health Perspect
|
2008
|
1.51
|
|
11
|
Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment.
|
Chem Res Toxicol
|
2011
|
1.38
|
|
12
|
Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database.
|
Toxicol Sci
|
2009
|
1.38
|
|
13
|
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
|
Toxicology
|
2011
|
1.36
|
|
14
|
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
|
Chem Res Toxicol
|
2010
|
1.32
|
|
15
|
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
|
Toxicol Sci
|
2010
|
1.30
|
|
16
|
Systems toxicology: from basic research to risk assessment.
|
Chem Res Toxicol
|
2014
|
1.23
|
|
17
|
Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB.
|
Reprod Toxicol
|
2009
|
1.22
|
|
18
|
The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.
|
Drug Discov Today
|
2013
|
1.21
|
|
19
|
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.
|
Toxicol Sci
|
2011
|
1.16
|
|
20
|
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.
|
Chem Res Toxicol
|
2013
|
1.13
|
|
21
|
Predictive model of rat reproductive toxicity from ToxCast high throughput screening.
|
Biol Reprod
|
2011
|
1.07
|
|
22
|
Understanding mechanisms of toxicity: insights from drug discovery research.
|
Toxicol Appl Pharmacol
|
2007
|
1.06
|
|
23
|
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
|
Environ Health Perspect
|
2015
|
1.05
|
|
24
|
Environmental impact on vascular development predicted by high-throughput screening.
|
Environ Health Perspect
|
2011
|
1.05
|
|
25
|
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.
|
Toxicol Sci
|
2012
|
1.00
|
|
26
|
Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity.
|
Toxicol Sci
|
2007
|
0.98
|
|
27
|
Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems.
|
J Biomol Screen
|
2009
|
0.96
|
|
28
|
Gene-environment interactions: a review of effects on reproduction and development.
|
Crit Rev Toxicol
|
2004
|
0.95
|
|
29
|
Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains.
|
Birth Defects Res A Clin Mol Teratol
|
2003
|
0.93
|
|
30
|
Developmental toxicity testing for safety assessment: new approaches and technologies.
|
Birth Defects Res B Dev Reprod Toxicol
|
2011
|
0.90
|
|
31
|
Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.
|
Toxicol Sci
|
2012
|
0.86
|
|
32
|
DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues.
|
Toxicol Sci
|
2002
|
0.84
|
|
33
|
Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009.
|
Neurotoxicol Teratol
|
2010
|
0.83
|
|
34
|
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.
|
Environ Health Perspect
|
2015
|
0.80
|
|
35
|
Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.
|
Chem Res Toxicol
|
2013
|
0.79
|
|
36
|
Using nuclear receptor activity to stratify hepatocarcinogens.
|
PLoS One
|
2011
|
0.79
|
|
37
|
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.
|
Environ Health Perspect
|
2015
|
0.78
|
|
38
|
Gender-based differences in endocrine and reproductive toxicity.
|
Environ Res
|
2006
|
0.77
|
|
39
|
Function of sexual glands and mechanism of sex differentiation.
|
J Toxicol Sci
|
2004
|
0.76
|
|
40
|
In vivo assessment of prenatal developmental toxicity in rodents.
|
Curr Protoc Toxicol
|
2003
|
0.75
|
|
41
|
Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program.
|
Syst Biol Reprod Med
|
2012
|
0.75
|